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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
.... They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IFN stimulated genes (ISGs... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
BMC infectious diseases, ISSN 1471-2334, 12/2015, Volume 15, Issue 1, pp. 95 - 95
Background: Reducing acute respiratory infection burden in children in Africa remains a major priority and challenge... 
SYSTEMATIC ANALYSIS | GLOBAL BURDEN | CHILDHOOD PNEUMONIA | INFECTIOUS DISEASES | DISEASE | SYNCYTIAL VIRUS | NATIONAL CAUSES | YOUNG-CHILDREN | TRACT INFECTIONS | MYCOPLASMA-PNEUMONIAE | HOSPITALIZED CHILDREN | Adenoviridae Infections - virology | Urban Population - statistics & numerical data | Kenya - epidemiology | Humans | Influenza A virus - genetics | Child, Preschool | Male | Paramyxoviridae Infections - epidemiology | Respirovirus Infections - virology | Picornaviridae Infections - virology | Pneumonia, Mycoplasma - epidemiology | Incidence | Adenoviridae - isolation & purification | Rubulavirus Infections - epidemiology | Picornaviridae Infections - epidemiology | Legionellosis - epidemiology | Population Density | Influenza, Human - virology | Real-Time Polymerase Chain Reaction | Acute Disease | Parainfluenza Virus 1, Human - isolation & purification | Respiratory Syncytial Viruses - isolation & purification | Epidemiological Monitoring | Respiratory Syncytial Viruses - genetics | Mycoplasma pneumoniae - isolation & purification | Poverty Areas | Legionellosis - microbiology | Orthomyxoviridae - isolation & purification | Rhinovirus - genetics | Metapneumovirus - isolation & purification | Respiratory Syncytial Virus Infections - epidemiology | Legionella - isolation & purification | Pneumonia, Mycoplasma - microbiology | Infant | Rhinovirus - isolation & purification | Metapneumovirus - genetics | Adenoviridae Infections - epidemiology | Paramyxoviridae Infections - virology | Pneumonia, Viral - epidemiology | Adenoviridae - genetics | Rubulavirus Infections - virology | Female | Respiratory Tract Infections - virology | Respiratory Syncytial Virus Infections - virology | Parainfluenza Virus 1, Human - genetics | Influenza, Human - epidemiology | Influenza A virus - isolation & purification | Parainfluenza Virus 2, Human - isolation & purification | Orthomyxoviridae - genetics | Parainfluenza Virus 2, Human - genetics | Respirovirus Infections - epidemiology | Respiratory Tract Infections - epidemiology | Pneumonia, Viral - virology | Viral proteins | Analysis | Diseases
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 2, p. e1003196
Journal Article
PloS one, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0130378
Acute Respiratory Infections (ARIs) are responsible for considerable morbidity and mortality worldwide... 
REAL-TIME PCR | PERFORMANCE | MULTIDISCIPLINARY SCIENCES | ACID AMPLIFICATION TESTS | VIRAL PANEL FAST | FILMARRAY RP | FAST ASSAY | RVP | VIRUSES | PATHOGENS | Humans | Middle Aged | Reagent Kits, Diagnostic - standards | Child, Preschool | Infant | Rhinovirus - isolation & purification | Parechovirus - isolation & purification | Respirovirus - genetics | Gram-Negative Bacteria - isolation & purification | Gram-Positive Bacteria - genetics | Respiratory Tract Infections - microbiology | Adenoviridae - isolation & purification | Human bocavirus - genetics | Enterovirus - genetics | Adenoviridae - genetics | Adult | Gram-Negative Bacteria - genetics | Respiratory Tract Infections - virology | Child | Coronavirus - isolation & purification | Cytomegalovirus - genetics | Cytomegalovirus - isolation & purification | Acute Disease | Parechovirus - genetics | Respiratory Syncytial Viruses - isolation & purification | Enterovirus - isolation & purification | Human bocavirus - isolation & purification | Respiratory Tract Infections - diagnosis | Multiplex Polymerase Chain Reaction - standards | Respiratory Syncytial Viruses - genetics | Adolescent | Orthomyxoviridae - genetics | Coronavirus - genetics | Gram-Positive Bacteria - isolation & purification | Respirovirus - isolation & purification | Aged | Orthomyxoviridae - isolation & purification | Rhinovirus - genetics | Comparative analysis | Health aspects | Mortality | Influenza | Lung diseases | Multiplexing | Pathogens | Microbiology | Laboratories | Health risks | Life assessment | Viruses | Infections | Nucleic acids | Medical diagnosis | Disease control | Morbidity | Molecular chains | Virology | Hospitals | Respiratory diseases | Bacteria | Influenza A | Diagnostic systems | Diagnosis | Public health | Viral infections | Life Sciences | Human health and pathology | Infectious diseases | Biochemistry, Molecular Biology
Journal Article
Nature immunology, ISSN 1529-2916, 2013, Volume 14, Issue 5, pp. 480 - 488
NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-kappaB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been... 
LISTERIA-MONOCYTOGENES | IMMUNE-RESPONSE | 1918 INFLUENZA-VIRUS | DOUBLE-STRANDED-RNA | IFN-GAMMA PRODUCTION | DENDRITIC CELLS | IL-1-BETA PRODUCTION | INNATE | AUTOPHAGY | IMMUNOLOGY | CD8(+) T-CELLS | Immune response | Influenza | Physiological aspects | Causes of | Genetic aspects | Cellular signal transduction | Research | Protein kinases | mitophagy | autophagy | RIPK2 | NLR | inflammasome | IL-18 | Caspase-1
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5108 - 5117
.... Lung Ag-specific CD8(+) T cells (T-CD8) are impaired during acute viral lower respiratory infection by the inhibitory receptor programmed death-1 (PD-1... 
PROTECTIVE IMMUNITY | HUMAN METAPNEUMOVIRUS INFECTION | FUSION PROTEIN | FUNCTIONAL IMPAIRMENT | INHIBITORY RECEPTORS | INFLUENZA-VIRUS | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | SYNCYTIAL VIRUS | RAT SIGMODON-HISPIDUS | TRACT INFECTIONS | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Humans | Paramyxoviridae Infections - genetics | Antigens, CD - genetics | Respiratory Tract Infections - genetics | Viral Load | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | Lung - virology | Paramyxoviridae Infections - virology | B-Lymphocytes - pathology | Receptors, Immunologic - immunology | Respiratory Tract Infections - virology | Respiratory Tract Infections - pathology | Metapneumovirus - immunology | Lung - pathology | Signal Transduction | Orthomyxoviridae Infections - pathology | Gene Expression Regulation | Signaling Lymphocytic Activation Molecule Family | Cell Degranulation - immunology | Viral Vaccines - administration & dosage | Paramyxoviridae Infections - immunology | Animals | B-Lymphocytes - immunology | Immune Evasion | Virus Replication | CD8-Positive T-Lymphocytes - virology | Respiratory Tract Infections - immunology | Lymphocyte Count | Mice | Paramyxoviridae Infections - prevention & control | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Orthomyxoviridae Infections - virology | Programmed Cell Death 1 Receptor - genetics | Viral Vaccines - immunology | Lung - immunology | Orthomyxoviridae Infections - immunology
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 10, p. e1003703
Journal Article
Journal of virology, ISSN 0022-538X, 10/2018, Volume 92, Issue 19
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 2, p. e0212236
.... Interleukin-1 beta (IL-1 beta) is an important immune signaling cytokine responsible for inflammation and has been previously shown to contribute to disease severity in numerous infections... 
BACTERIAL PNEUMONIA | ACTIVATION | INFECTIONS | GASDERMIN D | PANDEMIC INFLUENZA | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SUSCEPTIBILITY | PNEUMOCOCCAL PNEUMONIA | INFLAMMATORY CASPASES | ALVEOLAR MACROPHAGE PHAGOCYTOSIS | Influenza A Virus, H1N1 Subtype - immunology | Brain | Toll-Like Receptor 2 - genetics | Interleukin-1beta - genetics | Orthomyxoviridae Infections - genetics | Streptococcus pneumoniae - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Signal Transduction - immunology | Pneumococcal Infections - immunology | Pneumococcal Infections - genetics | Myeloid Differentiation Factor 88 - immunology | Cell Line | Coinfection - immunology | Orthomyxoviridae Infections - pathology | Myeloid Differentiation Factor 88 - genetics | Pneumococcal Infections - pathology | Interleukin-1beta - immunology | Signal Transduction - genetics | Chick Embryo | Mice, Knockout | Animals | Coinfection - genetics | Coinfection - pathology | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Toll-Like Receptor 2 - immunology | Mice | Orthomyxoviridae Infections - immunology | Health sciences | Pediatrics | Pneumonia | Pandemics | Interleukin | Viruses | Biology | Kinases | Streptococcus infections | Proteins | Immunology | Toll-like receptors | Bacterial infections | Cytokines | Inflammation | Gene expression | IL-1β | Substrates | Pathology | Signaling | Streptococcus | Influenza | TLR2 protein | MyD88 protein | Laboratory animals
Journal Article