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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 30, pp. 11987 - 11992
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH₃)₂(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double... 
Cell culture techniques | HT29 cells | Reactivity | Platinum | DNA | Cell lines | Antineoplastics | Ligands | Kinetics | Adducts | X-ray crystallography | Metals in medicine | Cancer therapy | DNA damage | Transcription inhibition | cancer therapy | RESPONSES | COMPLEX | CISPLATIN | MULTIDISCIPLINARY SCIENCES | KINETIC CONTROL | metals in medicine | ADDUCTS | CIS-DIAMMINEDICHLOROPLATINUM(II) | transcription inhibition | Phenanthridines - chemistry | Crystallography, X-Ray | Drug Discovery - methods | Platinum Compounds - chemistry | Platinum Compounds - pharmacokinetics | Phenanthridines - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Luciferases | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Deoxyguanine Nucleotides - metabolism | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | Organoplatinum Compounds - chemistry | Phenanthridines - pharmacokinetics | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Genetic Vectors | Phenanthridines - metabolism | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Antimitotic agents | Composition | Platinum compounds | Physiological aspects | Genetic aspects | DNA binding proteins | Research | Antineoplastic agents | Health aspects | Pharmaceutical chemistry | Chemistry | RNA polymerase | Chemical compounds | Deoxyribonucleic acid--DNA | Binding sites | Pharmaceuticals | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2018, Volume 140, Issue 24, pp. 7730 - 7736
Light-emitting supramolecular coordination complexes (SCCs) have been widely studied for applications in the chemical and biological sciences. Herein, we... 
DRUG | METALLACAGES | METAL-ORGANIC FRAMEWORKS | FLUORESCENCE | COMPLEXES | POLYMER | AGENTS | DISCRETE ORGANOPLATINUM(II) METALLACYCLES | CANCER | RECTANGLES | CHEMISTRY, MULTIDISCIPLINARY | Fluorescent Dyes - chemical synthesis | Photosensitizing Agents - chemistry | Theranostic Nanomedicine | Nanoparticles - chemistry | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Fluorescent Dyes - radiation effects | Organoplatinum Compounds - pharmacology | Photosensitizing Agents - pharmacology | Boron Compounds - chemical synthesis | Light | Antineoplastic Agents - radiation effects | Coordination Complexes - pharmacology | Fluorescent Dyes - pharmacology | Antineoplastic Agents - pharmacology | Organoplatinum Compounds - chemistry | Boron Compounds - chemistry | Photosensitizing Agents - chemical synthesis | Photosensitizing Agents - radiation effects | Boron Compounds - pharmacology | Fluorescent Dyes - chemistry | Coordination Complexes - radiation effects | Boron Compounds - radiation effects | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Necrosis - chemically induced | Organoplatinum Compounds - chemical synthesis | Microscopy, Confocal | Organoplatinum Compounds - radiation effects | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Index Medicus
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Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 3, pp. 370 - 383
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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2005, Volume 39, Issue 5, pp. 696 - 703
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together with glutathione reductase (GR)... 
Selenoprotein | Daunorubicin | Oxaliplatin | Glutathione reductase | Alkylating agents | Selenocysteine | Thioredoxin reductase | Doxorubicin | Cisplatin | RAT-LIVER | alkylating agents | MAMMALIAN THIOREDOXIN | HUMAN PLACENTA | REDOX STATE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | thioredoxin reductase | daunorubicin | selenocysteine | selenoprotein | RIBONUCLEOTIDE REDUCTASE | ENDOCRINOLOGY & METABOLISM | oxaliplatin | glutathione reductase | doxorubicin | cisplatin | Busulfan - pharmacology | Antibiotics, Antineoplastic - pharmacology | Antioxidants - metabolism | Daunorubicin - pharmacology | Rats | Substrate Specificity | Antineoplastic Agents, Alkylating - pharmacology | Spectrophotometry - methods | Cisplatin - pharmacology | Chlorambucil - pharmacology | Organoplatinum Compounds - pharmacology | Dose-Response Relationship, Drug | Animals | Time Factors | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Binding Sites | Glutathione Reductase - antagonists & inhibitors | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Antioxidants | Proteins | Antimitotic agents | Care and treatment | Coenzymes | Thiols | Nitrites | Serum albumin | Antineoplastic agents | Cancer | Glutathione | Index Medicus
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 11/2018, Volume 57, Issue 22, pp. 14374 - 14385
Monofunctional pyriplatin analogues cis-[Pt(NH3)(2)(L)Cl](NO3) (1-3) having boron-dipyrromethene (BODIPY) pendants (L) with... 
BODIPY DYES | PHENANTHRIPLATIN | DNA | CONSEQUENCES | ABSORPTION | EXCHANGE | BINDING | CANCER | DERIVATIVES | PLATINUM COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | Photosensitizing Agents - chemistry | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Membrane Potential, Mitochondrial - drug effects | Organoplatinum Compounds - pharmacology | Singlet Oxygen - metabolism | Photosensitizing Agents - pharmacology | G2 Phase Cell Cycle Checkpoints - drug effects | Boron Compounds - chemical synthesis | Cattle | Light | Antineoplastic Agents - radiation effects | Antineoplastic Agents - pharmacology | Porphobilinogen - analogs & derivatives | Organoplatinum Compounds - chemistry | Boron Compounds - chemistry | Photosensitizing Agents - chemical synthesis | Photosensitizing Agents - radiation effects | Boron Compounds - pharmacology | Mitochondria - metabolism | Boron Compounds - radiation effects | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Porphobilinogen - chemistry | Organoplatinum Compounds - chemical synthesis | Microscopy, Confocal | Porphobilinogen - pharmacology | DNA - chemistry | Animals | Organoplatinum Compounds - radiation effects | Cell Line, Tumor | Porphobilinogen - chemical synthesis | Porphobilinogen - radiation effects | G1 Phase Cell Cycle Checkpoints - drug effects | Microscopy, Fluorescence | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 32, pp. 8087 - 8092
Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It is known to exhibit anticancer properties via inhibiting the... 
Drug delivery | Metallacycle | Orthogonal self-assembly | Supramolecular coordination complex | Cancer | APOPTOSIS | POLYMERS | MULTIDISCIPLINARY SCIENCES | ENCAPSULATION | DOXORUBICIN | drug delivery | RELEASE | metallacycle | IN-VITRO | THERAPY | PEPTIDES | PRODRUGS | cancer | ORGANIC FRAMEWORK | orthogonal self-assembly | supramolecular coordination complex | Apoptosis - drug effects | Biocompatible Materials - chemistry | Curcumin - chemistry | Humans | Imidazoles - chemistry | Biological Availability | Cell Line, Tumor - drug effects | Breast Neoplasms | Organoplatinum Compounds - pharmacology | Drug Delivery Systems | Bridged-Ring Compounds - chemistry | MCF-7 Cells | Bridged-Ring Compounds - pharmacology | Water - chemistry | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Molecular Structure | STAT3 Transcription Factor - metabolism | Organoplatinum Compounds - chemistry | Cell Survival - drug effects | Curcumin - pharmacology | Melanoma | Rodentia | Solubility | Biocompatible Materials - pharmacology | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Animals | Paraquat | Curcuma - chemistry | Turmeric | Drugs | Drug delivery systems | Usage | Care and treatment | Platinum compounds | Health aspects | Methods | Vehicles | Self assembly | Phosphorylation | Complex formation | Organometallic compounds | Cancer therapies | Anticancer properties | Rodents | Curcumin | Inhibition | Deoxyribonucleic acid--DNA | Methyl viologen | Stat3 protein | Breast cancer | Bioavailability | Gene expression | Chemical compounds | Self-assembly | Cellular biology | Cell lines | Molecular biology | Combinatorial analysis | Apoptosis | Index Medicus | Physical Sciences
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