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1. Full Text Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists
by Shimono, Kengo and Tung, Wei-En and MacOlino, Christine and Chi, Amber Hsu-Tsai and Didizian, Johanna H and Mundy, Christina and Chandraratna, Roshantha A and Mishina, Yuji and Enomoto-Iwamoto, Motomi and Pacifici, Maurizio and Iwamoto, Masahiro
Nature medicine, ISSN 1078-8956, 04/2011, Volume 17, Issue 4, pp. 454 - 460
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Ossification, Heterotopic - drug therapy | Chondrogenesis - drug effects | Receptors, Retinoic Acid - deficiency | Ossification, Heterotopic - pathology | Humans | Activin Receptors, Type I - metabolism | Mice, Transgenic | Activin Receptors, Type I - genetics | Receptors, Retinoic Acid - genetics | Mice, Knockout | Bone Morphogenetic Proteins - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice, Mutant Strains | Mice, Nude | Mesenchymal Stem Cells - drug effects | Ossification, Heterotopic - metabolism | Receptors, Retinoic Acid - agonists | Mice | Mesenchymal Stem Cells - metabolism | Mesenchymal Stem Cell Transplantation | Index Medicus
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2. Full Text BMP type I receptor inhibition reduces heterotopic ossification
by Mishina, Yuji and Bloch, Kenneth D and Hong, Charles C and Fukuda, Tomokazu and Peterson, Randall T and Cuny, Gregory D and Yu, Paul B and Sachidanandan, Chetana and McManus, Patrick M and Kamiya, Nobuhiro and Lai, Carol S and Hong, Deborah W and Bouxsein, Mary L and Katagiri, Takenobu and Deng, Donna Y
Nature medicine, ISSN 1078-8956, 12/2008, Volume 14, Issue 12, pp. 1363 - 1369
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Bone Morphogenetic Protein Receptors, Type I - antagonists & inhibitors | Ossification, Heterotopic - drug therapy | Cell Line | Myositis Ossificans - metabolism | Pyrazoles - therapeutic use | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Tomography, X-Ray Computed | Bone Morphogenetic Protein Receptors, Type I - metabolism | Pyrimidines - chemistry | Pyrazoles - chemistry | Animals | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Ossification, Heterotopic - metabolism | Myositis Ossificans - genetics | Myositis Ossificans - pathology | Mice | Molecular Structure | Ossification, Heterotopic - genetics | Disease Models, Animal | Cell receptors | Care and treatment | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Research | Health aspects | Ossification | Signal transduction | Congenital diseases | Cellular biology | Gene expression | Tissues | Rodents | Index Medicus
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3. Full Text Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling
by Wang, Haitao and Lindborg, Carter and Lounev, Vitali and Kim, Jung‐Hoon and McCarrick‐Walmsley, Ruth and Xu, Meiqi and Mangiavini, Laura and Groppe, Jay C and Shore, Eileen M and Schipani, Ernestina and Kaplan, Frederick S and Pignolo, Robert J
Journal of bone and mineral research, ISSN 0884-0431, 09/2016, Volume 31, Issue 9, pp. 1652 - 1665
CELL/TISSUE SIGNALING | PRECLINICAL STUDIES | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | Fibrodysplasia ossificans progressiva | Preclinical studies | Cell/tissue signaling | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Inflammation - pathology | Ossification, Heterotopic - pathology | Signal Transduction | Humans | Tooth, Deciduous - pathology | Activin Receptors, Type I - metabolism | Male | Mice, Transgenic | Stem Cells - metabolism | Endosomes - metabolism | Cell Hypoxia | Bone Morphogenetic Proteins - metabolism | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Models, Biological | Ossification, Heterotopic - metabolism | Stem Cells - pathology | Female | Ligands | Myositis Ossificans - pathology | Tooth Exfoliation - pathology | Chondrogenesis | Disease Models, Animal | Bone morphogenetic proteins | Analysis | Index Medicus | tissue signaling | Cell
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4. Full Text Heterotopic ossification: Mechanistic insights and clinical challenges
by Xu, Ruoshi and Hu, Jiajie and Zhou, Xuedong and Yang, Yingzi
Bone (New York, N.Y.), ISSN 8756-3282, 04/2018, Volume 109, pp. 134 - 142
ACVR1 | ALK | Gsα | BMP | Gli | FOP | POH | AHO | PTHrP | Imprint | Trauma-induced | Hedgehog | Malignancies | Osseous metaplasia | GNAS | Osteoblast | TGF-β | NESP55 | Neurogenic | XLαs | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Bone Diseases, Metabolic - metabolism | Myositis Ossificans - metabolism | Animals | Ossification, Heterotopic - pathology | Humans | Ossification, Heterotopic - metabolism | Skin Diseases, Genetic - pathology | Bone Diseases, Metabolic - pathology | Myositis Ossificans - pathology | Skin Diseases, Genetic - metabolism | Medicine, Experimental | Medical research | Bone morphogenetic proteins | Transforming growth factors | Index Medicus
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5. Full Text Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
by Sorkin, Michael and Huber, Amanda K and Hwang, Charles and Carson, William F and Menon, Rajasree and Li, John and Vasquez, Kaetlin and Pagani, Chase and Patel, Nicole and Li, Shuli and Visser, Noelle D and Niknafs, Yashar and Loder, Shawn and Scola, Melissa and Nycz, Dylan and Gallagher, Katherine and McCauley, Laurie K and Xu, Jiajia and James, Aaron W and Agarwal, Shailesh and Kunkel, Stephen and Mishina, Yuji and Levi, Benjamin
Nature communications, ISSN 2041-1723, 02/2020, Volume 11, Issue 1, pp. 722 - 722
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cytokines - metabolism | Macrophages - pathology | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Transforming Growth Factor beta1 - metabolism | Gene Expression Regulation | Male | Mice, Transgenic | Transforming Growth Factor beta1 - genetics | CD47 Antigen - metabolism | Mesenchymal Stem Cells - pathology | Peptides - pharmacology | Animals | Burns - pathology | Mesenchymal Stem Cells - drug effects | Monocytes - pathology | Cell Differentiation | Wound Healing - physiology | Phagocytosis | Disease Models, Animal | Mesenchyme | Peptides | Differentiation (biology) | Stem cell transplantation | Inflammatory response | Myocytes | Macrophages | Cell activation | Biomedical materials | Trajectory analysis | Growth factors | Injuries | Injury analysis | Phenotypes | Wound healing | Tissue engineering | Inflammation | Bone healing | Cell differentiation | Gene expression | Trauma | Regeneration | Monocytes | Stem cells | Aberration | Ossification (ectopic) | Index Medicus
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6. Full Text Histopathology of periarticular non-hereditary heterotopic ossification
by Foley, Kristin L and Hebela, Nader and Keenan, Mary Ann and Pignolo, Robert J
Bone (New York, N.Y.), ISSN 8756-3282, 04/2018, Volume 109, pp. 65 - 70
Traumatic brain injury | Injury | Arthropathy | Cerebrovascular accident | Aging | Heterotopic ossification | Arthroplasty | Spinal cord injury | Trauma | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Immunohistochemistry | Osteogenesis - physiology | Ossification, Heterotopic - pathology | Spinal Cord Injuries - metabolism | Wounds and Injuries - pathology | Humans | Middle Aged | Male | Brain Injuries, Traumatic | Cell Movement - physiology | Spinal Cord Injuries - pathology | Stroke - pathology | Young Adult | Wounds and Injuries - metabolism | Stroke - metabolism | Ossification, Heterotopic - metabolism | Adult | Female | Aged | Stroke (Disease) | Medical colleges | Brain | Analysis | Histochemistry | Injuries | Index Medicus
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7. Full Text Vascular patterning in human heterotopic ossification
by Cocks, Margaret, MD and Mohan, Aditya and Meyers, Carolyn A., BS and Ding, Catherine, BS and Levi, Benjamin, MD and McCarthy, Edward, MD and James, Aaron W., MD, PhD
Human pathology, ISSN 0046-8177, 2017, Volume 63, pp. 165 - 170
Pathology | Angiogenesis | Heterotopic bone | Vasculogenesis | Ectopic bone | Osteogenesis | Life Sciences & Biomedicine | Science & Technology | Bone and Bones - pathology | Capillaries - pathology | Blood Vessels - pathology | Humans | Middle Aged | Neovascularization, Pathologic | Male | Blood Vessels - physiopathology | Young Adult | Time Factors | Adult | Female | Child | Capillaries - physiopathology | Ossification, Heterotopic - pathology | Arteries - pathology | Osteoblasts - pathology | Bone and Bones - physiopathology | Ossification, Heterotopic - physiopathology | Baltimore | Biopsy | Veins - physiopathology | Arteries - physiopathology | Adolescent | Aged | Los Angeles | Veins - pathology | Proteins | Bone cancer | Rodents | Hypoxia | Photographs | Spinal cord injuries | Joint surgery | Burns | Patients | Vascular endothelial growth factor | Trauma | Index Medicus | vasculogenesis | osteogenesis | angiogenesis | ectopic bone | heterotopic bone
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8. Full Text Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation
by Chakkalakal, Salin A and Uchibe, Kenta and Convente, Michael R and Zhang, Deyu and Economides, Aris N and Kaplan, Frederick S and Pacifici, Maurizio and Iwamoto, Masahiro and Shore, Eileen M
Journal of bone and mineral research, ISSN 0884-0431, 09/2016, Volume 31, Issue 9, pp. 1666 - 1675
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Growth Plate - pathology | Ossification, Heterotopic - drug therapy | Bone and Bones - pathology | Pyrazoles - therapeutic use | Stilbenes - therapeutic use | Humans | Homeostasis | Stilbenes - pharmacology | Chondrocytes - drug effects | Growth Plate - drug effects | Disease Models, Animal | Pyrazoles - pharmacology | Chondrocytes - pathology | Movement | Ossification, Heterotopic - pathology | Mice, Transgenic | Mutation - genetics | Activin Receptors, Type I - genetics | Disease Progression | Ossification, Heterotopic - physiopathology | Animals | Myositis Ossificans - genetics | Cell Proliferation - drug effects | Bone and Bones - abnormalities | Extremities - growth & development | Osteogenesis | Extremities - physiopathology | Index Medicus
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