X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (6092) 6092
Publication (983) 983
Book Chapter (130) 130
Book Review (61) 61
Dissertation (40) 40
Conference Proceeding (23) 23
Book / eBook (12) 12
Magazine Article (7) 7
Web Resource (7) 7
Government Document (4) 4
Reference (2) 2
Data Set (1) 1
Newspaper Article (1) 1
Paper (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (3370) 3370
orexins (3083) 3083
index medicus (2791) 2791
male (2390) 2390
neurosciences (2363) 2363
orexin (2207) 2207
humans (2011) 2011
rats (1717) 1717
neurons (1488) 1488
sleep (1460) 1460
narcolepsy (1210) 1210
hypothalamus (1147) 1147
neuropeptides - metabolism (1090) 1090
hypocretin (1080) 1080
female (1051) 1051
mice (1021) 1021
orexin receptors (929) 929
brain (874) 874
intracellular signaling peptides and proteins - metabolism (842) 842
clinical neurology (757) 757
rats, sprague-dawley (733) 733
intracellular signaling peptides and proteins (709) 709
neurons - metabolism (699) 699
pharmacology & pharmacy (647) 647
endocrinology & metabolism (581) 581
nervous system (574) 574
rat-brain (574) 574
hypothalamus - metabolism (561) 561
neuropeptides (555) 555
orexin-a (547) 547
physiology (543) 543
peptides (540) 540
hypocretin orexin (537) 537
neuropeptides - pharmacology (533) 533
article (526) 526
rats, wistar (520) 520
rat (506) 506
melanin-concentrating hormone (505) 505
neuropeptides - physiology (499) 499
food-intake (496) 496
neurology (482) 482
adult (480) 480
cataplexy (455) 455
biochemistry & molecular biology (451) 451
immunohistochemistry (449) 449
expression (424) 424
sleep - physiology (419) 419
psychiatry (417) 417
neuropeptides - genetics (409) 409
physiological aspects (407) 407
analysis (400) 400
neuropeptide-y (397) 397
arousal (395) 395
wakefulness (395) 395
neurons - drug effects (392) 392
middle aged (391) 391
neurons - physiology (385) 385
obesity (378) 378
lateral hypothalamus (366) 366
leptin (362) 362
rodents (360) 360
sleep disorders (359) 359
intracellular signaling peptides and proteins - physiology (357) 357
dose-response relationship, drug (355) 355
receptors (349) 349
mental disorders (348) 348
mice, inbred c57bl (340) 340
ventral tegmental area (340) 340
receptors, neuropeptide - metabolism (331) 331
receptors, g-protein-coupled (325) 325
orexin neurons (321) 321
wakefulness - physiology (317) 317
feeding-behavior (313) 313
research (303) 303
messenger-rna (302) 302
behavior (290) 290
intracellular signaling peptides and proteins - pharmacology (288) 288
dopamine (287) 287
activation (286) 286
psychological phenomena and processes (286) 286
gene expression (285) 285
orexins - metabolism (284) 284
reward (283) 283
brain - metabolism (270) 270
intracellular signaling peptides and proteins - genetics (264) 264
orexin receptors - metabolism (261) 261
urea - analogs & derivatives (261) 261
insomnia (258) 258
system (257) 257
behavioral sciences (255) 255
narcolepsy - physiopathology (252) 252
receptor (252) 252
disease models, animal (246) 246
orexin a (246) 246
food intake (244) 244
receptors, g-protein-coupled - metabolism (244) 244
digestive, oral, and skin physiology (243) 243
cell biology (241) 241
aged (239) 239
stress (239) 239
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (5956) 5956
Japanese (85) 85
Chinese (50) 50
Spanish (27) 27
German (24) 24
French (23) 23
Polish (17) 17
Russian (17) 17
Czech (7) 7
Turkish (7) 7
Italian (5) 5
Hungarian (3) 3
Swedish (3) 3
Danish (2) 2
Korean (2) 2
Persian (2) 2
Portuguese (2) 2
Slovak (2) 2
Croatian (1) 1
Dutch (1) 1
Finnish (1) 1
Hebrew (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 7 - 19.e5
Orexin peptides in the brain regulate physiological functions such as the sleep-wake cycle, and are thus drug targets for the treatment of insomnia. Using... 
X-ray crystallography | GPCR | subtype selective ligand | X-ray free-electron laser | serial femtosecond crystallography | orexin receptor | ACTIVATION | SODIUM | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATOMIC CHARGES | X-RAY-DIFFRACTION | FREE-ENERGIES | DISCOVERY | FAMILY | CELL BIOLOGY | BIOPHYSICS | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | PROTEINS | Baculoviridae - metabolism | Triazoles - chemistry | Humans | Crystallography - methods | Baculoviridae - genetics | Aminopyridines - metabolism | Spodoptera | Aminopyridines - chemistry | Orexin Receptor Antagonists - metabolism | Thermodynamics | Sf9 Cells | Azepines - chemistry | Synchrotrons | Cloning, Molecular | Orexin Receptors - genetics | Orexin Receptor Antagonists - chemistry | Protein Interaction Domains and Motifs | Orexin Receptors - chemistry | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Orexin Receptors - metabolism | Genetic Vectors - chemistry | Orexins - metabolism | Sulfonamides - chemistry | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Triazoles - metabolism | Animals | Hydrogen Bonding | Protein Conformation, beta-Strand | Azepines - metabolism | Sulfonamides - metabolism | Orexins - chemistry | Protein Binding | Kinetics | Peptides | Lasers | Analysis | Crystals | Physiological aspects | Drug discovery | Structure
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2017, Volume 57, Issue 1, pp. 509 - 533
Journal Article
Nature, ISSN 0028-0836, 02/2019, Volume 566, Issue 7744, pp. 383 - 387
Sleep is integral to life(1). Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular... 
SYSTEM | CELLS | NARCOLEPSY | METAANALYSIS | HYPOCRETIN | MULTIDISCIPLINARY SCIENCES | OREXIN | DIFFERENTIATION | DURATION | STEM | REVEALS | Hypothalamic Area, Lateral - metabolism | Male | Monocytes - metabolism | Hematopoiesis - drug effects | Sleep Deprivation - prevention & control | Antigens, Ly - metabolism | Female | Hematopoiesis - physiology | Sleep - physiology | Neutrophils - metabolism | Myelopoiesis - drug effects | Orexins - biosynthesis | Orexins - pharmacology | Atherosclerosis - pathology | Orexin Receptors - metabolism | Orexins - metabolism | Sleep - drug effects | Sleep Deprivation - metabolism | Atherosclerosis - metabolism | Orexins - deficiency | Monocytes - drug effects | Sleep Deprivation - physiopathology | Animals | Orexin Receptors - deficiency | Mice | Atherosclerosis - prevention & control | Bone Marrow Cells - metabolism | Physiological aspects | Sleep | Hematopoiesis | Health aspects | Risk factors | Atherosclerosis | Development and progression | Orexins | Neutrophils | Health risks | Hypothalamus (lateral) | Nervous system | Neuropeptides | Leukocytes (neutrophilic) | Hypothalamus | Monocytosis | Sleep disorders | Molecular modelling | Rodents | Arteriosclerosis | Stem cells | Bone marrow | Supplementation | Myelopoiesis | Lesions | Ly-6 antigen | Cardiovascular diseases | Alzheimers disease
Journal Article
IUBMB Life, ISSN 1521-6543, 07/2018, Volume 70, Issue 7, pp. 633 - 641
Dysfunction of osteoblastic bone formation and matrix mineralization plays a key role in the pathological development of osteoporosis. The orexin peptide... 
mineralization | osteoblastic differentiation | orexin‐1 receptor | orexin‐A | orexin-1 receptor | orexin-A | SYSTEM |