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The international journal of neuropsychopharmacology, ISSN 1461-1457, 08/2014, Volume 17, Issue 8, pp. 1193 - 1206
The present study investigated the effects of systemic or intra-dorsolateral periaqueductal gray (dlPAG) administration of CB1 agonists on behavioural changes... 
dorsolateral periaqueductal gray | Cannabinoids | nitric oxide | predator exposure | panic | CAT ODOR | DEFENSIVE BEHAVIORS | RAT | AVERSIVE RESPONSES | PSYCHIATRY | NITRIC-OXIDE SYNTHASE | ENDOCANNABINOID SYSTEM | TYPE-1 RECEPTORS | ANXIETY-LIKE BEHAVIOR | NEUROSCIENCES | CLINICAL NEUROLOGY | DINUCLEOTIDE PHOSPHATE DIAPHORASE | PHARMACOLOGY & PHARMACY | FOS ACTIVATION | Endocannabinoids - pharmacology | Periaqueductal Gray - drug effects | Fear - drug effects | Ornithine - analogs & derivatives | Male | Cannabinoid Receptor Agonists - pharmacology | Fear - physiology | Dose-Response Relationship, Drug | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | Nitric Oxide Synthase Type I - antagonists & inhibitors | Cannabinoid Receptor Antagonists - pharmacology | Pyrazoles - pharmacology | Predatory Behavior | Cats | Microinjections | Enzyme Inhibitors - pharmacology | Ornithine - pharmacology | Morpholines - pharmacology | Rats | Polyunsaturated Alkamides - antagonists & inhibitors | Cannabinoid Receptor Agonists - administration & dosage | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Polyunsaturated Alkamides - administration & dosage | Receptor, Cannabinoid, CB1 - metabolism | Animals | Arachidonic Acids - antagonists & inhibitors | Endocannabinoids - administration & dosage | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - antagonists & inhibitors
Journal Article
Journal of Experimental Biology, ISSN 0022-0949, 2001, Volume 204, Issue 10, pp. 1719 - 1727
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 2b, pp. 570 - 583
BACKGROUND AND PURPOSE Statins, a major component of the prevention of cardiovascular disease, aid progenitor cell functions in vivo and in vitro. Statins... 
circulating angiogenic cells | statin | diabetes | angiogenesis | APOPTOSIS | ACTIVATION | MARROW MONONUCLEAR-CELLS | TRANSPLANTATION | SYNTHASE | ENDOTHELIAL PROGENITOR CELLS | ACUTE MYOCARDIAL-INFARCTION | PHARMACOLOGY & PHARMACY | NEOVASCULARIZATION | DYSFUNCTION | UP-REGULATION | Leukocytes, Mononuclear - metabolism | Neovascularization, Physiologic - drug effects | Apoptosis - drug effects | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Cellular Senescence - drug effects | Nitrates - pharmacology | Ornithine - analogs & derivatives | Male | Stem Cells - cytology | Stem Cells - metabolism | Female | Nitric Oxide Donors - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Leukocytes, Mononuclear - drug effects | Cardiovascular Diseases - metabolism | Cells, Cultured | Ornithine - pharmacology | Imidazoles - pharmacology | Cardiovascular Agents - pharmacology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Cell Movement - drug effects | Diabetes Mellitus, Type 2 - blood | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Benzoates - pharmacology | Stem Cells - drug effects | Aged | Cell Proliferation - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Anticholesteremic Agents - pharmacology | Themed Section | Cardiovascular Pharmacology
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2002, Volume 63, Issue 2, pp. 105 - 115
We determined the mechanisms of resistance of human CCRF-CEM leukemia cells to methotrexate (MTX) vs. those to six novel antifolates: the polyglutamatable... 
Reduced folate carrier | Thymidylate synthase | Folate homeostasis | Antifolate resistance | Folylpolyglutamate synthetase | Polyglutamylation | Drug Resistance, Multiple/physiology | Peptide Synthases/metabolism | Thymidylate Synthase/metabolism | Humans | Leukemia | Folic Acid/metabolism | Homeostasis | Glutamates/pharmacology | Thiophenes/pharmacology | Quinazolines/pharmacology | Pemetrexed | Guanine/analogs & derivatives | Polyglutamic Acid/analogs & derivatives | Biological Transport | gamma-Glutamyl Hydrolase/metabolism | Methotrexate/analogs & derivatives | Tumor Cells, Cultured | Ornithine/analogs & derivatives | Tetrahydrofolates/pharmacology | Drug Screening Assays, Antitumor | Folic Acid Antagonists/pharmacology | Pterins/pharmacology | MOLECULAR CHARACTERIZATION | polyglutamylation | THYMIDYLATE SYNTHASE INHIBITOR | ACQUIRED-RESISTANCE | folate homeostasis | thymidylate synthase | MULTITARGETED ANTIFOLATE | FOLIC-ACID | IN-VITRO | folylpolyglutamate synthetase | DIHYDROFOLATE-REDUCTASE | HUMAN-BREAST | PHARMACOLOGY & PHARMACY | reduced folate carrier | antifolate resistance | FOLYLPOLYGLUTAMATE SYNTHETASE-ACTIVITY | CELLULAR PHARMACOLOGY | Methotrexate - pharmacology | Guanine - analogs & derivatives | gamma-Glutamyl Hydrolase - metabolism | Ornithine - analogs & derivatives | Polyglutamic Acid - analogs & derivatives | Guanine - pharmacology | Drug Resistance, Multiple - physiology | Polyglutamic Acid - metabolism | Methotrexate - metabolism | Ornithine - pharmacology | Thiophenes - pharmacology | Thymidylate Synthase - metabolism | Peptide Synthases - metabolism | Pterins - pharmacology | Glutamates - pharmacology | Folic Acid - metabolism | Tetrahydrofolates - pharmacology | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology | Methotrexate - analogs & derivatives
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2014, Volume 171, Issue 18, pp. 4222 - 4232
Journal Article
PloS one, ISSN 1932-6203, 2020, Volume 15, Issue 2, pp. e0228996 - e0228996
..., Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan, Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine... 
DRUG | MICROTI | IN-VITRO | MULTICENTER | TRYPANOSOMA-BRUCEI | THERAPY | MULTIPLICATION | MULTIDISCIPLINARY SCIENCES | GROWTH | BIGEMINA | COMBINATION | Atovaquone - adverse effects | Cell Survival - drug effects | Diminazene - pharmacology | Hydroxyurea - pharmacology | NIH 3T3 Cells | Humans | Babesia - drug effects | Antineoplastic Agents | Eflornithine - adverse effects | Eflornithine - pharmacology | Male | Diminazene - analogs & derivatives | Clofazimine - adverse effects | Clofazimine - pharmacology | Antiprotozoal Agents - pharmacology | Animals | Hydroxyurea - adverse effects | Foreskin - cytology | Atovaquone - pharmacology | Antiprotozoal Agents - administration & dosage | Dogs | Theileria - drug effects | Mice | Diminazene - adverse effects | Multiplication | Toxicity | Prophylaxis | Cytotoxicity | Hydroxyurea | Cell viability | Biochemistry | Parasites | Polyamines | Drug development | Veterinary medicine | Ribonucleotide reductase | Cattle | Cell cycle | Biocompatibility | Physiology | All terrain vehicles | African trypanosomiasis | Vector-borne diseases | Medical research | Enzymes | Free radicals | Clofazimine | Kidneys | Atovaquone | Oral administration | Pharmacology | Embryo fibroblasts | Chemotherapy | Blood parasites | In vivo methods and tests | Cholecystokinin | Ornithine | Eflornithine | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/1997, Volume 99, Issue 1, pp. 110 - 116
The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide... 
immunocytochemistry | leukocytes | nitric oxide | inflammation | urinary tract infection | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | POLYMORPHONUCLEAR LEUKOCYTES | STIMULATION | HUMAN MACROPHAGES | K QA MEDICINE, RESEARCH & EXPERIMENTAL | PATHWAY | FUNCTIONAL EXPRESSION | CALMODULIN | L-ARGININE | PURIFICATION | ASSOCIATION | Immunohistochemistry | Bacterial Infections - enzymology | Bacterial Infections - urine | Citrulline - analogs & derivatives | Trifluoperazine - pharmacology | Humans | Middle Aged | Nitric Oxide Synthase - drug effects | Ornithine - analogs & derivatives | RNA, Messenger - analysis | Guanidines - pharmacology | Male | omega-N-Methylarginine - pharmacology | Thiourea - pharmacology | Isoenzymes - isolation & purification | Leukocyte Common Antigens - immunology | Isoenzymes - metabolism | Polymerase Chain Reaction | Adult | Female | Nitric Oxide Synthase - biosynthesis | NG-Nitroarginine Methyl Ester - pharmacology | Neutrophils - enzymology | Ornithine - pharmacology | Sulfonamides - pharmacology | Blotting, Western | Urinary Tract Infections - enzymology | Nitroarginine - pharmacology | Cell Membrane - enzymology | Citrulline - pharmacology | Arginine - pharmacology | Canavanine - pharmacology | Aged | Anti-Bacterial Agents - pharmacology | Nitric Oxide Synthase - isolation & purification | Urinary Tract Infections - urine | Isoenzymes - biosynthesis | Thiourea - analogs & derivatives
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 681 - 692
Journal Article
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2004, Volume 4, Issue 10, pp. 781 - 792
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine... 
COLON-CANCER | BREAST-CANCER | ONCOLOGY | INITIATION-FACTOR 5A | PROSTATE-CANCER | PHASE-I CHEMOPREVENTION | ORNITHINE-DECARBOXYLASE ACTIVITY | FAMILIAL ADENOMATOUS POLYPOSIS | ALPHA-DIFLUOROMETHYLORNITHINE OTOTOXICITY | SACCHAROMYCES-CEREVISIAE | CERVICAL INTRAEPITHELIAL NEOPLASIA | Neoplasms - metabolism | Ornithine Decarboxylase - metabolism | Cyclooxygenase 2 | Humans | Eflornithine - pharmacology | Neoplasms - prevention & control | Antineoplastic Agents - therapeutic use | Eflornithine - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neoplasms - genetics | Prostaglandin-Endoperoxide Synthases | Drug Design | Antineoplastic Agents - pharmacology | Genes, Tumor Suppressor | Oncogenes | Ornithine Decarboxylase - genetics | Chemoprevention | Enzyme Inhibitors - pharmacology | Colorectal Neoplasms - prevention & control | Enzyme Inhibitors - therapeutic use | Forecasting | Cyclooxygenase Inhibitors - pharmacology | Neoplasms - drug therapy | Polyamines - metabolism | Membrane Proteins | Ornithine Decarboxylase Inhibitors | Cyclooxygenase 2 Inhibitors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Models, Biological | Cyclooxygenase Inhibitors - therapeutic use | Isoenzymes - antagonists & inhibitors | Causes of | Genetic aspects | Research | Polyamines | Health aspects | Cancer
Journal Article