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by Meng, S and Zhang, L and Tang, Y and Tu, Q and Zheng, L and Yu, L and Murray, D and Cheng, J and Kim, S.H and Zhou, X and Chen, J
Journal of dental research, ISSN 1544-0591, 2014, Volume 93, Issue 7, pp. 657 - 662
...) inhibitor, JQ1, was proved to suppress oncogene transcription and inflammatory responses. The present study was aimed to investigate the effects of JQ1 on inflammatory response and bone destruction in experimental periodontitis... 
Epigenetics | Osteoclasts | BRD4 protein | Experimental animal models | Periodontitis | Anti-inflammatory agents | SELECTIVE-INHIBITION | HOMEOSTASIS | PROTEIN | CHROMATIN | experimental animal models | C-MYC | BRD4 INHIBITION | epigenetics | RESPONSES | DISRUPTION | DENTISTRY, ORAL SURGERY & MEDICINE | periodontitis | osteoclasts | BROMODOMAIN INHIBITION | anti-inflammatory agents | Interleukin-1beta - drug effects | Transcription Factor AP-1 - drug effects | Toll-Like Receptor 2 - antagonists & inhibitors | Alveolar Bone Loss - prevention & control | Cathepsin K - drug effects | Tartrate-Resistant Acid Phosphatase | Promoter Regions, Genetic - drug effects | Lipopolysaccharides - adverse effects | RANK Ligand - drug effects | Proto-Oncogene Proteins c-ets - drug effects | Cell Differentiation | Toll-Like Receptor 4 - antagonists & inhibitors | Acid Phosphatase - drug effects | Transcription Factors - therapeutic use | Cell Line | Proto-Oncogene Proteins c-fos - drug effects | Nuclear Proteins - therapeutic use | Periodontitis - prevention & control | NFATC Transcription Factors - drug effects | Animals | Tumor Necrosis Factor-alpha - drug effects | Isoenzymes - drug effects | Mice | Osteoclasts - drug effects | NF-kappa B - drug effects | Research Reports
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 10, p. e25900
...) and measured effects on pro-catabolic gene expression. Sclerostin dose-dependently up-regulated the expression of receptor activator of nuclear factor kappa B (RANKL... 
MESSENGER-RNA | BONE MORPHOGENETIC PROTEIN | MULTIDISCIPLINARY SCIENCES | HUMAN PRIMARY OSTEOBLASTS | RECEPTOR ACTIVATOR | MECHANICAL STIMULATION | PARATHYROID-HORMONE | CELL-DIFFERENTIATION | WNT | EXPRESSION | KAPPA-B LIGAND | Osteocytes - drug effects | RANK Ligand - metabolism | Apoptosis - drug effects | Humans | Tartrate-Resistant Acid Phosphatase | Osteoclasts - cytology | Cell Differentiation - genetics | Acid Phosphatase - metabolism | Isoenzymes - metabolism | Adult | Osteoblasts - cytology | Bone Morphogenetic Proteins - pharmacology | Osteogenesis - genetics | Cell Survival - drug effects | Calcification, Physiologic - drug effects | Osteocytes - metabolism | Osteoblasts - drug effects | Osteocytes - cytology | Osteogenesis - drug effects | Cells, Cultured | Genetic Markers | Recombinant Proteins - pharmacology | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | RANK Ligand - genetics | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice | Osteoblasts - metabolism | Osteoclasts - drug effects | Bones | RNA | Gene expression | Density | Genes | Homeostasis | Osteocytes | Leukocytes (mononuclear) | SOST protein | Biology | Kinases | Osteoprotegerin | Monoculture | Ethics | Genotype & phenotype | Splenocytes | Peripheral blood mononuclear cells | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Discipline | Cytokines | Caspase | Bone mass | Osteoblastogenesis | Low density lipoprotein receptors | Osteoclasts | Acid phosphatase (tartrate-resistant) | Apoptosis
Journal Article
Nature medicine, ISSN 1546-170X, 2014, Volume 20, Issue 11, pp. 1279 - 1288
..., whereas vertebral fracture risk is determined mainly by trabecular bone mass (2-4). Currently used anti-resorptive drugs reduce the risk of vertebral fractures... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | METAANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | MINERAL DENSITY | SOST GENE | MASS | GENOME-WIDE | DIFFERENTIATION | HOMODIMERIZATION | Osteocytes - drug effects | Humans | Wnt Proteins - deficiency | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Cell Lineage - drug effects | Fractures, Bone - genetics | Cell Differentiation - genetics | RANK Ligand - pharmacology | Wnt Proteins - genetics | Skull - pathology | Gene Deletion | Organ Size - genetics | Osteogenesis - genetics | Cell Line | Osteoclasts - pathology | Disease Susceptibility | Osteocytes - metabolism | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Cells, Cultured | Signal Transduction - genetics | Osteoclasts - metabolism | Fractures, Bone - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Osteoblasts - pathology | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Osteocytes - pathology | Fractures, Bone - pathology | Osteoprotegerin - metabolism | Osteoblasts - metabolism | Fractures, Bone - prevention & control | Osteoclasts - drug effects | Physiological aspects | Fractures | Research | Wnt proteins | Analysis | Osteoclasts (Biology) | Osteoporosis | Signal transduction | Bones | Glycoproteins | Porosity | Clinical Medicine | Endokrinologi och diabetes | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7656, pp. 107 - 112
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the beta-subunit of the pituitary hormone... 
WHITE | OBESITY | ENERGY-EXPENDITURE | BROWN-FAT | OSTEOCLAST FORMATION | MULTIDISCIPLINARY SCIENCES | FOLLICLE-STIMULATING-HORMONE | RECEPTOR | BONE MASS | MENOPAUSAL TRANSITION | OVARIECTOMIZED MICE | Obesity - drug therapy | Receptors, FSH - genetics | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Follicle Stimulating Hormone, beta Subunit - antagonists & inhibitors | Male | Osteoporosis - drug therapy | Adipocytes - drug effects | Uncoupling Protein 1 - biosynthesis | Adipose Tissue - metabolism | Antibodies - immunology | Female | Receptors, FSH - metabolism | Adiposity - drug effects | Ovariectomy | Mitochondria - metabolism | Mitochondria - drug effects | Receptors, FSH - antagonists & inhibitors | Haploinsufficiency | Antibodies - pharmacology | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Obesity - prevention & control | Follicle Stimulating Hormone, beta Subunit - immunology | Adipose Tissue, Beige - drug effects | Mice | Thermogenesis - drug effects | Adipose Tissue - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Physiological research | Follicle-stimulating hormone | Thermogenesis | Research | Binding | Obesity | Immunoglobulins | Adipose tissue | Pituitary hormones | Body fat | Menopause | Blocking | Adipocytes | Hormones | Metabolism | Density | Osteoporosis | Mitochondria | Biomedical materials | Bone mass | Pituitary | Biocompatibility | Bone loss | Adipose tissue (brown)
Journal Article
Osteoarthritis and cartilage, ISSN 1063-4584, 2016, Volume 24, Issue 1, pp. 178 - 187
Summary Objective To determine whether mandibular condylar cartilage degradation induced by experimentally abnormal occlusion could be ameliorated via systemic... 
Rheumatology | Strontium | Cartilage | Subchondral bone | NBD (NEMO-binding domain) peptide | Temporomandibular joint | Osteoarthritis | Dental occlusion | TGF-BETA | CHONDROCYTES | BLOCKS OSTEOCLASTOGENESIS | RHEUMATOLOGY | TRABECULAR BONE | SUBCHONDRAL BONE LOSS | RANELATE | INHIBITION | TEMPOROMANDIBULAR-JOINT | ORTHOPEDICS | NF-KAPPA-B | KNEE OSTEOARTHRITIS | Immunohistochemistry | RANK Ligand - metabolism | Collagen Type II - drug effects | Tumor Necrosis Factor-alpha - genetics | ADAM Proteins - drug effects | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Proteoglycans - drug effects | Collagen Type II - metabolism | Cartilage, Articular - metabolism | Interleukin-1beta - metabolism | Malocclusion | Receptor Activator of Nuclear Factor-kappa B - metabolism | Aggrecans - drug effects | Real-Time Polymerase Chain Reaction | ADAMTS5 Protein | NF-KappaB Inhibitor alpha | Proteoglycans - metabolism | I-kappa B Proteins - drug effects | Aggrecans - metabolism | ADAM Proteins - metabolism | Tumor Necrosis Factor-alpha - drug effects | Strontium - pharmacology | Mice | Osteoprotegerin - metabolism | ADAM Proteins - genetics | Interleukin-1beta - drug effects | Tumor Necrosis Factor-alpha - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Receptor Activator of Nuclear Factor-kappa B - drug effects | Transcription Factor RelA - genetics | RANK Ligand - drug effects | Mandibular Condyle - pathology | Osteoprotegerin - genetics | Female | Mandibular Condyle - drug effects | Osteoprotegerin - drug effects | RNA, Messenger - drug effects | Mice, Inbred C57BL | Aggrecans - genetics | Osteoclasts - metabolism | Collagen Type II - genetics | Peptides - pharmacology | RANK Ligand - genetics | Animals | Transcription Factor RelA - metabolism | Receptor Activator of Nuclear Factor-kappa B - genetics | Transcription Factor RelA - drug effects | Cartilage, Articular - drug effects | Mandibular Condyle - metabolism | Dental Occlusion | Osteoclasts - drug effects | Peptides
Journal Article
Nature medicine, ISSN 1546-170X, 2014, Volume 20, Issue 11, pp. 1270 - 1278
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | CORTICAL BONE | OSTEOCLASTS | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BONE-FORMATION | CATHEPSIN-K | MICE | DIFFERENTIATION | Neovascularization, Physiologic - drug effects | Cell Count | Tartrate-Resistant Acid Phosphatase | Osteoclasts - secretion | Culture Media, Conditioned - pharmacology | Femur - diagnostic imaging | X-Ray Microtomography | Protease Inhibitors - pharmacology | Acid Phosphatase - metabolism | Mesenchymal Stromal Cells - cytology | Isoenzymes - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cathepsin K - antagonists & inhibitors | Mesenchymal Stromal Cells - drug effects | Ovariectomy | Endothelial Cells - metabolism | Femur - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Mesenchymal Stromal Cells - metabolism | Femur - drug effects | Cell Movement - drug effects | Animals | Cathepsin K - metabolism | Endothelial Cells - cytology | Proto-Oncogene Proteins c-sis - secretion | Osteoclasts - enzymology | Osteoclasts - drug effects | Endothelial Cells - drug effects | Platelet-derived growth factor | Growth | Analysis | Physiological aspects | Bones | Research | Osteoclasts (Biology) | Homeostasis | Angiogenesis | Cell growth | Blood platelets
Journal Article
Journal of dental research, ISSN 1544-0591, 2016, Volume 77, Issue 1, pp. 8 - 15
Studies of osteopetrotic rodents suggest that localized alveolar bone resorption must occur if the tooth is to To test this hypothesis directly, we injected... 
Bone resorption | Osteoclasts | Pamidronate | Tooth eruption | C-FOS | bone resorption | tooth eruption | EPIDERMAL GROWTH-FACTOR | STIMULATING FACTOR-I | BONE-RESORPTION | pamidronate | (3-AMINO-1-HYDROXYPROPYLIDENE)-1,1-BISPHOSPHONATE | APD | DENTISTRY, ORAL SURGERY & MEDICINE | osteoclasts | DENTAL FOLLICLE | DIPHOSPHONATE | PAGETS-DISEASE | Isoenzymes - analysis | Tooth Eruption - drug effects | Dental Sac - drug effects | Cell Count | Coloring Agents | Tartrate-Resistant Acid Phosphatase | Alveolar Process - drug effects | RNA - genetics | Injections, Subcutaneous | Dental Sac - metabolism | Molar - drug effects | Macrophage Colony-Stimulating Factor - genetics | Animals, Newborn | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Bone Resorption - physiopathology | Osteoclasts - pathology | Acid Phosphatase - analysis | Incisor - drug effects | RNA - analysis | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Cell Size - drug effects | Alveolar Process - pathology | Biomarkers - analysis | Rats | Diphosphonates - administration & dosage | Microscopy, Electron | Osteoclasts - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Monocytes - drug effects | Animals | Proto-Oncogene Proteins c-fos - genetics | Cell Nucleus - drug effects | Diphosphonates - pharmacology | Osteoclasts - drug effects
Journal Article
Bone, ISSN 8756-3282, 2015, Volume 83, pp. 127 - 140
Abstract Lycopene supplementation decreases oxidative stress and exhibits beneficial effects on bone health, but the mechanisms through which it alters bone metabolism in vivo remain unclear... 
Orthopedics | Osteoclastogenesis | Oxidative stress | Bone turnover | Ovariectomy | Bone mass and microarchitecture | Lycopene | SYSTEM | RESORPTION | RAT MODEL | SUPPLEMENTATION | WOMEN | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | ESTROGEN-DEFICIENCY | OSTEOCLAST DIFFERENTIATION | Humans | Body Weight - drug effects | Femur - diagnostic imaging | Humerus - physiopathology | X-Ray Microtomography | Biomechanical Phenomena - drug effects | Carotenoids - blood | Hormones - blood | Lumbar Vertebrae - physiopathology | Tibia - physiopathology | Disease Models, Animal | Bone Resorption - physiopathology | Diaphyses - diagnostic imaging | Lumbar Vertebrae - diagnostic imaging | Bone Resorption - drug therapy | Tibia - diagnostic imaging | Lumbar Vertebrae - drug effects | Biomarkers - blood | Absorptiometry, Photon | Osteoporosis, Postmenopausal - drug therapy | Diaphyses - drug effects | Osteoporosis, Postmenopausal - blood | Diaphyses - physiopathology | Minerals - blood | Uterus - pathology | Bone and Bones - pathology | Deoxyguanosine - blood | Rats, Wistar | Uterus - drug effects | Bone Remodeling - drug effects | Carotenoids - pharmacology | Bone and Bones - drug effects | Humerus - drug effects | Carotenoids - therapeutic use | Bone and Bones - diagnostic imaging | Female | Deoxyguanosine - analogs & derivatives | Bone Resorption - blood | Femur - drug effects | Humerus - diagnostic imaging | Femur - physiopathology | Tibia - drug effects | Bone Resorption - diagnostic imaging | Bone Density - drug effects | Bone and Bones - physiopathology | Organ Size - drug effects | Animals | Osteoporosis, Postmenopausal - physiopathology | Enzymes - blood | Osteoporosis | Analysis | Bone densitometry | Physiological aspects | Superoxide | Postmenopausal women
Journal Article
Journal of bone and mineral research, ISSN 0884-0431, 2011, Volume 26, Issue 7, pp. 1517 - 1532
Journal Article