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1. Full Text Catechols as membrane anion transporters
by Berezin, Sofya Kostina and Davis, Jeffery T
Journal of the American Chemical Society, ISSN 0002-7863, 02/2009, Volume 131, Issue 7, pp. 2458 - 2459
We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | NMR | EXTRACTION | LIPID-BILAYERS | CHLORIDE TRANSPORT | CONFORMATIONAL CONTROL | ION CHANNELS | RECEPTORS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | Chloride Channels - chemistry | Organic Anion Transporters - chemistry | Cell Membrane Permeability | Models, Molecular | Catechols - chemistry | Anions - chemistry | Organic Anion Transporters - metabolism | Chloride Channels - metabolism | Thermodynamics | Liposomes - chemistry | Liposomes - metabolism | Kinetics | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Catechols - metabolism | Substitution reactions | Catechin | Chemical properties | Structure | Biological transport | Analysis | Index Medicus
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2. Full Text GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters
by Ramesh, Sunita A and Tyerman, Stephen D and Xu, Bo and Bose, Jayakumar and Kaur, Satwinder and Conn, Vanessa and Domingos, Patricia and Ullah, Sana and Wege, Stefanie and Shabala, Sergey and Feijó, José A and Ryan, Peter R and Gillham, Matthew
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, pp. 7879 - 7879
The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant... 
POLLEN-TUBE GROWTH | ARABIDOPSIS-THALIANA | ALUMINUM TOLERANCE | CHANNEL | MULTIDISCIPLINARY SCIENCES | MALATE TRANSPORTER | BINDING-SITE | RECEPTOR | GAMMA-AMINOBUTYRIC-ACID | TAALMT1 | WHEAT | Muscimol - pharmacology | Membrane Potentials - genetics | gamma-Aminobutyric Acid - metabolism | Vitis | Pollen Tube - metabolism | Oocytes | Organic Anion Transporters - metabolism | Aluminum - metabolism | Organic Anion Transporters - genetics | Triticum | GABA-A Receptor Agonists - pharmacology | Plant Proteins - metabolism | GABA-A Receptor Antagonists - pharmacology | Mutagenesis, Site-Directed | Hordeum | Signal Transduction | Arabidopsis | Stress, Physiological - genetics | Xenopus laevis | Bicuculline - pharmacology | gamma-Aminobutyric Acid - drug effects | Amino Acid Motifs | Microscopy, Confocal | Plant Proteins - genetics | Patch-Clamp Techniques | Tobacco | Animals | Acidosis | Pollen Tube - drug effects | Pollen Tube - growth & development | Physiological effects | Transport properties | Aluminum | Amino acids | Metabolism | pH effects | Proteins | Signal transduction | Signaling | Anions | γ-Aminobutyric acid | Mutagenesis | Plant growth | Malate | Bioaccumulation | Site-directed mutagenesis | Pollen | Protein transport | Transporter | Index Medicus
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3. Full Text Acylthioureas as anion transporters: The effect of intramolecular hydrogen bonding
by Haynes, Cally J. E and Busschaert, Nathalie and Kirby, Isabelle L and Herniman, Julie and Light, Mark E and Wells, Neil J and Marques, Igor and Félix, Vítor and Gale, Philip A
Organic and Biomolecular Chemistry, ISSN 1477-0520, 01/2014, Volume 12, Issue 1, pp. 62 - 72
Small molecule synthetic anion transporters may have potential application as therapeutic agents for the treatment of diseases including cystic fibrosis and... 
RECOGNITION | CRYSTAL-STRUCTURE | COMPLEXES | SYNTHETIC CHLORIDE | CHEMISTRY, ORGANIC | TRANSMEMBRANE CHLORIDE TRANSPORT | CONVENIENT | FACILITATE | POTENTIALS | SOLVENT-EXTRACTION | BINDING | Nitrates - chemistry | Quantum Theory | Hydrogen Bonding | Thiourea - chemical synthesis | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Anions - chemistry | Chlorides - chemistry | Lipid Bilayers - chemistry | Phosphatidylcholines - chemistry | Thiourea - chemistry | Index Medicus
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4. Full Text Anion Transporters Based on Noncovalent Balance including Anion-pi, Hydrogen, and Halogen Bonding
by Huang, WL and Wang, XD and Li, S and Zhang, R and Ao, YF and Tang, J and Wang, QQ and Wang, DX
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 07/2019, Volume 84, Issue 14, pp. 8859 - 8869
Anion transmembrane transport mediated by novel noncovalent interactions is of central interest in supramolecular chemistry. In this work, a series of... 
RECOGNITION | MODELS | PRODIGIOSIN | CHEMISTRY, ORGANIC | SYNTHETIC ION CHANNELS | RECEPTORS | BINDING | PORES | MOLECULES
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5. Full Text Calix[4]pyrrole-based anion transporters with tuneable transport properties
by Yano, Masafumi and Tong, Christine C and Light, Mark E and Schmidtchen, Franz P and Gale, Philip A
Organic and Biomolecular Chemistry, ISSN 1477-0520, 10/2010, Volume 8, Issue 19, pp. 4356 - 4363
Three new bis-1,2,3-triazole strapped calix[4]pyrroles have been prepared via 'click' chemistry and their anion complexation and lipid bilayer transport... 
MEMBRANE TRANSPORTERS | CHLORIDE TRANSPORT | HOFMEISTER BIAS | CLICK CHEMISTRY | COMPLEXES | CONFORMATIONAL CONTROL | CHEMISTRY, ORGANIC | ION-PAIR RECEPTOR | BINDING PROPERTIES | SHAPE-PERSISTENT | HYDROGEN-BONDS | Magnetic Resonance Spectroscopy | Porphyrins - chemistry | Models, Molecular | Porphyrins - chemical synthesis | Calixarenes - chemical synthesis | Crystallography, X-Ray | Porphyrins - metabolism | Phosphatidylcholines - metabolism | Anions - metabolism | Calixarenes - metabolism | Calixarenes - chemistry | Titrimetry | Calorimetry | Ion Transport | Lipid Bilayers - metabolism | Index Medicus
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6. Full Text Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: Role of human organic anion transporters
by Leonhardt, Mirko and Keiser, Markus and Oswald, Stefan and Kühn, Jens and Jia, Jia and Grube, Markus and Kroemer, Heyo K and Werner, Siegmund and Werner, Weitschies
Drug Metabolism and Disposition, ISSN 0090-9556, 2010, Volume 38, Issue 7, pp. 1024 - 1028
Contrast-enhancing magnetic resonance imaging with the liver-specific agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) has been... 
BILE-ACID | PHARMACOKINETICS | BILIARY-EXCRETION | ENHANCEMENT | DRUGS | RATS | PHARMACOLOGY & PHARMACY | HUMAN LIVER | TAUROCHOLATE | UPTAKE SYSTEMS | POLYPEPTIDE | Binding, Competitive | Cell Line | Cell Survival - drug effects | Gadolinium DTPA - pharmacology | Organic Anion Transporters - antagonists & inhibitors | Taurocholic Acid - metabolism | Humans | Liver - metabolism | Magnetic Resonance Imaging - methods | Substrate Specificity | Gadolinium DTPA - metabolism | Organic Anion Transporters - metabolism | Symporters - metabolism | Sulfobromophthalein - metabolism | Contrast Media - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Rifampin - metabolism | Index Medicus
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7. Full Text Tripodal squaramide conjugates as highly effective transmembrane anion transporters
by Cai, Xiong-Jie and Li, Zhi and Chen, Wen-Hua
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2017, Volume 27, Issue 9, pp. 1999 - 2002
Two tripodal squaramide conjugates were synthesized and found to exhibit highly efficient transmembrane anionophoric activity. Two tripodal squaramide... 
Anionophore | Squaramide | Anionophoric activity | Ion selectivity | CELLS | CHEMISTRY, MEDICINAL | RECOGNITION | MEMBRANE | SULFATE | CHEMISTRY, ORGANIC | RECEPTORS | ANIONOPHORES | Quinine - analogs & derivatives | Sulfates - metabolism | Chlorides - metabolism | Halogenation | Quinine - pharmacology | Ion Transport - drug effects | Liposomes - metabolism | Methylation | Quinine - chemistry | Anions - metabolism | Sulfates | Index Medicus
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8. Full Text Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney
by Zhou, Yan and Yang, Yuquan and Wang, Pei and Wei, Mengmeng and Ma, Yanrong and Wu, Xin'an
Life Sciences, ISSN 0024-3205, 05/2019, Volume 224, pp. 41 - 50
Common characteristics of drug induced nephrotoxicity are renal tubular and interstitial injury. Many studies have only focused on renal tubular injury.... 
Organic anion transporters | Drug-drug interaction | Drug-induced nephrotoxicity | Renal interstitium | MEDICINE, RESEARCH & EXPERIMENTAL | INJURY | TOXICITY | EXCRETION | INHIBITION | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | OCT2 | PHARMACOLOGY & PHARMACY | TENOFOVIR | Adenine - analogs & derivatives | Antiviral Agents - pharmacokinetics | Kidney Tubules - drug effects | Rats, Wistar | Antiviral Agents - toxicity | Kidney Diseases - pathology | Rats | Adenine - pharmacokinetics | Adenine - toxicity | Organic Anion Transporters - metabolism | Organophosphonates - pharmacokinetics | Organophosphonates - toxicity | Tissue Distribution | Animals | Kidney Diseases - chemically induced | Kidney Tubules - pathology | Kidney Tubules - metabolism | Kidney Diseases - metabolism | Adefovir dipivoxil | Drugstores | Medical colleges | Analysis | Pharmacy | Drug interactions | Anions | Adefovir | Microdialysis | Kidneys | Oats | Rodents | Fibrosis | Liquid chromatography | Pharmacology | Pharmacokinetics | High-performance liquid chromatography | Index Medicus
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9. Full Text Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects
by Lisa R. Treviño and Noriko Shimasaki and Wenjian Yang and John C. Panetta and Cheng Cheng and Deqing Pei and Diana Chan and Alex Sparreboom and Kathleen M. Giacomini and Ching-Hon Pui and William E. Evans and Mary V. Relling
Journal of Clinical Oncology, ISSN 0732-183X, 12/2009, Volume 27, Issue 35, pp. 5972 - 5978
Purpose Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in... 
RHEUMATOID-ARTHRITIS | DRUG-THERAPY | INFLAMMATORY-BOWEL-DISEASE | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE LYMPHOCYTIC-LEUKEMIA | HIGH-DOSE METHOTREXATE | SLCO1B1 POLYMORPHISM | OATP-C | GENOME-WIDE ASSOCIATION | SINGLE NUCLEOTIDE POLYMORPHISMS | Prospective Studies | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Methotrexate - pharmacokinetics | Child, Preschool | Infant | Male | Organic Anion Transporters - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Organic Anion Transporters - genetics | Antimetabolites, Antineoplastic - blood | Germ-Line Mutation | Female | Child | Genetic Predisposition to Disease | Genome-Wide Association Study | Risk Assessment | Risk Factors | Linear Models | Logistic Models | Treatment Outcome | Methotrexate - blood | Linkage Disequilibrium | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Methotrexate - adverse effects | Phenotype | Gastrointestinal Diseases - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Antimetabolites, Antineoplastic - adverse effects | Polymorphism, Single Nucleotide | Solute Carrier Organic Anion Transporter Family Member 1b1 | Gastrointestinal Diseases - chemically induced | Index Medicus | Original Reports | Pedi2
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10. Full Text Biflavonoids from Juniperus oblonga inhibit organic anion transporter 3
by Qiao, Yilin and Liu, Xueling and Li, Caiyu and Li, Xue and Wang, Xue and Khutsishvili, Manana and Alizade, Valida and Atha, Daniel and Zhang, Youcai and Borris, Robert P
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 4, pp. 931 - 936
Organic anion transporters (OATs in humans, Oats in rodents) play an important role in the distribution and excretion of numerous endogenous metabolic products... 
Biflavonoids | Pharmacokinetics | Drug-drug interaction | Organic anion transporter | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOXORUBICIN | GINKGETIN | FLAVONOIDS | OAT1 | IDENTIFICATION | AMENTOFLAVONE | NMR | BIOPHYSICS | ROOTS | ACCUMULATION | CONSTITUENTS
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11. Full Text Interaction of Organic Cations with Organic Anion Transporters
by Sun-Young Ahn and Satish A. Eraly and Igor Tsigelny and Sanjay K. Nigam
Journal of Biological Chemistry, ISSN 0021-9258, 11/2009, Volume 284, Issue 45, pp. 31422 - 31430
Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was... 
LOCALIZATION | OLFACTORY MUCOSA | RAT-KIDNEY | VESICLES | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYSTEMS | SUBSTANCES | IDENTIFICATION | BASOLATERAL MEMBRANE | VERAPAMIL | Organic Anion Transport Protein 1 - metabolism | Oocytes - metabolism | Cations - metabolism | Oocytes - chemistry | Organic Anion Transporters - chemistry | Xenopus laevis | Models, Molecular | Organic Anion Transport Protein 1 - chemistry | Organic Anion Transport Protein 1 - genetics | Organic Anion Transporters - metabolism | Anions - metabolism | Mice, Knockout | Kidney - metabolism | Organic Anion Transporters - genetics | Animals | Biological Transport | Protein Binding | Kidney - chemistry | Mice | Kinetics | Index Medicus | Membrane Transport, Structure, Function, and Biogenesis
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12. Full Text Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier: High affinity transporter for thyroxine
by Sugiyama, Daisuke and Kusuhara, Hiroyuki and Taniguchi, Hirokazu and Ishikawa, Shumpei and Nozaki, Yoshitane and Aburatani, Hiroyuki and Sugiyama, Yuichi
Journal of Biological Chemistry, ISSN 0021-9258, 10/2003, Volume 278, Issue 44, pp. 43489 - 43495
Oatp14/blood-brain barrier-specific anion transporter 1 (Slc21a14) is a novel member of the organic anion transporting polypeptide (Oatp/OATP) family. Northern... 
XENOBIOTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | THYROID-HORMONES | CEREBROSPINAL-FLUID BARRIER | CENTRAL-NERVOUS-SYSTEM | CHOROID-PLEXUS | HUMAN LIVER | TAUROCHOLATE | IDENTIFICATION | EFFLUX TRANSPORT | POLYPEPTIDE | Immunohistochemistry | Brain - embryology | Humans | Organic Anion Transporters - chemistry | Substrate Specificity | Male | Central Nervous System - embryology | Brain - metabolism | Tissue Distribution | Anions | Transfection | Triiodothyronine - metabolism | Biological Transport | Time Factors | Thyroxine - chemistry | Cloning, Molecular | Carrier Proteins - chemistry | Cell Line | Carrier Proteins - biosynthesis | Down-Regulation | Rats | Rats, Sprague-Dawley | Blotting, Western | Blotting, Northern | Animals | Pyridines - metabolism | Organic Anion Transporters - physiology | Thyroxine - metabolism | Protein Binding | Cations | Kinetics | Organic Anion Transporters - biosynthesis | Genetic Vectors | DNA, Complementary - metabolism | Blood-Brain Barrier | Index Medicus
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13. Full Text Renal expression of organic anion transporters is modified after mercuric chloride exposure: Gender-related differences
by Hazelhoff, María H and Bulacio, Romina P and Chevalier, Alberto and Torres, Adriana M
Toxicology Letters, ISSN 0378-4274, 10/2018, Volume 295, pp. 390 - 396
Mercuric ions (Hg ) gain access to proximal tubule cells primarily by the Organic Anion Transporter 1 (Oat1) and 3 (Oat3) in the basolateral plasma membrane.... 
Sex differences | Organic anion transporters | Nephrotoxicity | Renal failure | Mercuric chloride | MRP2 | RAT-KIDNEY | KIDNEY PROXIMAL TUBULES | MEMBRANE | INJURY | OAT1 | DRUG TRANSPORTERS | PROTEIN EXPRESSION | TOXICOLOGY | ISCHEMIA-REPERFUSION | Drug resistance in microorganisms | Analysis | Index Medicus
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14. Full Text Synthetic anion transporters that bear a terminal ethynyl group
by Lee, Eun-Bee and Ryu, Hyunil and Lee, Insu and Choi, Sangbaek and Hong, Jung-Ho and Kim, Sun Min and Jeon, Tae-Joon and Cho, Dong-Gyu
Chemical Communications, ISSN 1359-7345, 06/2015, Volume 51, Issue 45, pp. 9339 - 9342
Cl- transporters that bear a terminal ethynyl group were synthesized; they consist of non-pyrrolic hydrogen bond motifs such as phenolic OH, amide NH, and... 
IN-VITRO | H+/CL-SYMPORT | BICARBONATE | PRODIGIOSIN | MEMBRANES | TRANSMEMBRANE CHLORIDE TRANSPORT | PI SLIDES | CHANNELS | CYSTIC-FIBROSIS | RECEPTORS | CHEMISTRY, MULTIDISCIPLINARY | Acetylene - chemistry | Models, Biological | Organic Anion Transporters - chemistry | Organic Anion Transporters - chemical synthesis | Acetylene - analogs & derivatives | Ion Transport | Molecular Structure | Index Medicus | Efflux | Amides | Anions | Hydrogen bonds | Triazoles | Chlorides
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15. Full Text Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
by Wong, Chi Chun and Botting, Nigel P and Orfila, Caroline and Al-Maharik, Nawaf and Williamson, Gary
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 81, Issue 7, pp. 942 - 949
Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this... 
Organic anion transporters | Bioavailability | Food–drug interaction | Quercetin | Isoflavones | Food-drug interaction | QUERCETIN GLUCURONIDES | GENISTEIN | RENAL-CELLS | POLYPHENOLS | PLASMA | METABOLISM | URINE | PHARMACOLOGY & PHARMACY | ABSORPTION | KIDNEY | NEPHROTOXICITY | Cell Line | Antiviral Agents - pharmacology | Organic Anion Transport Protein 1 - metabolism | Organophosphonates - pharmacology | Adenine - analogs & derivatives | Humans | Adenine - pharmacology | Flavonoids - pharmacology | Chromatography, High Pressure Liquid | Kinetics | Index Medicus | Life Sciences | Pharmacology | Pharmaceutical sciences
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16. Full Text Effects of phenylpropanoids on human organic anion transporters hOAT1 and hOAT3
by Kawasaki, Tatsuya and Takeichi, Yoshiyasu and Tomita, Masashi and Uwai, Yuichi and Epifano, Francesco and Fiorito, Serena and Taddeo, Vito A and Genovese, Salvatore and Nabekura, Tomohiro
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2017, Volume 489, Issue 4, pp. 375 - 380
Human organic anion transporters hOAT1/ and hOAT3/ are highly expressed on the basolateral membrane of renal proximal tubules and mediate tubular uptake of... 
hOAT1 | Organic anion transporter | hOAT3 | Phenylpropanoid |