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Biomaterials, ISSN 0142-9612, 12/2019, Volume 225, p. 119521
Epithelial cells experience constant mechanical forces, including fluid shear stress (FSS) on their apical surface. These forces alter both structure and... 
Intestinal models | Fluid shear stress | Organ-on-chip | Microfluidics
Journal Article
Trends in biotechnology, ISSN 0167-7799, 05/2019
Therapeutic options for neurological disorders currently remain limited. The intrinsic complexity of the brain architecture prevents potential therapeutics... 
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 11/2019, Volume 144, pp. 11 - 17
With rapid advances in micro-fabrication processes and the availability of biologically-relevant lung cells, the development of platforms is offering novel... 
Aerosols | Inhalation assays | Organ-on-chip | Microfluidics | Cellular airway barrier
Journal Article
Cell Stem Cell, ISSN 1934-5909, 06/2019, Volume 24, Issue 6, pp. 995 - 1005.e6
The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain and is disrupted in several neurological diseases. Using... 
blood-brain barrier | iPSCs | BBB | neural | thyroid | neurological disease | MCT8 | organ-on-chip | personalized medicine | disease model
Journal Article
Trends in biotechnology, ISSN 0167-7799, 07/2019
Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC,... 
Journal Article
Trends in Biotechnology, ISSN 0167-7799, 2016, Volume 34, Issue 9, pp. 722 - 732
Journal Article
Annual Review of Biomedical Engineering, ISSN 1523-9829, 6/2019, Volume 21, Issue 1, pp. 219 - 239
The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver... 
organ on chip | microphysiological systems | human on chip | liver | in vitro models | Integrated circuits | Measurement | Usage | Medical examination | Patient monitoring equipment | Liver | Design and construction | Xenobiotics | Semiconductor chips
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 09/2019, Volume 26, Issue 3, pp. 435 - 444.e4
Intestinal epithelial cells are constantly exposed to pathogens and mechanical forces. However, the impact of mechanical forces on infections leading to... 
peristalsis | Intestine-Chip | host-pathogen interactions | intestine | shear stress | microengineering | Gut-on-Chip | enterocyte | stretching | Organ-on-Chip | PLATFORM | FLEXNERI | CELLS | VIROLOGY | PLASMID | MICROBIOLOGY | INOCULUM | SECRETION | DEFORMATION | PARASITOLOGY | Diarrhea | Biological products | Health aspects | Microfluidics
Journal Article
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2019, Volume 25, Issue 27, pp. 2953 - 2968
Nanomaterial-based drug delivery holds tremendous promise for improving targeting capacity, biodistribution, and performance of therapeutic/diagnostic agents.... 
Nano edicine | nanoparticle | drug evaluation | drug delivery | BLOOD-BRAIN-BARRIER | CANCER | organ-on-chip | QUANTUM DOTS | ON-A-CHIP | NANOPARTICLES | IN-VITRO | TUMOR SPHEROIDS | ENHANCED PERMEABILITY | PHARMACOLOGY & PHARMACY | SINGLE-CELL ANALYSIS | microfluidic | CLINICAL TRANSLATION
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2017, Volume 23, Issue 2, pp. 204 - 215
AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused... 
METABOLIC SYNDROME | Liver disease | DRUG DISCOVERY | Organ-on-chip | Three-dimensional cell culture | ORGANS-ON-CHIPS | Fatty liver | PIOGLITAZONE | Hepatocytes | HUMAN HEPATOCYTES | HEPG2 CELLS | PPAR-GAMMA | STEATOHEPATITIS | Non-alcoholic fatty liver disease | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | EXPRESSION | Primary cell culture
Journal Article