Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (7105) 7105
Newspaper Article (3563) 3563
Newsletter (1325) 1325
Magazine Article (343) 343
Book Chapter (213) 213
Book / eBook (116) 116
Government Document (99) 99
Transcript (83) 83
Paper (34) 34
Dissertation (25) 25
Trade Publication Article (24) 24
Web Resource (23) 23
Book Review (21) 21
Conference Proceeding (17) 17
Reference (10) 10
Report (7) 7
Streaming Video (5) 5
Publication (4) 4
Journal / eJournal (3) 3
Archival Material (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
orphan drugs (6334) 6334
science & technology (3570) 3570
life sciences & biomedicine (3333) 3333
humans (3049) 3049
orphans (2492) 2492
drug therapy (2188) 2188
pharmaceutical industry (2100) 2100
animals (1716) 1716
liver x receptors (1340) 1340
clinical trials (1117) 1117
care and treatment (1029) 1029
cancer (944) 944
male (914) 914
mice (892) 892
product development (827) 827
drugs (826) 826
pharmacology & pharmacy (767) 767
female (719) 719
research (700) 700
biological and medical sciences (681) 681
fda approval (669) 669
biochemistry & molecular biology (615) 615
orphan nuclear receptors (608) 608
orphan nuclear receptors - metabolism (606) 606
rare diseases (596) 596
biotechnology industry (576) 576
medical research (573) 573
disease (542) 542
drug approval (532) 532
medical sciences (523) 523
orphan drug production (512) 512
united states (512) 512
health aspects (455) 455
patients (424) 424
pediatrics (422) 422
orphan drug production - economics (417) 417
laws, regulations and rules (400) 400
analysis (393) 393
receptors, cytoplasmic and nuclear - metabolism (388) 388
orphan drug (382) 382
medicine (380) 380
medicine, experimental (377) 377
rare diseases - drug therapy (373) 373
ligands (360) 360
cell biology (355) 355
children & youth (351) 351
gene expression (350) 350
cholesterol - metabolism (348) 348
children (341) 341
orphan nuclear receptors - genetics (340) 340
mice, inbred c57bl (333) 333
orphan drug production - legislation & jurisprudence (332) 332
oncology (331) 331
proteins (324) 324
cell line (320) 320
lipids (314) 314
child (308) 308
cholesterol (306) 306
cells, cultured (301) 301
physiological aspects (296) 296
rats (287) 287
orphan nuclear receptors - agonists (283) 283
abridged index medicus (281) 281
dna-binding proteins - metabolism (276) 276
liver (276) 276
adult (266) 266
liver - metabolism (257) 257
medicine, research & experimental (257) 257
research & experimental medicine (255) 255
rna, messenger - metabolism (254) 254
public health (253) 253
marketing (252) 252
social sciences (250) 250
aids (247) 247
studies (246) 246
endocrinology & metabolism (241) 241
cell line, tumor (239) 239
hiv (237) 237
sulfonamides - pharmacology (237) 237
fundamental and applied biological sciences. psychology (235) 235
general & internal medicine (235) 235
monoclonal antibodies (235) 235
signal transduction (235) 235
acquired immune deficiency syndrome--aids (234) 234
biotechnology (234) 234
antineoplastic agents (232) 232
receptors, cytoplasmic and nuclear - genetics (231) 231
atherosclerosis (229) 229
families & family life (229) 229
dna-binding proteins - genetics (227) 227
research & development--r&d (227) 227
adolescent (226) 226
science & technology - other topics (226) 226
gene expression regulation - drug effects (224) 224
medicine, general & internal (224) 224
united states food and drug administration (224) 224
multidisciplinary sciences (221) 221
liver x receptor (220) 220
genetics & heredity (213) 213
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Online Resources - Online (27) 27
Gerstein Science - Stacks (22) 22
Robarts - Stacks (9) 9
UofT Schools - Stacks (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (4) 4
OISE - Children's Literature (2) 2
UofT at Scarborough - Stacks (2) 2
Victoria University E.J. Pratt - Stacks (2) 2
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Gerstein Science - Circulation Desk (1) 1
Markham Stouffville Hospital - Stacks (1) 1
New College (Ivey) - Stacks (1) 1
Scarborough Hospital - Online (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
St. Michael's College (John M. Kelly) - 3rd Floor (1) 1
Thomas Fisher Rare Book - May be requested at Fisher (1) 1
Thomas Fisher Rare Book - May be requested in 6-10 wks (1) 1
Thomas Fisher Rare Book - Rare Book (1) 1
University College (Laidlaw) - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (12785) 12785
French (71) 71
German (53) 53
Japanese (41) 41
Portuguese (33) 33
Spanish (31) 31
Chinese (24) 24
Russian (22) 22
Dutch (12) 12
Hungarian (8) 8
Italian (7) 7
Swedish (5) 5
Czech (4) 4
Korean (4) 4
Slovak (4) 4
Norwegian (3) 3
Afrikaans (2) 2
Polish (2) 2
Serbian (2) 2
Turkish (2) 2
Danish (1) 1
Georgian (1) 1
Hebrew (1) 1
Hindi (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Rare diseases and orphan products
: accelerating research and development
by Field, Marilyn J. (Marilyn Jane) and Boat, Thomas F and Institute of Medicine (U.S.). Committee on Accelerating Rare Diseases Research and Orphan Product Development and National Academies Press (U.S.) and Board on Health Sciences Policy and Institute of Medicine and Committee on Accelerating Rare Diseases Research and Orphan Product Development
2010, ISBN 9780309158077, xxi, 420
Rare diseases | Drugs | Design | Orphan drugs | Orphan Drug Production | Treatment | drug therapy | Drug Evaluation | Policy Making | Health Policy | Drug Discovery
Book
Details down arrow
2. Full Text Liver X receptors in lipid metabolism: Opportunities for drug discovery
by Hong, Cynthia and Tontonoz, Peter
Nature reviews. Drug discovery, ISSN 1474-1776, 2014, Volume 13, Issue 6, pp. 433 - 444
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Intestines - drug effects | Intestinal Mucosa - metabolism | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - therapeutic use | Orphan Nuclear Receptors - metabolism | Brain - metabolism | Drugs, Investigational - chemistry | Protein Isoforms - metabolism | Liver - drug effects | Alzheimer Disease - prevention & control | Liver X Receptors | Drug Design | Neurons - metabolism | Hypolipidemic Agents - chemistry | Drug Evaluation, Preclinical | Neurons - drug effects | Hypolipidemic Agents - adverse effects | Nerve Tissue Proteins - antagonists & inhibitors | Molecular Targeted Therapy - adverse effects | Atherosclerosis - drug therapy | Liver - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Clinical Trials as Topic | Hypolipidemic Agents - pharmacology | Nootropic Agents - adverse effects | Nootropic Agents - chemistry | Drug Discovery | Atherosclerosis - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Lipid Metabolism - drug effects | Hypolipidemic Agents - therapeutic use | Atherosclerosis - prevention & control | Nootropic Agents - pharmacology | Protein Isoforms - antagonists & inhibitors | Care and treatment | Research | Drug discovery | Patient outcomes | Risk factors | Atherosclerosis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Orphan drugs, orphan diseases. The first decade of orphan drug legislation in the EU
by Joppi, Roberta and Joppi, Roberta and Bertele’, Vittorio and Bertele’, Vittorio and Garattini, Silvio and Garattini, Silvio
European journal of clinical pharmacology, ISSN 0031-6970, 4/2013, Volume 69, Issue 4, pp. 1009 - 1024
Preclinical studies | Biomedicine | Rare disease | Drug regulation | Clinical efficacy | Placebo | Development | Clinical trials | Outcome measures | Pharmacology/Toxicology | Orphan drug | Pharmacological research | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Clinical trial. Drug monitoring | Pharmacology. Drug treatments | Drug Approval - statistics & numerical data | Orphan Drug Production - legislation & jurisprudence | Outcome Assessment (Health Care) | Drug Evaluation, Preclinical - standards | Legislation, Drug | Orphan Drug Production - statistics & numerical data | Humans | Rare Diseases - drug therapy | Drugs, Investigational - therapeutic use | Drugs, Investigational - toxicity | Health Policy - trends | Evidence-Based Medicine | Drug Approval - legislation & jurisprudence | Marketing | Animals | European Union | Health Policy - legislation & jurisprudence | Orphan Drug Production - economics | Clinical Trials as Topic - standards | Drugs, Investigational - economics | Drug approval | Orphan drugs | Health insurance | Decades | Orphans | Drug therapy | Legislation | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Orphan drugs
by Messori, Andrea and Attanasio, Francesco and Trippoli, Sabrina and Banfi, Roberto
The Lancet (British edition), ISSN 0140-6736, 04/2019, Volume 393, Issue 10181, pp. 1595 - 1595
Commerce | Orphan Drug Production | Rare Diseases | Social Behavior | Humans | Costs | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Pricing for orphan drugs: Will the market bear what society cannot?
by O'Sullivan, Brian P and Orenstein, David M and Milla, Carlos E
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 2013, Volume 310, Issue 13, pp. 1343 - 1344
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Drug Costs | Quinolones - economics | Social Justice | United States | Drug Industry - ethics | Humans | Aminophenols - therapeutic use | Health Expenditures | Drug Discovery | Drug Industry - economics | Quinolones - therapeutic use | Aminophenols - economics | Orphan Drug Production - economics | Cost Sharing | Cystic Fibrosis - drug therapy | Drugs | Prices | Cystic fibrosis | Genetic disorders | Pharmaceutical industry
Journal Article
Details down arrow
6. Full Text Fair pricing of old orphan drugs: Considerations for Canada's orphan drug policy
by Roberts, Eve A and Herder, Matthew and Hollis, Aidan
Canadian Medical Association journal (CMAJ), ISSN 0820-3946, 04/2015, Volume 187, Issue 6, pp. 422 - 425
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Orphan Drug Production - legislation & jurisprudence | Hepatolenticular Degeneration - economics | Humans | Rare Diseases - drug therapy | Costs and Cost Analysis - legislation & jurisprudence | Rare Diseases - economics | Trientine - economics | Trientine - therapeutic use | Canada | Chelating Agents - economics | Costs and Cost Analysis - economics | Orphan Drug Production - economics | Hepatolenticular Degeneration - drug therapy | Health Policy | Chelating Agents - therapeutic use | Drug Costs - legislation & jurisprudence | Orphan drugs | Industrial research | United States | Pricing | Prices and rates | Pharmaceutical industry | Drugs | Patient safety | Drug policy | Orphans | Index Medicus | Abridged Index Medicus | Analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Rare diseases and orphan drugs
by Melnikova, Irena
Nature reviews. Drug discovery, ISSN 1474-1776, 04/2012, Volume 11, Issue 4, pp. 267 - 268
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Orphan Drug Production | Drug Approval | Drug Discovery | Humans | Rare Diseases - drug therapy | Rare diseases | Orphan drugs | Usage | Demographic aspects | Laws, regulations and rules | Economic aspects | Research | Drug therapy
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text OATP1B1-related drug–drug and drug–gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis
by Tamraz, Bani and Fukushima, Hisayo and Wolfe, Alan R and Kaspera, Rüdiger and Totah, Rheem A and Floyd, James S and Ma, Benjamin and Chu, Catherine and Marciante, Kristin D and Heckbert, Susan R and Psaty, Bruce M and Kroetz, Deanna L and Kwok, Pui-Yan
Pharmacogenetics and genomics, ISSN 1744-6872, 07/2013, Volume 23, Issue 7, pp. 355 - 364
Clopidogrel | Oatp1B1 | Rhabdomyolysis | Cerivastatin | Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Haplotypes | Humans | Cells, Cultured | Male | Genetic Variation | Organic Anion Transporters - genetics | Pyridines - adverse effects | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Rhabdomyolysis - genetics | Rhabdomyolysis - drug therapy | HEK293 Cells | Female | Polymorphism, Single Nucleotide | Solute Carrier Organic Anion Transporter Family Member 1b1 | Index Medicus | clopidogrel | rhabdomyolysis | cerivastatin | OATP1B1
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Orphan drugs
: research and reviews
2011
Orphan drugs
eJournal
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Pressure for drug development in lysosomal storage disorders - A quantitative analysis thirty years beyond the US orphan drug act
by Mechler, Konstantin and Mountford, William K and Hoffmann, Georg F and Ries, Markus
Orphanet journal of rare diseases, ISSN 1750-1172, 04/2015, Volume 10, Issue 1, pp. 46 - 46
Orphan disease | Drug development | Small clinical trials | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Drug Approval - statistics & numerical data | Orphan Drug Production - legislation & jurisprudence | Drug Industry - statistics & numerical data | Lysosomal Storage Diseases - drug therapy | United States | Drug Industry - economics | Humans | Rare Diseases - drug therapy | Drug Discovery | United States Food and Drug Administration | Enzymes | Medical research | Nervous system diseases | Orphan drugs | Stem cells | Bills, Legislative | Medicine, Experimental | Transplantation | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Orphan drugs: the regulatory environment
by Franco, Pedro
Drug discovery today, ISSN 1359-6446, 02/2013, Volume 18, Issue 3-4, pp. 163 - 172
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Canada | Orphan Drug Production - legislation & jurisprudence | Singapore | Motivation | European Union | Legislation, Drug | United States | Drug Industry | Japan | Taiwan | Australia | Orphan drugs | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Estimating the clinical cost of drug development for orphan versus non-orphan drugs
by Jayasundara, Kavisha and Hollis, Aidan and Krahn, Murray and Mamdani, Muhammad and Hoch, Jeffrey S and Grootendorst, Paul
Orphanet journal of rare diseases, ISSN 1750-1172, 01/2019, Volume 14, Issue 1, pp. 12 - 12
Rare diseases | Cost of drug development | Orphan drugs | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Drug Costs - statistics & numerical data | Health Expenditures - statistics & numerical data | Humans | Rare Diseases - drug therapy | Orphan Drug Production - economics | Rare Diseases - economics | Drug Development - economics | Dosage and administration | Comparative analysis | Analysis | Medical care, Cost of | Research & development--R&D | Clinical trials | FDA approval | Drug development | Studies | Prices | Prescription drugs | Databases | Cost estimates | Research & development expenditures | Pharmacy | Product development | Pharmaceutical industry | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Abuses of FDA Regulatory Procedures — The Case of Suboxone
by Haffajee, Rebecca L and Frank, Richard G
The New England journal of medicine, ISSN 0028-4793, 02/2020, Volume 382, Issue 6, pp. 496 - 498
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Orphan Drug Production - legislation & jurisprudence | Buprenorphine - economics | Drug Development - legislation & jurisprudence | United States | Drug Industry - ethics | Drug Industry - legislation & jurisprudence | Humans | Narcotic Antagonists - economics | Drug Development - economics | Drug Approval - legislation & jurisprudence | Buprenorphine - therapeutic use | Narcotic Antagonists - therapeutic use | Drug Industry - economics | Buprenorphine, Naloxone Drug Combination - therapeutic use | Economic Competition | Government Regulation | Orphan Drug Production - economics | Buprenorphine, Naloxone Drug Combination - economics | United States Food and Drug Administration | Drugs, Generic | Generic drugs | Buprenorphine | Laws, regulations and rules | Proprietary drugs | Product development | Pharmaceutical industry | Marketing | Competition | Market entry | Bioequivalence | Litigation | Federal regulation | FDA approval | Empowerment | Brand names | Prices | Corporate profits | Petitions | Medicaid | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights