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Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4740 - 4763
Journal Article
Kidney International, ISSN 0085-2538, 08/2014, Volume 86, Issue 2, pp. 350 - 357
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1400 - 1407
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism mediated by two cytochrome P450... 
PHARMACOKINETICS | METABOLISM | HEALTHY MALE-SUBJECTS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HUMAN LIVER | RIFAMYCIN SV | EXPRESSION | DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | DRUG-DRUG INTERACTION | Cytochrome P-450 CYP2C9 | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Cyclosporine - pharmacology | Cytochrome P-450 CYP3A | Humans | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Sulfones - pharmacology | Organic Anion Transporters - metabolism | Pyrimidines - chemistry | Pyrimidines - metabolism | Sildenafil Citrate | Organic Anion Transporters - genetics | Bosentan | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Biological Transport - drug effects | Molecular Structure | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Sulfonamides - chemistry | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Sulfonamides - metabolism | Liver-Specific Organic Anion Transporter 1 | Rifampin - pharmacology | Index Medicus
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2014, Volume 78, Issue 3, pp. 587 - 598
AIMS Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their... 
organic anion‐transporting polypeptide | regulatory guidance | breast cancer resistance protein | pitavastatin | rosuvastatin | drug–drug interactions | drug-drug interactions | organic anion-transporting polypeptide 1B | RIFAMPICIN | DRUG-DRUG INTERACTION | HEPATIC-CLEARANCE | P-GLYCOPROTEIN | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | METABOLIZING-ENZYMES | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Area Under Curve | Humans | Middle Aged | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Adult | Female | Rifampin - administration & dosage | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Administration, Oral | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Rosuvastatin | Drug resistance | Investigations | Antilipemic agents | Index Medicus | Drug Metabolism
Journal Article
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2006, Volume 130, Issue 6, pp. 1793 - 1806
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism | Index Medicus
Journal Article
Journal Article