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Journal of the American Chemical Society, ISSN 0002-7863, 09/2008, Volume 130, Issue 38, pp. 12570 - 12571
A family of lipophilic, cationic Au(I) complexes of N-heterocyclic carbenes (NHCs) have been designed as new mitochondria-targeted antitumor agents that... 
SYSTEM | APOPTOSIS | INHIBITION | ANTICANCER | LIGANDS | AURANOFIN | THIOREDOXIN REDUCTASE | TUMOR-CELLS | SELENOCYSTEINE | INDUCTION | CHEMISTRY, MULTIDISCIPLINARY | Mitochondria - enzymology | Selenocysteine - metabolism | Methane - pharmacokinetics | Apoptosis - drug effects | Methane - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Breast Neoplasms - metabolism | Heterocyclic Compounds - chemistry | Mitochondrial Proteins - metabolism | Drug Design | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cysteine - metabolism | Gold - chemistry | Methane - pharmacology | Organometallic Compounds - pharmacokinetics | Mitochondria - metabolism | Gold - pharmacology | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Gold - pharmacokinetics | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Heterocyclic Compounds - pharmacokinetics | Methane - chemistry | Organometallic Compounds - chemistry | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Methane - chemical synthesis | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor | Mitochondria | Gold compounds | Chemical properties | Analysis | Electric properties | Apoptosis | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2014, Volume 136, Issue 33, pp. 11748 - 11756
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug... 
GOLD NANOPARTICLES | THERAPEUTICS | STABILITY | IN-VIVO | NANOMEDICINE | RESISTANCE | SUPRAMOLECULAR NANOSTRUCTURES | NANOCAPSULES | COPOLYMER MICELLES | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | Prodrugs - administration & dosage | Small Molecule Libraries - pharmacology | Nanoparticles - chemistry | Apoptosis - drug effects | Small Molecule Libraries - administration & dosage | Drug Resistance, Multiple - drug effects | Humans | Prodrugs - chemistry | Chlorambucil - pharmacology | MCF-7 Cells | Mammary Neoplasms, Experimental - pathology | Molecular Structure | Iridium - chemistry | Mammary Neoplasms, Experimental - drug therapy | Chlorambucil - chemistry | Rats | Breast Neoplasms - drug therapy | Surface-Active Agents - pharmacology | Small Molecule Libraries - chemistry | Animals | Surface-Active Agents - administration & dosage | Breast Neoplasms - pathology | Mice, Nude | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Mice | Nanoparticles - administration & dosage | Surface-Active Agents - chemistry | Cell Cycle - drug effects | Surface-Active Agents - chemical synthesis | Drug Delivery Systems - methods | Prodrugs - pharmacology | Organometallic Compounds - pharmacology | Drug Resistance, Neoplasm - drug effects | Organometallic Compounds - administration & dosage | Drugs | Drug delivery systems | Care and treatment | Prodrugs | Dosage and administration | Research | Methods | Cancer | Vehicles | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 82 - 92
A series of benzimidazole-based N-heterocyclic carbene (NHC) proligands {1-benzyl-3-(2-methylbenzyl)-benzimidazolium bromide/hexafluorophosphate ( / ),... 
Carbene complex | HT29 | Anticancer agent | Ag–NHC complex | HCT 116 | Antibacterial agent | CHEMISTRY, MEDICINAL | TRANSITION-METAL-COMPLEXES | STABILITY | GOLD COMPOUNDS | LIPOXYGENASE | AG(I) | DNA | AGENTS | Ag-NHC complex | PALLADIUM(II) | MERCURY(II) | CYTOTOXICITY | Antineoplastic Agents - chemical synthesis | Escherichia coli - drug effects | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Structure-Activity Relationship | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Carbolines - chemistry | Heterocyclic Compounds - chemistry | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Carbolines - chemical synthesis | Silver - pharmacology | Silver - chemistry | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Organometallic Compounds - chemical synthesis | Ligands | Organometallic Compounds - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Organometallic Compounds - pharmacology | Bacillus subtilis - drug effects | Carbolines - pharmacology | Drug Screening Assays, Antitumor | Heterocyclic compounds | Analysis | Colorectal cancer | Crystals | Nuclear magnetic resonance spectroscopy | Fluorides | Structure | Antibacterial agents | Index Medicus
Journal Article
Osteoporosis International, ISSN 0937-941X, 1/2012, Volume 23, Issue 1, pp. 305 - 315
Strontium ranelate appears to influence more than alendronate distal tibia bone microstructure as assessed by high-resolution peripheral quantitative computed... 
Osteoporosis | Medicine & Public Health | Alendronate | Orthopedics | Gynecology | Rheumatology | Finite elements analysis | Strontium ranelate | HR-pQCT | Microstructure | Endocrinology | HRpQCT | CORTICAL BONE | ELASTIC PROPERTIES | STRENGTH | QUANTITATIVE COMPUTED-TOMOGRAPHY | TRABECULAR BONE | VERTEBRAL FRACTURES | DISTAL RADIUS | ENDOCRINOLOGY & METABOLISM | ARCHITECTURE | PARATHYROID-HORMONE | POSTMENOPAUSAL WOMEN | Bone and Bones - pathology | Thiophenes - therapeutic use | Radius - pathology | Humans | Middle Aged | Osteoporosis, Postmenopausal - pathology | Tomography, X-Ray Computed | Tibia - pathology | Alendronate - therapeutic use | Bone and Bones - drug effects | Bone and Bones - diagnostic imaging | Osteoporosis, Postmenopausal - diagnostic imaging | Radius - drug effects | Organometallic Compounds - therapeutic use | Female | Finite Element Analysis | Lumbar Vertebrae - physiopathology | Double-Blind Method | Tibia - diagnostic imaging | Bone Density Conservation Agents - therapeutic use | Thiophenes - pharmacology | Tibia - drug effects | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Bone Density - drug effects | Alendronate - pharmacology | Femur Neck - physiopathology | Osteoporosis, Postmenopausal - physiopathology | Aged | Organometallic Compounds - pharmacology | Radius - diagnostic imaging | Structure | Bones | Analysis | Index Medicus | Dual energy X-ray absorptiometry | Radius | Transformation | Bone turnover | Bisphosphonates | Stress | Post-menopause | Strontium | Alendronic acid | Fractures | Computed tomography | Tibia | Risk assessment | Bone mineral density | Bone strength | Age
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 7, pp. 2739 - 2747
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1217 - 1225
RATIONALE:The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. OBJECTIVE:We... 
Hypertension | Angiogenesis | Carbon monoxide | Nitric oxide | Redox regulation | INDUCED ACTIVATION | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | redox regulation | angiogenesis | carbon monoxide | ANGIOTENSIN-II | BLOOD-PRESSURE | NAD(P)H OXIDASE | ENDOTHELIAL-CELLS | IN-VIVO | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | HEMATOLOGY | hypertension | UP-REGULATION | Catalase - pharmacology | Heme Oxygenase-1 - metabolism | Humans | NADPH Oxidases - metabolism | Male | Ischemia - genetics | Carbonates - pharmacology | RNA, Messenger - metabolism | NADPH Oxidases - deficiency | Time Factors | NADPH Oxidases - genetics | Carbonates - metabolism | Hemin - pharmacology | Hypertension - enzymology | Hypertension - genetics | Ischemia - pathology | Cytoprotection | Disease Models, Animal | Muscle, Skeletal - blood supply | NADH, NADPH Oxidoreductases - genetics | Hypertension - pathology | Hydrogen Peroxide - metabolism | Mice, Knockout | Human Umbilical Vein Endothelial Cells - enzymology | Organometallic Compounds - metabolism | Mice | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - enzymology | Hypertrophy | Ischemia - enzymology | Boranes - metabolism | Transfection | NADH, NADPH Oxidoreductases - deficiency | Hypertension - chemically induced | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Angiotensin II | Polyethylene Glycols - pharmacology | Carbon Dioxide - metabolism | Mice, Inbred C57BL | Cells, Cultured | Boranes - pharmacology | Antioxidants - pharmacology | Ischemia - physiopathology | NADPH Oxidase 4 | Hypertension - physiopathology | NADPH Oxidase 1 | Animals | Lung - blood supply | Neovascularization, Physiologic | Organometallic Compounds - pharmacology | Apoptosis | Endothelial Cells - drug effects | Index Medicus
Journal Article
Journal Article