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1. Full Text The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae
by Li, Ruiwen and Wang, Hengqi and Mi, Chuang and Feng, Chenglian and Zhang, Ling and Yang, Lihua and Zhou, Bingsheng
Chemosphere, ISSN 0045-6535, 04/2019, Volume 220, pp. 811 - 817
Tris (1-chloro-2-propyl) phosphate (TCIPP) and tris (2-chloroethyl)phosphate (TCEP) are two widely used chlorinated organophosphate flame retardants (ClOPFRs),... 
Neurodevelopment | Zebrafish | Acetylcholin esterase | TCIPP | TCEP | DEVELOPMENTAL NEUROTOXICITY | PROFILES | PROTEIN | ENVIRONMENTAL SCIENCES | METABOLISM | PHOSPHATE TDCPP | NEUROTRANSMITTERS | ORGANOPHOSPHATE FLAME RETARDANTS | EXPRESSION | EXPOSURE | PLASTICIZERS | Proteins | Phosphates | Complications and side effects | Enzyme inhibitors | Fireproofing agents | Locomotives | Analysis | Choline | Index Medicus
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2. Full Text Adverse effects of lactational exposure to chlorpyrifos in suckling rats
by Mansour, SA and Mossa, AH
Human & Experimental Toxicology, ISSN 0960-3271, 02/2010, Volume 29, Issue 2, pp. 77 - 92
The present study was undertaken to evaluate the oxidative damage, biochemical and histopathological alterations in sucking rats whose mothers were exposed to... 
Chlorpyrifos | Lipid peroxidation | Lactation | Suckling rats | Antioxidant enzymes | Liver and kidney dysfunction | OXIDATIVE STRESS | LIPID-PEROXIDATION | INDUCED TOXICITY | liver and kidney dysfunction | antioxidant enzymes | lipid peroxidation | BREAST-MILK | ZINC | CHILDREN | chlorpyrifos | lactation | LIVER | PESTICIDE-RESIDUES | ORGANOPHOSPHATE | TOXICOLOGY | suckling rats | ADIPOSE-TISSUE | Liver - pathology | Cholinesterase Inhibitors - toxicity | Kidney - pathology | Rats, Wistar | Body Weight - drug effects | Male | Dose-Response Relationship, Drug | Insecticides - administration & dosage | Liver - drug effects | Time Factors | Kidney Diseases - chemically induced | Maternal Exposure - adverse effects | Female | Chemical and Drug Induced Liver Injury - pathology | Animals, Suckling - blood | Kidney - drug effects | Kidney Diseases - pathology | Chlorpyrifos - administration & dosage | Rats | Biomarkers - blood | Animals, Suckling - growth & development | Organ Size - drug effects | Animals | Cholinesterase Inhibitors - administration & dosage | Chlorpyrifos - toxicity | Oxidative Stress - drug effects | Insecticides - toxicity | Animal reproduction | Insecticides | Toxicology | Biochemistry | Rodents | Index Medicus
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3. Full Text Will buffer zones around schools in agricultural areas be adequate to protect children from the potential adverse effects of pesticide exposure?
by Gunier, Robert B and Bradman, Asa and Harley, Kim G and Eskenazi, Brenda
PLoS Biology, ISSN 1544-9173, 12/2017, Volume 15, Issue 12, pp. e2004741 - e2004741
California has proposed limiting agricultural pesticide use within 0.4 km of schools and child-care facilities. However, the 0.4-km buffer may not be... 
RESIDENTIAL PROXIMITY | ATTENTION | DEFECTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYL | BIOLOGY | HOUSE-DUST | ORGANOPHOSPHATE | DISORDERS | HEALTH | ASSOCIATION | CHILDHOOD | Conservation of Natural Resources - methods | Agrochemicals - toxicity | Pesticides - toxicity | Humans | Government Regulation | Environmental Exposure - prevention & control | Agriculture - methods | California | Child | Schools | Conservation of Natural Resources - legislation & jurisprudence | Urine | Agricultural chemicals | Respiratory function | Toxicity | Pesticides | Environmental health | Agricultural commodities | Exposure | Pregnancy | Dust | Metabolites | Agrochemicals | Womens health | Agriculture | Regulation | Buffer zones | Internet | Children | Environmental monitoring | Pesticide toxicity | Public health | Index Medicus
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4. Full Text Does the home environment and the sex of the child modify the adverse effects of prenatal exposure to chlorpyrifos on child working memory?
by Horton, Megan K and Kahn, Linda G and Perera, Frederica and Barr, Dana Boyd and Rauh, Virginia
Neurotoxicology and Teratology, ISSN 0892-0362, 2012, Volume 34, Issue 5, pp. 534 - 541
Abstract Prenatal exposure to chlorpyrifos (CPF), an organophosphorus insecticide, has long been associated with delayed neurocognitive development and most... 
Medical Education | Emergency | Chlorpyrifos | Neurodevelopment | Working memory | HOME inventory | Sex-specific | ORGANOPHOSPHATE PESTICIDE EXPOSURE | LEAD-EXPOSURE | BEHAVIORAL-ASSESSMENT SCALE | LOW-BIRTH-WEIGHT | COGNITIVE-DEVELOPMENT | NEUROSCIENCES | EXECUTIVE FUNCTION | PHTHALATE EXPOSURE | 1ST 3 YEARS | TOXICOLOGY | GENDER-DIFFERENCES | INNER-CITY CHILDREN | Prospective Studies | Prenatal Exposure Delayed Effects - psychology | Humans | Male | Memory, Short-Term - drug effects | Sex Characteristics | Urban Population | Cognition - drug effects | Insecticides - blood | Socioeconomic Factors | Chlorpyrifos - blood | Pregnancy | Regression Analysis | Parenting - psychology | Fetal Blood - chemistry | Chlorpyrifos - toxicity | Female | Surveys and Questionnaires | Child | Insecticides - toxicity | Prenatal Exposure Delayed Effects - chemically induced | Cohort Studies | Parenting | Complications and side effects | Enzyme inhibitors | Employment | Child labor practices | Pregnant women | Short-term memory | Children | Index Medicus | Side effects | Cognitive ability | Sex | Development | Insecticides | Cognition | Environmental factors | Prenatal experience | Short term memory | Age | sex-specific | neurodevelopment | chlorpyrifos | working memory
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5. Full Text Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level
by García-García, Carmen R and Parrón, Tesifón and Requena, Mar and Alarcón, Raquel and Tsatsakis, Aristidis M and Hernández, Antonio F
Life Sciences, ISSN 0024-3205, 01/2016, Volume 145, pp. 274 - 283
Although epidemiological studies have investigated associations between occupational pesticide exposures and different adverse health outcomes, they have... 
Occupational health | Chronic toxicity | Cholinesterase | Pesticides | Serum enzymes | MEDICINE, RESEARCH & EXPERIMENTAL | ACETYLCHOLINESTERASE ACTIVITY | OXIDATIVE STRESS | LIPID-PEROXIDATION | SPRAYERS | RISK | INHIBITION | GLUCOSE-METABOLISM | ORGANOPHOSPHATE | PHARMACOLOGY & PHARMACY | ENVIRONMENTAL EXPOSURE | Skin Diseases - chemically induced | Farmers | Occupational Exposure - adverse effects | Humans | Middle Aged | Male | Agriculture - methods | Agricultural Workers' Diseases - enzymology | Blood Cell Count | Skin Diseases - blood | Eye Diseases - chemically induced | Eye Diseases - enzymology | Spain - epidemiology | Eye Diseases - blood | Adult | Female | Pesticides - adverse effects | Skin Diseases - enzymology | Acetylcholinesterase - metabolism | Agricultural Workers' Diseases - blood | Agricultural Workers' Diseases - chemically induced | Health aspects | Epidemiology | Index Medicus
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6. Full Text Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers
by Araoud, Manel and Neffeti, Fadoua and Douki, Wahiba and Hfaiedh, Hassen Ben and Akrout, Mohamed and Hassine, Mohssen and Najjar, Mohamed Fadhel and Kenani, Abderraouf
Journal of Exposure Science and Environmental Epidemiology, ISSN 1559-0631, 05/2012, Volume 22, Issue 3, pp. 243 - 247
Biomonitoring of effects in agricultural workers is necessary to assess the individual risk of handling pesticides. In this study, biochemical and... 
LIPID-PEROXIDATION | cholinesterase | SPRAYERS | occupational health | CANCER | BIOMARKERS | HEALTH SYMPTOMS | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | GENOTOXICITY | pesticides | serum enzymes | FARM-WORKERS | ENZYMES | ORGANOPHOSPHATE PESTICIDES | TOXICOLOGY | cytotoxicity | EXPOSURE | Pesticides - toxicity | Erythrocyte Indices - drug effects | Humans | Middle Aged | Hematocrit | Adult | Female | Male | Surveys and Questionnaires | Agriculture | Clinical Chemistry Tests | Tunisia | Occupational health and safety | Biochemical toxicology | Research | Agricultural laborers | Health aspects | Pesticides | Index Medicus | Creatinine | Alkaline phosphatase | biomonitoring | Hematology | Creatine kinase | biomarkers | Biochemistry | Uric acid | Occupational exposure | L-Lactate dehydrogenase | Chronic exposure | Proteins | Urea | Side effects | Workers | Alanine transaminase | Hemoglobin | Bioindicators | Cell size
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7. Full Text Acetylcholinesterase inhibition as a biomarker of adverse effect: A study of Mytilus edulis exposed to the priority pollutant chlorfenvinphos
by Rickwood, Carrie J and Galloway, Tamara S
Aquatic Toxicology, ISSN 0166-445X, 2004, Volume 67, Issue 1, pp. 45 - 56
The inhibition of acetylcholinesterase (AChE) activity has been used widely as a biomarker of exposure to organophosphorous pesticides (OPs). However,... 
Biomarker | Organophosphorous pesticide | Ecotoxicology | Mytilus edulis | Immunotoxicity | Acetylcholinesterase | Chlorfenvinphos | METHYL PARATHION | organophosphorous pesticide | ecotoxicology | HEAVY-METALS | acetylcholinesterase | biomarker | BIVALVE MOLLUSK | PESTICIDES | MUSSEL | MARINE & FRESHWATER BIOLOGY | RAPID ASSESSMENT | immunotoxicity | chlorfenvinphos | ORGANOPHOSPHATE | TOXICOLOGY | INVERTEBRATES | CYTOTOXICITY | Phagocytosis - drug effects | Acetylcholinesterase - blood | Cholinesterase Inhibitors - toxicity | Toxicity Tests, Acute | Down-Regulation - drug effects | Dose-Response Relationship, Drug | Chlorfenvinphos - toxicity | Animals | Water Pollutants, Chemical - toxicity | Hemocytes - drug effects | Biomarkers | Bivalvia - metabolism | Insecticides - toxicity | Neutral Red | Index Medicus
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8. Full Text Metabolome disruption of pregnant rats and their offspring resulting from repeated exposure to a pesticide mixture representative of environmental contamination in Brittany
by Bonvallot, Nathalie and Canlet, Cécile and Blas-Y-Estrada, Florence and Gautier, Roselyne and Tremblay-Franco, Marie and Chevolleau, Sylvie and Cordier, Sylvaine and Cravedi, Jean-Pierre
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, pp. e0198448 - e0198448
The use of pesticides exposes humans to numerous harmful molecules. Exposure in early-life may be responsible for adverse effects in later life. This study... 
LONG-TERM | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | CHLORPYRIFOS | MULTIDISCIPLINARY SCIENCES | URINE | PYRETHROID INSECTICIDE EXPOSURE | ORGANOPHOSPHATE PESTICIDES | METABONOMIC TECHNIQUES | SERUM | SUBCHRONIC EXPOSURE | CHILDREN | Glycine - analogs & derivatives | Glycine - adverse effects | Oxidative Stress | Humans | Proton Magnetic Resonance Spectroscopy | Female | Neonicotinoids - adverse effects | France | Morpholines - adverse effects | Disease Models, Animal | Animals, Newborn | Organophosphorus Compounds - adverse effects | Rats | Nitro Compounds - adverse effects | Toluidines - adverse effects | Chlormequat - adverse effects | Metabolomics - methods | Environmental Exposure - adverse effects | Pregnancy | Animals | Metabolome - drug effects | Carbofuran - adverse effects | Lipid Metabolism - drug effects | Pesticides - adverse effects | Infectious Disease Transmission, Vertical - statistics & numerical data | Nitriles - adverse effects | Metabolomics | Usage | Pesticides | Rattus | Influence | Research | Tricarboxylic acid cycle | Brain | Oxidative stress | Energy metabolism | Carbofuran | Cereals | Nuclear magnetic resonance--NMR | Liver | Amino acids | Insecticides | Glucose | Glyphosate | Glucose metabolism | Herbicides | Toxicology | Mitochondria | Metabolites | Energy | Rodents | Lipid metabolism | Urine | Carbohydrates | Liver diseases | Carbohydrate metabolism | Exposure | Pharmacology | Metabolism | Contamination | Molecular chains | Studies | Progeny | Offspring | Acetochlor | Imidacloprid | Females | Energy storage | Index Medicus | Life Sciences | Santé publique et épidémiologie | Nuclear magnetic resonance | NMR
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9. Full Text Tedizolid population pharmacokinetics, exposure response, and target attainment
by Flanagan, S and Passarell, J and Lu, Q and Fiedler-Kelly, J and Ludwig, E and Prokocimer, P
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6462 - 6470
Tedizolid phosphate is a novel antibacterial prodrug that is rapidly and extensively converted to its active moiety, tedizolid. We developed a population... 
PHOSPHATE | STRAINS | TRIAL | ACUTE BACTERIAL SKIN | SINGLE | OXAZOLIDINONE | PRODRUG | SKIN-STRUCTURE INFECTIONS | TR-701 | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | Organophosphates - adverse effects | Anti-Bacterial Agents - blood | Area Under Curve | Humans | Middle Aged | Biological Availability | Male | Oxazolidinones - adverse effects | Skin Diseases, Bacterial - drug therapy | Tetrazoles - blood | Microbial Sensitivity Tests | Young Adult | Oxazoles - blood | Oxazoles - adverse effects | Adult | Female | Anti-Bacterial Agents - adverse effects | Oxazolidinones - blood | Staphylococcal Infections - microbiology | Staphylococcal Infections - drug therapy | Organophosphates - blood | Methicillin-Resistant Staphylococcus aureus - drug effects | Neutrophils - drug effects | Oxazolidinones - pharmacokinetics | Platelet Count | Prodrugs - pharmacokinetics | Adolescent | Anti-Bacterial Agents - pharmacokinetics | Aged | Tetrazoles - adverse effects | Tetrazoles - pharmacokinetics | Index Medicus | Pharmacology
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10. Full Text Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children
by Gunier, Robert B and Bradman, Asa and Harley, Kim G and Kogut, Katherine and Eskenazi, Brenda
Environmental Health Perspectives, ISSN 0091-6765, 05/2017, Volume 125, Issue 5, pp. 057002 - 057002
BACKGROUND: Residential proximity to agricultural pesticide use has been associated with neural tube defects and autism, but more subtle outcomes such as... 
NEURAL-TUBE DEFECTS | CARBAMATE PESTICIDES | AUTISM SPECTRUM DISORDERS | PRESCHOOL-CHILDREN | ENVIRONMENTAL SCIENCES | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | SAN-JOAQUIN VALLEY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MEXICAN-AMERICAN CHILDREN | PREGNANT-WOMEN | TOXICOLOGY | URINARY METABOLITE LEVELS | CHAMACOS COHORT | Residence Characteristics | Organophosphorus Compounds - adverse effects | Prenatal Exposure Delayed Effects - epidemiology | California - epidemiology | Humans | Male | Environmental Exposure - adverse effects | Pregnancy | Fungicides, Industrial - adverse effects | Maternal Exposure - adverse effects | Female | Intelligence - drug effects | Insecticides - adverse effects | Child | Prenatal Exposure Delayed Effects - chemically induced | Agricultural chemicals | Child development deviations | Children | Research | Health aspects | Risk factors | Developmental disabilities | Fungicides | Intelligence | Toxicity | Pyrethroids | Cognition | Diazinon | Remote sensing | Defects | Organophosphates | Confidence intervals | Neurotoxicity | Regression models | Agrochemicals | Risk assessment | Standard deviation | Organophosphorus pesticides | Pesticide toxicity | Geographic information systems | Chlorpyrifos | Proximity | Statistical analysis | Neural tube defects | Pesticides | Residential location | Malathion | Regression analysis | Oxydemeton | Autism | Carbamates (tradename) | Polybrominated diphenyl ethers | Cognition & reasoning | Womens health | Pesticides (carbamates) | Manganese | Environmental protection | Index Medicus
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11. Full Text Preclinical characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a novel, intravenous, glutamate N-methyl-D-aspartate 2B receptor negative allosteric modulator with potential in major depressive disorder
by Bristow, Linda J and Gulia, Jyoti and Weed, Michael R and Srikumar, Bettadapura N and Li, Yu-Wen and Graef, John D and Naidu, Pattipati S and Sanmathi, Charulatha and Aher, Jayant and Bastia, Tanmaya and Paschapur, Mahesh and Kalidindi, Narasimharaju and Kumar, Kuchibhotla Vijaya and Molski, Thaddeus and Pieschl, Rick and Fernandes, Alda and Brown, Jeffrey M and Sivarao, Digavalli V and Newberry, Kimberly and Bookbinder, Mark and Polino, Joseph and Keavy, Deborah and Newton, Amy and Shields, Eric and Simmermacher, Jean and Kempson, James and Li, Jianqing and Zhang, Huiping and Mathur, Arvind and Kallem, Raja Reddy and Sinha, Meenakshee and Ramarao, Manjunath and Vikramadithyan, Reeba K and Thangathirupathy, Srinivasan and Warrier, Jayakumar and Islam, Imadul and Bronson, Joanne J and Olson, Richard E and Macor, John E and Albright, Charlie F and King, Dalton and Thompson, Lorin A and Marcin, Lawrence R and Sinz, Michael
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 377 - 393
( )-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3 ,4... 
Xenopus | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Organophosphates - adverse effects | Allosteric Regulation | Organophosphates - therapeutic use | Pyrrolidinones - pharmacokinetics | Receptors, N-Methyl-D-Aspartate - metabolism | Macaca fascicularis | Motor Activity - drug effects | Male | Brain - metabolism | Dissociative Disorders - chemically induced | Brain Waves - drug effects | Piperidines - pharmacokinetics | Radioligand Assay | Depressive Disorder, Major - drug therapy | Depressive Disorder, Major - physiopathology | Organophosphates - pharmacokinetics | Pyrrolidinones - adverse effects | Brain - physiopathology | Pyrrolidinones - therapeutic use | Memory, Short-Term - drug effects | Rats, Sprague-Dawley | Antidepressive Agents - therapeutic use | Brain - drug effects | Depressive Disorder, Major - psychology | Prodrugs - adverse effects | Administration, Intravenous | Animals | Prodrugs - pharmacokinetics | Piperidines - therapeutic use | Piperidines - adverse effects | Mice | Prodrugs - therapeutic use | Antidepressive Agents - adverse effects | Antidepressive Agents - pharmacokinetics | Index Medicus
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