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Environmental Health Perspectives, ISSN 0091-6765, 8/2011, Volume 119, Issue 8, pp. 1142 - 1148
Background: The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing... 
Chemical hazards | Receptors | Genomics | Environmental health | Agonists | Ligands | Cytotoxicity | Libraries | Environmental agencies | Research | Nuclear receptors | Chemical genomics | qHTS | Assay performance | Tox21 | assay performance | TOXICITY | ANTAGONISM | IDENTIFICATION | ESTROGEN-RECEPTOR | nuclear receptors | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EVOLUTION | DISEASE | ASSAYS | SUPERFAMILY | HEALTH | chemical genomics | cytotoxicity | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Retinoid X Receptor alpha - metabolism | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Humans | Orphan Nuclear Receptors - agonists | Receptors, Androgen - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Receptors, Thrombin - antagonists & inhibitors | Retinoid X Receptor alpha - agonists | Fragile X Mental Retardation Protein | Orphan Nuclear Receptors - antagonists & inhibitors | Retinoid X Receptor alpha - antagonists & inhibitors | PPAR gamma - antagonists & inhibitors | Receptors, Thrombin - agonists | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - metabolism | Receptors, Thrombin - metabolism | Estrogen Receptor alpha - metabolism | Environmental Pollutants - toxicity | Receptors, Cytoplasmic and Nuclear - metabolism | Environmental aspects | Physiological aspects | Cell receptors | Health aspects | Chemicals | Index Medicus
Journal Article
Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 26, pp. 21628 - 21639
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 04/2014, Volume 276, Issue 1, pp. 73 - 81
Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for... 
Fatty acid oxidation | Hepatocytes | Non-alcoholic steatohepatitis | Hepatotoxicity | Fatty acid overload | BETA-OXIDATION | GAMMA | CYTOCHROMES P450 | FATTY LIVER-DISEASE | NUCLEAR RECEPTORS | NONALCOHOLIC STEATOHEPATITIS | RECEPTOR-ALPHA/GAMMA AGONIST | BODY-FAT | IN-VITRO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATIC STEATOSIS | Glycine - analogs & derivatives | Humans | Oleic Acid - adverse effects | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Liver - drug effects | Liver X Receptors | Non-alcoholic Fatty Liver Disease | Drug Evaluation, Preclinical | Fatty Acids, Nonesterified - adverse effects | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Fatty Liver - metabolism | Oxidation-Reduction | Liver - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Orphan Nuclear Receptors - genetics | Fatty Liver - drug therapy | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Orphan Nuclear Receptors - antagonists & inhibitors | Glycine - pharmacology | Lipogenesis - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Lipid Metabolism - drug effects | PPAR gamma - agonists | Peroxisome Proliferator-Activated Receptors - metabolism | Lipotropic Agents - pharmacology | PPAR alpha - agonists | Oxazoles - pharmacology | PPAR alpha - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Monounsaturated fatty acids | Triglycerides | Index Medicus | Oleic Acid | Liver | Gene Expression Regulation | PPAR alpha | Lipid Metabolism | Pharmacology | Glycine | PPAR gamma | Receptors, Cytoplasmic and Nuclear | Fatty Liver | Life Sciences | Oxazoles | Peroxisome Proliferator-Activated Receptors | Fatty Acids, Nonesterified | Lipotropic Agents | Orphan Nuclear Receptors | Lipogenesis | Pharmaceutical sciences | OXIDATION | TRIGLYCERIDES | IN VIVO | PATHOLOGY | 60 APPLIED LIFE SCIENCES | OLEIC ACID | DISEASES | METABOLISM | IN VITRO | GENES | LIVER | LIVER CELLS | RECEPTORS
Journal Article
Cancer Discovery, ISSN 2159-8274, 10/2011, Volume 1, Issue 5, pp. 442 - 456
Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. Epidermal growth factor receptor... 
GROWTH-FACTOR RECEPTOR | ONCOLOGY | LDL RECEPTOR | SIGNALING PATHWAY | NUCLEAR RECEPTORS | PROTEIN-KINASE | LIPID RAFTS | PROSTATE-CANCER | IN-VIVO | KINASE INHIBITORS | FATTY-ACID SYNTHASE | Receptor, Epidermal Growth Factor - genetics | Humans | Brain Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Orphan Nuclear Receptors - metabolism | Cholesterol - genetics | Brain Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | ATP-Binding Cassette Transporters - genetics | Cell Death - genetics | Glioblastoma - genetics | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | Glioblastoma - metabolism | Cell Death - drug effects | ATP Binding Cassette Transporter 1 | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Receptors, LDL - genetics | Orphan Nuclear Receptors - agonists | Brain Neoplasms - genetics | Receptors, LDL - metabolism | Brain Neoplasms - drug therapy | Cholesterol - metabolism | Mice, SCID | Orphan Nuclear Receptors - genetics | Phosphatidylinositol 3-Kinases - genetics | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Quinazolines - therapeutic use | Glioblastoma - pathology | Mice | HeLa Cells | Glioblastoma - drug therapy | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 2011, Volume 31, Issue 3, pp. 513 - U72
Objective-Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes, but the factors connecting alterations in glucose metabolism with... 
nuclear receptors | apolipoproteins | lipids | metabolism | type II diabetes | RECEPTOR LXR | LOW-DENSITY-LIPOPROTEIN | TRIGLYCERIDE-RICH LIPOPROTEINS | ELEMENT-BINDING PROTEIN | APOC-III | PLASMA | INSULIN-RESISTANCE | C-III LEVELS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | A-I | GENE-TRANSCRIPTION | RNA-Binding Proteins - agonists | Up-Regulation | Humans | Middle Aged | Transcriptional Activation | Male | Orphan Nuclear Receptors - metabolism | RNA, Messenger - metabolism | Obesity - blood | RNA Interference | Time Factors | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Diabetes Complications - genetics | Dyslipidemias - etiology | Diabetes Complications - metabolism | Rats | Hepatocyte Nuclear Factor 4 - genetics | Orphan Nuclear Receptors - genetics | Mice, Knockout | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Dyslipidemias - metabolism | Glucose - metabolism | Mice | Transcription Factors - agonists | Blood Glucose - metabolism | RNA-Binding Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Dyslipidemias - genetics | Diabetes Mellitus, Type 2 - genetics | Receptor, Insulin - deficiency | Apolipoprotein C-III - genetics | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Insulin - blood | Transfection | Receptor, Insulin - genetics | Liver X Receptors | Adult | Diabetes Mellitus, Type 2 - complications | Hepatocyte Nuclear Factor 4 - metabolism | Promoter Regions, Genetic | Heat-Shock Proteins - metabolism | Apolipoprotein C-III - blood | Cells, Cultured | Receptors, Cytoplasmic and Nuclear - agonists | Diabetes Complications - etiology | Transcription Factors - metabolism | Heat-Shock Proteins - agonists | Animals | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2011, Volume 334, Issue 1, pp. 39 - 48
Nuclear hormone receptors (NHRs) are transcription factors that work in concert with co-activators and co-repressors to regulate gene expression. Some examples... 
Molecular evolution | Ciona intestinalis | Oxysterols | Drug modeling | Phylogeny | Bile acids and salts | Cholesterol | CRYSTAL-STRUCTURE | VITAMIN-D-RECEPTOR | XENOBIOTIC RECEPTOR | PREGNANE-X-RECEPTOR | STRUCTURAL DETERMINANTS | CELL BIOLOGY | BILE-ACID METABOLISM | ENDOCRINOLOGY & METABOLISM | LIGAND-BINDING DOMAIN | CIONA-INTESTINALIS | NF-KAPPA-B | CONSTITUTIVE-ANDROSTANE RECEPTOR | Retinoids - metabolism | Receptors, Steroid - metabolism | Humans | Bile Acids and Salts - chemistry | Homeostasis | Vitamin D - chemistry | Orphan Nuclear Receptors - metabolism | Receptors, Calcitriol - genetics | Thyroid Hormones - chemistry | Liver X Receptors | Retinoids - chemistry | Sensitivity and Specificity | Gonadal Steroid Hormones - metabolism | Gene Expression Regulation | Gonadal Steroid Hormones - chemistry | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Calcitriol - metabolism | Transcription Factors - genetics | Cholesterol - metabolism | Orphan Nuclear Receptors - genetics | Transcription Factors - metabolism | Vertebrates | Animals | Energy Metabolism | Receptors, Steroid - genetics | Thyroid Hormones - metabolism | Vitamin D - metabolism | Invertebrates | Evolution, Molecular | Receptors, Cytoplasmic and Nuclear - metabolism | Cellular | Receptors | Evolutionary | Ligands | Evolution | Hormones | Vitamins | Beta | Index Medicus | oxysterols | cholesterol | phylogeny | drug modeling | molecular evolution
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1436 - 1443
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 124 - 128
Journal Article