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1. Full Text The early research and development of ebselen
by Parnham, Michael J and Sies, Helmut
Biochemical Pharmacology, ISSN 0006-2952, 11/2013, Volume 86, Issue 9, pp. 1248 - 1253
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one; PZ-51, DR-3305), is an organoselenium compound with glutathione peroxidase (GPx)-like, thiol-dependent,... 
Glutathione peroxidase | Selenium | Enzyme mimic | Selenoorganic compounds | PZ-51 | PERFUSED RAT-LIVER | ANTIOXIDANT ACTIVITY | SELENOORGANIC COMPOUND | GLUTATHIONE-PEROXIDASE ACTIVITY | PZ-51 EBSELEN | POLYMORPHONUCLEAR LEUKOCYTE | SELENO-ORGANIC COMPOUND | ACTIVE ORGANOSELENIUM COMPOUND | PHARMACOLOGY & PHARMACY | THIOREDOXIN REDUCTASE | CEREBRAL-ISCHEMIA | Clinical Trials as Topic - history | Toxicity Tests - history | History, 21st Century | History, 20th Century | Humans | Biomedical Research - history | Azoles - therapeutic use | Azoles - pharmacology | Organoselenium Compounds - pharmacology | Organoselenium Compounds - history | Animals | Azoles - history | Organoselenium Compounds - therapeutic use | Index Medicus
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2. Full Text Can you teach old drugs new tricks?
by Nosengo, Nicola
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, pp. 314 - 316
Off-Label Use | Sildenafil Citrate - therapeutic use | Humans | Azoles - adverse effects | Organoselenium Compounds - pharmacology | Drugs, Generic - therapeutic use | Drug Industry - methods | Drug Industry - economics | Organoselenium Compounds - adverse effects | Dipyridamole - therapeutic use | Sildenafil Citrate - pharmacology | Drug Approval - statistics & numerical data | Drug Evaluation, Preclinical - methods | Dry Eye Syndromes - drug therapy | Drugs, Generic - pharmacology | Zidovudine - pharmacology | Azoles - pharmacology | Bipolar Disorder - drug therapy | Patents as Topic | Neoplasms - drug therapy | Animals | Drug Repositioning - methods | Epilepsy - drug therapy | Zidovudine - therapeutic use | Carbazoles - therapeutic use | Mice | Carbazoles - pharmacology | Clinical Trials, Phase II as Topic | Multiple Sclerosis - drug therapy
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3. Full Text Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen
by Luo, Zonghua and Sheng, Jianfei and Sun, Yang and Lu, Chuanjun and Yan, Jun and Liu, Anqiu and Luo, Hai-Bin and Huang, Ling and Li, Xingshu
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9089 - 9099
A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed... 
MAMMALIAN THIOREDOXIN | CHEMISTRY, MEDICINAL | ACETYLCHOLINESTERASE | PEROXYNITRITE | DIPHENYL DISELENIDE | AMYLOID-BETA-PEPTIDES | ORGANOSELENIUM COMPOUNDS | HUMAN HEALTH | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | BIOLOGICAL ASSESSMENT | Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
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4. Full Text Therapeutic nanocarriers with hydrogen peroxide-triggered drug release for cancer treatment
by Liu, Jinyao and Pang, Yan and Zhu, Zhaoyang and Wang, Dali and Li, Chunting and Huang, Wei and Zhu, Xinyuan and Yan, Deyue
Biomacromolecules, ISSN 1525-7797, 05/2013, Volume 14, Issue 5, pp. 1627 - 1636
Chemotherapy is an important modality in cancer treatment. The major challenge of recent works in this research field is to develop new types of smart... 
POLYMERS | CELLS | POLYMER SCIENCE | FE3O4 NANOPARTICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUTATHIONE-PEROXIDASE | CHEMISTRY, ORGANIC | MESOPOROUS SILICA NANOPARTICLES | MICELLES | SELENIUM | DELIVERY | PROSTATE-CANCER | HYPERBRANCHED POLYPHOSPHATES | NIH 3T3 Cells | Organoselenium Compounds - chemical synthesis | Nanoparticles - chemistry | Humans | Antineoplastic Agents - administration & dosage | Organoselenium Compounds - pharmacology | Micelles | Organophosphorus Compounds - pharmacology | Antineoplastic Agents - pharmacology | Doxorubicin - administration & dosage | Cell Survival - drug effects | Organophosphorus Compounds - chemical synthesis | Oxidation-Reduction | Polymers - chemical synthesis | Drug Carriers - chemical synthesis | Drug Carriers - pharmacology | Hydrogen Peroxide - metabolism | Surface-Active Agents - pharmacology | Animals | Polymers - pharmacology | Hydrophobic and Hydrophilic Interactions | Mice | HeLa Cells | Surface-Active Agents - chemical synthesis | Delayed-Action Preparations | Doxorubicin - pharmacology | Hydrogen-Ion Concentration | Index Medicus
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5. Full Text Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease
by Barbosa, Flavio A.R and Canto, Rômulo F.S and Saba, Sumbal and Rafique, Jamal and Braga, Antonio L
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 22, pp. 5762 - 5770
This paper describes the synthesis and evaluation of new dihydropyrimidinone (DHPM)-derived selenoesters as potential multi-targeted agents for the treatment... 
Dihydropyrimidinones | Selenium | Selenoesters | Antioxidant | Alzheimer's disease | DESIGN | CHEMISTRY, MEDICINAL | ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | MEMORY | DIPHENYL DISELENIDE | PHARMACOLOGY | MICE | ACETYLCHOLINESTERASE INHIBITORS | DERIVATIVES | Organoselenium Compounds - chemical synthesis | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Alzheimer Disease - enzymology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Esters - chemical synthesis | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Pyrimidinones - chemistry | Dose-Response Relationship, Drug | Cholinesterase Inhibitors - pharmacology | Esters - chemistry | Pyrimidinones - pharmacology | Molecular Structure | Esters - pharmacology | Analysis | Antioxidants | Photoionization | Therapeutics | Diagnostic imaging | Mass spectrometry | Galanthamine | Homeopathy | Materia medica and therapeutics | Index Medicus
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6. Full Text Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation
by Shaaban, Saad and Negm, Amr and Sobh, Mohamed A and Wessjohann, Ludger A
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, pp. 190 - 201
Oxidative stress (OS) and disturbed intracellular redox balance have been predominantly observed in different types of cancer, including hepatocellular... 
GPx mimics | Ebselen | Diselenides | Multicomponent reactions | Organoselenocyanates | ANTIOXIDANT ACTIVITY | CHEMISTRY, MEDICINAL | SELENOORGANIC COMPOUND | GLUTATHIONE-PEROXIDASE | AMIDE CARBOXYLIC-ACID | CIS-CYCLOHEXANE-1,2-CARBOXYLIC ANHYDRIDE | DIPHENYL DISELENIDE | ORGANOSELENIUM COMPOUND | THIOREDOXIN REDUCTASE | PEROXIDASE-LIKE ACTIVITY | Cell Survival - drug effects | Organoselenium Compounds - chemical synthesis | Antioxidants - chemistry | Oxidation-Reduction | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Selenium Compounds - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Hep G2 Cells | Cyanates - pharmacology | Anti-Infective Agents - chemistry | Carboxylic Acids - chemistry | Drug Design | Selenium Compounds - pharmacology | Selenium Compounds - chemistry | Antineoplastic Agents - pharmacology | Cyanates - chemistry | Cyanates - chemical synthesis | Antioxidants | Enzymes | Online assets | Escherichia coli | Organic acids | Index Medicus
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7. Full Text A safe lithium mimetic for bipolar disorder
by Singh, Nisha and Halliday, Amy C and Thomas, Justyn M and Kuznetsova, Olga and Baldwin, Rhiannon and Woon, Esther C. Y and Aley, Parvinder K and Antoniadou, Ivi and Sharp, Trevor and Vasudevan, Sridhar R and Churchill, Grant C
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1332 - 1332
Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many... 
TARGET | MECHANISM | INOSITOL MONOPHOSPHATASE | MOOD DISORDERS | GLUTATHIONE | RESEARCH-AND-DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | PREVENTION | EBSELEN | EXPRESSION | BRAIN | Humans | Male | Azoles - therapeutic use | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Lithium - therapeutic use | Molecular Mimicry | Inositol - deficiency | Enzyme Inhibitors - chemistry | Behavior, Animal - drug effects | Organoselenium Compounds - therapeutic use | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Inositol - pharmacology | Lithium - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Azoles - pharmacology | Bipolar Disorder - drug therapy | Blood-Brain Barrier - drug effects | Enzyme Inhibitors - therapeutic use | Azoles - chemistry | Blood-Brain Barrier - pathology | Animals | Blood-Brain Barrier - enzymology | Bipolar Disorder - pathology | Bipolar Disorder - enzymology | Mice | Phosphoric Monoester Hydrolases - metabolism | Index Medicus
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8. Full Text 4-Phenylselenyl-7-chloroquinoline, a new quinoline derivative containing selenium, has potential antinociceptive and anti-inflammatory actions
by Pinz, Mikaela and Reis, Angélica S and Duarte, Vanessa and da Rocha, Márcia J and Goldani, Bruna S and Alves, Diego and Savegnago, Lucielli and Luchese, Cristiane and Wilhelm, Ethel A
European Journal of Pharmacology, ISSN 0014-2999, 06/2016, Volume 780, pp. 122 - 128
The development of new drugs to treat painful and inflammatory clinical conditions continues to be of great interest. The present study evaluated the... 
Nociception | Quinoline | Myeloperoxidase | Inflammation | Mice | Selenium | MELOXICAM-LOADED NANOCAPSULES | OXIDATIVE STRESS | ANALGESIC ACTIVITY | ORGANOSELENIUM | ANIMAL-MODELS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FORMALIN TEST | Analgesics - pharmacology | Analgesics - metabolism | Male | Anti-Inflammatory Agents - metabolism | Biphenyl Compounds - metabolism | Organoselenium Compounds - pharmacology | Quinolines - pharmacology | Anti-Inflammatory Agents - therapeutic use | Behavior, Animal - drug effects | Quinolines - toxicity | Benzothiazoles - metabolism | Organoselenium Compounds - therapeutic use | Analgesics - therapeutic use | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Picrates - metabolism | Edema - drug therapy | Analgesics - toxicity | Organoselenium Compounds - toxicity | Sulfonic Acids - metabolism | Quinolines - metabolism | Animals | Quinolines - therapeutic use | Organoselenium Compounds - metabolism | Peroxidase - metabolism | Meloxicam | Antioxidants | Acetic acid | Organic acids | Formaldehyde | Alkaloids | Anti-inflammatory drugs | Index Medicus
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9. Full Text Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity
by Sancineto, Luca and Mariotti, Alice and Bagnoli, Luana and Marini, Francesca and Desantis, Jenny and Iraci, Nunzio and Santi, Claudio and Pannecouque, Christophe and Tabarrini, Oriana
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 24, pp. 9601 - 9614
The interest in the synthesis of Se-containing compounds is growing with the discovery of derivatives exhibiting various biological activities. In this... 
TARGET | POTENT | CHEMISTRY, MEDICINAL | TAT-MEDIATED TRANSCRIPTION | ANALOGS | COLORIMETRIC ASSAY | RESISTANCE | PATIENT | MUTATIONS | SELENIUM | 6-DESFLUOROQUINOLONES | Anti-HIV Agents - pharmacology | Glycine - analogs & derivatives | Humans | Drug Resistance, Viral | Structure-Activity Relationship | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Isoleucine - pharmacology | Isoleucine - chemistry | Glycine - chemistry | HIV-1 - isolation & purification | Benzamides - pharmacology | Benzamides - chemistry | Glutamic Acid - pharmacology | HIV-1 - drug effects | gag Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Molecular Dynamics Simulation | Anti-HIV Agents - chemistry | Glutamic Acid - analogs & derivatives | Glycine - pharmacology | Isoleucine - analogs & derivatives | Cell Line, Tumor | Molecular Docking Simulation | Simian Immunodeficiency Virus - drug effects | Glutamic Acid - chemistry | Index Medicus
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10. Full Text A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity
by Palomba, M and Rossi, L and Sancineto, L and Tramontano, E and Corona, A and Bagnoli, L and Santi, C and Pannecouque, C and Tabarrini, O and Marini, F
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 6, pp. 2015 - 2024
Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/intramolecular nucleophilic substitution pathway with... 
DESIGN | REVERSE-TRANSCRIPTASE INHIBITORS | ASYMMETRIC-SYNTHESIS | CYCLIC DIAZOAMIDES | ORGANOCATALYTIC MICHAEL ADDITION | DIASTEREOSELECTIVE SYNTHESIS | ONE-POT SYNTHESIS | COLORIMETRIC ASSAY | FREE CYCLOPROPANATION | CHEMISTRY, ORGANIC | BIOLOGICAL EVALUATIONS | Anti-HIV Agents - pharmacology | HIV - enzymology | Vinyl Compounds - chemistry | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Molecular Conformation | Indoles - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacology | Anti-HIV Agents - chemical synthesis | Vinyl Compounds - pharmacology | HIV - drug effects | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Cyclopropanes - chemistry | Microbial Sensitivity Tests | Reverse Transcriptase Inhibitors - chemical synthesis | Cyclopropanes - chemical synthesis | Spiro Compounds - chemical synthesis | Indoles - pharmacology | Spiro Compounds - chemistry | Cyclopropanes - pharmacology | Cell Survival - drug effects | Virus Replication - drug effects | HIV Reverse Transcriptase - metabolism | Anti-HIV Agents - chemistry | Cell Line, Tumor | Indoles - chemistry | Spiro Compounds - pharmacology | Index Medicus
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11. Full Text Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
by Takaya, Kai and Suzuki, Takafumi and Motohashi, Hozumi and Onodera, Ko and Satomi, Susumu and Kensler, Thomas W and Yamamoto, Masayuki
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
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12. Full Text Induction of reactive oxygen species by diphenyl diselenide is preceded by changes in cell morphology and permeability in Saccharomyces cerevisiae
by Galant, Leticia Selinger and Braga, Marcos Martins and de Souza, Diego and de Bem, Andreza Fabro and Sancineto, Luca and Santi, Claudio and da Rocha, Joao Batista Teixeira
Free Radical Research, ISSN 1071-5762, 08/2017, Volume 51, Issue 7-8, pp. 657 - 668
Organoselenium compounds, such as diphenyl diselenide (PhSe) 2 and phenylselenium zinc chloride (PhSeZnCl), show protective activities related to their thiol... 
toxicity | Diphenyl diselenide | Saccharomyces cerevisiae | phenylselenium zinc chloride | reactive oxygen species | OXIDATIVE STRESS | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO | ORGANOSELENIUM COMPOUND | SELENIUM-COMPOUNDS | PHARMACOLOGY | AMYLOID-BETA-PEPTIDE | EBSELEN | GLUTATHIONE-S-TRANSFERASE | BRAIN | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Sulfhydryl Compounds - pharmacology | Zinc Compounds - pharmacology | Chlorides - pharmacology | Cell Membrane Permeability - drug effects | Selenium Compounds - pharmacology | Saccharomyces cerevisiae - drug effects | Benzene Derivatives - pharmacology | Organoselenium Compounds - pharmacology | Index Medicus
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13. Full Text Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent
by Liu, Jinyao and Pang, Yan and Chen, Jun and Huang, Ping and Huang, Wei and Zhu, Xinyuan and Yan, Deyue
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 31, pp. 7765 - 7774
Abstract This work presents a highly efficient, broad spectrum and self-delivery anticancer agent, which is the hyperbranched polydiselenide (HPSe) consisting... 
Advanced Basic Science | Dentistry | Broad spectrum | Self-delivery | Anticancer agent | Hyperbranched | Polydiselenide | APOPTOSIS | MATERIALS SCIENCE, BIOMATERIALS | GENE DELIVERY | CANCER CELLS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | MICELLES | POLYMER THERAPEUTICS | SELENIUM | SYNTHETIC-POLYMERS | POLYPHOSPHOESTERS | NANOMEDICINES | Cell Line | Cell Survival - drug effects | Microscopy, Electron, Transmission | Organoselenium Compounds - chemical synthesis | Magnetic Resonance Spectroscopy | Antineoplastic Agents - chemical synthesis | Humans | Caspase 3 - metabolism | Fluorescence | Antineoplastic Agents - chemistry | Organoselenium Compounds - toxicity | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Antineoplastic Agents - toxicity | Microscopy, Confocal | Glutathione - pharmacology | Animals | Flow Cytometry | Micelles | Antineoplastic Agents - pharmacology | Mice | Cell Death - drug effects | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Phosphates | Care and treatment | Anthracyclines | Biological products | Permeability | Cancer | Index Medicus
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14. Full Text Selenium compounds activate early barriers of tumorigenesis
by Wu, Min and Kang, Mandy M and Schoene, Norberta W and Cheng, Wen-Hsing
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 16, pp. 12055 - 12062
Selenium chemoprevention by apoptosis has been well studied, but it is not clear whether selenium can activate early barriers of tumorigenesis, namely... 
GENOMIC INSTABILITY | LUNG-CANCER | OXIDATIVE STRESS | VITAMIN-E | DEPENDENT PHOSPHORYLATION | INDUCED APOPTOSIS | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER CELLS | TRIGGERS SENESCENCE | PREVENTION TRIAL SELECT | Cell Line | Cysteine - analogs & derivatives | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Cell Cycle Proteins - metabolism | Cellular Senescence - drug effects | Male | Neoplasms - prevention & control | Sodium Selenite - pharmacology | Antioxidants - pharmacology | Ataxia Telangiectasia Mutated Proteins | Organoselenium Compounds - pharmacology | DNA-Binding Proteins - metabolism | Cysteine - pharmacology | Cell Line, Tumor | Selenium Compounds - pharmacology | DNA Damage | Histones - metabolism | Selenocysteine - analogs & derivatives | Anticarcinogenic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | Checkpoint Control | Senescence | Signal Transduction | Tumor | ATM | Selenium | Cell Biology
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