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Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 48 - 53
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2017, Volume 23, Issue 8, pp. 954 - 963
Journal Article
Nature Biotechnology, ISSN 1087-0156, 07/2017, Volume 35, Issue 7, pp. 659 - 666
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7702, pp. 437 - 462
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences... 
HUMAN COLON | GENOMIC INSTABILITY | MUTATIONAL PROCESSES | BIOCONDUCTOR PACKAGE | EXPRESSION ANALYSIS | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | CHRONIC LYMPHOCYTIC-LEUKEMIA | SEQUENCING REVEALS | SOMATIC MUTATIONS | Intestines - drug effects | Intestinal Mucosa - metabolism | Cell Proliferation | Clone Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | DNA Methylation | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Organoids - metabolism | Antineoplastic Agents - pharmacology | Single-Cell Analysis | Colorectal Neoplasms - metabolism | Intestines - pathology | Organoids - pathology | Organoids - cytology | Mutation Rate | Clone Cells - metabolism | Clone Cells - pathology | Organoids - drug effects | Mutation | Colorectal Neoplasms - pathology | Evolution, Molecular | Intestines - cytology | Physiological aspects | Development and progression | Colorectal cancer | Genomics | Colorectal carcinoma | Genomes | Phylogeny | Population genetics | Antitumor agents | Organoids | Intestine | DNA methylation | Phylogenetics | Bioinformatics | Deoxyribonucleic acid--DNA | Trees | Phenotypes | Cloning | Genetic diversity | Diversification | Gene expression | Algorithms | Crypts | Methylation | Cancer | Tumors | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2017, Volume 23, Issue 7, pp. 878 - 884
With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | POPULATIONS | ENDODERM | PATTERNS | RESTORATION | POLYPS | CELL BIOLOGY | MUCOSA | EPITHELIUM | DIFFERENTIATION | EXPRESSION | Colon - cytology | Immunohistochemistry | Antibiotics, Antineoplastic - pharmacology | Human Embryonic Stem Cells | Adenoma - genetics | Heterocyclic Compounds, 3-Ring - pharmacology | Colorectal Neoplasms - genetics | Humans | Colon - drug effects | Gene Expression Profiling | Enteroendocrine Cells - cytology | Flow Cytometry | Gentamicins - pharmacology | Organoids - metabolism | Germ-Line Mutation | Cell Differentiation | Adenomatous Polyposis Coli - genetics | Real-Time Polymerase Chain Reaction | Wnt Signaling Pathway | Adenomatous Polyposis Coli Protein - genetics | Organoids - pathology | Organoids - cytology | Sirolimus - pharmacology | Blotting, Western | Colon - metabolism | Microscopy, Confocal | Fluorescent Antibody Technique | Organoids - drug effects | Adenoma - pathology | Cell Proliferation - drug effects | Mutation | Colorectal Neoplasms - pathology | Induced Pluripotent Stem Cells | Drug Screening Assays, Antitumor | Goblet Cells - cytology | Stem cells | Colorectal cancer | Rapamycin | Dosage and administration | Research | Drug therapy | Gene expression | Cell proliferation | Profiling | Wnt protein | Familial adenomatous polyposis | Colorectal carcinoma | Embryo cells | Drug testing | Small intestine | Cell growth | Organoids | Modelling | Colon | Translation | Patients | Transit | Adenomatous polyposis coli | Amplification | Geneticin | Antibiotics | Large intestine | Strategy | Models | Drug discovery | Pluripotency | Cancer | Inhibitory postsynaptic potentials | Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 187 - 187
The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells that fuels tumour growth. The existence of human CSCs is mainly... 
HETEROGENEITY | MULTIDISCIPLINARY SCIENCES | MOUSE | CRYPT | NICHE | INTESTINE | PLASTICITY | Colonic Neoplasms - genetics | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Neoplastic Stem Cells - drug effects | Colonic Neoplasms - drug therapy | Humans | Male | Molecular Targeted Therapy | Organoids - transplantation | Colonic Neoplasms - metabolism | Keratin-20 - genetics | Cell Tracking | Cell Self Renewal | Neoplastic Stem Cells - metabolism | Organoids - metabolism | Neoplastic Stem Cells - pathology | Cell Differentiation | Organoids - pathology | Neoplastic Stem Cells - transplantation | Gene Knock-In Techniques | Xenograft Model Antitumor Assays | Cell Lineage | Animals | Colonic Neoplasms - pathology | Mice | Receptors, G-Protein-Coupled - genetics | Keratin-20 - metabolism | Prevention | Colon cancer | Health aspects | Cancer cells | Cell culture | Surgical implants | Leukemia | Colorectal carcinoma | Colorectal cancer | Fluorescence | Smooth muscle | Transplantation | Genomes | Drug resistance | Assaying | Fragmentation | Metastases | Heterogeneity | Interleukin 4 | Allografts | Organoids | Intestine | Actin | Cell cycle | Plasticity | Libraries | Lesions | Medical research | Kidneys | Preservation | Probability theory | Color | Regrowth | Histology | Regression analysis | Gene expression | Ablation | Chemotherapy | Image analysis | Detachment | Nuclear fuels | Lymphocytes B | Microscopy | Stem cells | Alleles | Light microscopy | Anoikis | Genetic engineering | Gene mapping | Differentiation | Tumors | Index Medicus
Journal Article