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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 45, pp. E10740 - E10747
Orexin (also known as hypocretin) neurons in the hypothalamus play an essential role in sleep-wake control, feeding, reward, and energy homeostasis. The... 
Anesthesia | Pain | Hypocretin | Orexin | DREADD | pain | MULTIDISCIPLINARY SCIENCES | NEUROENDOCRINE | COERULEUS NORADRENERGIC SYSTEM | RECEPTOR | GENERAL-ANESTHESIA | anesthesia | HYPOCRETIN OREXIN | NARCOLEPSY | CARDIOVASCULAR ACTIONS | hypocretin | LOCUS-COERULEUS | NEURONS | orexin | OREXINS/HYPOCRETINS | Dependovirus - genetics | Neurons - pathology | Male | Electroencephalography | Clozapine - pharmacology | Pain - genetics | Orexin Receptors - genetics | Neurons - metabolism | Hypothalamus - drug effects | Neurons - drug effects | Anesthetics, Inhalation | Orexin Receptors - metabolism | Orexins - genetics | Dependovirus - metabolism | Genetic Vectors - chemistry | Orexins - metabolism | Pain - prevention & control | Mice, Inbred C57BL | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Genetic Vectors - metabolism | Mice, Transgenic | Hot Temperature | Serotonin Antagonists - pharmacology | Hypothalamus - physiopathology | Isoflurane | Stereotaxic Techniques | Patch-Clamp Techniques | Animals | Hypothalamus - metabolism | Pain - physiopathology | Anesthesia Recovery Period | Proto-Oncogene Proteins c-fos - genetics | Mice | Pain Measurement | Dosage and administration | Neural circuitry | Observations | Health aspects | Drug interactions | Brain | Homeostasis | Viruses | Activation | Hypothalamus | Formaldehyde | Receptors | Emergence | Reinforcement | Thermal stimuli | c-Fos protein | Sleep and wakefulness | Pain sensitivity | Pain perception | Orexins | Research & development--R&D | Neurons | EEG | Transgenic mice | Clozapine | Latency | Energy balance | Sleep | Recording | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
IUBMB Life, ISSN 1521-6543, 07/2018, Volume 70, Issue 7, pp. 633 - 641
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 09/2017, Volume 95, Issue 6, pp. 1365 - 1380.e5
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0182707 - e0182707
Cardiac arrest (CA) entails significant risks of coma resulting in poor neurological and behavioral outcomes after resuscitation. Significant subsequent... 
QUANTITATIVE EEG | THERAPEUTIC HYPOTHERMIA | BRAIN-INJURY | MULTIDISCIPLINARY SCIENCES | PARVALBUMIN NEURONS | GLOBAL CEREBRAL-ISCHEMIA | TNF-ALPHA | TARGETED TEMPERATURE MANAGEMENT | INFLAMMATORY RESPONSE | NEURONAL GLYCOCALYX | SLEEP-WAKE | Orexins - administration & dosage | Inflammation - pathology | Rats, Wistar | Sodium Chloride - pharmacology | Coma - physiopathology | Male | Electroencephalography | RNA, Messenger - metabolism | Arousal - drug effects | Coma - complications | Inflammation - complications | Inflammation - drug therapy | Orexin Receptors - genetics | Behavior, Animal - drug effects | Orexins - therapeutic use | Orexins - pharmacology | Resuscitation | Biomarkers - metabolism | Orexin Receptors - metabolism | Gamma Rhythm - drug effects | Brain - physiopathology | RNA, Messenger - genetics | Sodium Chloride - administration & dosage | Treatment Outcome | Heart Arrest - physiopathology | Administration, Intranasal | Brain - drug effects | Animals | Brain - pathology | Coma - drug therapy | Hemodynamics - drug effects | Genetic aspects | Research | Drug therapy | Cardiac arrest | Coma | Brain | Neuroprotection | Neurosciences | Singers | Medical services | Cognitive ability | mRNA | Hypothalamus | Recovery | Engineering | Receptors | Ischemia | Orexin receptOrs | Cerebral blood flow | Rodents | Arousal | Interleukin 1 | Tumor necrosis factor-TNF | Heart diseases | Biomedical engineering | Medical research | Cortex (prefrontal) | CD11b antigen | Cytokines | Orexins | Neurons | Glial fibrillary acidic protein | EEG | Markers | Inflammation | Risk taking | Nitric-oxide synthase | Morbidity | Medicine | Studies | Sleep | Tumor necrosis factor | Hypothermia | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 09/2012, Volume 37, Issue 10, pp. 2210 - 2221
Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major depression, but little is known... 
hypothalamic-pituitary-adrenal axis | orexin/hypocretin | depression | antidepressant | dual orexin/hypocretin receptor antagonist | hippocampal neurogenesis | ADULT HIPPOCAMPUS | PSYCHIATRY | CHRONIC MILD STRESS | CELL-PROLIFERATION | OREXIN/HYPOCRETIN NEURONS | REWARD-SEEKING | MAJOR DEPRESSION | CEREBROSPINAL-FLUID | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | RAT-BRAIN | Cell Proliferation | Neuropeptides - physiology | Depression - drug therapy | Acetamides - therapeutic use | Behavior, Animal - drug effects | Fluoxetine - therapeutic use | Disease Models, Animal | Neuropeptides - analysis | Hypothalamo-Hypophyseal System - drug effects | Microtubule-Associated Proteins - analysis | Orexins | Pituitary-Adrenal System - drug effects | Receptors, Neuropeptide - antagonists & inhibitors | Orexin Receptors | Antidepressive Agents - therapeutic use | Animals | Ki-67 Antigen - analysis | Neurogenesis - physiology | Bromodeoxyuridine - analysis | Receptors, G-Protein-Coupled - antagonists & inhibitors | Biomarkers | Isoquinolines - therapeutic use | Mice | Mice, Inbred BALB C | Intracellular Signaling Peptides and Proteins - physiology | Index Medicus | Cell proliferation | Neonates | Animal models | Dexamethasone | Fluoxetine | Bromodeoxyuridine | Depression | Hypothalamic-pituitary-adrenal axis | Neurogenesis | Stress | Antidepressants | Feedback | Orexin receptors | Doublecortin protein | Hippocampus | animal models | dual orexin | hypocretin receptor antagonist | neuropeptides | unipolar | psychopharmacology | hypocretin | bipolar | orexin | Original
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 07/2017, Volume 95, Issue 7, pp. 1415 - 1426
Journal Article
FEBS Letters, ISSN 0014-5793, 2011, Volume 585, Issue 9, pp. 1368 - 1374
► Receptor interaction with orexin peptides investigated. ► Construction of chimaeric OX –OX receptors. ► Evaluation of the potency of orexin-A, orexin-B and... 
Orexin-B | Calcium | Orexin-A | Orexin | Hypocretin | extracellular loops of orexin receptor 1–3 | intracellular loops of orexin receptor 1–3 | green fluorescent protein | chimaeric orexin receptors 1–8 | GFP | IC1–3 | transmembrane helices of orexin receptor 1–7 | Ch1–8 | Ala | TM1–7 | C-terminus of orexin receptors | EC1–3 | Leu | N-terminus of orexin receptors | orexin-B | NARCOLEPSY | BIOPHYSICS | BEHAVIOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | OX1 | SEEKING | CELL BIOLOGY | Intracellular Signaling Peptides and Proteins - pharmacology | Humans | Molecular Sequence Data | Receptors, G-Protein-Coupled - agonists | Dose-Response Relationship, Drug | Protein Isoforms - agonists | Protein Isoforms - chemistry | Neuropeptides - pharmacology | HEK293 Cells | Receptors, Neuropeptide - agonists | Recombinant Fusion Proteins - agonists | Amino Acid Sequence | Orexins | Protein Structure, Secondary | Models, Molecular | Receptors, Neuropeptide - genetics | Binding Sites - genetics | Orexin Receptors | Recombinant Fusion Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Receptors, Neuropeptide - chemistry | Neuropeptides - chemistry | Protein Isoforms - genetics | Peptides | Fluorescence | Physiological aspects | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
Journal Article