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PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e59354
Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from... 
ADHESION MOLECULE-1 | HUMAN PLACENTA | HUMAN BONE-MARROW | UMBILICAL-CORD | IFN-GAMMA | TOLERANCE | MULTIDISCIPLINARY SCIENCES | TNF-ALPHA | STROMAL CELLS | EXPRESSION | ADIPOSE-TISSUE | Humans | Umbilical Cord - cytology | Adipose Tissue - cytology | Adipocytes - cytology | Adipose Tissue - immunology | Chorion - cytology | Mesenchymal Stromal Cells - immunology | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - classification | T-Lymphocytes, Helper-Inducer - immunology | Bone Marrow Cells - immunology | T-Lymphocytes, Helper-Inducer - cytology | Chorion - immunology | Adult | Female | Osteocytes - immunology | Vascular Cell Adhesion Molecule-1 - genetics | Cell Differentiation | Adipocytes - immunology | Cytokines - immunology | Biomarkers - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Gene Expression | Bone Marrow Cells - cytology | Immunomodulation | Osteocytes - cytology | Umbilical Cord - immunology | Pregnancy | Cytokines - biosynthesis | Gene expression | Stem cells | B cells | Biological properties | Vascular cell adhesion molecule 1 | Mesenchyme | Laboratories | Tissues | Cell adhesion & migration | Biomedical materials | Rodents | Bone marrow | Tumor necrosis factor-TNF | Biocompatibility | Subpopulations | Cytokines | Hematology | Dendritic cells | Immunoregulation | Hospitals | Placenta | Engineering research | Umbilical cord | Differentiation | Blood diseases
Journal Article
PLoS ONE, ISSN 1932-6203, 2017, Volume 12, Issue 10, p. e0186317
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a key role in maintainingimmune homeostasis. IL-10-mediated responses are triggered upon... 
Laboratorium voor Nematologie | Laboratory of Nematology | EPS | PE&RC | INTERLEUKIN-10 RECEPTOR COMPLEX | SOCS3 | HUMAN NEUTROPHILS | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MECHANISMS | MODEL | EXPRESSION | BINDING | T-CELLS | Dendritic Cells - immunology | Tumor Necrosis Factor-alpha - genetics | TYK2 Kinase - deficiency | TYK2 Kinase - immunology | Signal Transduction - immunology | Bone Marrow Cells - immunology | Cloning, Molecular | Tumor Necrosis Factor-alpha - immunology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Protein Interaction Domains and Motifs | Protein Isoforms - deficiency | Suppressor of Cytokine Signaling 3 Protein - immunology | Macrophages - immunology | STAT3 Transcription Factor - genetics | Receptors, Interleukin-10 - immunology | Recombinant Proteins - metabolism | Mast Cells - immunology | Gene Expression | Bone Marrow Cells - cytology | Tobacco - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein - genetics | Macrophages - cytology | Organ Specificity | Mast Cells - drug effects | Mice, Knockout | Animals | Tobacco - genetics | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Mast Cells - cytology | Protein Binding | Macrophages - drug effects | Dendritic Cells - cytology | Mice | Primary Cell Culture | Receptors, Interleukin-10 - deficiency | STAT3 Transcription Factor - immunology | TYK2 Kinase - genetics | Protein Isoforms - immunology | Interleukin-10 - immunology | Interleukin-10 - pharmacology | Protein Isoforms - genetics | Receptors, Interleukin-10 - genetics | Homeostasis | Research | Interleukin-10 | Dendritic cells | Tyk2 protein | Laboratories | Interleukin | Intracellular signalling | Activation | Kinases | Macrophages | Experiments | Lipopolysaccharides | Bone marrow | Janus kinase | Plant sciences | Antigens | Cytokines | Neutrophils | Stat3 protein | Inflammation | Tumor necrosis factor-α | Biological activity | Studies | Molecular modelling | Interleukin 10 | Mast cells | Bone | Intracellular
Journal Article
Amino Acids, ISSN 0939-4451, 3/2017, Volume 49, Issue 3, pp. 683 - 693
Osteoporosis (OP) and osteoarthritis (OA) are the most common joint diseases, with a high incidence in the elderly population. OP is characterized by... 
Life Sciences | Biochemistry, general | Osteoporosis | Cartilage | Analytical Chemistry | Life Sciences, general | Biochemical Engineering | Proteomics | Neurobiology | Bone remodeling | Osteoarthritis | Transglutaminase 2 | ENDOCHONDRAL OSSIFICATION | CELLS | FEMORAL-NECK FRACTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | HIP | MESSENGER-RNA | ARTICULAR-CARTILAGE | EXTRACELLULAR-MATRIX | SUBCHONDRAL BONE | KNEE OSTEOARTHRITIS | Osteopontin - genetics | Bone and Bones - pathology | Bone Morphogenetic Proteins - immunology | Chondrocytes - immunology | Humans | Middle Aged | Osteocalcin - genetics | Transglutaminases - genetics | Male | GTP-Binding Proteins - genetics | Transglutaminases - immunology | Osteocalcin - immunology | Female | Osteocytes - immunology | Osteoporosis - genetics | Osteoarthritis - pathology | Bone Morphogenetic Proteins - genetics | Biomarkers - metabolism | Chondrocytes - pathology | Gene Expression | Osteoporosis - immunology | GTP-Binding Proteins - immunology | Osteoarthritis - immunology | Osteoblasts - immunology | Genetic Markers - immunology | Osteoarthritis - genetics | Osteopontin - immunology | Cartilage, Articular - pathology | Osteoblasts - pathology | Osteoporosis - pathology | Genetic Markers - genetics | Osteocytes - pathology | Aged | Bone and Bones - immunology | Primary Cell Culture | Cartilage, Articular - immunology | Immunohistochemistry | Comparative analysis | Biological markers | Resveratrol
Journal Article
International Immunopharmacology, ISSN 1567-5769, 2009, Volume 9, Issue 6, pp. 677 - 682
Journal Article
Journal Article
Cellular Immunology, ISSN 0008-8749, 2011, Volume 271, Issue 1, pp. 147 - 156
► We investigated effects of ligation of TLR2 or TLR4 on activity of murine MSC. ► TLR2 ligation, but not TLR4, inhibited chemotaxis of MSC. ► TLR2 ligation,... 
Allogeneic mixed lymphocytes reaction | TLR4 | Mesenchymal stem cells | TLR2 | MACROPHAGES | INTERFERON-BETA | IMMUNOLOGY | VERSUS-HOST-DISEASE | CELL BIOLOGY | RESISTANT | RESPONSES | THERAPY | TOLL-LIKE RECEPTORS | REGULATORY T-CELLS | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Antigens, Ly - genetics | Lymphocyte Culture Test, Mixed | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Cell Movement - immunology | Dose-Response Relationship, Drug | Lymphocyte Activation - immunology | Flow Cytometry | Bone Marrow Cells - immunology | Cysteine - pharmacology | Antigens, Ly - metabolism | Osteocytes - immunology | Membrane Proteins - metabolism | Chemotaxis - immunology | Adipocytes - immunology | Osteocytes - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Toll-Like Receptor 4 - immunology | Chemotaxis - drug effects | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Toll-Like Receptor 4 - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Chemokine CXCL10 - genetics | Lipoproteins - pharmacology | Adipocytes - metabolism | Toll-Like Receptor 2 - immunology | Mice | Chemokine CXCL10 - metabolism | Bone Marrow Cells - metabolism | Nitric Oxide Synthase Type II - metabolism
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 01/2016, Volume 1364, Issue 1, pp. 11 - 24
Osteoimmunology is a field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that... 
T cells | Pacifici, R. 2015. T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone. In “MARROW,” ed. by M. Zaidi. Ann. N.Y. Acad. Sci. 1364: 11–24 | PTH | stromal cells | bone | osteoblasts | osteocytes | Pacifici, R. 2015. T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone. In “MARROW,” ed. by M. Zaidi. Ann. N.Y. Acad. Sci. 1364: 11-24 | Stromal cells | Osteocytes | Bone | T cells | Osteoblasts | C-REACTIVE PROTEIN | DIFFERENTIATED OSTEOBLASTS | CD40 LIGAND | BETA-CATENIN | TUMOR-NECROSIS-FACTOR | CANCELLOUS BONE | OSTEOCLAST FORMATION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | TNF-ALPHA | POSTMENOPAUSAL WOMEN | Osteoblasts - secretion | Humans | T-Lymphocytes - metabolism | Parathyroid Hormone - metabolism | Bone Marrow Cells - immunology | Bone and Bones - metabolism | Osteocytes - immunology | Osteoblasts - cytology | Bone and Bones - cytology | Osteocytes - secretion | Parathyroid Hormone - secretion | T-Lymphocytes - secretion | Osteocytes - metabolism | Bone Marrow Cells - cytology | Osteocytes - cytology | Stromal Cells - metabolism | Bone Marrow Cells - pathology | Cytokines - secretion | Osteoblasts - immunology | Bone Morphogenetic Proteins - secretion | Cell Communication | Wnt Proteins - secretion | Stromal Cells - immunology | Genetic Markers | Parathyroid Hormone - immunology | Proto-Oncogene Proteins - secretion | Cell Lineage | Stromal Cells - secretion | Animals | T-Lymphocytes - cytology | Models, Biological | T-Lymphocytes - immunology | Bone and Bones - immunology | Osteoblasts - metabolism | Bone Remodeling | Bone Marrow Cells - metabolism | Stromal Cells - cytology | Parathyroid hormone | Immune systems | Biomedical materials | Lymphocytes | Biocompatibility | Bones | Mice | Hormones
Journal Article
Journal Article
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2017, Volume 101, Issue 6, pp. 1289 - 1300
Osteoclasts and osteoblasts express IL‐27 under specific stimulation in vitro; IL‐27‐producing bone cells are detected in situ in human bone tissues in various... 
osteoclast | osteoblast | osteoimmunology | Osteoblast | Osteoimmunology | Osteoclast | STEM-CELLS | DENDRITIC CELLS | C-FOS | CD4(+) T-CELLS | IMMUNOLOGY | HUMAN MONOCYTES | CELL BIOLOGY | INTERFERON-GAMMA | INTERLEUKIN-27 | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | HEMATOLOGY | OSTEOCLAST DIFFERENTIATION | Inflammation - pathology | Cytokines - metabolism | Monocytes - cytology | Humans | Cells, Cultured | Monocytes - metabolism | Bone Neoplasms - immunology | Inflammation - immunology | Monocytes - immunology | Osteoclasts - cytology | Bone Neoplasms - pathology | Osteoclasts - metabolism | Interleukins - metabolism | Bone Neoplasms - metabolism | Inflammation - metabolism | Osteosarcoma - immunology | Osteoclasts - immunology | Bone and Bones - metabolism | Cell Differentiation | Bone and Bones - immunology | Toll-Like Receptors - metabolism | Osteosarcoma - metabolism | Osteosarcoma - pathology | Bone and Bones - cytology | Homeostasis | Osteocytes | Stimulation | Lymphocytes T | Remodeling | Tissues | Osteoblasts | Interleukin 27 | Metastases | Proteins | Biomedical materials | Hematopoiesis | Toll-like receptors | Biocompatibility | Erosion control | Autocrine signalling | Immune system | Immune response | Erosion mechanisms | TLR7 protein | Cytokines | Bone remodelling | Interleukin 11 | Inflammation | Poly (I:C) | TLR4 protein | Bone turnover | Tumor necrosis factor-α | TLR3 protein | Hemopoiesis | Osteomyelitis | Monocytes | γ-Interferon | Chondrocytes | Osteoclasts | Interferon | Bone
Journal Article