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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2018, Volume 35, Issue 12, pp. 1 - 10
The organic cation transporters (OCTs) and multidrug and toxin extrusions (MATEs) together are regarded as an organic cation transport system critical to the... 
Biochemistry, general | Biomedicine | irinotecan | Pharmacy | Medical Law | organic cation transporters | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | drug and drug interactions | morphine | DRUG | METFORMIN | TOXIN | GENETIC-VARIANTS | CHEMISTRY, MULTIDISCIPLINARY | POLYMORPHISMS | PAIN | PHARMACOKINETICS | MATES | SUBSTRATE | MULTIDRUG | PHARMACOLOGY & PHARMACY | Ondansetron - pharmacology | Humans | Organic Cation Transporter 2 - antagonists & inhibitors | Organic Cation Transporter 2 - metabolism | Organic Cation Transporter 1 - metabolism | Tissue Distribution | Drug Interactions | HEK293 Cells | Ondansetron - metabolism | Irinotecan - pharmacology | Fluoxetine - pharmacology | Organic Cation Transport Proteins - metabolism | Mice, Inbred C57BL | Amitriptyline - metabolism | Morphine - metabolism | Irinotecan - metabolism | Verapamil - pharmacology | Animals | Imipramine - metabolism | Fluoxetine - metabolism | Organic Cation Transporter 1 - antagonists & inhibitors | Narcotics - metabolism | Amitriptyline - pharmacology | Imipramine - pharmacology | Verapamil - metabolism | Antidepressants | Morphine | Drug interactions | Drugs | Organic cation transporter | Amitriptyline | Kidneys | Fluoxetine | Oct-2 protein | Substrates | Irinotecan | Imipramine | Verapamil | Extrusion | Mice | In vivo methods and tests | Drug interaction | Cations | Inhibition | Transporter
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0169480 - e0169480
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes.... 
ORGANIC CATION TRANSPORTER-2 | RESISTANCE PROTEIN ABCG2 | SODIUM-CHANNELS | MULTIDISCIPLINARY SCIENCES | HUMAN MDR1 | PREGNANE-X-RECEPTOR | RISK-ASSESSMENT | RAT NA(V)1.6 | INSECTICIDES | P-GLYCOPROTEIN | HEPATIC DRUG | Solute Carrier Proteins - metabolism | Cell Line | Pyrethrins - toxicity | Humans | Organic Cation Transporter 1 - metabolism | Structure-Activity Relationship | Allethrin - chemistry | HEK293 Cells - drug effects | Organic Cation Transporter 1 - genetics | Pyrethrins - chemistry | Solute Carrier Proteins - antagonists & inhibitors | Allethrin - toxicity | Pesticides - toxicity | Organic Cation Transporter 1 - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Pesticides - chemistry | Toxicity Tests | Dopamine - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Drug resistance in microorganisms | Insecticides | Research | Regulators | Molecular structure | Toxicity | Material requirements planning | Pyrethroids | Oct-2 protein | Structure-activity relationships | Molecular weight | Proteins | Neurotoxicity | Tetramethrin | Anions | Insecticide resistance | Agrochemicals | Rodents | Inhibition | Protein transport | P-Glycoprotein | Enzymes | Organic cation transporter | Multidrug resistance | Pesticides | Detoxification | Glycoprotein | Breast cancer | Exposure | Mammals | Organic anion transporting polypeptide | Acids | Extrusion | Transporter | Lipophilicity | Cancer | Index Medicus | Life Sciences | Toxicology | Ecology, environment | Health
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144667
Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro... 
GLYCOGEN-SYNTHASE | GF 109203X | DRUG-INTERACTIONS | RAT ADIPOCYTES | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | SELECTIVE INHIBITORS | S6 KINASE | MULTIDRUG-RESISTANCE | POTENT INHIBITORS | CELL-LINE | Green Fluorescent Proteins - metabolism | Organic Cation Transport Proteins - metabolism | Humans | Enzyme Inhibitors - pharmacology | Maleimides - pharmacology | Organic Cation Transporter 1 - metabolism | Green Fluorescent Proteins - genetics | Protein Kinase C - antagonists & inhibitors | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Microscopy, Confocal | Organic Cation Transport Proteins - antagonists & inhibitors | Protein Kinase C - metabolism | Tetraethylammonium - metabolism | HEK293 Cells | Organic Cation Transporter 1 - antagonists & inhibitors | Cell Line, Tumor | Indoles - pharmacology | Organic Cation Transport Proteins - genetics | Enzyme inhibitors | Heterocyclic compounds | Patient outcomes | Dosage and administration | Ion channels | Protein kinases | Health aspects | Drugs | Diabetic retinopathy | Protein kinase C | Staurosporine | Liver | Chelerythrine | Tetraethylammonium | Oct-2 protein | Structure-activity relationships | Kinases | Drug resistance | Blockage | Proteins | Rodents | Penicillin | Organic cation transporter | Polypeptides | Substrate inhibition | Breast cancer | Chemicals | Prescription drugs | Inhibitors | Extrusion | Cations | Diabetes | Transporter | Cancer | Bile | Life Sciences
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2015, Volume 12, Issue 8, pp. 2633 - 2641
Journal Article
Journal Article