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Cell, ISSN 0092-8674, 06/2006, Volume 125, Issue 5, pp. 971 - 986
Journal Article
by Sun, F and Wan, M and Xu, X and Gao, B and Zhou, Y and Sun, J and Cheng, L and Klein, O.D and Zhou, X and Zheng, L
Journal of Dental Research, ISSN 0022-0345, 6/2014, Volume 93, Issue 6, pp. 589 - 595
Stem cells from the apical papilla (SCAPs) are important for the formation and regeneration of root dentin. Here, we examined the expression of Notch signaling... 
tooth development | cell fate determination | microRNA | epigenetic | tooth regeneration | stem cells from apical papilla | MOUSE | OSTEOBLASTIC DIFFERENTIATION | TOOTH | EPITHELIAL-MESENCHYMAL INTERACTIONS | IN-VITRO | PERIODONTITIS | DENTISTRY, ORAL SURGERY & MEDICINE | MINERALIZATION | FOLLICLE | EXPRESSION | IMMATURE PERMANENT TEETH | Sialoglycoproteins - genetics | Transcription Factor HES-1 | Humans | Osteocalcin - genetics | 3' Untranslated Regions - genetics | Odontogenesis - genetics | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Receptor Cross-Talk - physiology | Young Adult | Jagged-2 Protein | Cell Differentiation - physiology | Child | Intracellular Signaling Peptides and Proteins - genetics | Osteogenesis - genetics | Tooth Apex - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Expression Regulation - genetics | Membrane Proteins - genetics | Extracellular Matrix Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Notch - physiology | Repressor Proteins - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Adolescent | Sp7 Transcription Factor | Receptor, Notch3 | Signal Transduction - physiology | Stem Cells - physiology | MicroRNAs - physiology | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
Bone, ISSN 8756-3282, 2003, Volume 33, Issue 6, pp. 889 - 898
Distraction osteogenesis is a unique and effective way to treat limb length inequality resulting from congenital and posttraumatic skeletal defects. However,... 
Angiogenesis | Extracellular matrix | Bone morphogenetic protein | Distraction osteogenesis | mRNA expression | angiogenesis | STABILITY | RECEPTOR | ANGIOPOIETIN-2 | MODEL | bone morphogenetic protein | distraction osteogenesis | CARTILAGE | VASCULARIZATION | GROWTH | ENDOCRINOLOGY & METABOLISM | BONE | DIFFERENTIATION | LIGAND | extracellular matrix | Immunohistochemistry | Receptor, Fibroblast Growth Factor, Type 4 | Sialoglycoproteins - genetics | Femur - pathology | Oligonucleotide Array Sequence Analysis | Osteocalcin - genetics | Male | Gene Expression Profiling | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Hypoxia-Inducible Factor 1, alpha Subunit | Osteogenesis, Distraction | Fibroblast Growth Factor 2 - analysis | Angiogenesis Inducing Agents - metabolism | Receptors, Fibroblast Growth Factor - genetics | Fracture Healing - physiology | Collagen - genetics | Femur - surgery | Neuropilins - genetics | Receptors, Vascular Endothelial Growth Factor - genetics | Bone Morphogenetic Proteins - genetics | Cytokines - genetics | Transforming Growth Factor beta2 | Osteogenesis - genetics | von Willebrand Factor - analysis | Gene Expression | Femur - metabolism | Neovascularization, Physiologic - genetics | RNA, Messenger - genetics | Osteopontin | Rats | Vascular Endothelial Growth Factor A - analysis | Transcription Factors - genetics | Rats, Sprague-Dawley | Receptors, TIE - genetics | Carrier Proteins - genetics | Animals | Transforming Growth Factor beta - genetics | Fibroblast Growth Factor 2 - genetics | Vascular Endothelial Growth Factors - genetics | Fracture Healing - genetics | Angiopoietins - genetics
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 12/2010, Volume 191, Issue 7, pp. 1271 - 1283
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2... 
Osteomyelitis | Phenotypes | Antibodies | Bones | Mice | Repression | Bone marrow cells | Osteoblasts | Zinc | Mesenchymal stem cells | CLEIDOCRANIAL DYSPLASIA | CELLS | OSTEOBLAST DIFFERENTIATION | TGF-BETA | OSTEOCALCIN GENE | HOMEODOMAIN PROTEINS | CBFA1 | PARATHYROID-HORMONE | EXPRESSION | TRANSGENIC MICE | CELL BIOLOGY | Osteopontin - genetics | Bone and Bones - pathology | Transcription, Genetic - drug effects | Osteogenesis - physiology | Fractures, Spontaneous - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Bone Development - physiology | Cell Count | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Bone Remodeling - physiology | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Bone and Bones - metabolism | Osteoprotegerin - genetics | Osteoblasts - cytology | Response Elements - physiology | Animals, Newborn | Calcification, Physiologic - genetics | Histone Deacetylases - genetics | Extracellular Matrix Proteins - genetics | Rats | Histone Deacetylases - metabolism | Mice, Transgenic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Inbred Strains | Bone Diseases, Metabolic - metabolism | RANK Ligand - genetics | Animals | Sp7 Transcription Factor | Heterozygote | Histone Deacetylase Inhibitors - pharmacology | Zinc Fingers - physiology | Bone Diseases, Metabolic - genetics | Transcription, Genetic - genetics | Bone and Bones - abnormalities | Bone and Bones - embryology | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Protein Binding - physiology | Proteins | Enzymes | Transcription factors | Research | Properties | Density
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2011, Volume 37, Issue 5, pp. 662 - 666
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e77701
Bone tissue is continuously remodeled by bone cells and maintenance of its mass relies on the balance between the processes of resorption and formation. We... 
LIPOPROTEIN | SCAVENGER RECEPTOR | METABOLISM | ANGIOGENESIS | CHAIN FATTY-ACIDS | MULTIDISCIPLINARY SCIENCES | THROMBOSPONDIN-1 | DOWN-REGULATION | CALCIFICATION | NEOVASCULARIZATION | OSTEOPOROSIS | Bone and Bones - pathology | CD36 Antigens - deficiency | Osteogenesis - physiology | CD36 Antigens - genetics | Femur - pathology | Bone Density - physiology | Gene Expression - genetics | Genetic Diseases, Inborn - genetics | Osteocalcin - genetics | Bone Density - genetics | Genetic Diseases, Inborn - pathology | Blood Platelet Disorders - complications | Tibia - pathology | Cell Differentiation - genetics | Osteocalcin - blood | CD36 Antigens - metabolism | Bone and Bones - metabolism | Genetic Diseases, Inborn - complications | Genetic Diseases, Inborn - metabolism | Tibia - metabolism | Cell Differentiation - physiology | Peptide Fragments - genetics | Osteogenesis - genetics | Blood Platelet Disorders - genetics | Cell Line | Peptide Fragments - metabolism | Procollagen - genetics | Femur - metabolism | Osteocalcin - metabolism | Mice, Inbred C57BL | Scavenger Receptors, Class B - genetics | Procollagen - metabolism | Mice, Knockout | Osteoblasts - pathology | Phenotype | Animals | Mice | Scavenger Receptors, Class B - metabolism | Osteoblasts - metabolism | Blood Platelet Disorders - metabolism | Blood Platelet Disorders - pathology | Bones | Genetic aspects | Genetic transcription | Density | Analysis | Collagen | Cell culture | Femur | Spine | Bone sialoprotein | Lipids | Bone (trabecular) | Osteoblasts | Bone resorption | Osteoporosis | Receptors | Biomedical materials | Bone growth | Mouse devices | Computed tomography | Mineralization | Bone marrow | Scavenger receptors | Biocompatibility | Physiology | Cbfa-1 protein | Vertebrae | Osteocalcin | Procollagen | Cell survival | Markers | Histology | CD36 antigen | Bone turnover | Metabolism | Gene expression | Fatty acids | Lipoproteins | Bone mass | Stromal cells | Plasma levels | Bone | Osteogenesis
Journal Article
Biomaterials, ISSN 0142-9612, 2005, Volume 26, Issue 25, pp. 5158 - 5166
Functional engineering of musculoskeletal tissues generally involves the use of differentiated or progenitor cells seeded with specific growth factors in... 
Mesenchymal stem cell | Electrospinning | Nanofiber | Chondrogenesis | Osteogenesis | Adipogenesis | PROGENITOR CELLS | mesenchymal stem cell | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | nanofiber | TISSUE | MUSCLE | CHONDROGENIC DIFFERENTIATION | osteogenesis | CULTURE | CARTILAGE | HUMAN MARROW | IN-VITRO | adipogenesis | THERAPY | electrospinning | chondrogenesis | BONE | Sialoglycoproteins - genetics | Chondrocytes - cytology | Gene Expression - genetics | Integrin-Binding Sialoprotein | Humans | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Adipocytes - cytology | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Aggrecans | Adipocytes - ultrastructure | Cell Culture Techniques | Osteoblasts - cytology | Cell Lineage - genetics | Chondrocytes - metabolism | PPAR gamma - genetics | Osteoblasts - ultrastructure | Microscopy, Electron, Scanning | Alkaline Phosphatase - genetics | Fibrillar Collagens - genetics | Lipoprotein Lipase - genetics | Extracellular Matrix Proteins - genetics | Lectins, C-Type | Mesenchymal Stromal Cells - metabolism | Polyesters - chemistry | Chondrocytes - ultrastructure | Adipocytes - metabolism | Histocytochemistry | Nanostructures - chemistry | Osteoblasts - metabolism | Proteoglycans - genetics | Biological products | Gene expression | Analysis | Collagen | Nanotechnology | Stem cells
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 07/2017, Volume 42, Issue 4, pp. 1277 - 1293
Background/Aims: The aim of this study was to investigate the influence of Cx43-and Smad-mediated TGF-beta/BMP signaling pathway on the differentiation of bone... 
Smad1 | BMP2 | Bone marrow mesenchymal stem cells | Cartilage differentiation | Cx43 | Osteoblast differentiation | AMINO-PROPEPTIDE | DEFECTS | PHYSIOLOGY | CHONDROGENIC DIFFERENTIATION | CELL BIOLOGY | UMBILICAL-CORD | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | EXTRACELLULAR-MATRIX | MORPHOGENETIC PROTEINS | STROMAL CELLS | BMSCS | Osteopontin - genetics | Chondrocytes - cytology | Rats, Wistar | Chondrogenesis - genetics | Osteocalcin - genetics | Osteopontin - metabolism | Rats, Nude | Core Binding Factor Alpha 1 Subunit - metabolism | Collagen Type II - metabolism | Transfection | Bone Morphogenetic Protein 2 - metabolism | Injections, Subcutaneous | Mesenchymal Stem Cells - cytology | Cartilage - cytology | Smad1 Protein - genetics | Adenoviridae - genetics | Cell Differentiation | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | Osteogenesis - genetics | Connexin 43 - genetics | Bone Morphogenetic Protein 2 - genetics | Connexin 43 - metabolism | Genetic Vectors - chemistry | Signal Transduction | Bone Marrow Cells - cytology | Osteocalcin - metabolism | Gene Expression Regulation | Genetic Vectors - metabolism | Rats | Aggrecans - metabolism | Cartilage - metabolism | Aggrecans - genetics | Collagen Type II - genetics | Animals | Transforming Growth Factor beta - genetics | Smad1 Protein - metabolism | Adenoviridae - metabolism | Primary Cell Culture | Transforming Growth Factor beta - metabolism | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Mesenchymal Stem Cell Transplantation | Biomedical materials | Tissue engineering | Stem cells | Cell cycle | Bone marrow | Arthritis | Gene expression | Potassium
Journal Article
Stem Cell Research and Therapy, ISSN 1757-6512, 02/2017, Volume 8, Issue 1, p. 39
Background: Magnesium is essential for numerous physiological functions. Magnesium exists mostly in bone and the amount is dynamically regulated by skeletal... 
Mesenchymal stromal cells | Magnesium transporter | SLC41A1 | Mineralization | Osteogenic differentiation | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | MARROW | MATRIX GLA PROTEIN | PROLIFERATION | CELL BIOLOGY | IN-VITRO | EXTRACELLULAR MAGNESIUM | MOLECULAR-IDENTIFICATION | CALCIUM | CALCIFICATION | DIFFERENTIATION | Osteopontin - genetics | RNA, Small Interfering - genetics | Cation Transport Proteins - antagonists & inhibitors | Humans | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Male | Osteopontin - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Mesenchymal Stromal Cells - cytology | Collagen Type I - genetics | Protein Isoforms - metabolism | Cation Transport Proteins - metabolism | Bone Morphogenetic Protein 2 - metabolism | Bone Marrow Cells - drug effects | Cation Transport Proteins - genetics | Cell Differentiation | Ion Transport | Extracellular Matrix Proteins - metabolism | Osteogenesis - genetics | Wnt Signaling Pathway | Calcification, Physiologic - genetics | Calcium-Binding Proteins - metabolism | Bone Morphogenetic Protein 2 - genetics | Mesenchymal Stromal Cells - drug effects | Alkaline Phosphatase - genetics | Collagen Type I - metabolism | Calcification, Physiologic - drug effects | Bone Marrow Cells - cytology | Osteocalcin - metabolism | Extracellular Matrix Proteins - genetics | Osteogenesis - drug effects | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Mesenchymal Stromal Cells - metabolism | Magnesium - metabolism | Transcription Factors - genetics | Magnesium - pharmacology | Transcription Factors - metabolism | Animals | Sp7 Transcription Factor | Mice | Mice, Inbred BALB C | Bone Marrow Cells - metabolism | Protein Isoforms - antagonists & inhibitors | Calcium-Binding Proteins - genetics | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Growth | Analysis | Physiological aspects | Bone morphogenetic proteins | Bones | Genetic aspects | Research | Gene expression | Magnesium compounds | Density
Journal Article
Journal of Periodontology, ISSN 0022-3492, 07/2011, Volume 82, Issue 7, pp. 1007 - 1017
Journal Article
Gene, ISSN 0378-1119, 2006, Volume 366, Issue 1, pp. 51 - 57
Bone morphogenetic protein (BMP)-2 strongly induces bone formation. Introduction of the protein in muscle tissue results in ectopic bone formation. Similarly,... 
Msx2 | Osx | Dlx5 | Osteoblast | TGF-β | Smad | Bone | BMP-2 | Differentiation | Runx2 | CLEIDOCRANIAL DYSPLASIA | SIGNALING PATHWAYS | differentiation | OSTEOBLAST DIFFERENTIATION | BONE MORPHOGENETIC PROTEIN-2 | HOMEODOMAIN PROTEINS | C2C12 MYOBLASTS | bone | osteoblast | TGF-beta | GROWTH-FACTOR-BETA | INHIBITS MYOGENIC DIFFERENTIATION | OSTEOCALCIN GENE | GENETICS & HEREDITY | CRANIAL SUTURE MORPHOGENESIS | Protein Kinases - metabolism | Protein Kinases - genetics | Bone Morphogenetic Protein 2 | Gene Expression Regulation - genetics | Bone Morphogenetic Protein Receptors - genetics | Humans | Osteocytes - cytology | Bone Morphogenetic Protein Receptors - metabolism | Signal Transduction - genetics | Mesoderm - cytology | Transcription Factors - genetics | Transforming Growth Factor beta - biosynthesis | Osteocytes - physiology | Muscle Cells - cytology | Transcription Factors - metabolism | Cell Differentiation - genetics | Muscle Cells - physiology | Animals | Transforming Growth Factor beta - genetics | Mesoderm - physiology | Bone Morphogenetic Proteins - biosynthesis | Enzyme Activation - genetics | Bone Morphogenetic Proteins - genetics | Osteogenesis - genetics | Phosphatases | Developmental biology | Analysis | Stem cells | DNA binding proteins | Universities and colleges | Protein kinases | Growth factors | Mitogens
Journal Article