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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 9, p. e0184976
Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide... 
BACTERIA | EFFICACY | VIRUS INFECTION | MULTIDISCIPLINARY SCIENCES | FERMENTED DAIRY PRODUCT | PROBIOTICS | MICROBIOTA | INNATE LYMPHOID-CELLS | DURATION | CONSUMPTION | CASEI DN-114 001 | Orthomyxoviridae Infections - prevention & control | Probiotics - administration & dosage | Orthomyxoviridae Infections - microbiology | Respiratory Tract Infections - prevention & control | Colony Count, Microbial | Orthomyxoviridae - immunology | Respiratory Tract Infections - microbiology | Immunity, Cellular - immunology | Animals | Respiratory Tract Infections - immunology | Female | Mice | Mice, Inbred BALB C | Lactobacillus paracasei - physiology | Orthomyxoviridae Infections - immunology | Probiotics | Care and treatment | Immune response | Influenza | Physiological aspects | Development and progression | Research | Lactobacillus | Laboratories | Immune clearance | Homeostasis | Infections | Genomes | Multivariate analysis | Immunity | Modulators | Accumulation | Respiratory tract | Intestine | Bacteria | Respiratory tract diseases | Children | Bioinformatics | Myeloid cells | Bacterial infections | Immunomodulation | Lactobacilli | Peptidoglycans | Inflammation | Gene expression | Morbidity | Feeding | Lungs | Adults | Methods | Viral infections | Immunity, Cellular/immunology | Respiratory Tract Infections/immunology | Orthomyxoviridae Infections/prevention & control | Probiotics/administration & dosage | Respiratory Tract Infections/prevention & control | Orthomyxoviridae/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Human health and pathology | Infectious diseases | Respiratory Tract Infections/microbiology | Food and Nutrition | Orthomyxoviridae Infections/microbiology | Lactobacillus paracasei/physiology
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
.... They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IFN stimulated genes (ISGs... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal of virology, ISSN 0022-538X, 2013, Volume 87, Issue 12, pp. 6911 - 6924
Journal Article
Journal Article
PLoS pathogens, ISSN 1553-7366, 09/2013, Volume 9, Issue 9, p. e1003615
Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine... 
LUNG | EOSINOPHILS | MICROBIOLOGY | T(H)2-TYPE RESPONSES | INTERLEUKIN-5 | CD8(+) T-CELLS | ADAPTIVE IMMUNITY | IL-1-LIKE CYTOKINE IL-33 | VIROLOGY | IN-VIVO | TYPE-2 IMMUNITY | RESPIRATORY SYNCYTIAL VIRUS | PARASITOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Up-Regulation | Eosinophils - metabolism | Macrophages, Alveolar - pathology | Killer Cells, Natural - pathology | Eosinophils - immunology | Interleukins - metabolism | Protein Subunits - metabolism | Receptors, Interleukin - metabolism | Lung - virology | Killer Cells, Natural - immunology | Eosinophils - pathology | Lung - metabolism | Respiratory Tract Infections - virology | Macrophages, Alveolar - immunology | Respiratory Tract Infections - pathology | Macrophages, Alveolar - virology | Eosinophilia - etiology | Lung - pathology | Respiratory Tract Infections - metabolism | Specific Pathogen-Free Organisms | Interleukin-33 | Interleukin-5 - metabolism | Killer Cells, Natural - virology | Orthomyxoviridae Infections - metabolism | Eosinophils - virology | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Cells, Cultured | Immunity, Innate | Mice, Knockout | Animals | Respiratory Tract Infections - immunology | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Macrophages, Alveolar - metabolism | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Killer cells | Interleukins | Influenza | Physiological aspects | Host-parasite relationships | Research | Health aspects | T cell receptors | Immunology | Lungs | Rodents | Immune system
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5108 - 5117
.... Lung Ag-specific CD8(+) T cells (T-CD8) are impaired during acute viral lower respiratory infection by the inhibitory receptor programmed death-1 (PD-1... 
PROTECTIVE IMMUNITY | HUMAN METAPNEUMOVIRUS INFECTION | FUSION PROTEIN | FUNCTIONAL IMPAIRMENT | INHIBITORY RECEPTORS | INFLUENZA-VIRUS | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | SYNCYTIAL VIRUS | RAT SIGMODON-HISPIDUS | TRACT INFECTIONS | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Humans | Paramyxoviridae Infections - genetics | Antigens, CD - genetics | Respiratory Tract Infections - genetics | Viral Load | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | Lung - virology | Paramyxoviridae Infections - virology | B-Lymphocytes - pathology | Receptors, Immunologic - immunology | Respiratory Tract Infections - virology | Respiratory Tract Infections - pathology | Metapneumovirus - immunology | Lung - pathology | Signal Transduction | Orthomyxoviridae Infections - pathology | Gene Expression Regulation | Signaling Lymphocytic Activation Molecule Family | Cell Degranulation - immunology | Viral Vaccines - administration & dosage | Paramyxoviridae Infections - immunology | Animals | B-Lymphocytes - immunology | Immune Evasion | Virus Replication | CD8-Positive T-Lymphocytes - virology | Respiratory Tract Infections - immunology | Lymphocyte Count | Mice | Paramyxoviridae Infections - prevention & control | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Orthomyxoviridae Infections - virology | Programmed Cell Death 1 Receptor - genetics | Viral Vaccines - immunology | Lung - immunology | Orthomyxoviridae Infections - immunology
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7450, pp. 498 - 502
There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection... 
UNITED-STATES | 1918 SPANISH INFLUENZA | ACTIVATION | VIRUS | ENDOTOXIN ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INHIBITORS | TETRASODIUM E5564 | SEVERE SEPSIS | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Lipopolysaccharide Receptors - metabolism | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Time Factors | Acute Lung Injury - prevention & control | Female | Acute Lung Injury - drug therapy | Disaccharides - therapeutic use | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - genetics | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Antiviral Agents - pharmacology | Sugar Phosphates - therapeutic use | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Acute Lung Injury - pathology | Animals | Sugar Phosphates - metabolism | Survival Analysis | Toll-Like Receptor 2 - immunology | Ligands | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Acute Lung Injury - complications | Prevention | Toll-like receptors | Health aspects | Influenza | Pathology | Cell culture | Respiratory distress syndrome | Cytokines | Mortality | Rodents | Sepsis | Infections | Gene expression | Drug dosages
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2010, Volume 184, Issue 4, pp. 2048 - 2056
Journal Article