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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2012, Volume 109, Issue 13, pp. 4756 - 4761
Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex... 
Molecules | Cell culture techniques | Neurons | Epithelial cells | Gap junctions | Cell lines | HeLa cells | Fluorescence | Esters | Kidney cells | Cellular imaging | Microscopy | Pharmacological agents | Enzyme substrates | Fluorophores | fluorophores | cellular imaging | NITROREDUCTASE | MULTIDISCIPLINARY SCIENCES | JUNCTIONAL INTERCELLULAR COMMUNICATION | enzyme substrates | pharmacological agents | DYE TRANSFER | CARBOXYLESTERASE | IN-VIVO | GENE-EXPRESSION | ABLATION | microscopy | ENDOPLASMIC-RETICULUM | PIG-LIVER ESTERASE | LIVING CELLS | Organ Specificity - drug effects | Gap Junctions - metabolism | Small Molecule Libraries - pharmacology | Hydrolysis - drug effects | Coculture Techniques | Humans | Fluorescent Dyes - metabolism | Esters - metabolism | Neurons - cytology | Biocatalysis - drug effects | Neurons - metabolism | Neurons - drug effects | Astrocytes - cytology | Astrocytes - drug effects | Cell Survival - drug effects | Cells - drug effects | Fluorescent Dyes - chemistry | Permeability - drug effects | Esterases - metabolism | Rats | Hippocampus - cytology | Animals | Cells - metabolism | Mice | HeLa Cells | Gap Junctions - drug effects | Microscopy, Fluorescence | Astrocytes - metabolism | Molecular dynamics | Biomolecules | Chemical properties | Research | Biological Sciences | Physical Sciences
Journal Article
Cell Stem Cell, ISSN 1934-5909, 01/2015, Volume 16, Issue 1, pp. 51 - 66
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues... 
REGULATOR | ORIGIN | SONIC HEDGEHOG | PATHWAY | BONE-MARROW NICHE | MYOFIBROBLASTS | NG2 PROTEOGLYCAN | EXPRESSION | MESENCHYMAL STEM-CELLS | GROWTH FACTOR-AA | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Organ Specificity - drug effects | Diphtheria Toxin - pharmacology | Neovascularization, Physiologic - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Fibrosis - metabolism | Cell Lineage - drug effects | Myofibroblasts - metabolism | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Kruppel-Like Transcription Factors - metabolism | Pericytes - pathology | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Aorta - physiopathology | Homeostasis - drug effects | Heart Ventricles - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mesenchymal Stromal Cells - drug effects | Endothelial Cells - metabolism | Aorta - drug effects | Pericytes - metabolism | Cells, Cultured | Proteoglycans - metabolism | Antigens - metabolism | Aorta - pathology | Myofibroblasts - cytology | Animals | Heart Ventricles - physiopathology | Cell Differentiation - drug effects | Endothelial Cells - cytology | Blood Vessels - drug effects | Mice | Stem Cell Niche - drug effects | Zinc Finger Protein GLI1 | Fibrosis - pathology | Bone Marrow Cells - metabolism | Endothelial Cells - drug effects | Heart Ventricles - drug effects
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 96 - 108
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and... 
SKELETAL-MUSCLE | PPAR-ALPHA | ACTIVATION | MITOCHONDRIAL UNCOUPLING PROTEIN | PGC-1-ALPHA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MICE | EXPRESSION | EXERCISE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects
Journal Article
Cell Reports, ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2013, Volume 17, Issue 2, pp. 225 - 235
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. Bile acid synthesis is under... 
ACTIVATION | DISRUPTION | STEROIDS | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FARNESOID-X-RECEPTOR | GERM-FREE | ABSORPTION | DIFFERENTIAL REGULATION | BINDING | CELL BIOLOGY | Organ Specificity - drug effects | Taurocholic Acid - metabolism | Fibroblast Growth Factors - genetics | Ileum - metabolism | Gene Expression Profiling | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Ileum - drug effects | Metagenome - genetics | Absorption | Liver - drug effects | Taurocholic Acid - analogs & derivatives | Taurocholic Acid - pharmacology | Metagenome - drug effects | Liver - metabolism | Gastrointestinal Tract - microbiology | Bile Acids and Salts - metabolism | Gastrointestinal Tract - drug effects | Gene Expression Regulation - drug effects | Cholesterol 7-alpha-Hydroxylase - genetics | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Models, Biological | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Feedback, Physiological - drug effects | Anti-Bacterial Agents - pharmacology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Fibroblast growth factors | Universities and colleges | Cytochrome P-450 | Deoxycholic acid | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Cellbiologi | Klinisk medicin | Cell Biology | Endocrinology and Diabetes
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 476 - 491
Journal Article
Plant Cell, ISSN 1040-4651, 11/2015, Volume 27, Issue 11, pp. 3143 - 3159
The plant hormones strigolactones and smoke-derived karrikins are butenolide signals that control distinct aspects of plant development. Perception of both... 
Phenotypes | Hypocotyls | Cotyledons | RESEARCH ARTICLES | Germination | Plant roots | Auxins | Photoperiod | Plants | Seedlings | Plant cells | SYSTEM | SEED-GERMINATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL REPRESSION | BOX PROTEIN MAX2 | CHEMICAL SIGNALS | PLANT SCIENCES | CELL BIOLOGY | AUXIN TRANSPORT | LEAF SENESCENCE | SMOKE | PLANT HORMONE | RICE | Organ Specificity - drug effects | Plant Shoots - growth & development | Multigene Family | Arabidopsis - growth & development | Furans - pharmacology | Lactones - pharmacology | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Proteolysis - drug effects | Protein Binding - drug effects | Plant Shoots - drug effects | Biological Transport - drug effects | Plant Leaves - drug effects | Plant Roots - growth & development | Pyrans - pharmacology | Germination - drug effects | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Hypocotyl - growth & development | Mutation - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Carrier Proteins - metabolism | Plant Stems - drug effects | Plant Stems - metabolism | Models, Biological | Alleles | Plant Leaves - anatomy & histology | Hypocotyl - drug effects | Arabidopsis thaliana | Physiological aspects | Botanical research | Research | Biological control systems | Plant hormones
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 63 - 74
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota... 
BODY-WEIGHT | NORFLOXACIN | VANCOMYCIN | CHAIN FATTY-ACIDS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | CHROMATOGRAPHY-MASS SPECTROMETRY | SECRETION | GLUCOSE-TOLERANCE | MODULATION | CELL BIOLOGY | Organ Specificity - drug effects | Inflammation - pathology | Humans | Middle Aged | Male | Adipocytes - drug effects | Obesity - genetics | Obesity - microbiology | Vancomycin - pharmacology | Placebos | Adult | Butyric Acid - blood | Biomarkers - metabolism | Insulin - pharmacology | Double-Blind Method | Permeability | Adipocytes - pathology | Obesity - metabolism | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Feces - chemistry | Gastrointestinal Microbiome - drug effects | Substrate Specificity - drug effects | Amoxicillin - pharmacology | Adipocytes - metabolism | Aged | Anti-Bacterial Agents - pharmacology | Energy Metabolism - drug effects | Obesity | Metabolites | Microbiota (Symbiotic organisms) | Physiological aspects | Clinical trials | Electric power production | Gene expression | Fatty acids | Antibacterial agents | Prediabetic state | Deoxycholic acid | Nutrition, Metabolism and Genomics | Microbiologie | Microbiology | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | Laboratorium voor Microbiologie | Microbiological Laboratory | HNE Nutrition, Metabolism and Genomics | WIMEK
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 15, pp. 5874 - 5879
Journal Article