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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
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