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bone morphogenetic protein 2 - adverse effects (15) 15
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treatment outcome (15) 15
bone morphogenetic proteins - pharmacology (14) 14
expression (14) 14
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transforming growth factor beta - pharmacology (13) 13
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bone morphogenetic protein (12) 12
bone regeneration (12) 12
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rhbmp-2 (12) 12
stem cells (12) 12
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bone morphogenetic protein-2 (11) 11
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Spine, ISSN 0362-2436, 12/2007, Volume 32, Issue 25, pp. 2885 - 2890
Study Design. Observational study with prospective CT analysis. Objective. To assess the incidence and clinical sequelae of epidural bone formation following... 
Minimally invasive surgery | Bone morphogenetic protein | Posterior lumbar interbody fusion | Transforaminal interbody fusion | minimally invasive surgery | SAFETY | posterior lumbar interbody fusion | bone morphogenetic protein | CLINICAL NEUROLOGY | NOGGIN | trans-foraminal | interbody fusion | SPINE | CAGES | ORTHOPEDICS | RADIOGRAPHIC OUTCOMES | MORPHOGENETIC PROTEIN-2 | Prospective Studies | Follow-Up Studies | Spinal Cord Diseases - physiopathology | Humans | Middle Aged | Bone Transplantation - adverse effects | Male | Tomography, X-Ray Computed | Recombinant Proteins - adverse effects | Spinal Fusion - adverse effects | Ossification, Heterotopic - chemically induced | Incidence | Lumbar Vertebrae - surgery | Back Pain - surgery | Time Factors | Transforming Growth Factor beta - adverse effects | Adult | Female | Spinal Cord Diseases - diagnostic imaging | Minimally Invasive Surgical Procedures | Back Pain - etiology | Disability Evaluation | Severity of Illness Index | Spinal Fusion - methods | Spinal Diseases - surgery | Spinal Diseases - complications | Bone Morphogenetic Protein 2 | Ossification, Heterotopic - diagnostic imaging | Treatment Outcome | Epidural Space - diagnostic imaging | Bone Morphogenetic Proteins - adverse effects | Spinal Cord Diseases - chemically induced | Ossification, Heterotopic - physiopathology | Epidural Space - drug effects | Aged | Pain Measurement | Index Medicus
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 02/2014, Volume 32, Issue 2, pp. 183 - 188
Journal Article
Medicine (United States), ISSN 0025-7974, 07/2017, Volume 96, Issue 27, pp. e7413 - e7413
Despite the wide use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in bone defect, its application in treating osteonecrosis of femoral head... 
heterotopic ossification | bone regeneration | recombinant human bone morphogenetic protein-2 | bone grafting | osteonecrosis of femoral head | BONE MORPHOGENETIC PROTEIN-2 | ARTHROPLASTY | INDUCTION | HIP | FAMILY | MEDICINE, GENERAL & INTERNAL | GROWTH-FACTOR-BETA | INTERBODY FUSION | NECROSIS | FRACTURES | DIFFERENTIATION | Recombinant Proteins - therapeutic use | Femur Head Necrosis - diagnostic imaging | Follow-Up Studies | Intraoperative Care - adverse effects | Humans | Middle Aged | Male | Recombinant Proteins - adverse effects | Ossification, Heterotopic - chemically induced | Femur Head - drug effects | Femur Head Necrosis - drug therapy | Bone Morphogenetic Protein 2 - adverse effects | Young Adult | Transforming Growth Factor beta - therapeutic use | Bone Morphogenetic Protein 2 - therapeutic use | Transforming Growth Factor beta - adverse effects | Adult | Female | Retrospective Studies | Femur Head Necrosis - complications | Femur Head - diagnostic imaging | Postoperative Complications - chemically induced | Femur Head Necrosis - surgery | Risk Factors | Ossification, Heterotopic - diagnostic imaging | Femur Head - surgery | Growth Substances - adverse effects | Growth Substances - therapeutic use | Bone Transplantation | Survival Analysis | Postoperative Complications - diagnostic imaging | CT imaging | Usage | Care and treatment | Bone morphogenetic proteins | Bones | Bone-grafting | Necrosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 02/2018, Volume 233, Issue 2, pp. 1017 - 1028
Leptin promotes the osteogenic differentiation of tendon‐derived stem cells (TDSCs) in heterotopic ossification (HO). mTORC1 signaling favors differentiation... 
tendon‐derived stem cells | leptin | osteogenic differentiation | tendon-derived stem cells | RAPAMYCIN | STEM-CELLS | ACTIVATION | PHYSIOLOGY | CELL BIOLOGY | INHIBITION | BONE-FORMATION | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | STROMAL CELLS | PROMOTES | Tendons - drug effects | Male | Core Binding Factor Alpha 1 Subunit - metabolism | Ossification, Heterotopic - chemically induced | Tendons - enzymology | Dose-Response Relationship, Drug | Stem Cells - enzymology | Disease Models, Animal | Ossification, Heterotopic - pathology | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Leptin - toxicity | Rats, Sprague-Dawley | Mechanistic Target of Rapamycin Complex 1 - metabolism | Transcription Factors - metabolism | Osteoblasts - pathology | Phenotype | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Tendons - pathology | Stem Cells - drug effects | Stem Cells - pathology | Receptors, Leptin - metabolism | Ossification, Heterotopic - enzymology | Leptin | Phosphatases | Stem cells | Alkaline phosphatase | Phosphorylation | Pathogenesis | Stem cell transplantation | Tissues | Bone growth | Biomedical materials | Allografts | Mineralization | Rodents | Biocompatibility | Bioindicators | Osteocalcin | Rapamycin | Bone turnover | Metabolism | Tendons | Ribosomal protein S6 kinase | Signaling | Biomarkers | Achilles tendon | In vivo methods and tests | Bone | Differentiation | Ossification (ectopic) | Osteogenesis | Index Medicus
Journal Article
Spine, ISSN 0362-2436, 08/2013, Volume 38, Issue 17, pp. 1452 - 1458
STUDY DESIGN.A rodent model of posterior spinal fusion. OBJECTIVE.The aim of this study was to evaluate the efficacy of low-dose recombinant human bone... 
heparin | localization of bone formation | control release | seroma | BMP-2 complications | rat model | heterotopic ossifi cation | polyelectrolyte complexes | posterior spinal fusion | alginate microbeads | UNITED-STATES | SURGERY | STANDARDIZATION | BONE MORPHOGENETIC PROTEIN-2 | SPINAL-FUSION PROCEDURES | heterotopic ossification | CLINICAL NEUROLOGY | NOMENCLATURE | HISTOMORPHOMETRY | IN-VIVO | ANTERIOR CERVICAL DISKECTOMY | COMPLICATIONS | ORTHOPEDICS | Bone Morphogenetic Protein 2 - pharmacology | Inflammation - chemically induced | Seroma - prevention & control | Humans | Bone Morphogenetic Protein 2 - chemistry | Polylysine - chemistry | Recombinant Proteins - adverse effects | Transforming Growth Factor beta - chemistry | Ossification, Heterotopic - chemically induced | X-Ray Microtomography | Drug Carriers - chemistry | Bone Morphogenetic Protein 2 - adverse effects | Microspheres | Anticoagulants - chemistry | Transforming Growth Factor beta - adverse effects | Heparin - pharmacology | Seroma - chemically induced | Spinal Fusion - methods | Rats | Recombinant Proteins - chemistry | Treatment Outcome | Random Allocation | Recombinant Proteins - pharmacology | Rats, Sprague-Dawley | Transforming Growth Factor beta - pharmacology | Animals | Alginates - chemistry | Anticoagulants - pharmacology | Ossification, Heterotopic - prevention & control | Inflammation - prevention & control | Heparin - chemistry | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182454 - e0182454
We previously reported the development of a new acquired neurogenic HO (NHO) mouse model, combining spinal cord transection (SCI) and chemical muscle injury.... 
NERVOUS-SYSTEM | IMPACT | TRAUMATIC BRAIN-INJURY | BONE-FORMATION | INFLAMMATION | REGENERATION | MULTIDISCIPLINARY SCIENCES | SUBSTANCE-P | CEREBROSPINAL-FLUID | EXPRESSION | DEGENERATION | Cobra Cardiotoxin Proteins | Spinal Cord - drug effects | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Spinal Cord - diagnostic imaging | Spinal Cord Injuries - etiology | Ossification, Heterotopic - diagnostic imaging | Ossification, Heterotopic - etiology | Muscles - pathology | Ossification, Heterotopic - chemically induced | X-Ray Microtomography | Bone Morphogenetic Protein 2 - analysis | Spinal Cord Injuries - pathology | Animals | Spinal Cord - pathology | Spinal Cord Injuries - chemically induced | Muscles - drug effects | Spinal Cord Injuries - diagnostic imaging | Muscles - innervation | Female | Denervation | Disease Models, Animal | Care and treatment | Growth | Patient outcomes | Physiological aspects | Bones | Spinal cord injuries | Models | Research | Spinal cord | Id1 protein | Nervous system | Spinal cord injury | Bone surgery | Biomedical materials | Computed tomography | Surgery | Rodents | Biocompatibility | Injuries | Peripheral nervous system | Bone morphogenetic protein 2 | Imaging techniques | Muscles | Inflammation | Thorax | Polymerase chain reaction | Brain research | Experimental design | Collagen | Mice | Ossification (ectopic) | Osteogenesis | Index Medicus
Journal Article
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 05/2007, Volume 25, Issue 5, pp. 665 - 677
Efficacious bone regeneration could revolutionize the clinical management of many bone and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can... 
bone regeneration | marrow stromal stem cell differentiation | osteogenesis | bone morphogenetic protein (BMP) signaling | osteogenic differentiation | Bone morphogenetic protein (BMP) signaling | Bone regeneration | Marrow stromal stem cell differentiation | Osteogenic differentiation | Osteogenesis | SMAD PROTEINS | FAMILY-MEMBERS | IDENTIFICATION | OSTEOBLASTS IN-VITRO | LOOP-HELIX PROTEINS | GROWTH-FACTOR-BETA | MESSENGER-RNA | WIDE EXPRESSION ANALYSIS | SUPERFAMILY | MICROARRAYS | ORTHOPEDICS | Humans | Gene Expression Profiling | Helix-Loop-Helix Motifs | Ossification, Heterotopic - chemically induced | Mesenchymal Stromal Cells - cytology | Growth Differentiation Factors | Osteoblasts - cytology | Growth Differentiation Factor 2 | Bone Morphogenetic Proteins - pharmacology | Osteogenesis - genetics | Bone Morphogenetic Protein 6 | Mesenchymal Stromal Cells - drug effects | Bone Morphogenetic Protein 3 | Bone Morphogenetic Protein 2 | Osteogenesis - drug effects | Cells, Cultured | Kidney - cytology | Injections, Intramuscular | Recombinant Proteins - pharmacology | Mice, Inbred C3H | Transforming Growth Factor beta - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice, Nude | Biomarkers | Mice | Ossification, Heterotopic - genetics | Bone Morphogenetic Protein 7 | Index Medicus
Journal Article
Journal of Rehabilitation Research and Development, ISSN 0748-7711, 2014, Volume 51, Issue 7, pp. 1109 - 1118
Journal Article
Clinical Orthopaedics and Related Research, ISSN 0009-921X, 12/2009, Volume 467, Issue 12, pp. 3257 - 3262
Journal Article