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Journal of Clinical Oncology, ISSN 0732-183X, 08/2017, Volume 35, Issue 22, pp. 2490 - 2498
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4948 - 4964
In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC),... 
CELL LUNG-CANCER | WILD-TYPE | CHEMISTRY, MEDICINAL | SRC TYROSINE KINASE | THERAPEUTIC TARGET | RESISTANCE | ATOMS-IN-MOLECULES | ALK INHIBITOR | IDENTIFICATION | ALK/ROS1 INHIBITOR | SMALL-MOLECULE INHIBITOR | Lung Neoplasms - drug therapy | Phosphines - pharmacology | Humans | Molecular Conformation | Lung Neoplasms - pathology | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Protein Kinase Inhibitors - chemistry | Phosphines - chemistry | Organophosphorus Compounds - pharmacology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Lung Neoplasms - enzymology | Administration, Oral | Pyrimidines - administration & dosage | Rats | Organophosphorus Compounds - chemistry | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Protein Kinase Inhibitors - administration & dosage | Animals | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Organophosphorus Compounds - administration & dosage | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Annals of Oncology, ISSN 0923-7534, 03/2014, Volume 25, Issue 3, pp. 742 - 746
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 9, pp. 879 - 886
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 48, Issue 1, pp. 161 - 172
Journal Article
Toxicology Letters, ISSN 0378-4274, 02/2016, Volume 244, pp. 154 - 160
Journal Article
Journal Article
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 11/2018, Volume 171, pp. 358 - 367
New mixed cationic liposomes based on L-α-phosphatidylcholine and dihexadecylmethylhydroxyethylammonium bromide (DHDHAB) were designed to overcome the BBB... 
Self-assembly | Drug delivery systems | Organophosphorus agent | Cationic liposomes | Paraoxon | Surfactant | Acetylcholinesterase | Pralidoxime chloride | SYSTEM | SOLUBILIZATION | MATERIALS SCIENCE, BIOMATERIALS | SYNTHETIC AMPHIPHILE VESICLES | LIGHT-SCATTERING | CHEMISTRY, PHYSICAL | SURFACE-TENSION | NANOPARTICLES | BIOPHYSICS | FLUORESCENCE | NOSE | CHARGE | DIOCTADECYLDIMETHYLAMMONIUM BROMIDE | Cholinesterase Reactivators - administration & dosage | Pralidoxime Compounds - pharmacology | Rhodamines - administration & dosage | Cholinesterase Reactivators - pharmacology | Pralidoxime Compounds - administration & dosage | Paraoxon - antagonists & inhibitors | Quaternary Ammonium Compounds - chemistry | Drug Delivery Systems | Paraoxon - pharmacology | Brain - metabolism | Anti-Bacterial Agents - chemistry | Surface Properties | Bacillus cereus - drug effects | Rhodamines - chemistry | Pralidoxime Compounds - chemistry | Cations - chemistry | Cholinesterase Reactivators - chemistry | Administration, Intranasal | Anti-Bacterial Agents - chemical synthesis | Brain - drug effects | Particle Size | Liposomes - chemistry | Anti-Bacterial Agents - pharmacology | Quaternary Ammonium Compounds - chemical synthesis | Staphylococcus aureus - drug effects | Anti-Bacterial Agents - administration & dosage | Acetylcholinesterase - metabolism | Quaternary Ammonium Compounds - pharmacology | Drugs | Surface active agents | Analysis | Vehicles | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 03/2019, Volume 136, pp. 174 - 183
Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis(hydroxymethyl)phosphonium chloride as crosslinking... 
Camptothecin | Chemotherapy | Drug delivery | Hydrogel | Mucoadhesivity | Oral administration | VITRO | RAT | PERMEABILITY ESTIMATION | CONTROLLED-RELEASE | MECHANISMS | GLUTARALDEHYDE | TRANSPORT | PHARMACOLOGY & PHARMACY | SINGLE-PASS VS | ABSORPTION | IN-SITU | Camptothecin - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Rats, Wistar | Humans | Drug Carriers - administration & dosage | Male | Drug Carriers - chemistry | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Cross-Linking Reagents - pharmacokinetics | Caco-2 Cells | Camptothecin - pharmacokinetics | Cross-Linking Reagents - chemistry | Administration, Oral | Chitosan - administration & dosage | Rats | Antineoplastic Agents, Phytogenic - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacokinetics | Organophosphorus Compounds - chemistry | Cross-Linking Reagents - administration & dosage | Animals | Chitosan - chemistry | Chitosan - pharmacokinetics | Drug Carriers - pharmacokinetics | Organophosphorus Compounds - administration & dosage | Drug Delivery Systems - methods | Organophosphorus Compounds - pharmacokinetics | Index Medicus
Journal Article
MEDICINE, ISSN 0025-7974, 07/2018, Volume 97, Issue 27, pp. e11254 - e11254
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, pp. e0131861 - e0131861
Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and... 
NEUROPATHIC PAIN | NAAG PEPTIDASE INHIBITOR | MEMBRANE ANTIGEN | MULTIDISCIPLINARY SCIENCES | GLUTAMATE-CARBOXYPEPTIDASE-II | COGNITIVE IMPAIRMENT | SPINAL-CORD | GROWTH-FACTOR | NASAL DRUG-DELIVERY | N-ACETYLASPARTYLGLUTAMATE | NAALADASE INHIBITION | Sulfhydryl Compounds - administration & dosage | Central Nervous System - metabolism | Glutamate Carboxypeptidase II - antagonists & inhibitors | Rats, Wistar | Area Under Curve | Glutarates - analysis | Cerebellar Cortex - metabolism | Half-Life | Macaca fascicularis | Male | Olfactory Bulb - metabolism | Chromatography, High Pressure Liquid | Tandem Mass Spectrometry | Glutamate Carboxypeptidase II - metabolism | Glutarates - pharmacokinetics | Organophosphorus Compounds - analysis | Glutarates - administration & dosage | Injections, Intraperitoneal | Rats | Administration, Intranasal | Sulfhydryl Compounds - pharmacokinetics | Sulfhydryl Compounds - analysis | Animals | ROC Curve | Organophosphorus Compounds - administration & dosage | Organophosphorus Compounds - pharmacokinetics | Glutamate | Health aspects | Cerebellum | Brain | Cortex (olfactory) | Neurosciences | Animal models | Spinal cord | Traumatic brain injury | Laboratories | Central nervous system | Nervous system | Enzymatic activity | Carboxypeptidase A | Rodents | Metalloproteinase | Glutamate carboxypeptidase | Drug dosages | Enzymes | Neurodegenerative diseases | Intranasal administration | Exposure | Bioavailability | Behavioral sciences | Neurological diseases | Medicine | Studies | Urea | Neurology | Penetration | Inhibitors | Acids | Olfactory bulb | Prostate | Psychiatry | Glutamic acid receptors (metabotropic) | N-Acetylaspartylglutamic acid | Index Medicus
Journal Article