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Environmental Health Perspectives, ISSN 0091-6765, 8/2011, Volume 119, Issue 8, pp. 1142 - 1148
Background: The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing... 
Chemical hazards | Receptors | Genomics | Environmental health | Agonists | Ligands | Cytotoxicity | Libraries | Environmental agencies | Research | Nuclear receptors | Chemical genomics | qHTS | Assay performance | Tox21 | assay performance | TOXICITY | ANTAGONISM | IDENTIFICATION | ESTROGEN-RECEPTOR | nuclear receptors | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EVOLUTION | DISEASE | ASSAYS | SUPERFAMILY | HEALTH | chemical genomics | cytotoxicity | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Retinoid X Receptor alpha - metabolism | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Humans | Orphan Nuclear Receptors - agonists | Receptors, Androgen - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Receptors, Thrombin - antagonists & inhibitors | Retinoid X Receptor alpha - agonists | Fragile X Mental Retardation Protein | Orphan Nuclear Receptors - antagonists & inhibitors | Retinoid X Receptor alpha - antagonists & inhibitors | PPAR gamma - antagonists & inhibitors | Receptors, Thrombin - agonists | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - metabolism | Receptors, Thrombin - metabolism | Estrogen Receptor alpha - metabolism | Environmental Pollutants - toxicity | Receptors, Cytoplasmic and Nuclear - metabolism | Environmental aspects | Physiological aspects | Cell receptors | Health aspects | Chemicals | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2011, Volume 119, Issue 5, pp. 1119 - 1136
Loss of dopaminergic neurons and a-synuclein accumulation are the two major pathological hallmarks of Parkinsons disease. Currently, the mechanisms governing... 
Parkinson's disease | 27-hydroxycholesterol | liver X receptor | estrogen receptors | α-synuclein | tyrosine hydroxylase | CAMP RESPONSE ELEMENT | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | MESSENGER-RNA LEVELS | LXR-ALPHA | NUCLEAR RECEPTOR | BETA-DEFICIENT MICE | GENE-EXPRESSION | INDUCED DOPAMINE DEPLETION | NEURONAL CELLS | RAT-BRAIN | a-synuclein | Humans | Neuroblastoma - enzymology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | alpha-Synuclein - biosynthesis | Estrogen Receptor beta - biosynthesis | Liver X Receptors | Up-Regulation - physiology | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Estrogen Receptor beta - antagonists & inhibitors | Neuroblastoma - pathology | Orphan Nuclear Receptors - agonists | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Signal Transduction - genetics | Down-Regulation - drug effects | Hydroxycholesterols - pharmacology | Orphan Nuclear Receptors - biosynthesis | Disease Progression | Down-Regulation - physiology | Up-Regulation - drug effects | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Orphan Nuclear Receptors - antagonists & inhibitors | Parkinson Disease - prevention & control | Parkinson Disease - enzymology | Cell Line, Tumor | Signal Transduction - physiology | Estrogen Receptor alpha - biosynthesis | Neuroblastoma - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 04/2014, Volume 276, Issue 1, pp. 73 - 81
Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for... 
Fatty acid oxidation | Hepatocytes | Non-alcoholic steatohepatitis | Hepatotoxicity | Fatty acid overload | BETA-OXIDATION | GAMMA | CYTOCHROMES P450 | FATTY LIVER-DISEASE | NUCLEAR RECEPTORS | NONALCOHOLIC STEATOHEPATITIS | RECEPTOR-ALPHA/GAMMA AGONIST | BODY-FAT | IN-VITRO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATIC STEATOSIS | Glycine - analogs & derivatives | Humans | Oleic Acid - adverse effects | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Liver - drug effects | Liver X Receptors | Non-alcoholic Fatty Liver Disease | Drug Evaluation, Preclinical | Fatty Acids, Nonesterified - adverse effects | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Fatty Liver - metabolism | Oxidation-Reduction | Liver - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Orphan Nuclear Receptors - genetics | Fatty Liver - drug therapy | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Orphan Nuclear Receptors - antagonists & inhibitors | Glycine - pharmacology | Lipogenesis - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Lipid Metabolism - drug effects | PPAR gamma - agonists | Peroxisome Proliferator-Activated Receptors - metabolism | Lipotropic Agents - pharmacology | PPAR alpha - agonists | Oxazoles - pharmacology | PPAR alpha - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Monounsaturated fatty acids | Triglycerides | Index Medicus | Oleic Acid | Liver | Gene Expression Regulation | PPAR alpha | Lipid Metabolism | Pharmacology | Glycine | PPAR gamma | Receptors, Cytoplasmic and Nuclear | Fatty Liver | Life Sciences | Oxazoles | Peroxisome Proliferator-Activated Receptors | Fatty Acids, Nonesterified | Lipotropic Agents | Orphan Nuclear Receptors | Lipogenesis | Pharmaceutical sciences | OXIDATION | TRIGLYCERIDES | IN VIVO | PATHOLOGY | 60 APPLIED LIFE SCIENCES | OLEIC ACID | DISEASES | METABOLISM | IN VITRO | GENES | LIVER | LIVER CELLS | RECEPTORS
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2010, Volume 120, Issue 12, pp. 4415 - 4424
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2012, Volume 446, Issue 2, pp. 191 - 201
There is growing evidence showing that prostate cancer cells have perturbed cholesterol homoeostasis, accumulating cholesterol to promote cell growth.... 
Betulin | Tocotrienol | Sterol-regulatory-element-binding protein isoform 2 (SREBP-2) | Vitamin E | Prostate cancer | Cholesterol | sterol-regulatory-element-binding protein isoform 2 (SREBP-2) | ANDROGEN RECEPTOR | VITAMIN-E | BIOCHEMISTRY & MOLECULAR BIOLOGY | vitamin E | TRANSCRIPTION | SUPPRESSION | ELEMENT-BINDING PROTEINS | tocotrienol | TOCOTRIENOL-RICH FRACTION | prostate cancer | GAMMA-TOCOTRIENOL | IN-VIVO | betulin | cholesterol | REDUCTASE | DEPENDENT DEGRADATION | Prostatic Neoplasms - metabolism | Triterpenes - pharmacology | Cricetulus | Humans | Sterol Regulatory Element Binding Protein 2 - antagonists & inhibitors | Vitamin E - analogs & derivatives | Male | Neoplasm Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Orphan Nuclear Receptors - metabolism | Tocotrienols - pharmacology | Chromans - pharmacology | Liver X Receptors | Membrane Proteins - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Prostatic Neoplasms - drug therapy | CHO Cells | Recombinant Proteins - metabolism | Cell Survival - drug effects | Cricetinae | Recombinant Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mutant Proteins - metabolism | Cholesterol - metabolism | Orphan Nuclear Receptors - genetics | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Membrane Proteins - antagonists & inhibitors | Cell Line, Tumor | Antineoplastic Agents, Phytogenic - pharmacology | Vitamin E - pharmacology | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 2014, Volume 281, Issue 3, pp. 970 - 982
Liver X receptors (LXRs) are ligand-activated members of the nuclear receptor superfamily that regulate the expression of genes involved in lipid metabolism... 
Extracellular signal-related kinase (ERK)1/2 | Liver X receptor α | Inflammation | Human leukocytes | Platelet-activating factor | human leukocytes | SIGNALING PATHWAYS | OXIDATIVE STRESS | extracellular signal-related kinase (ERK)1/2 | PHOSPHORYLATION | NUCLEAR RECEPTORS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | platelet-activating factor | ANGIOTENSIN-II | liver X receptor alpha | INTEGRATION | inflammation | NF-KAPPA-B | BINDING | Neutrophils - cytology | Oxidants - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Receptors, G-Protein-Coupled - metabolism | Humans | Platelet Activating Factor - antagonists & inhibitors | Orphan Nuclear Receptors - metabolism | Sterol Regulatory Element Binding Protein 1 - agonists | Platelet Membrane Glycoproteins - antagonists & inhibitors | ATP-Binding Cassette Transporters - genetics | Platelet Membrane Glycoproteins - metabolism | ATP Binding Cassette Transporter 1 - agonists | Phosphorylation - drug effects | Neutrophils - metabolism | Lymphocytes - metabolism | Neutrophils - drug effects | Orphan Nuclear Receptors - agonists | Lymphocytes - cytology | Orphan Nuclear Receptors - genetics | Platelet Activating Factor - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Anticholesteremic Agents - antagonists & inhibitors | Oxidative Stress - drug effects | ATP Binding Cassette Transporter 1 - genetics | ATP-Binding Cassette Transporters - antagonists & inhibitors | Neutrophil Activation - drug effects | Receptors, G-Protein-Coupled - agonists | ATP Binding Cassette Transporter 1 - metabolism | ATP-Binding Cassette Transporters - agonists | Lymphocytes - immunology | Protein Isoforms - metabolism | Protein Processing, Post-Translational - drug effects | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | Platelet Membrane Glycoproteins - agonists | Macrophages - immunology | Sterol Regulatory Element Binding Protein 1 - metabolism | Cells, Cultured | Neutrophils - immunology | Platelet Activating Factor - agonists | Antioxidants - pharmacology | Macrophages - cytology | Down-Regulation - drug effects | Orphan Nuclear Receptors - antagonists & inhibitors | Protein Isoforms - biosynthesis | Sterol Regulatory Element Binding Protein 1 - genetics | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | ATP Binding Cassette Transporter 1 - antagonists & inhibitors | Anticholesteremic Agents - pharmacology | Protein Isoforms - genetics | Index Medicus
Journal Article