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Nature (London), ISSN 1476-4687, 2019, Volume 566, Issue 7744, pp. 383 - 387
Sleep is integral to life(1). Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular... 
SYSTEM | CELLS | NARCOLEPSY | METAANALYSIS | HYPOCRETIN | MULTIDISCIPLINARY SCIENCES | OREXIN | DIFFERENTIATION | DURATION | STEM | REVEALS | Hypothalamic Area, Lateral - metabolism | Macrophage Colony-Stimulating Factor - biosynthesis | Male | Monocytes - metabolism | Hematopoiesis - drug effects | Macrophage Colony-Stimulating Factor - deficiency | Sleep Deprivation - prevention & control | Antigens, Ly - metabolism | Female | Hematopoiesis - physiology | Sleep - physiology | Neutrophils - metabolism | Myelopoiesis - drug effects | Orexins - biosynthesis | Orexins - pharmacology | Atherosclerosis - pathology | Orexin Receptors - metabolism | Orexins - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Sleep - drug effects | Sleep Deprivation - metabolism | Atherosclerosis - metabolism | Orexins - deficiency | Monocytes - drug effects | Sleep Deprivation - physiopathology | Animals | Orexin Receptors - deficiency | Mice | Atherosclerosis - prevention & control | Bone Marrow Cells - metabolism | Physiological aspects | Sleep | Hematopoiesis | Health aspects | Risk factors | Atherosclerosis | Development and progression | Orexins | Neutrophils | Health risks | Hypothalamus (lateral) | Nervous system | Neuropeptides | Leukocytes (neutrophilic) | Hypothalamus | Monocytosis | Sleep disorders | Molecular modelling | Rodents | Arteriosclerosis | Stem cells | Bone marrow | Supplementation | Myelopoiesis | Lesions | Ly-6 antigen | Cardiovascular diseases | Alzheimers disease
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 95, Issue 6, pp. 1365 - 1380.e5
Journal Article
FEBS letters, ISSN 0014-5793, 2011, Volume 585, Issue 9, pp. 1368 - 1374
► Receptor interaction with orexin peptides investigated. ► Construction of chimaeric OX 1–OX 2 receptors. ► Evaluation of the potency of orexin-A, orexin-B... 
Orexin-B | Calcium | Orexin-A | Orexin | Hypocretin | A11,dL15-orexin-B | Ala11, d-Leu15-orexin-B | extracellular loops of orexin receptor 1–3 | intracellular loops of orexin receptor 1–3 | green fluorescent protein | chimaeric orexin receptors 1–8 | GFP | IC1–3 | transmembrane helices of orexin receptor 1–7 | Ch1–8 | TM1–7 | C-terminus of orexin receptors | EC1–3 | N-terminus of orexin receptors | NARCOLEPSY | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OX1 | CELL BIOLOGY | Intracellular Signaling Peptides and Proteins - pharmacology | Humans | Molecular Sequence Data | Receptors, G-Protein-Coupled - agonists | Dose-Response Relationship, Drug | Protein Isoforms - agonists | Protein Isoforms - chemistry | Neuropeptides - pharmacology | HEK293 Cells | Receptors, Neuropeptide - agonists | Recombinant Fusion Proteins - agonists | Amino Acid Sequence | Orexins | Protein Structure, Secondary | Models, Molecular | Receptors, Neuropeptide - genetics | Binding Sites - genetics | Orexin Receptors | Recombinant Fusion Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Receptors, Neuropeptide - chemistry | Neuropeptides - chemistry | Protein Isoforms - genetics | Peptides | Fluorescence | Physiological aspects
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 34, pp. 17061 - 17070
Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are exclusively produced by the lateral hypothalamus and play important roles in... 
transcription factor | LATERAL HYPOTHALAMUS | SLEEP | Peg3 | AROUSAL | MULTIDISCIPLINARY SCIENCES | iPSC | MCH NEURONS | NARCOLEPSY | MCH | HYPOTHALAMIC OREXIN NEURONS | GENE | MICE | HCRT/OREXIN | RECEPTORS | DISTINCT POPULATIONS | Orexins - genetics | Orexins - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Neurons - cytology | Melanins - genetics | Melanins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Hypothalamus - metabolism | Hypothalamus - cytology | Hypothalamic Hormones - metabolism | Pituitary Hormones - genetics | Pituitary Hormones - metabolism | Hypothalamic Hormones - genetics | Mice | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | RNA sequencing | Sleep | RNA | Neurons | Analysis | Stem cells | Bone morphogenetic proteins | Narcolepsy | Hormones | Cell differentiation | Animal models | Peg3 protein | Ascorbic acid | Menopause | Differentiation (biology) | Stem cell transplantation | Neuropeptides | Hypothalamus | Gene sequencing | Sleep disorders | Receptors | Motivation | Ataxin | Reinforcement | Orexins | Hypothalamus (lateral) | Zebrafish | Ribonucleic acid--RNA | Gene expression | Embryos | Cataplexy | Melanin-concentrating hormone | Metabolic disorders | Melanin | Bone morphogenetic protein 7 | Biological Sciences | PNAS Plus | OREXIN | HCRT
Journal Article
Journal Article