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Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2011, Volume 152, Issue 2, pp. 232 - 240
A strategy has been designed to develop hyaluronic acid (HA) hydrogel for bone augmentation using minimal invasive technique. A mild synthetic procedure was... 
In vivo | Bone tissue engineering | Hydrogel | Hyaluronic acid | BMP (bone morphogenetic protein) | Controlled release | CELLS | FUSION | RECONSTRUCTION | REGENERATION | STRATEGY | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | RHBMP-2 | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | SCAFFOLDS | MORPHOGENETIC PROTEIN-2 | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Humans | Delayed-Action Preparations - chemistry | Male | Delayed-Action Preparations - administration & dosage | Bone Morphogenetic Protein 2 - administration & dosage | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Skull - drug effects | Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism | Cell Line | Hyaluronic Acid - administration & dosage | Cross-Linking Reagents - chemistry | Cell Survival | Osteogenesis - drug effects | Hyaluronic Acid - chemistry | Hydrazones - administration & dosage | Rats | Hydrazones - metabolism | Rats, Sprague-Dawley | Hydrazones - chemistry | Delayed-Action Preparations - metabolism | Injections | Animals | Hyaluronic Acid - metabolism | Skull - ultrastructure | Aldehydes - chemistry | Osteocalcin | Bone morphogenetic protein 2 | Osteopontin | Cytotoxicity | hydrogels | Aldehydes | pH effects | Angiogenesis | Orthopedics | Bone marrow | Oxidation | Osteogenesis | Medical and Health Sciences | Polymer Chemistry | Medicin och hälsovetenskap | Klinisk medicin | MEDICINE | Chemical Sciences | Kemi med inriktning mot polymerkemi | Polymerkemi | Surgery | Chemistry with specialization in Polymer Chemistry | Natural Sciences | Kirurgi | Clinical Medicine | Organic chemistry | Chemistry | Naturvetenskap | Kemi | MEDICIN | Organisk kemi
Journal Article
Journal Article
The AAPS Journal, ISSN 1550-7416, 4/2013, Volume 15, Issue 2, pp. 367 - 376
Simvastatin (SIM), a drug commonly administered for the treatment of hypercholesterolemia, has been recently reported to induce bone regeneration/formation. In... 
Biochemistry, general | Biotechnology | Biomedicine | hydrogel | Pharmacy | MC3T3-E1 | MMP-3 | simvastatin | osteocalcin | osteogenesis | Pharmacology/Toxicology | OSTEOBLAST DIFFERENTIATION | BLOCK-COPOLYMERS | GELS | REGENERATION | 4-ARM-PPO-PEO | BIODEGRADABLE HYDROGELS | MINERALIZATION | DISC DEGENERATION | PHARMACOLOGY & PHARMACY | DRUG-DELIVERY SYSTEMS | PROGRESSION | Hydrogels | Osteocalcin - genetics | Polyethylene Glycols - chemistry | Simvastatin - pharmacology | Horseradish Peroxidase - chemistry | Dose-Response Relationship, Drug | Hydrogen Peroxide - chemistry | Tyramine - chemistry | Polymerase Chain Reaction | Drug Compounding | Buffers | Gelatin - chemistry | Tyramine - analogs & derivatives | Bone Density Conservation Agents - chemistry | Biomarkers - metabolism | Cell Line | Cross-Linking Reagents - chemistry | Simvastatin - chemistry | Osteocalcin - metabolism | Matrix Metalloproteinase 13 - genetics | Osteoblasts - drug effects | Osteogenesis - drug effects | Solubility | Technology, Pharmaceutical - methods | Blotting, Western | Chemistry, Pharmaceutical | Bone Density Conservation Agents - pharmacology | Matrix Metalloproteinase 13 - metabolism | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mice | Kinetics | Osteoblasts - metabolism | Delayed-Action Preparations | Hydrogen-Ion Concentration | Drugstores | Medical colleges | Ethylene glycol | Hypercholesterolemia | Simvastatin | Antilipemic agents
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0118164
Two-photon polymerization (2PP) is applied for the fabrication of 3-D Zr-Si scaffolds for bone tissue engineering. Zr-Si scaffolds with 150, 200, and 250 mu m... 
POROSITY | HUMAN ADIPOSE-TISSUE | CONTACT | MEDICAL APPLICATIONS | MULTIDISCIPLINARY SCIENCES | BONE | EXPRESSION | MARROW STROMAL CELLS | Cell Proliferation | Calcium - metabolism | Humans | Alkaline Phosphatase - metabolism | Adipose Tissue - cytology | Elastic Modulus | Stem Cells - cytology | Stem Cells - metabolism | Cell Culture Techniques - methods | Chemistry Techniques, Synthetic - methods | Tissue Scaffolds - chemistry | Inorganic Chemicals - chemistry | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Time Factors | Zirconium - chemistry | Cell Differentiation | Microscopy, Electron, Scanning | Reproducibility of Results | Tissue Engineering - methods | Osteocalcin - metabolism | Cells, Cultured | Organic Chemicals - chemistry | Mesenchymal Stromal Cells - metabolism | Polymerization | Hardness | Stem Cells - ultrastructure | Silicon - chemistry | Osteogenesis | Alkaline phosphatase | Adipose tissue | Transplants & implants | Calcium | Mesenchyme | Differentiation (biology) | Staining | Alcohol | Fabrication | Engineering | Biomedical materials | Pore size | Bone growth | Cell growth | Lasers | Mineralization | Bone marrow | Aging | Biocompatibility | Scanning transmission electron microscopy | Bone matrix | Biomedical engineering | Scanning electron microscopy | Autografts | Osteocalcin | Tissue engineering | Nanoindentation | Mechanical properties | Modulus of elasticity | Gene expression | Zirconium | Skin & tissue grafts | Stem cells | Porosity | Scaffolds | Nanotechnology
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 121, Issue 1, pp. 91 - 99
As an efficient sustained release system of BMP-2, a functional nanoparticle–hydrogel complex, composed of heparin-functionalized nanoparticles and fibrin gel,... 
Fibrin | Heparin | Bone graft | Controlled release | Growth factor | HEPARIN-BINDING | CONTROLLED-RELEASE | FIBROBLAST-GROWTH-FACTOR | CHEMISTRY, MULTIDISCIPLINARY | HYALURONIC-ACID | DELIVERY | growth factor | heparin | controlled release | bone graft | IN-VIVO | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | fibrin | RAT CALVARIAL DEFECTS | MORPHOGENETIC PROTEIN-2 | FIBRIN MATRICES | Immunohistochemistry | Nanoparticles - chemistry | Calcium - metabolism | Alkaline Phosphatase - metabolism | Calcium - analysis | Bone Morphogenetic Proteins - metabolism | Fibrin - chemistry | Alkaline Phosphatase - analysis | Bone Morphogenetic Proteins - genetics | Bone Morphogenetic Proteins - pharmacology | Osteocalcin - analysis | Recombinant Proteins - metabolism | Bone Density | Lactic Acid - chemistry | Bone Morphogenetic Protein 2 | Bone Substitutes | Rats | Bone Regeneration | Recombinant Proteins - pharmacology | Rats, Sprague-Dawley | Particle Size | Transforming Growth Factor beta - pharmacology | Animals | Transforming Growth Factor beta - genetics | Polyglycolic Acid - chemistry | Skull - cytology | Polymers - chemistry | Phosphates - analysis | Delayed-Action Preparations | Transforming Growth Factor beta - metabolism | Heparin - chemistry | Hydrogels - chemistry | Phosphates | Phosphatases | Analysis | Growth factors | Nanotechnology
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2012, Volume 162, Issue 1, pp. 19 - 27
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e84584
The water soluble matrix of nacre is a proven osteoinductive material. In spite of the differences in the biomolecular compositions of nacre obtained from... 
PINCTADA-MAXIMA | IN-VITRO | BONE-FORMATION | MULTIDISCIPLINARY SCIENCES | MATRIX PROTEIN | PEARL OYSTER | OSTEOGENIC DIFFERENTIATION | HYDROGEN-PEROXIDE | SCALLOP SHELL EXTRACT | ORGANIC MATRIX | HALIOTIS-TUBERCULATA | Lipid Peroxidation - radiation effects | Transcription, Genetic - drug effects | Antioxidants - chemistry | Nacre - chemistry | Keratinocytes - radiation effects | Humans | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Transcription, Genetic - radiation effects | Biological Products - pharmacology | Sulfonic Acids - chemistry | Collagen Type I - genetics | Picrates - chemistry | Lipid Peroxidation - drug effects | Water - chemistry | Biphenyl Compounds - chemistry | Osteoblasts - cytology | Cell Differentiation - radiation effects | Cell Line | Calcification, Physiologic - drug effects | Osteoblasts - drug effects | Osteogenesis - drug effects | Hydrogen Peroxide - pharmacology | Solubility | Keratinocytes - cytology | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | Biological Products - chemistry | Animals | Keratinocytes - drug effects | Cell Differentiation - drug effects | Keratinocytes - metabolism | Benzothiazoles - chemistry | Mice | Osteoblasts - metabolism | Antioxidants | Collagen | Oxidative stress | Hydrogen peroxide | Lipid peroxidation | Oysters | Drug development | Phosphatase | Osteoblasts | Proteins | Osteoporosis | Bone growth | Biomedical materials | Mineralization | Biocompatibility | Nacre | Pretreatment | Peroxidation | Water chemistry | Osteocalcin | Free radicals | Committees | Keratinocytes | Bone turnover | Metabolism | Biological activity | Studies | Regeneration | Osteoblastogenesis | Calcium carbonate | Bone | Differentiation | Osteogenesis
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 2, pp. 422 - 433
Journal Article