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Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2016, Volume 75, Issue 2, pp. 422 - 429
ObjectiveTo investigate the effects of BET bromodomain protein inhibition on inflammatory activation and functional properties of rheumatoid arthritis synovial... 
TRIAL | KNEE | EPIGENETICS | ACTIVATION | SECUKINUMAB | CHROMATIN | TISSUE | DOUBLE-BLIND | ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY | RHEUMATOLOGY | BET PROTEIN | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Lipopolysaccharides - metabolism | Arthritis, Rheumatoid - enzymology | Matrix Metalloproteinase 3 - metabolism | Nuclear Proteins - metabolism | RNA, Messenger - metabolism | Synovial Membrane - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacology | Osteoarthritis - genetics | Osteoarthritis - enzymology | Transcription Factors - metabolism | Arthritis, Rheumatoid - genetics | Interleukin-1beta - metabolism | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Matrix Metalloproteinase 1 - metabolism | Interleukin-6 - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - metabolism | Fibroblasts - metabolism | Epigenetic inheritance | Care and treatment | Interleukins | Tumor necrosis factor | Rheumatoid arthritis | Dosage and administration | Research | Enzymes | Immunoglobulins | Statistical analysis | Disease | Cytokines | Laboratories | Gene expression | Variance analysis | Bone surgery | Studies | Proteins | Pathology | Rodents | DNA methylation | Epigenetics | Fibroblasts | Tumor necrosis factor-TNF | Chemokines | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 04/2008, Volume 10, Issue 2, pp. R43 - R43
Introduction Cannabis-based medicines have a number of therapeutic indications, including anti- inflammatory and analgesic effects. The endocannabinoid... 
C-REACTIVE PROTEIN | CB2 RECEPTORS | NEUROPATHIC PAIN | ACTIVATION | RAT | ACID AMIDE HYDROLASE | INFLAMMATORY PAIN | RHEUMATOLOGY | MECHANICALLY EVOKED-RESPONSES | BONE MASS | DORSAL-HORN | Mitogen-Activated Protein Kinase 3 - analysis | Cytokines - analysis | Humans | Middle Aged | Synovial Fluid - metabolism | RNA, Messenger - analysis | Male | Synovial Fluid - chemistry | Arthritis, Rheumatoid - metabolism | Arachidonic Acids - analysis | Arachidonic Acids - metabolism | Piperidines - pharmacology | Glycerides - analysis | Mass Spectrometry | Chromatography, Liquid | Female | Phosphorylation - drug effects | Amidohydrolases - analysis | Endocannabinoids | Fibroblasts - metabolism | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Knee Joint - metabolism | Cytokines - metabolism | Cells, Cultured | Osteoarthritis - metabolism | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mitogen-Activated Protein Kinase 1 - analysis | Polyunsaturated Alkamides - analysis | Synovial Membrane - metabolism | Blotting, Western | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Aged | Mitogen-Activated Protein Kinase 1 - metabolism | Synovial fluid | Cannabinoids | Dosage and administration | Research | Drug therapy | Osteoarthritis | Health aspects | Index Medicus
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 23, Issue 12, pp. 2288 - 2296
Summary Objective Hypoxia-inducible factor-2α (HIF-2α) transcriptionally upregulates Nampt in articular chondrocytes. NAMPT, which exhibits nicotinamide... 
Rheumatology | NAD+ biosynthesis | Hypoxia-inducible factor (HIF) | Sirtuin | Osteoarthritis | Chondrocytes | NAD | biosynthesis | APOPTOSIS | RHEUMATOLOGY | SIRTUINS | NAD(+) biosynthesis | SIRT1 | CARTILAGE | NUCLEUS PULPOSUS CELLS | METABOLISM | BIOLOGY | GROWTH | STRESS | ORTHOPEDICS | EXPRESSION | Sirtuin 1 - metabolism | Up-Regulation | Arthritis, Experimental - genetics | Immunoprecipitation | Matrix Metalloproteinase 12 - genetics | RNA, Messenger - metabolism | Sirtuin 1 - genetics | Arthritis, Experimental - metabolism | Sirtuin 2 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nicotinamide Phosphoribosyltransferase - metabolism | Cartilage, Articular - metabolism | Sirtuins - genetics | Cytokines - genetics | Chondrocytes - metabolism | NAD - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Matrix Metalloproteinase 13 - metabolism | Sirtuin 2 - genetics | Nicotinamide Phosphoribosyltransferase - genetics | Animals | Osteoarthritis, Knee - genetics | Mice | Matrix Metalloproteinase 3 - genetics | Sirtuins - metabolism | Osteoarthritis, Knee - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1875 - 1880
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development.... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | CELLS | OSTEOBLAST DIFFERENTIATION | MULTIDISCIPLINARY SCIENCES | skeletal development | BONE-DEVELOPMENT | KNEE-JOINT INSTABILITY | LIGANDS | ARTICULAR-CARTILAGE | PATHWAY | GROWTH | cartilage degradation | EXPERIMENTAL MOUSE MODELS | EXPRESSION | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Proteins | Knee | Tissue | Rodents | Arthritis | Cells | Index Medicus | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2011, Volume 17, Issue 12, pp. 1674 - 1679
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | COLLAGEN | RHEUMATOLOGY | DIFFERENTIATED PHENOTYPE | HYPERTROPHY | IN-VITRO | SYNOVIAL FIBROBLASTS | HUMAN OSTEOARTHRITIC CARTILAGE | SIGNALING PATHWAY | beta-Catenin | ARTICULAR CHONDROCYTES | ORTHOPEDICS | KNEE OSTEOARTHRITIS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Index Medicus
Journal Article
Spine, ISSN 0362-2436, 10/2004, Volume 29, Issue 19, pp. 2091 - 2095
Journal Article
Archives of Oral Biology, ISSN 0003-9969, 02/2019, Volume 98, pp. 17 - 25
To investigate the changes in insulin-like growth factor-1 (IGF-1) expression levels in the degenerative mandibular condylar cartilage. Thirty-six rats were... 
Temporomandibular joint | Insulin-like growth factor-1 (IGF-1) | Articular cartilage | Chondrocyte | Osteoarthritis | Dental occlusion | IGF-I | PERICELLULAR MATRIX | ALKALINE-PHOSPHATASE | BINDING-PROTEINS | CHONDROCYTE HYPERTROPHY | ARTICULAR-CARTILAGE | TEMPOROMANDIBULAR-JOINT | DENTISTRY, ORAL SURGERY & MEDICINE | DEGRADATION | PLATE | EXPRESSION | Receptor, IGF Type 1 - metabolism | Up-Regulation | Alkaline Phosphatase - metabolism | Glucuronidase - metabolism | Malocclusion - complications | Gene Expression Profiling | ADAMTS5 Protein - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Mandibular Condyle - pathology | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Female | Insulin-Like Growth Factor Binding Protein 5 - metabolism | Cartilage Diseases - etiology | Disease Models, Animal | Chondrocytes - pathology | Rats | Matrix Metalloproteinase 3 - metabolism | ADAMTS4 Protein - metabolism | Aggrecans - metabolism | Rats, Sprague-Dawley | Matrix Metalloproteinase 13 - metabolism | Gene Expression Regulation, Enzymologic | Cartilage, Articular - pathology | Collagen - metabolism | Animals | Temporomandibular Joint Disorders - etiology | Mandibular Condyle - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Insulin-Like Growth Factor I - metabolism | Index Medicus | Dentistry
Journal Article
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, ISSN 0392-856X, 07/2017, Volume 35, Issue 4, pp. 630 - 637
Objective To determine the differential expressions of nucleotide oligomerisation domain (NOD)-like receptors (NLRs) and to investigate their association with... 
cytokine | NOD-like receptors | NF-.B | ACTIVATION | NLRX1 | CROHNS-DISEASE | NUCLEOTIDE-BINDING | NOD2 | RHEUMATOLOGY | rheumatoid arthritis | FAMILY-MEMBER | SYNOVIAL FIBROBLASTS | TOLL-LIKE RECEPTORS | PANETH CELLS | NF-KAPPA-B | INNATE IMMUNITY | Arthritis, Rheumatoid - surgery | Immunohistochemistry | Up-Regulation | Humans | Caspase 1 - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | RNA, Messenger - metabolism | Nod1 Signaling Adaptor Protein - metabolism | Case-Control Studies | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Arthritis, Rheumatoid - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Synoviocytes - metabolism | I-kappa B Kinase - metabolism | RNA Interference | Mitochondrial Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Arthroplasty, Replacement, Knee | Osteoarthritis, Knee - surgery | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Enzyme-Linked Immunosorbent Assay | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Down-Regulation | Intercellular Signaling Peptides and Proteins - genetics | Synovial Membrane - metabolism | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - genetics | Nod2 Signaling Adaptor Protein - metabolism | Osteoarthritis, Knee - genetics | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Osteoarthritis, Knee - metabolism | Nod1 Signaling Adaptor Protein - genetics
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 1, pp. 146 - 157
Summary Objective Mechanical signals control key cellular processes in articular cartilage. Previously we have shown that mechanical compression is an... 
Rheumatology | Mechanosensitivity | Cartilage | Signal transduction | TGF-beta | Smad2/3P signaling | Ageing | CHONDROCYTES | TENSILE PROPERTIES | RHEUMATOLOGY | GROWTH-FACTOR-BETA | IN-VITRO | AGE-RELATED-CHANGES | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | OSTEOARTHRITIS | PROMOTER | ORTHOPEDICS | GLYCATION END-PRODUCTS | Receptors, Transforming Growth Factor beta - genetics | Transforming Growth Factor beta1 - metabolism | Gene Expression Profiling | Smad3 Protein - metabolism | Cartilage, Articular - physiology | Collagen Type II - metabolism | Smad3 Protein - genetics | Aging - genetics | Heparan Sulfate Proteoglycans - genetics | Plasminogen Activator Inhibitor 1 - metabolism | Cartilage, Articular - metabolism | Cattle | Bone Morphogenetic Protein 2 - metabolism | Smad2 Protein - genetics | Plasminogen Activator Inhibitor 1 - genetics | Protein-Serine-Threonine Kinases - metabolism | Bone Morphogenetic Protein 2 - genetics | Extracellular Matrix | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Osteoarthritis - metabolism | Transforming Growth Factor beta1 - genetics | Aggrecans - metabolism | Aggrecans - genetics | Pressure | Collagen Type II - genetics | Fibronectins - metabolism | Osteoarthritis - genetics | Animals | Aging - physiology | Receptors, Transforming Growth Factor beta - metabolism | Heparan Sulfate Proteoglycans - metabolism | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Connective Tissue Growth Factor - metabolism | Aging - metabolism | Index Medicus
Journal Article
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