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1. Full Text Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): Influence of protein expression on drug-drug interactions
by Karlgren, Maria and Vildhede, Anna and Norinder, Ulf and Wisniewski, Jacek R and Kimoto, Emi and Lai, Yurong and Haglund, Ulf and Artursson, Per and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Gastrointestinalkirurgi and Farmaceutiska fakulteten and Uppsala universitet and Institutionen för kirurgiska vetenskaper and Institutionen för farmaci
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4740 - 4763
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug... 
IN-VITRO | CHEMISTRY, MEDICINAL | RAT | MAJOR DETERMINANT | LIVER | SULFASALAZINE | RESISTANCE-ASSOCIATED PROTEIN-2 | FUNCTIONAL-CHARACTERIZATION | IDENTIFICATION | ERLOTINIB | ATORVASTATIN | Multivariate Analysis | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Pyrroles - pharmacokinetics | Heptanoic Acids - pharmacokinetics | Humans | Structure-Activity Relationship | Organic Anion Transporters - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | Drug Interactions | Protein Isoforms - metabolism | Transfection | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Biological Transport - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Liver - metabolism | Models, Molecular | Atorvastatin Calcium | Estradiol - pharmacokinetics | Estrone - analogs & derivatives | Least-Squares Analysis | Estrone - pharmacokinetics | In Vitro Techniques | Solute Carrier Organic Anion Transporter Family Member 1b1 | Protein Isoforms - antagonists & inhibitors | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
by Lepist, Eve-Irene and Zhang, Xuexiang and Hao, Jia and Huang, Yong and Huang, Jane and Kosaka, Alan and Birkus, Gabriel and Murray, Bernard P and Bannister, Roy and Cihlar, Tomas and Ray, Adrian S
Kidney International, ISSN 0085-2538, 08/2014, Volume 86, Issue 2, pp. 350 - 357
Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the... 
creatinine | creatinine clearance | proximal tubule | glomerular filtration rate | antibiotics | Cockcroft–Gault | Cockcroft-Gault | CLEARANCE | HEALTHY-SUBJECTS | CO-FORMULATED ELVITEGRAVIR | INITIAL TREATMENT | HUMAN KIDNEY | GLOMERULAR-FILTRATION-RATE | DISOPROXIL FUMARATE | DOUBLE-BLIND | UROLOGY & NEPHROLOGY | HIV-1 INFECTION | DRUG-DRUG INTERACTIONS | Recombinant Proteins - metabolism | Cell Line | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Kidney Tubules - drug effects | Organic Cation Transport Proteins - metabolism | Biological Transport, Active - drug effects | Humans | Cells, Cultured | Organic Cation Transporter 2 | Creatinine - metabolism | Animals | Organic Cation Transport Proteins - antagonists & inhibitors | Organic Anion Transporters, Sodium-Independent - metabolism | Dogs | HEK293 Cells | Cimetidine - pharmacology | Creatinine - blood | Thiazoles - pharmacology | Kinetics | Kidney Tubules - metabolism | Cobicistat | CHO Cells | Carbamates - pharmacology | Index Medicus | Basic Research
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3. Full Text Prediction of organic anion-transporting polypeptide 1B1- and 1B3- mediated hepatic uptake of statins based on transporter protein expression and activity data
by Kunze, Annett and Huwyler, Jörg and Camenisch, Gian and Poller, Birk
Drug Metabolism and Disposition, ISSN 0090-9556, 2014, Volume 42, Issue 9, pp. 1514 - 1521
Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 are drug transporters mediating the active hepatic uptake of their substrates. Because they... 
CLEARANCE | COA REDUCTASE INHIBITORS | UDP-GLUCURONOSYLTRANSFERASES | PITAVASTATIN | HUMAN HEPATOCYTES | CYTOCHROME-P450 ENZYMES | HUMANS | PHARMACOLOGY & PHARMACY | ABSOLUTE QUANTIFICATION | DRUG-DRUG INTERACTIONS | OATP1B1 | Cell Line | Humans | Liver - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Drug Interactions - physiology | HEK293 Cells | Membrane Transport Proteins - metabolism | Biological Transport - physiology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Solute Carrier Organic Anion Transporter Family Member 1B3 | Index Medicus
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4. Full Text Hepatocellular carcinoma: Signal intensity at gadoxetic acid - Enhanced MR imaging - Correlation with molecular transporters and histopathologic features
by Kitao, Azusa and Zen, Yoh and Matsui, Osamu and Gabata, Toshifumi and Kobayashi, Satoshi and Koda, Wataru and Kozaka, Kazuto and Yoneda, Norihide and Yamashita, Tatsuya and Kaneko, Shuichi and Nakanuma, Yasuni
Radiology, ISSN 0033-8419, 09/2010, Volume 256, Issue 3, pp. 817 - 826
Purpose: To analyze the correlation between signal intensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging and the... 
ORGANIZATION | DIAGNOSIS | FOCAL LIVER-LESIONS | GENE | SAFETY | GD-EOB-DTPA | MULTIDRUG-RESISTANCE PROTEIN | IDENTIFICATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CONTRAST AGENT | POLYPEPTIDE | Immunohistochemistry | Humans | Middle Aged | Contrast Media - pharmacokinetics | Magnetic Resonance Imaging - methods | Male | RNA, Messenger - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Statistics, Nonparametric | Aged, 80 and over | Adult | Female | Gadolinium DTPA - pharmacokinetics | Liver Neoplasms - pathology | Retrospective Studies | Solute Carrier Organic Anion Transporter Family Member 1B3 | Carcinoma, Hepatocellular - diagnosis | Chi-Square Distribution | Reverse Transcriptase Polymerase Chain Reaction | Liver Neoplasms - diagnosis | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Aged | Multidrug Resistance-Associated Proteins - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus | Abridged Index Medicus
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5. Full Text Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression
by Shen, Hong and Liu, Tongtong and Morse, Bridget L and Zhao, Yue and Zhang, Yueping and Qiu, Xi and Chen, Cliff and Lewin, Anne C and Wang, Xi-Tao and Liu, Guowen and Christopher, Lisa J and Marathe, Punit and Lai, Yurong
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2015, Volume 43, Issue 7, pp. 984 - 993
The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion of creatinine and its exact localization in the kidney are... 
SERUM CREATININE | INDOMETHACIN TREATMENT | HEPATOCYTES | OAT2 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | LIVER | MULTIDRUG | METHOTREXATE | PHARMACOLOGY & PHARMACY | SECRETION | HUMAN KIDNEY | Immunohistochemistry | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Organic Cation Transport Proteins - metabolism | Species Specificity | Sulfobromophthalein - pharmacology | Humans | Macaca fascicularis | Rats | Antiporters - metabolism | Male | Rats, Sprague-Dawley | Indomethacin - pharmacology | Creatinine - metabolism | Animals | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Kidney Tubules, Proximal - metabolism | Kinetics | Kidney Tubules - metabolism | Index Medicus
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6. Full Text Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil
by Alexander Treiber and Ralph Schneiter and Stephanie Häusler and Bruno Stieger
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1400 - 1407
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism mediated by two cytochrome P450... 
PHARMACOKINETICS | METABOLISM | HEALTHY MALE-SUBJECTS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HUMAN LIVER | RIFAMYCIN SV | EXPRESSION | DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | DRUG-DRUG INTERACTION | Cytochrome P-450 CYP2C9 | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Cyclosporine - pharmacology | Cytochrome P-450 CYP3A | Humans | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Sulfones - pharmacology | Organic Anion Transporters - metabolism | Pyrimidines - chemistry | Pyrimidines - metabolism | Sildenafil Citrate | Organic Anion Transporters - genetics | Bosentan | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Biological Transport - drug effects | Molecular Structure | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Sulfonamides - chemistry | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Sulfonamides - metabolism | Liver-Specific Organic Anion Transporter 1 | Rifampin - pharmacology | Index Medicus
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7. Full Text The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut–liver– kidney axis
by Bush, Kevin T and Wu, Wei and Lun, Christina and Nigam, Sanjay K
Journal of Biological Chemistry, ISSN 0021-9258, 09/2017, Volume 292, Issue 38, pp. 15789 - 15803
The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) have similar substrate specificity for drugs, but it is far from clear whether this holds for... 
ORGANIC ANION TRANSPORTER | METABOLOMICS | OLFACTORY MUCOSA | UREMIC TOXINS | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOROID-PLEXUS | KNOCKOUT MICE | URIC-ACID | BASOLATERAL MEMBRANE-VESICLES | SYSTEMS BIOLOGY | Metabolomics | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transport Protein 1 - metabolism | Organic Anion Transporters, Sodium-Independent - deficiency | Liver - metabolism | Mice, Inbred C57BL | Gastrointestinal Microbiome | Substrate Specificity | Bile Acids and Salts - metabolism | Lipid Metabolism | Male | Intestines - metabolism | Gene Knockout Techniques | Amino Acids - metabolism | Kidney - metabolism | Animals | Intestines - microbiology | Diet | Energy Metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Ligands | Mice | Xenobiotics - metabolism | Index Medicus | kidney | renal physiology | organic anion | multidrug transporter | OAT3 | drug transport | uremic toxin | Metabolism | xenobiotic | kidney drug transport | solute carrier
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8. Full Text Pitavastatin is a more sensitive and selective organic anion‐transporting polypeptide 1B clinical probe than rosuvastatin
by Prueksaritanont, Thomayant and Chu, Xiaoyan and Evers, Raymond and Klopfer, Stephanie O and Caro, Luzelena and Kothare, Prajakti A and Dempsey, Cynthia and Rasmussen, Scott and Houle, Robert and Chan, Grace and Cai, Xiaoxin and Valesky, Robert and Fraser, Iain P and Stoch, S. Aubrey
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2014, Volume 78, Issue 3, pp. 587 - 598
AIMS Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their... 
organic anion‐transporting polypeptide | regulatory guidance | breast cancer resistance protein | pitavastatin | rosuvastatin | drug–drug interactions | drug-drug interactions | organic anion-transporting polypeptide 1B | RIFAMPICIN | DRUG-DRUG INTERACTION | HEPATIC-CLEARANCE | P-GLYCOPROTEIN | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | METABOLIZING-ENZYMES | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Area Under Curve | Humans | Middle Aged | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Adult | Female | Rifampin - administration & dosage | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Administration, Oral | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Rosuvastatin | Drug resistance | Investigations | Antilipemic agents | Index Medicus | Drug Metabolism
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9. Full Text DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1
by Masaru Hirano and Kazuya Maeda and Yoshihisa Shitara and Yuichi Sugiyama
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2006, Volume 34, Issue 7, pp. 1229 - 1236
It has already been demonstrated that pitavastatin, a novel potent HMG-coenzyme A reductase inhibitor, is taken up into human hepatocytes mainly by organic... 
TRANSPORT | COA REDUCTASE INHIBITORS | MECHANISM | ORGANIC-ANIONS | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-2 | FUNCTIONAL-CHARACTERIZATION | CERIVASTATIN | HEPATIC-UPTAKE | SIMVASTATIN | CYCLOSPORINE | Cell Line | Estradiol - metabolism | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Estrone - pharmacology | Organic Anion Transporters - antagonists & inhibitors | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cyclosporine - pharmacology | Humans | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Estrone - analogs & derivatives | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Transfection | Organic Anion Transporters, Sodium-Independent - metabolism | Estrone - metabolism | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Estradiol - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Index Medicus
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10. Full Text Investigation of endogenous compounds applicable to drug-drug interaction studies involving the renal organic anion transporters, OAT1 and OAT3, in humans
by Tsuruya, Yuri and Kato, Koji and Sano, Yamato and Imamura, Yuichiro and Maeda, Kazuya and Kumagai, Yuji and Sugiyama, Yuichi and Kusuhara, Hiroyuki
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2016, Volume 44, Issue 12, pp. 1825 - 1933
This study was a comprehensive analysis of metabolites in plasma and urine specimens from subjects who received probenecid, a potent inhibitor of renal organic... 
CATION TRANSPORTERS | INHIBITION | UREMIC TOXIN | HEALTHY-SUBJECTS | EXPORT PUMP | TOXIN EXTRUSION PROTEINS | URINARY-EXCRETION | PHARMACOLOGY & PHARMACY | KIDNEY | MASS-SPECTROMETRY | BILE-ACIDS | Cell Line | Organic Anion Transport Protein 1 - metabolism | Kidney - drug effects | Humans | Probenecid - pharmacology | Hydrocortisone - metabolism | Male | Probenecid - metabolism | Penicillin G - pharmacology | Hydrocortisone - analogs & derivatives | Young Adult | Kidney - metabolism | Animals | Organic Anion Transporters, Sodium-Independent - metabolism | Drug Interactions - physiology | HEK293 Cells | Adult | Hydrocortisone - pharmacology | Penicillin G - metabolism | Taurine - pharmacology | Taurine - metabolism | Index Medicus
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11. Full Text Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters
by Mooij, Miriam G and Schwarz, Ute I and de Koning, Barbara A. E and Leeder, J. Steven and Gaedigk, Roger and Samsom, Janneke N and Spaans, Edwin and van Goudoever, Johannes B and Tibboel, Dick and Kim, Richard B and de Wildt, Saskia N
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 2014, Volume 42, Issue 8, pp. 1268 - 1274
Many drugs prescribed to children are drug transporter substrates. Drug transporters are membrane-bound proteins that mediate the cellular uptake or efflux of... 
DNA METHYLATION | MESSENGER-RNA EXPRESSION | HUMAN HEPATOCYTES | GRAPEFRUIT JUICE | RECEPTOR SXR | PHARMACOLOGY & PHARMACY | P-GLYCOPROTEIN EXPRESSION | HUMAN LIVER | FETAL TISSUES | DRUG-METABOLISM | CHILDREN | Organic Anion Transporters, Sodium-Independent - genetics | Gene Expression - genetics | Humans | Liver - metabolism | Child, Preschool | Infant | Male | Intestines - metabolism | Organic Anion Transporters - metabolism | Organic Anion Transporters - genetics | Membrane Transport Proteins - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Adolescent | Adult | Female | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Biological Transport - genetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Child | Multidrug Resistance-Associated Proteins - metabolism | Gene Ontology | Infant, Newborn | Solute Carrier Organic Anion Transporter Family Member 1B3 | Index Medicus
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12. Full Text Organic anion transporter 2 mediates hepatic uptake of tolbutamide, a CYP2C9 probe drug
by Bi, Yi-An and Mathialagan, Sumathy and Tylaska, Laurie and Fu, Myra and Keefer, Julie and Vildhede, Anna and Costales, Chester and Rodrigues, A. David and Varma, Manthena V.S
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2018, Volume 364, Issue 3, pp. 390 - 398
Tolbutamide is primarily metabolized by CYP2C9, and, thus, is frequently applied as a clinical probe substrate for CYP2C9 activity. However, there is a marked... 
COTRANSPORTING POLYPEPTIDE | INTESTINAL-ABSORPTION | GENETIC POLYMORPHISMS | HUMAN HEPATOCYTES | RENAL CLEARANCE | GLUCOSE RESPONSE | QUANTITATIVE PREDICTION | PHARMACOLOGY & PHARMACY | METABOLIC-CLEARANCE | HUMAN LIVER | HEALTHY-VOLUNTEERS | Tissue Distribution | Tolbutamide - pharmacology | Tolbutamide - pharmacokinetics | Biological Transport | Organic Anion Transporters, Sodium-Independent - metabolism | Humans | Liver - metabolism | HEK293 Cells | Hepatocytes - metabolism | Cytochrome P-450 CYP2C9 - metabolism | Tolbutamide - metabolism | Index Medicus
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13. Full Text Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics
by Ho, Richard H and Tirona, Rommel G and Leake, Brenda F and Glaeser, Hartmut and Lee, Wooin and Lemke, Christopher J and Wang, Yi and Kim, Richard B
Gastroenterology, ISSN 0016-5085, 2006, Volume 130, Issue 6, pp. 1793 - 1806
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, target liver HMG-CoA and are of proven benefit in the prevention of... 
CYCLOSPORINE-A | POLYMORPHISMS | RAT HEPATOCYTES | PHARMACOKINETICS | PHARMACOLOGY | TRANSPLANT RECIPIENTS | GASTROENTEROLOGY & HEPATOLOGY | STATINS | OATP-C SLC21A6 | DISPOSITION | POLYPEPTIDE | Organic Anion Transporters, Sodium-Independent - genetics | Fluorobenzenes - pharmacokinetics | Species Specificity | Humans | Molecular Sequence Data | RNA, Messenger - analysis | Male | Organic Anion Transporters, Sodium-Dependent - genetics | Fluorobenzenes - pharmacology | Hepatocytes - cytology | Organic Anion Transporters, Sodium-Independent - metabolism | Base Sequence | Biological Transport - drug effects | Hepatocytes - drug effects | Taurocholic Acid - pharmacology | Pharmacogenetics | Cells, Cultured | Gene Expression Regulation | Probability | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Animals | Pyrimidines - pharmacokinetics | Symporters - drug effects | Organic Anion Transporters, Sodium-Dependent - metabolism | Coenzymes | Thiols | Polypeptides | Messenger RNA | Analysis | Physiological aspects | Rosuvastatin | Coronary heart disease | Deoxycholic acid | Index Medicus | Abridged Index Medicus
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14. Full Text Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3
by Johannes Noà and Renée Portmann and Marie-Elise Brun and Christoph Funk
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism | Index Medicus
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15. Full Text Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide
by Zimmerman, Eric I and Hu, Shuiying and Roberts, Justin L and Gibson, Alice A and Orwick, Shelley J and Li, Lie and Sparreboom, Alex and Baker, Sharyn D
Clinical Cancer Research, ISSN 1078-0432, 03/2013, Volume 19, Issue 6, pp. 1458 - 1466
Purpose: Many tyrosine kinase inhibitors (TKI) undergo extensive hepatic metabolism, but mechanisms of their hepatocellular uptake remain poorly understood. We... 
POLYMORPHISMS | THERAPY | VARIANTS | ONCOLOGY | ANION-TRANSPORTING POLYPEPTIDE | ENZYMES | FUNCTIONAL-CHARACTERIZATION | KINASE INHIBITORS FOCUS | CLINICAL PHARMACOKINETICS | CARRIERS | CANCER | Niacinamide - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - genetics | Humans | Mice, Transgenic | Antineoplastic Agents - administration & dosage | Glucuronic Acid - blood | Organic Anion Transporters - metabolism | Neoplasms - drug therapy | Niacinamide - administration & dosage | Organic Anion Transporters - genetics | Animals | Neoplasms - blood | Neoplasms - genetics | Phenylurea Compounds - administration & dosage | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Niacinamide - pharmacokinetics | Mice | Phenylurea Compounds - pharmacokinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Solute Carrier Organic Anion Transporter Family Member 1B3 | Index Medicus | pharmacokinetics | mouse model | OATP1B | Sorafenib
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16. Full Text Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice
by Van De Steeg, Evita and Van Esch, Anita and Wagenaar, Els and Kenworthy, Kathryn E and Schinkel, Alfred H
Clinical Cancer Research, ISSN 1078-0432, 02/2013, Volume 19, Issue 4, pp. 821 - 832
Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and... 
DRUG | ABCC2 MRP2 | IMPACT | TOXIC METABOLITE 7-HYDROXYMETHOTREXATE | ONCOLOGY | ANION-TRANSPORTING POLYPEPTIDES | IN-VIVO | LIVER | EXPRESSION | CANCER | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Humans | Methotrexate - pharmacokinetics | Mice, Transgenic | Paclitaxel - pharmacokinetics | Organic Anion Transporters - metabolism | Tissue Distribution | Bilirubin - blood | Organic Anion Transporters - genetics | Animals | Liver - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | Methotrexate - administration & dosage | Mice | Paclitaxel - administration & dosage | Solute Carrier Organic Anion Transporter Family Member 1b1 | Solute Carrier Organic Anion Transporter Family Member 1B3 | Index Medicus
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