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index medicus (380) 380
humans (299) 299
animals (267) 267
pharmacology & pharmacy (235) 235
organic anion transporters, sodium-independent - metabolism (210) 210
organic anion transporters, sodium-independent - antagonists & inhibitors (149) 149
male (132) 132
organic anion transporters, sodium-independent - genetics (121) 121
rats (109) 109
organic anion transporters - metabolism (107) 107
solute carrier organic anion transporter family member 1b3 (99) 99
pharmacokinetics (89) 89
drug interactions (80) 80
female (74) 74
organic anion transporters - genetics (71) 71
liver - metabolism (68) 68
organic anion transporter (67) 67
solute carrier organic anion transporter family member 1b1 (67) 67
expression (65) 65
kidney - metabolism (64) 64
cell line (62) 62
organic anion transport protein 1 - metabolism (60) 60
kinetics (59) 59
organic anion transporters - antagonists & inhibitors (59) 59
hek293 cells (58) 58
biological transport (54) 54
identification (51) 51
organic anion transport protein 1 - antagonists & inhibitors (49) 49
rats, sprague-dawley (48) 48
transfection (47) 47
dose-response relationship, drug (45) 45
hepatocytes - metabolism (44) 44
human liver (44) 44
p-glycoprotein (44) 44
adult (43) 43
biological transport - drug effects (42) 42
mice (42) 42
hepatic-uptake (40) 40
kidney (39) 39
organic cation transport proteins - metabolism (39) 39
oatp (38) 38
estrone - analogs & derivatives (37) 37
in-vitro (36) 36
liver (35) 35
xenopus laevis (35) 35
functional-characterization (34) 34
proteins (34) 34
organic anion transporters, sodium-independent - physiology (32) 32
toxicology (32) 32
cells, cultured (31) 31
middle aged (31) 31
dogs (30) 30
molecular-cloning (30) 30
probenecid - pharmacology (30) 30
biochemistry & molecular biology (29) 29
drugs (29) 29
inhibition (29) 29
pharmaceutical preparations - metabolism (29) 29
physiology (29) 29
polypeptides (29) 29
article (28) 28
chemistry, multidisciplinary (28) 28
kidney - drug effects (28) 28
transporter (28) 28
cricetulus (27) 27
disposition (27) 27
organic anion transporters (27) 27
rats, wistar (27) 27
analysis (26) 26
cho cells (26) 26
drug-drug interactions (26) 26
organic anion transport protein 1 - genetics (26) 26
organic anion transporting polypeptide (26) 26
estrone - metabolism (25) 25
hepatocytes - drug effects (25) 25
oocytes - metabolism (25) 25
transporters (25) 25
biomedicine (24) 24
liver - drug effects (24) 24
transport (24) 24
organic cation transporter 2 (23) 23
enzyme inhibitors - pharmacology (22) 22
family (22) 22
membrane transport proteins - metabolism (22) 22
metabolism (22) 22
pharmacology (22) 22
research (22) 22
atp-binding cassette transporters - metabolism (21) 21
gene expression (21) 21
methotrexate (21) 21
oatp1b1 (21) 21
physiological aspects (21) 21
abridged index medicus (20) 20
area under curve (20) 20
carrier proteins - metabolism (20) 20
drug-drug interaction (20) 20
human kidney (20) 20
models, biological (20) 20
nonsteroidal antiinflammatory drugs (20) 20
oatp1b3 (20) 20
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Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4740 - 4763
Journal Article
Kidney International, ISSN 0085-2538, 08/2014, Volume 86, Issue 2, pp. 350 - 357
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1400 - 1407
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism mediated by two cytochrome P450... 
PHARMACOKINETICS | METABOLISM | HEALTHY MALE-SUBJECTS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HUMAN LIVER | RIFAMYCIN SV | EXPRESSION | DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | DRUG-DRUG INTERACTION | Cytochrome P-450 CYP2C9 | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Cyclosporine - pharmacology | Cytochrome P-450 CYP3A | Humans | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Sulfones - pharmacology | Organic Anion Transporters - metabolism | Pyrimidines - chemistry | Pyrimidines - metabolism | Sildenafil Citrate | Organic Anion Transporters - genetics | Bosentan | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Biological Transport - drug effects | Molecular Structure | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Sulfonamides - chemistry | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Sulfonamides - metabolism | Liver-Specific Organic Anion Transporter 1 | Rifampin - pharmacology | Index Medicus
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2014, Volume 78, Issue 3, pp. 587 - 598
AIMS Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their... 
organic anion‐transporting polypeptide | regulatory guidance | breast cancer resistance protein | pitavastatin | rosuvastatin | drug–drug interactions | drug-drug interactions | organic anion-transporting polypeptide 1B | RIFAMPICIN | DRUG-DRUG INTERACTION | HEPATIC-CLEARANCE | P-GLYCOPROTEIN | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | METABOLIZING-ENZYMES | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Area Under Curve | Humans | Middle Aged | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Adult | Female | Rifampin - administration & dosage | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Administration, Oral | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Rosuvastatin | Drug resistance | Investigations | Antilipemic agents | Index Medicus | Drug Metabolism
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2013, Volume 30, Issue 3, pp. 761 - 780
To apply physiologically-based pharmacokinetic (PBPK) modeling to investigate the consequences of reduction in activity of hepatic and intestinal uptake and... 
Biochemistry, general | Biomedical Engineering | cyclosporine | drug-drug interactions | Biomedicine | Pharmacy | OATP1B3 | Medical Law | Pharmacology/Toxicology | physiologically-based pharmacokinetic models | OATP1B1 | ERYTHROCYTE BINDING | IN-VITRO CLEARANCE | SLCO1B1 POLYMORPHISM | REPAGLINIDE PHARMACOKINETICS | MARROW TRANSPLANT PATIENTS | CHEMISTRY, MULTIDISCIPLINARY | MICROEMULSION FORMULATION | 1ST-PASS METABOLISM | PHYSIOLOGICALLY-BASED PHARMACOKINETICS | HEALTHY MALE-VOLUNTEERS | GRAPEFRUIT JUICE | PHARMACOLOGY & PHARMACY | Intestines - drug effects | Intestinal Mucosa - metabolism | Organic Anion Transporters - antagonists & inhibitors | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Cyclosporine - pharmacology | Humans | Liver - metabolism | Enzyme Inhibitors - pharmacology | Organic Anion Transporters - metabolism | Cytochrome P-450 CYP3A Inhibitors | Drug Interactions | Enzyme Inhibitors - pharmacokinetics | Liver - drug effects | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Cyclosporine - pharmacokinetics | Liver-Specific Organic Anion Transporter 1 | Cyclosporine - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Complications and side effects | Metabolites | Drug interactions | Cytochrome P-450 | Drugstores | Models | Physicians (General practice) | Cyclosporine | Side effects | Pharmacology | Kinetics | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6558 - 6567
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2017, Volume 117, pp. 182 - 194
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 8, pp. 4555 - 4564
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 2002, Volume 36, Issue 1, pp. 164 - 172
Journal Article