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Current medicinal chemistry, ISSN 0929-8673, 01/2017, Volume 24, Issue 2, pp. 193 - 214
.... These shortcomings include low targeting specificity, severe side effects (due to high doses) and poor pharmacokinetics... 
Cytotoxicity | Chemotherapy | Metal organic frameworks (MOFs) | Loading | Release | Cancer | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Succinates - pharmacokinetics | Antineoplastic Agents - administration & dosage | Busulfan - administration & dosage | Organoplatinum Compounds - pharmacology | Drug Carriers | Nanoparticles | Fluorouracil - administration & dosage | Organoplatinum Compounds - pharmacokinetics | Camptothecin - administration & dosage | Antineoplastic Agents - pharmacokinetics | Doxorubicin - administration & dosage | Camptothecin - pharmacokinetics | Busulfan - pharmacokinetics | Polymers - chemical synthesis | Doxorubicin - pharmacokinetics | Organometallic Compounds - chemical synthesis | Topotecan - pharmacokinetics | Cell Line, Tumor | Topotecan - administration & dosage | Organometallic Compounds - chemistry | Polymers - chemistry | Porosity | Fluorouracil - pharmacokinetics | Succinates - pharmacology | Drug carriers | Drug delivery systems | 5-Fluorouracil | Biodegradability | Metals | Polyelectrolytes | Drug delivery | Doxorubicin | Biomedical materials | Catalysis | Methotrexate | Polymers | Metal ions | Biodegradation | Medical imaging | Pharmacology | Tamoxifen | Cisplatin | Side effects | In vivo methods and tests | Liposomes | Pharmacokinetics | Metal-organic frameworks
Journal Article
Annals of oncology, ISSN 0923-7534, 06/2013, Volume 24, Issue 6, pp. 1560 - 1567
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2000, Volume 6, Issue 4, pp. 1205 - 1218
.... The pharmacokinetics (PKs) of unbound platinum in plasma ultrafiltrate after oxaliplatin administration was triphasic, characterized by a short initial distribution phase and a long terminal elimination phase ( t 1/2 , 252–273 h... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Agents - metabolism | Area Under Curve | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Biotransformation | Humans | Metabolic Clearance Rate | Antineoplastic Agents - pharmacokinetics | Index Medicus
Journal Article
Dalton transactions : an international journal of inorganic chemistry, ISSN 1477-9226, 01/2015, Volume 44, Issue 1, pp. 202 - 212
Journal Article
Nature communications, ISSN 2041-1723, 06/2014, Volume 5, Issue 1, pp. 4182 - 4182
Journal Article
British journal of cancer, ISSN 0007-0920, 04/2011, Volume 104, Issue 8, pp. 1262 - 1269
BACKGROUND: The identification of molecular and genetic markers to predict or monitor the efficacy of bevacizumab (BV) represents a key issue in the treatment... 
bevacizumab | colorectal cancer | biomarkers | VEGF | Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | Adenocarcinoma - pathology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - genetics | Bevacizumab | Vascular Endothelial Growth Factor Receptor-2 - genetics | Neoplasm Metastasis | Adenocarcinoma - metabolism | Leucovorin - adverse effects | Fluorouracil - adverse effects | Organoplatinum Compounds - pharmacokinetics | Colorectal Neoplasms - drug therapy | Thrombospondin 1 - genetics | Biomarkers, Tumor - metabolism | Camptothecin - administration & dosage | Camptothecin - analogs & derivatives | Vascular Endothelial Growth Factor A - blood | Antibodies, Monoclonal - pharmacokinetics | Vascular Endothelial Growth Factor Receptor-2 - blood | Adenocarcinoma - drug therapy | Leucovorin - pharmacokinetics | Biomarkers, Tumor - genetics | Neovascularization, Pathologic - metabolism | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antibodies, Monoclonal, Humanized | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Adult | Female | Neoadjuvant Therapy | Adenocarcinoma - genetics | Colorectal Neoplasms - metabolism | Camptothecin - pharmacokinetics | Camptothecin - adverse effects | Pharmacogenetics | Drug Administration Schedule | Biomarkers, Tumor - blood | Antibodies, Monoclonal - administration & dosage | Neovascularization, Pathologic - genetics | Aged | Colorectal Neoplasms - pathology | Fluorouracil - pharmacokinetics | Organoplatinum Compounds - adverse effects | Thrombospondin 1 - blood | Index Medicus | Clinical Study
Journal Article