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Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 45, pp. 35123 - 35132
The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated serum uric acid (urate). Uricase loss may have been beneficial to... 
HYPERURICEMIA | ORGANIC ANION TRANSPORT | GOUT | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | EXCRETION | APICAL MEMBRANE | URIC-ACID | HOMINOID EVOLUTION | FAMILY | EXCHANGER | Glucose Transport Proteins, Facilitative - metabolism | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transport Protein 1 - metabolism | Diuretics - pharmacokinetics | Sodium-Phosphate Cotransporter Proteins, Type I - genetics | Humans | Hyperuricemia - metabolism | Mutation, Missense | Organic Anion Transporters - metabolism | Urate Oxidase - metabolism | Organic Anion Transporters - genetics | Urate Oxidase - genetics | Furosemide - adverse effects | Organic Anion Transporters, Sodium-Independent - metabolism | Kidney Tubules, Proximal - secretion | Ion Transport - drug effects | Glucose Transport Proteins, Facilitative - genetics | Bumetanide - adverse effects | Genetic Predisposition to Disease | Uric Acid - metabolism | Organic Cation Transport Proteins - metabolism | Diuretics - pharmacology | Furosemide - pharmacokinetics | Liver - metabolism | Xenopus laevis | Organic Anion Transport Protein 1 - genetics | Bumetanide - pharmacokinetics | Bumetanide - pharmacology | Hyperuricemia - genetics | Gout - metabolism | Animals | Models, Biological | Gout - genetics | Furosemide - pharmacology | Organic Cation Transport Proteins - genetics | Sodium-Phosphate Cotransporter Proteins, Type I - metabolism | Diuretics - adverse effects | Hyperuricemia - chemically induced | Ion Transport - genetics | Index Medicus | Transport Drugs | Membrane Biology | Gout | Epithelial Cell | Uric Acid | Diuretics | Kidney
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2016, Volume 357, Issue 1, pp. 157 - 166
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2012, Volume 302, Issue 10, pp. F1293 - F1299
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2013, Volume 102, Issue 9, pp. 3302 - 3308
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 43, pp. 37874 - 37886
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2007, Volume 35, Issue 5, pp. 779 - 786
Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes. Transporter-mediated uptake of drugs into cells [e.g., by members... 
IN-VITRO | PHARMACOKINETICS | SLCO1B1 POLYMORPHISM | PHARMACOLOGY & PHARMACY | HUMAN LIVER | PRAVASTATIN | HEPATIC-UPTAKE | TRANSPORTING POLYPEPTIDE 1B1 | ROSUVASTATIN | P-GLYCOPROTEIN | PREDICTION | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transport Protein 1 - metabolism | Ketolides - pharmacology | Humans | Organic Chemicals - metabolism | Anions - pharmacokinetics | Immunoblotting | Anions - chemistry | Chromatography, High Pressure Liquid | Dose-Response Relationship, Drug | Organic Anion Transport Protein 1 - physiology | Tandem Mass Spectrometry | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Transfection | Macrolides - chemistry | Sulfobromophthalein - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Anti-Bacterial Agents - chemistry | Macrolides - pharmacology | Ketolides - metabolism | Transcription, Genetic | Biological Transport - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters, Sodium-Independent - physiology | Pravastatin - pharmacology | Cell Line | Pravastatin - metabolism | Organic Chemicals - chemistry | Anti-Bacterial Agents - metabolism | Organic Anion Transport Protein 1 - genetics | Macrolides - metabolism | Anions - metabolism | Pharmaceutical Preparations - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Organic Chemicals - pharmacokinetics | Pharmaceutical Preparations - chemistry | Anti-Bacterial Agents - pharmacology | Index Medicus
Journal Article