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Environmental Health Perspectives, ISSN 0091-6765, 8/2011, Volume 119, Issue 8, pp. 1142 - 1148
Background: The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing... 
Chemical hazards | Receptors | Genomics | Environmental health | Agonists | Ligands | Cytotoxicity | Libraries | Environmental agencies | Research | Nuclear receptors | Chemical genomics | qHTS | Assay performance | Tox21 | assay performance | TOXICITY | ANTAGONISM | IDENTIFICATION | ESTROGEN-RECEPTOR | nuclear receptors | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EVOLUTION | DISEASE | ASSAYS | SUPERFAMILY | HEALTH | chemical genomics | cytotoxicity | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Retinoid X Receptor alpha - metabolism | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Humans | Orphan Nuclear Receptors - agonists | Receptors, Androgen - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Receptors, Thrombin - antagonists & inhibitors | Retinoid X Receptor alpha - agonists | Fragile X Mental Retardation Protein | Orphan Nuclear Receptors - antagonists & inhibitors | Retinoid X Receptor alpha - antagonists & inhibitors | PPAR gamma - antagonists & inhibitors | Receptors, Thrombin - agonists | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - metabolism | Receptors, Thrombin - metabolism | Estrogen Receptor alpha - metabolism | Environmental Pollutants - toxicity | Receptors, Cytoplasmic and Nuclear - metabolism | Environmental aspects | Physiological aspects | Cell receptors | Health aspects | Chemicals | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 10/2011, Volume 1, Issue 5, pp. 442 - 456
Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. Epidermal growth factor receptor... 
GROWTH-FACTOR RECEPTOR | ONCOLOGY | LDL RECEPTOR | SIGNALING PATHWAY | NUCLEAR RECEPTORS | PROTEIN-KINASE | LIPID RAFTS | PROSTATE-CANCER | IN-VIVO | KINASE INHIBITORS | FATTY-ACID SYNTHASE | Receptor, Epidermal Growth Factor - genetics | Humans | Brain Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Orphan Nuclear Receptors - metabolism | Cholesterol - genetics | Brain Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | ATP-Binding Cassette Transporters - genetics | Cell Death - genetics | Glioblastoma - genetics | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | Glioblastoma - metabolism | Cell Death - drug effects | ATP Binding Cassette Transporter 1 | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Receptors, LDL - genetics | Orphan Nuclear Receptors - agonists | Brain Neoplasms - genetics | Receptors, LDL - metabolism | Brain Neoplasms - drug therapy | Cholesterol - metabolism | Mice, SCID | Orphan Nuclear Receptors - genetics | Phosphatidylinositol 3-Kinases - genetics | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Quinazolines - therapeutic use | Glioblastoma - pathology | Mice | HeLa Cells | Glioblastoma - drug therapy | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2016, Volume 59, Issue 7, pp. 3489 - 3498
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 35, pp. 21591 - 21602
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. E1898 - E1906
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2011, Volume 119, Issue 5, pp. 1119 - 1136
Loss of dopaminergic neurons and a-synuclein accumulation are the two major pathological hallmarks of Parkinsons disease. Currently, the mechanisms governing... 
Parkinson's disease | 27-hydroxycholesterol | liver X receptor | estrogen receptors | α-synuclein | tyrosine hydroxylase | CAMP RESPONSE ELEMENT | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | MESSENGER-RNA LEVELS | LXR-ALPHA | NUCLEAR RECEPTOR | BETA-DEFICIENT MICE | GENE-EXPRESSION | INDUCED DOPAMINE DEPLETION | NEURONAL CELLS | RAT-BRAIN | a-synuclein | Humans | Neuroblastoma - enzymology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | alpha-Synuclein - biosynthesis | Estrogen Receptor beta - biosynthesis | Liver X Receptors | Up-Regulation - physiology | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Estrogen Receptor beta - antagonists & inhibitors | Neuroblastoma - pathology | Orphan Nuclear Receptors - agonists | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Signal Transduction - genetics | Down-Regulation - drug effects | Hydroxycholesterols - pharmacology | Orphan Nuclear Receptors - biosynthesis | Disease Progression | Down-Regulation - physiology | Up-Regulation - drug effects | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Orphan Nuclear Receptors - antagonists & inhibitors | Parkinson Disease - prevention & control | Parkinson Disease - enzymology | Cell Line, Tumor | Signal Transduction - physiology | Estrogen Receptor alpha - biosynthesis | Neuroblastoma - metabolism | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2015, Volume 25, Issue 2, pp. 372 - 377
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6862 - 6872
High-fat diet and certain dietary patterns are associated with higher incidence of sporadic Alzheimer's disease (AD) and cognitive decline. However, no... 
ABCA1 | ALZHEIMER-DISEASE | TYPE-4 ALLELE | VASCULAR RISK-FACTORS | CHOLESTEROL | DEPOSITION | A-BETA | APOE | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | APOLIPOPROTEIN-E | Enzyme-Linked Immunosorbent Assay - methods | Microglia - metabolism | Age Factors | Memory Disorders - genetics | Humans | Retention (Psychology) - drug effects | Culture Media, Conditioned - chemistry | Culture Media, Conditioned - pharmacology | Hippocampus - drug effects | RNA, Messenger - metabolism | Cerebral Cortex - metabolism | ATP-Binding Cassette Transporters - genetics | Amyloid - metabolism | Liver X Receptors | Amyloid beta-Peptides - metabolism | ATP-Binding Cassette Transporters - metabolism | Cerebral Cortex - drug effects | ATP Binding Cassette Transporter 1 | Disease Models, Animal | Dietary Fats - adverse effects | Peptide Fragments - metabolism | Maze Learning - physiology | Microglia - drug effects | Mice, Inbred C57BL | Orphan Nuclear Receptors - agonists | Cells, Cultured | Mice, Transgenic | Maze Learning - drug effects | Mutation - genetics | Microglia - chemistry | Hippocampus - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - drug therapy | Memory Disorders - etiology | Microdialysis | Analysis of Variance | Sulfonamides - therapeutic use | Mice | Hydrocarbons, Fluorinated - therapeutic use | Index Medicus
Journal Article
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 07/2014, Volume 62, Issue 26, pp. 6130 - 6137
Journal Article