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American Journal of Pathology, The, ISSN 0002-9440, 2010, Volume 176, Issue 3, pp. 1169 - 1180
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2008, Volume 84, Issue 5, pp. 559 - 562
Journal Article
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 09/2012, Volume 17, Issue 9, pp. 926 - 939
High-affinity transporters for norepinephrine (NE) and serotonin (5-HT), which ensure neurotransmitter clearance at the synapse, are the principal targets of... 
antidepressant response | aminergic neurotransmission | depression | mood | organic cation transporter | REGIONAL-DISTRIBUTION | KNOCK-OUT MICE | MONOAMINE TRANSPORTER | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCED SWIM TEST | MAJOR DEPRESSION | NEUROSCIENCES | IN-VIVO | 5-HT TRANSPORTER | MEDIAL PREFRONTAL CORTEX | PITUITARY-ADRENAL AXIS | HIPPOCAMPAL NEUROGENESIS | Corticosterone | Radioligand Assay - psychology | Male | Anxiety - drug therapy | Limbic System - metabolism | Organic Cation Transport Proteins - physiology | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | Organic Cation Transporter 2 | Brain - metabolism | Depression - drug therapy | Depression - chemically induced | Radioligand Assay - methods | Female | Cyclohexanols - pharmacology | Action Potentials - drug effects | Disease Models, Animal | Limbic System - drug effects | Mice, Inbred C57BL | Molecular Imaging - psychology | Molecular Imaging - methods | Antidepressive Agents, Second-Generation - pharmacology | Organic Cation Transport Proteins - biosynthesis | Mice, Knockout | Action Potentials - physiology | Brain - drug effects | Venlafaxine Hydrochloride | Hippocampus - metabolism | Animals | Norepinephrine - metabolism | Serotonin - metabolism | Cyclohexanols - therapeutic use | Mice | Hippocampus - physiology | Organic Cation Transport Proteins - genetics | Brain | Serotonin | Antidepressants | Physiological aspects | Research | Health aspects | Noradrenaline | Drugs | Animal models | Electrophysiology | Limbic system | Oct-2 protein | Neurotransmitters | Mood | Venlafaxine | Anxiety | Norepinephrine | Hippocampus | monoamines | Life Sciences | Neurons and Cognition
Journal Article
International Immunopharmacology, ISSN 1567-5769, 12/2019, Volume 77, p. 105959
Hook. F. (TwHF), a traditional Chinese Medicine, is effective in treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive... 
Organic cation transporter 2 | TNF-α | Nephrotoxicity | Triptolide | Rheumatoid arthritis
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2551 - 2557
Journal Article
FASEB Journal, ISSN 0892-6638, 04/2017, Volume 31, Issue 4, pp. 1421 - 1433
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 10/2019, Volume 317, Issue 4, pp. F805 - F814
Hydrochlorothiazide (HCTZ) is the most widely used thiazide diuretic for the treatment of hypertension either alone or in combination with other... 
probenecid | MATE2-K | PHYSIOLOGY | THIAZIDE DIURETICS | RAT | organic cation transporters | EXCRETION | renal tubular secretion | hydrochlorothiazide | organic anion transporters | UROLOGY & NEPHROLOGY | valsartan | CROSSOVER | PHARMACOKINETIC INTERACTIONS | HYPERTENSION | KIDNEY | DRUG-DRUG INTERACTIONS
Journal Article