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by Meng, S and Zhang, L and Tang, Y and Tu, Q and Zheng, L and Yu, L and Murray, D and Cheng, J and Kim, S.H and Zhou, X and Chen, J
Journal of Dental Research, ISSN 0022-0345, 7/2014, Volume 93, Issue 7, pp. 657 - 662
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1270 - 1278
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | CORTICAL BONE | OSTEOCLASTS | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BONE-FORMATION | CATHEPSIN-K | MICE | DIFFERENTIATION | Neovascularization, Physiologic - drug effects | Cell Count | Tartrate-Resistant Acid Phosphatase | Osteoclasts - secretion | Culture Media, Conditioned - pharmacology | Femur - diagnostic imaging | X-Ray Microtomography | Protease Inhibitors - pharmacology | Acid Phosphatase - metabolism | Mesenchymal Stromal Cells - cytology | Isoenzymes - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cathepsin K - antagonists & inhibitors | Mesenchymal Stromal Cells - drug effects | Ovariectomy | Endothelial Cells - metabolism | Femur - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Mesenchymal Stromal Cells - metabolism | Femur - drug effects | Cell Movement - drug effects | Animals | Cathepsin K - metabolism | Endothelial Cells - cytology | Proto-Oncogene Proteins c-sis - secretion | Osteoclasts - enzymology | Osteoclasts - drug effects | Endothelial Cells - drug effects | Platelet-derived growth factor | Growth | Analysis | Physiological aspects | Bones | Research | Osteoclasts (Biology) | Homeostasis | Angiogenesis | Cell growth | Blood platelets | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, pp. e25900 - e25900
Sclerostin is a product of mature osteocytes embedded in mineralised bone and is a negative regulator of bone mass and osteoblast differentiation. While... 
BONE MORPHOGENETIC PROTEIN | IN-VIVO | BMP ANTAGONIST | BIOLOGY | HUMAN PRIMARY OSTEOBLASTS | RECEPTOR ACTIVATOR | MECHANICAL STIMULATION | PARATHYROID-HORMONE | CELL-DIFFERENTIATION | VAN-BUCHEM-DISEASE | KAPPA-B LIGAND | Osteocytes - drug effects | RANK Ligand - metabolism | Apoptosis - drug effects | Humans | Tartrate-Resistant Acid Phosphatase | Osteoclasts - cytology | Cell Differentiation - genetics | Acid Phosphatase - metabolism | Isoenzymes - metabolism | Adult | Osteoblasts - cytology | Bone Morphogenetic Proteins - pharmacology | Osteogenesis - genetics | Cell Survival - drug effects | Calcification, Physiologic - drug effects | Osteocytes - metabolism | Osteoblasts - drug effects | Osteocytes - cytology | Osteogenesis - drug effects | Cells, Cultured | Genetic Markers | Recombinant Proteins - pharmacology | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | RANK Ligand - genetics | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice | Osteoblasts - metabolism | Osteoclasts - drug effects | Bones | RNA | Gene expression | Density | Genes | Homeostasis | Osteocytes | Leukocytes (mononuclear) | SOST protein | Biology | Kinases | Osteoprotegerin | Monoculture | Ethics | Genotype & phenotype | Splenocytes | Peripheral blood mononuclear cells | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Discipline | Recombinant | Cytokines | Caspase | Cultures | Bone mass | Osteoblastogenesis | Low density lipoprotein receptors | Osteoclasts | Acid phosphatase (tartrate-resistant) | Bone | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7656, pp. 107 - 112
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the beta-subunit of the pituitary hormone... 
WHITE | OBESITY | ENERGY-EXPENDITURE | BROWN-FAT | OSTEOCLAST FORMATION | MULTIDISCIPLINARY SCIENCES | FOLLICLE-STIMULATING-HORMONE | RECEPTOR | BONE MASS | MENOPAUSAL TRANSITION | OVARIECTOMIZED MICE | Obesity - drug therapy | Receptors, FSH - genetics | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Follicle Stimulating Hormone, beta Subunit - antagonists & inhibitors | Male | Osteoporosis - drug therapy | Adipocytes - drug effects | Uncoupling Protein 1 - biosynthesis | Adipose Tissue - metabolism | Antibodies - immunology | Female | Receptors, FSH - metabolism | Adiposity - drug effects | Ovariectomy | Mitochondria - metabolism | Mitochondria - drug effects | Receptors, FSH - antagonists & inhibitors | Haploinsufficiency | Antibodies - pharmacology | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Obesity - prevention & control | Follicle Stimulating Hormone, beta Subunit - immunology | Adipose Tissue, Beige - drug effects | Mice | Thermogenesis - drug effects | Adipose Tissue - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Physiological research | Follicle-stimulating hormone | Thermogenesis | Research | Adipose tissue | Body fat | Menopause | Adipocytes | Hormones | Density | Osteoporosis | Mitochondria | Biomedical materials | Biocompatibility | Bone loss | Adipose tissue (brown) | Binding | Obesity | Immunoglobulins | Pituitary hormones | Blocking | Metabolism | Bone mass | Pituitary | Bone | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2011, Volume 26, Issue 7, pp. 1517 - 1532
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 3143 - 3148
The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes.... 
Bone resorption | Bone formation | Bone marrow | Bones | Osteoclasts | Fibroblast growth factors | Gene expression regulation | Adipocytes | Type 2 diabetes mellitus | Osteoblasts | Osteoblast | Adipocyte | Nuclear receptor | Bone metabolism | Thiazolidinediones | thiazolidinediones | FIBROBLAST-GROWTH-FACTOR-21 | MULTIDISCIPLINARY SCIENCES | ALPHA | osteoblast | ADIPOGENESIS | INSULIN SENSITIVITY | OSTEOCLAST | bone metabolism | METABOLISM | adipocyte | nuclear receptor | PPAR-GAMMA | MICE | ROSIGLITAZONE | FGF21 | Bone and Bones - pathology | RANK Ligand - metabolism | Adipogenesis - drug effects | Humans | PPAR gamma - metabolism | Bone and Bones - drug effects | Fibroblast Growth Factors - metabolism | Fibroblast Growth Factors - administration & dosage | Bone and Bones - metabolism | Bone Resorption - metabolism | Thiazolidinediones - pharmacology | Bone Marrow - drug effects | Osteoblasts - drug effects | Osteogenesis - drug effects | Drug Resistance - drug effects | Fibroblast Growth Factors - pharmacology | Mice, Knockout | Osteoblasts - pathology | Organ Size - drug effects | Animals | Bone Marrow - pathology | Bone Resorption - pathology | Mice | Osteoprotegerin - metabolism | Osteoblasts - metabolism | Drugs | Fibroblast growth factor | Energy metabolism | Mesenchyme | Diabetes mellitus | Homeostasis | Bone turnover | Hormones | Glucose metabolism | Side effects | Bone mass | Osteoblastogenesis | adipogenesis | Stem cells | rosiglitazone | Lipid metabolism | Peroxisome proliferator-activated receptors | Bone loss | Index Medicus | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1). Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | TUMOR SUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | IDENTIFICATION | OSTEOPOROSIS | CELL BIOLOGY | OSTEOCLASTOGENESIS | MASS | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | Bone | In vitro methods and tests | Osteogenesis | Index Medicus | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
Nature medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 11, pp. 1279 - 1288
The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | CELL BIOLOGY | MINERAL DENSITY | SOST GENE | MASS | RECEPTOR-RELATED PROTEIN-5 | GENOME-WIDE | DIFFERENTIATION | Osteocytes - drug effects | Humans | Wnt Proteins - deficiency | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Cell Lineage - drug effects | Fractures, Bone - genetics | Cell Differentiation - genetics | RANK Ligand - pharmacology | Wnt Proteins - genetics | Skull - pathology | Gene Deletion | Organ Size - genetics | Osteogenesis - genetics | Cell Line | Osteoclasts - pathology | Disease Susceptibility | Osteocytes - metabolism | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Cells, Cultured | Signal Transduction - genetics | Osteoclasts - metabolism | Fractures, Bone - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Osteoblasts - pathology | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Osteocytes - pathology | Fractures, Bone - pathology | Osteoprotegerin - metabolism | Osteoblasts - metabolism | Fractures, Bone - prevention & control | Osteoclasts - drug effects | Physiological aspects | Fractures | Research | Wnt proteins | Analysis | Osteoclasts (Biology) | Osteoporosis | Signal transduction | Bones | Glycoproteins | Porosity | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article