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eLife, ISSN 2050-084X, 11/2012, Volume 2012, Issue 1, p. e00049
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D... 
viruses | receptor | Sodium taurocholate cotransporting polypeptide | hepatitis D virus | infectious disease | liver | hepatitis B virus | biochemistry | microbiology | virus infection | CLOSED CIRCULAR DNA | IN-VITRO | HEPATOCELLULAR-CARCINOMA | DELTA-VIRUS | TUPAIA HEPATOCYTES | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | BIOLOGY | PRE-S SEQUENCE | LARGE SURFACE PROTEIN | ENVELOPE PROTEINS | Liver - virology | Liver - pathology | Receptors, Virus - metabolism | Taurocholic Acid - metabolism | Humans | Hepatitis Delta Virus - metabolism | Molecular Sequence Data | Hepatocytes - pathology | Hepatocytes - metabolism | Receptors, Virus - genetics | Virus Internalization | Organic Anion Transporters, Sodium-Dependent - genetics | Photochemical Processes | Organic Anion Transporters, Sodium-Dependent - chemistry | Biological Transport | Hepatitis B virus - chemistry | Tupaia | Viral Envelope Proteins - metabolism | Hepatitis Delta Virus - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Gene Expression | Viral Envelope Proteins - genetics | Peptides - chemistry | Liver - metabolism | Symporters - chemistry | Symporters - metabolism | Animals | Hepatitis Delta Virus - chemistry | Receptors, Virus - chemistry | Symporters - genetics | Viral Envelope Proteins - chemistry | Hepatitis B virus - genetics | Hepatocytes - virology | Protein Binding | Hepatitis B virus - metabolism | Primary Cell Culture | Organic Anion Transporters, Sodium-Dependent - metabolism | Antigens | Polypeptides | Liver | Envelope protein | Amino acids | Viruses | Infections | Genomes | Proteins | Hepatitis | Sodium | Rodents | Public health | Viral infections | Hepatitis B
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 10/2009, Volume 6, Issue 5, pp. 1591 - 1603
The human apical sodium-dependent bile acid transporter (ASBT; SLC10A2) is the primary mechanism for intestinal bile acid reabsorption. In the colon, secondary... 
Bile acids | Colon cancer | QSAR | SLC10A2 | Bayesian | Transporters | ASBT | MEDICINE, RESEARCH & EXPERIMENTAL | transporters | SERUM-CHOLESTEROL | ILEAL | colon cancer | ANTIHYPERTENSIVE DRUGS | RISK | GUINEA-PIGS | CALCIUM-CHANNEL BLOCKERS | PHARMACOPHORE MODELS | URSODEOXYCHOLIC ACID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | Humans | Intestinal Absorption - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Organic Anion Transporters, Sodium-Dependent - genetics | Organic Anion Transporters, Sodium-Dependent - chemistry | Transfection | Symporters - antagonists & inhibitors | Drug Evaluation, Preclinical | Colonic Neoplasms - etiology | Quantitative Structure-Activity Relationship | Intestinal Absorption - physiology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity | Artificial Intelligence | Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors | Risk Factors | Models, Molecular | Recombinant Proteins - chemistry | Bile Acids and Salts - metabolism | Recombinant Proteins - genetics | Models, Statistical | Symporters - chemistry | Drug Discovery | Calcium Channel Blockers - toxicity | Animals | Models, Biological | Symporters - genetics | Bayes Theorem | Diuretics - chemistry | Dogs | Calcium Channel Blockers - chemistry | Diuretics - toxicity | In Vitro Techniques | Index Medicus
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 01/2018, Volume 151, pp. 13 - 23
Oral absorption of protein/peptide-loaded nanoparticles is often limited by multiple barriers of the intestinal epithelium. In addition to mucus translocation... 
Functional nanoparticles | Bile acid pathway | Intestinal epithelium | Insulin | Oral delivery | Endolysosomal escape | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | BIODEGRADABLE NANOPARTICLES | SIRNA DELIVERY | CELLULAR UPTAKE | DEOXYCHOLIC-ACID | IN-VITRO | TRANSPORT | POLYMERIC NANOPARTICLES | MEDIATED ENDOCYTOSIS | ABSORPTION | Diabetes Mellitus, Experimental - drug therapy | Intestinal Mucosa - metabolism | Membrane Glycoproteins - metabolism | Nanoparticles - chemistry | Humans | Membrane Glycoproteins - chemistry | Deoxycholic Acid - chemistry | Biological Availability | Male | Drug Carriers - chemistry | Organic Anion Transporters, Sodium-Dependent - chemistry | Surface Properties | Carrier Proteins - chemistry | Mucus - metabolism | Caco-2 Cells | Insulin - pharmacology | Drug Trafficking | Administration, Oral | Insulin - administration & dosage | Permeability | Symporters - chemistry | Bile Acids and Salts | Rats, Sprague-Dawley | Symporters - metabolism | Particle Size | Animals | Carrier Proteins - metabolism | Chitosan - chemistry | Cardiovascular System - metabolism | Deoxycholic Acid - metabolism | Drug Liberation | Insulin - adverse effects | Insulin - pharmacokinetics | Organic Anion Transporters, Sodium-Dependent - metabolism | Nanoparticles | Analysis | Epithelium | Diabetes therapy | Protein binding | Deoxycholic acid
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2014, Volume 55, Issue 12, pp. 2576 - 2586
Statins are effective cholesterol-lowering drugs to treat CVDs. Bile acids (BAs), the end products of cholesterol metabolism in the liver, are important... 
Cholesterol 7 α-hydroxylase | Farnesoid X receptor signaling | Ultra-performance liquid chromatographytandem mass spectrometry | farnesoid X receptor signaling | SALT EXPORT PUMP | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | HEPATIC-UPTAKE | KNOCKOUT MICE | TARGETED DISRUPTION | URSODEOXYCHOLIC ACID | MEMBRANE-VESICLES | BILIARY-EXCRETION | ultra-performance liquid chromatography-tandem mass spectrometry | cholesterol 7-hydroxylase | CANCER RESISTANCE PROTEIN | Organic Anion Transporters, Sodium-Independent - genetics | RNA-Binding Proteins - genetics | Intestinal Mucosa - metabolism | Organic Anion Transporters, Sodium-Independent - agonists | Bile Acids and Salts - blood | Liver - enzymology | Lipoproteins - genetics | Humans | Organic Anion Transporters, Sodium-Dependent - agonists | Ileum - metabolism | Male | Lipoproteins - agonists | Intestinal Mucosa - drug effects | ATP-Binding Cassette Transporters - agonists | Organic Anion Transporters, Sodium-Dependent - genetics | Ileum - enzymology | Ileum - drug effects | Organic Anion Transporters, Sodium-Dependent - chemistry | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Enterohepatic Circulation - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | Intestinal Mucosa - enzymology | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Cholesterol 7-alpha-Hydroxylase - chemistry | Heptanoic Acids - pharmacology | RNA-Binding Proteins - antagonists & inhibitors | Liver - metabolism | Mice, Inbred C57BL | Cholestanetriol 26-Monooxygenase - chemistry | Bile Acids and Salts - metabolism | Symporters - chemistry | Symporters - agonists | Atorvastatin Calcium | Cholesterol 7-alpha-Hydroxylase - genetics | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholestanetriol 26-Monooxygenase - genetics | Signal Transduction - drug effects | Cholestanetriol 26-Monooxygenase - metabolism | Cholesterol 7-alpha-Hydroxylase - metabolism | Symporters - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Cytochrome P-450 Enzyme Inducers - pharmacology | RNA-Binding Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 5 | cholesterol 7α-hydroxylase
Journal Article
Journal Article