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Nature, ISSN 0028-0836, 03/2013, Volume 495, Issue 7442, pp. 467 - 473
Algorithms designed to identify canonical yeast prions predict that around 250 human proteins, including several RNA-binding proteins associated with... 
RNA-BINDING PROTEINS | DROSOPHILA MODEL | TDP-43 | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | VCP MUTATIONS | DISEASE | AMYOTROPHIC-LATERAL-SCLEROSIS | SACCHAROMYCES-CEREVISIAE | STRESS GRANULES | MULTIPLE ALIGNMENT | Prions - genetics | Humans | Molecular Sequence Data | Osteitis Deformans - metabolism | Male | Drosophila melanogaster - genetics | Osteitis Deformans - genetics | Drosophila melanogaster - metabolism | Frontotemporal Dementia - metabolism | Muscular Dystrophies, Limb-Girdle - genetics | Myositis, Inclusion Body - pathology | Female | Inclusion Bodies - metabolism | Muscular Dystrophies, Limb-Girdle - pathology | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics | Frontotemporal Dementia - pathology | RNA - metabolism | Frontotemporal Dementia - genetics | Amino Acid Sequence | Prions - metabolism | Peptide Termination Factors - genetics | Amyotrophic Lateral Sclerosis - genetics | Drosophila melanogaster - cytology | Mutant Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | Mutant Proteins - metabolism | Protein Structure, Tertiary - genetics | Prions - chemistry | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | Myositis, Inclusion Body - genetics | Peptide Termination Factors - metabolism | Amyotrophic Lateral Sclerosis - pathology | Inclusion Bodies - genetics | Osteitis Deformans - pathology | Animals | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - chemistry | Muscular Dystrophies, Limb-Girdle - metabolism | Mutant Proteins - chemistry | Amyotrophic Lateral Sclerosis - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Inclusion Bodies - pathology | Myositis, Inclusion Body - metabolism | Mice | Peptide Termination Factors - chemistry | HeLa Cells | Saccharomyces cerevisiae Proteins - chemistry | Pathology | Insects | Genomics | Genetics | Software | Genomes | Mutation | Genetic testing | Patients
Journal Article
Neuron, ISSN 0896-6273, 04/2013, Volume 78, Issue 1, pp. 57 - 64
Valosin-containing protein (VCP) is a highly expressed member of the type II AAA+ ATPase family. mutations are the cause of inclusion body myopathy, Paget’s... 
LIPID-PEROXIDATION | SPINAL-CORD PATHOLOGY | MOUSE MODEL | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | DYSFUNCTION | BONE | NEUROSCIENCES | PAGET-DISEASE | TRANSGENIC MICE | REVEALS | RNA, Small Interfering - genetics | Humans | Middle Aged | Male | Frontotemporal Dementia - metabolism | Neurons - ultrastructure | Muscular Dystrophies, Limb-Girdle - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Muscular Dystrophies, Limb-Girdle - pathology | NAD - metabolism | Fibroblasts - metabolism | Animals, Newborn | Frontotemporal Dementia - genetics | Magnesium - metabolism | Mitochondria - pathology | Fibroblasts - pathology | Mutation - genetics | Myositis, Inclusion Body - genetics | Osteitis Deformans - pathology | Muscular Dystrophies, Limb-Girdle - metabolism | Analysis of Variance | Luminescent Proteins - genetics | Adenosine Triphosphatases - genetics | Mice | Lipid Peroxidation - genetics | RNA, Small Interfering - metabolism | Valosin Containing Protein | Osteitis Deformans - metabolism | Family Health | Cerebral Cortex - cytology | Case-Control Studies | Osteitis Deformans - genetics | Transfection | Mitochondria - genetics | Cell Cycle Proteins - genetics | Myositis, Inclusion Body - pathology | Adult | Female | Neuroblastoma - pathology | Frontotemporal Dementia - pathology | Adenosine Triphosphatases - deficiency | Mice, Inbred C57BL | Cells, Cultured | Cell Cycle Proteins - deficiency | Mitochondria - metabolism | Animals | Oxygen Consumption - genetics | Myositis, Inclusion Body - metabolism | Aged | Nervous system diseases | Neurosciences | Genes | Amyotrophic lateral sclerosis | Genetic aspects | Adenosine triphosphatase | Dementia | Proteins | Medical research | Phosphorylation | Biomedical research | Disease | Rodents | Respiration | Experiments | Patients | Report
Journal Article
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 02/2007, Volume 66, Issue 2, pp. 152 - 157
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, p. e1003210
Journal Article
European Journal of Neurology, ISSN 1351-5101, 02/2013, Volume 20, Issue 2, pp. 251 - 258
Background and purpose The phenotype of IBMPFD [inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (FTD)] associated with... 
motor neuron disease | Parkinson's disease | neuropsychology | frontotemporal dementia | genetic and inherited disorders | neurodegenerative disorders (other than dementia) | myopathies | neuropathology | Genetic and inherited disorders | Neuropathology | Motor neuron disease | Neurodegenerative disorders (other than dementia) | Myopathies | Neuropsychology | Frontotemporal dementia | CRITERIA | DIAGNOSIS | VCP | DEMENTIA | PATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | PAGET-DISEASE | CLINICAL NEUROLOGY | INCLUSION-BODY MYOPATHY | DISORDER | BONE | Central Nervous System - metabolism | Humans | Middle Aged | Valosin Containing Protein | Muscular Dystrophies, Limb-Girdle - complications | Central Nervous System - pathology | Osteitis Deformans - metabolism | Male | Osteitis Deformans - diagnosis | Osteitis Deformans - genetics | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Frontotemporal Dementia - complications | Myositis, Inclusion Body - diagnosis | Muscular Dystrophies, Limb-Girdle - genetics | Cell Cycle Proteins - genetics | Myositis, Inclusion Body - pathology | Female | Parkinson Disease - metabolism | Muscular Dystrophies, Limb-Girdle - pathology | Frontotemporal Dementia - pathology | Frontotemporal Dementia - genetics | Parkinson Disease - complications | Genetic Predisposition to Disease - genetics | Muscular Dystrophies, Limb-Girdle - diagnosis | Parkinson Disease - pathology | Parkinson Disease - genetics | Frontotemporal Dementia - diagnosis | Myositis, Inclusion Body - genetics | Osteitis Deformans - complications | Osteitis Deformans - pathology | Phenotype | Muscular Dystrophies, Limb-Girdle - metabolism | Pedigree | Myositis, Inclusion Body - complications | Polymorphism, Single Nucleotide - genetics | Myositis, Inclusion Body - metabolism | Adenosine Triphosphatases - genetics | Aged | Aphasia | Nervous system diseases | Genetic aspects | Genetic disorders | Mutation | Parkinson’s disease
Journal Article