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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9089 - 9099
A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed... 
MAMMALIAN THIOREDOXIN | CHEMISTRY, MEDICINAL | ACETYLCHOLINESTERASE | PEROXYNITRITE | DIPHENYL DISELENIDE | AMYLOID-BETA-PEPTIDES | ORGANOSELENIUM COMPOUNDS | HUMAN HEALTH | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | BIOLOGICAL ASSESSMENT | Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 22, pp. 5762 - 5770
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, pp. 190 - 201
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2016, Volume 780, pp. 122 - 128
Journal Article
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 6, pp. 2015 - 2024
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
Journal Article
Journal Article
Journal Article