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Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7459, pp. 491 - 495
The tyrosine phosphatase SHP2, encoded by PTPN11, is required for the survival, proliferation and differentiation of various cell types(1,2). Germline... 
ENCHONDROMATOSIS | RANVIER | OSTEOCLASTS | MULTIDISCIPLINARY SCIENCES | OSSIFICATION GROOVE | PERICHONDRIAL RING | CELL PROLIFERATION | RECEPTOR | OSTEOGENESIS | CHONDROGENESIS | CARTILAGE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Cartilage - pathology | Hedgehog Proteins - metabolism | Monocytes - metabolism | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | MAP Kinase Signaling System | Fibroblast Growth Factors - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Mesenchymal Stromal Cells - cytology | Cell Division | Gene Deletion | Genes, Tumor Suppressor - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Exostoses, Multiple Hereditary - genetics | Bone Neoplasms - genetics | Bone Neoplasms - drug therapy | Osteopetrosis - genetics | Osteopetrosis - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Exostoses, Multiple Hereditary - metabolism | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Osteopetrosis - metabolism | Chondromatosis - metabolism | Hedgehog Proteins - antagonists & inhibitors | Cartilage - metabolism | Osteoclasts - metabolism | Parathyroid Hormone-Related Protein - metabolism | Exostoses, Multiple Hereditary - pathology | Mice, Knockout | Exostoses, Multiple Hereditary - drug therapy | Gene Expression Regulation - drug effects | Cell Lineage | Cathepsin K - genetics | Macrophages - metabolism | Animals | Chondromatosis - drug therapy | Cathepsin K - metabolism | Chondromatosis - genetics | Signal Transduction - drug effects | Chondromatosis - pathology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Cathepsin K - deficiency | Tyrosine | Phosphatases | Physiological aspects | Cellular signal transduction | Research | Bone diseases | Health aspects | Hedgehog proteins | Flow cytometry | Pathogenesis | Rodents | Bone density | Mutation | Kinases | Gene expression | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 07/2013, Volume 228, Issue 7, pp. 1506 - 1515
Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 147 - 158
We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using... 
cardiovascular disease | chronic kidney disease | bone | fibrosis | mineral metabolism | vascular calcification | TGF-BETA | CARDIOVASCULAR EVENTS | RENAL FIBROSIS | ARTERIAL CALCIFICATION | BONE MORPHOGENETIC PROTEIN-7 | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | LINKED ALPORT-SYNDROME | OSTEOCLAST DIFFERENTIATION | ATHEROSCLEROTIC LESION | Kidney - pathology | Recombinant Fusion Proteins - pharmacology | Blood Vessels - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - genetics | Vascular Calcification - metabolism | Kidney - metabolism | Bone Resorption - genetics | Bone and Bones - metabolism | Myocardium - metabolism | Renal Insufficiency, Chronic - genetics | Bone Resorption - metabolism | Disease Models, Animal | Bone Resorption - physiopathology | Glomerular Filtration Rate | Signal Transduction | Smad2 Protein - metabolism | Cardiomegaly - physiopathology | Nephritis, Hereditary - genetics | Renal Insufficiency, Chronic - physiopathology | Mice, Knockout | Renal Insufficiency, Chronic - prevention & control | Cardiomegaly - prevention & control | Nephritis, Hereditary - metabolism | Collagen Type IV - deficiency | Activin Receptors, Type II - genetics | Fibrosis | Sp7 Transcription Factor - metabolism | Collagen Type IV - genetics | Cardiomegaly - metabolism | Activin Receptors, Type II - metabolism | Bone and Bones - pathology | Phosphorylation | Vascular Remodeling | Blood Vessels - pathology | Vascular Calcification - genetics | Actins - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology | Activin Receptors, Type II - antagonists & inhibitors | Blood Vessels - physiopathology | Renal Insufficiency, Chronic - metabolism | Ventricular Remodeling | Chronic Kidney Disease-Mineral and Bone Disorder - prevention & control | Muscle Proteins - metabolism | Vascular Calcification - physiopathology | Microfilament Proteins - metabolism | Nephritis, Hereditary - physiopathology | Kidney - physiopathology | Vascular Calcification - prevention & control | Myocardium - pathology | Bone Resorption - prevention & control | Bone and Bones - physiopathology | Animals | Nephritis, Hereditary - drug therapy | Cardiomegaly - genetics | Bone Remodeling | Index Medicus | Chronic kidney disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 3143 - 3148
The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes.... 
Bone resorption | Bone formation | Bone marrow | Bones | Osteoclasts | Fibroblast growth factors | Gene expression regulation | Adipocytes | Type 2 diabetes mellitus | Osteoblasts | Osteoblast | Adipocyte | Nuclear receptor | Bone metabolism | Thiazolidinediones | thiazolidinediones | FIBROBLAST-GROWTH-FACTOR-21 | MULTIDISCIPLINARY SCIENCES | ALPHA | osteoblast | ADIPOGENESIS | INSULIN SENSITIVITY | OSTEOCLAST | bone metabolism | METABOLISM | adipocyte | nuclear receptor | PPAR-GAMMA | MICE | ROSIGLITAZONE | FGF21 | Bone and Bones - pathology | RANK Ligand - metabolism | Adipogenesis - drug effects | Humans | PPAR gamma - metabolism | Bone and Bones - drug effects | Fibroblast Growth Factors - metabolism | Fibroblast Growth Factors - administration & dosage | Bone and Bones - metabolism | Bone Resorption - metabolism | Thiazolidinediones - pharmacology | Bone Marrow - drug effects | Osteoblasts - drug effects | Osteogenesis - drug effects | Drug Resistance - drug effects | Fibroblast Growth Factors - pharmacology | Mice, Knockout | Osteoblasts - pathology | Organ Size - drug effects | Animals | Bone Marrow - pathology | Bone Resorption - pathology | Mice | Osteoprotegerin - metabolism | Osteoblasts - metabolism | Drugs | Fibroblast growth factor | Energy metabolism | Mesenchyme | Diabetes mellitus | Homeostasis | Bone turnover | Hormones | Glucose metabolism | Side effects | Bone mass | Osteoblastogenesis | adipogenesis | Stem cells | rosiglitazone | Lipid metabolism | Peroxisome proliferator-activated receptors | Bone loss | Index Medicus | Biological Sciences
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2004, Volume 19, Issue 11, pp. 1873 - 1881
We determined that sFRP‐1 mRNA was differentially expressed by osteoblast/stromal cell lines and that sFRP‐1 neutralizing antibodies and siRNA complementary to... 
secreted Frizzled‐related protein | RANKL | osteoclast | Wnt | Secreted Frizzled-related protein | Osteoclast | BONE-DENSITY | secreted frizzled-related protein | COLONY-STIMULATING FACTOR | MOUSE | DIFFERENTIATION FACTOR | RECEPTOR | OSTEOPROTEGERIN | CELL-LINES | ENDOCRINOLOGY & METABOLISM | LIGAND | CHONDROGENESIS | SPEMANN ORGANIZER | Receptor Activator of Nuclear Factor-kappa B | Membrane Glycoproteins - metabolism | Male | RANK Ligand | Gene Expression Profiling | Wnt Proteins | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Dose-Response Relationship, Drug | Intercellular Signaling Peptides and Proteins - metabolism | In Situ Hybridization | Membrane Glycoproteins - antagonists & inhibitors | Membrane Proteins - physiology | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Escherichia coli - metabolism | Polymerase Chain Reaction | Calcitriol - metabolism | Membrane Proteins - metabolism | Interleukin-6 - metabolism | Chondrocytes - metabolism | Recombinant Proteins - metabolism | Cell Line | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Glutathione Transferase - metabolism | Recombinant Proteins - chemistry | Interleukin-11 - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Osteoclasts - metabolism | Animals | Carrier Proteins - metabolism | Mice | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 05/2011, Volume 26, Issue 5, pp. 1035 - 1046
Journal Article
NATURE, ISSN 0028-0836, 02/2011, Volume 470, Issue 7335, pp. 548 - 553
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2016, Volume 43, Issue 2, pp. 203 - 209
Journal Article