Spine, ISSN 0362-2436, 05/2006, Volume 31, Issue 10, pp. 1067 - 1074
Study Design. A prospective, randomized and controlled study. Objectives. To evaluate the osteoinductive property of Osteogenic Protein-1 (OP-1 or BMP-7) and...
Histology | Posterolateral lumbar fusion | Bone morphogenetic protein | Osteogenic Protein-1 (OP-1) | Surgical exploration | INSTRUMENTATION | STENOSIS | NONHUMAN PRIMATE | DEGENERATIVE SPONDYLOLISTHESIS | posterolateral lumbar fusion | surgical exploration | MODEL | bone morphogenetic protein | CLINICAL NEUROLOGY | LAMINECTOMY | histology | ARTHRODESIS | SPINE FUSION | GROWTH-FACTOR | ORTHOPEDICS | MORPHOGENETIC PROTEIN-2 | Spinal Fusion - methods | Bone Morphogenetic Proteins - administration & dosage | Lumbar Vertebrae - diagnostic imaging | Bone Screws | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Transplantation, Autologous | Treatment Outcome | Ceramics | Bone Substitutes - administration & dosage | Spinal Fusion - instrumentation | Lumbar Vertebrae - surgery | Bone Substitutes - therapeutic use | Bone Transplantation | Female | Aged | Bone Morphogenetic Proteins - therapeutic use | Lumbar Vertebrae - pathology | Bone Morphogenetic Protein 7 | Osseointegration - drug effects
Histology | Posterolateral lumbar fusion | Bone morphogenetic protein | Osteogenic Protein-1 (OP-1) | Surgical exploration | INSTRUMENTATION | STENOSIS | NONHUMAN PRIMATE | DEGENERATIVE SPONDYLOLISTHESIS | posterolateral lumbar fusion | surgical exploration | MODEL | bone morphogenetic protein | CLINICAL NEUROLOGY | LAMINECTOMY | histology | ARTHRODESIS | SPINE FUSION | GROWTH-FACTOR | ORTHOPEDICS | MORPHOGENETIC PROTEIN-2 | Spinal Fusion - methods | Bone Morphogenetic Proteins - administration & dosage | Lumbar Vertebrae - diagnostic imaging | Bone Screws | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Transplantation, Autologous | Treatment Outcome | Ceramics | Bone Substitutes - administration & dosage | Spinal Fusion - instrumentation | Lumbar Vertebrae - surgery | Bone Substitutes - therapeutic use | Bone Transplantation | Female | Aged | Bone Morphogenetic Proteins - therapeutic use | Lumbar Vertebrae - pathology | Bone Morphogenetic Protein 7 | Osseointegration - drug effects
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 2002, Volume 1588, Issue 2, pp. 126 - 134
Articular cartilage has a poor reparative capacity. This feature is exacerbated with aging and during degenerative joint conditions, contributing to loss of...
Osteogenic protein-1 | Aging | Bone morphogenetic protein | Human articular cartilage | PCR | ELISA | TGF-BETA | PROTEOGLYCAN SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ARTICULAR CHONDROCYTES | bone morphogenetic protein | AGGRECAN | BIOPHYSICS | osteogenic protein-1 | BOVINE | BONE MORPHOGENETIC PROTEIN-7 | LINK PROTEIN | human articular cartilage | aging | OSTEOARTHRITIS | BINDING | GROWTH-FACTOR-I
Osteogenic protein-1 | Aging | Bone morphogenetic protein | Human articular cartilage | PCR | ELISA | TGF-BETA | PROTEOGLYCAN SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ARTICULAR CHONDROCYTES | bone morphogenetic protein | AGGRECAN | BIOPHYSICS | osteogenic protein-1 | BOVINE | BONE MORPHOGENETIC PROTEIN-7 | LINK PROTEIN | human articular cartilage | aging | OSTEOARTHRITIS | BINDING | GROWTH-FACTOR-I
Journal Article
Spine, ISSN 0362-2436, 06/2007, Volume 32, Issue 13, pp. 1388 - 1393
Study Design. To assess the safety of epidural administration of Osteogenic Protein-1 (OP-1). Objectives. To examine if epidural administration of OP-1 or...
Osteogenic protein-1 | Nucleus pulposus | Bone morphogenetic protein-7 | Epidural administration | Hyperalgesia | RAT TAIL MODEL | DENDRITIC GROWTH | THERMAL HYPERALGESIA | NECROSIS-FACTOR-ALPHA | NERVE ROOT | DORSAL-ROOT GANGLION | CLINICAL NEUROLOGY | bone morphogenetic protein-7 | RADICULOPATHY | osteogenic protein-1 | nucleus pulposus | NITRIC-OXIDE | epidural administration | INTERVERTEBRAL DISC CELLS | hyperalgesia | COMPRESSED NUCLEUS PULPOSUS | ORTHOPEDICS | Physical Stimulation | Ossification, Heterotopic - pathology | Intervertebral Disc Displacement - pathology | Rats | Male | Motor Activity | Injections, Epidural | Rats, Sprague-Dawley | Hyperalgesia - pathology | Transforming Growth Factor beta - pharmacology | Animals | Tail | Pain Threshold | Intervertebral Disc - drug effects | Lumbar Vertebrae | Spinal Nerve Roots - pathology | Intervertebral Disc - pathology | Intervertebral Disc Displacement - drug therapy | Bone Morphogenetic Proteins - pharmacology | Bone Morphogenetic Protein 7 | Disease Models, Animal
Osteogenic protein-1 | Nucleus pulposus | Bone morphogenetic protein-7 | Epidural administration | Hyperalgesia | RAT TAIL MODEL | DENDRITIC GROWTH | THERMAL HYPERALGESIA | NECROSIS-FACTOR-ALPHA | NERVE ROOT | DORSAL-ROOT GANGLION | CLINICAL NEUROLOGY | bone morphogenetic protein-7 | RADICULOPATHY | osteogenic protein-1 | nucleus pulposus | NITRIC-OXIDE | epidural administration | INTERVERTEBRAL DISC CELLS | hyperalgesia | COMPRESSED NUCLEUS PULPOSUS | ORTHOPEDICS | Physical Stimulation | Ossification, Heterotopic - pathology | Intervertebral Disc Displacement - pathology | Rats | Male | Motor Activity | Injections, Epidural | Rats, Sprague-Dawley | Hyperalgesia - pathology | Transforming Growth Factor beta - pharmacology | Animals | Tail | Pain Threshold | Intervertebral Disc - drug effects | Lumbar Vertebrae | Spinal Nerve Roots - pathology | Intervertebral Disc - pathology | Intervertebral Disc Displacement - drug therapy | Bone Morphogenetic Proteins - pharmacology | Bone Morphogenetic Protein 7 | Disease Models, Animal
Journal Article
HSS Journal, ISSN 1556-3316, 2/2013, Volume 9, Issue 1, pp. 90 - 95
Proximal tibiofibular joint (PTFJ) instability is rare, but when encountered can be difficult to manage. Previously reported forms of treatment, including cast...
OP-1 | knee | Surgical Orthopedics | Medicine & Public Health | Sports Medicine | osteogenic protein-1 | Orthopedics | Rheumatology | Anesthesiology | Imaging / Radiology | PTFJ | proximal tibiofibular joint | Case Report
OP-1 | knee | Surgical Orthopedics | Medicine & Public Health | Sports Medicine | osteogenic protein-1 | Orthopedics | Rheumatology | Anesthesiology | Imaging / Radiology | PTFJ | proximal tibiofibular joint | Case Report
Journal Article
Journal of Clinical and Diagnostic Research, ISSN 2249-782X, 08/2013, Volume 7, Issue 8, pp. 1565 - 1567
Age and oxidative stress have been implicated as the main causes of the cartilage damage in osteoarthritis (OA). The osteogenic protein-1(OP-1), a member of...
Antioxidants | Osteogenic protein-1 | Cartilage metabolic markers | Original
Antioxidants | Osteogenic protein-1 | Cartilage metabolic markers | Original
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 2002, Volume 87, Issue 3, pp. 292 - 304
The effects of Osteogenic Protein‐1 (OP‐1, BMP‐7) on the differentiation of the pluripotent mesenchymal cell line, C2C12, were examined. OP‐1 at 50 ng/ml...
BMP receptor expression | osteogenic protein‐1 | C2C12 | bone morphogenetic protein‐7 | osteoblastic cell differentiation | gene expression | BMP expression | Osteogenic protein-1 | Osteoblastic cell differentiation | Bone morphogenetic protein-7 | Gene expression | SIGNALING PATHWAYS | BONE MORPHOGENETIC PROTEIN-2 | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRIMARY CULTURES | CELL BIOLOGY | I RECEPTORS | bone morphogenetic protein-7 | osteogenic protein-1 | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | FACTOR-BETA SUPERFAMILY | TERMINAL DIFFERENTIATION | GROWTH-FACTOR BETA-1 | Gene Expression - drug effects | Integrin-Binding Sialoprotein | Microscopy, Phase-Contrast | Humans | Alkaline Phosphatase - metabolism | Mesoderm - drug effects | Mesoderm - cytology | Muscle Fibers, Skeletal - drug effects | Proto-Oncogene Proteins - biosynthesis | RNA, Messenger - biosynthesis | Sialoglycoproteins - biosynthesis | Core Binding Factor Alpha 2 Subunit | Bone Morphogenetic Proteins - biosynthesis | Osteoblasts - cytology | Bone Morphogenetic Proteins - genetics | Bone Morphogenetic Proteins - pharmacology | Transforming Growth Factor beta | Cell Line | Osteocalcin - biosynthesis | Neoplasm Proteins - biosynthesis | Osteoblasts - drug effects | Transcription Factors - biosynthesis | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Collagen Type I - biosynthesis | Animals | Cell Differentiation - drug effects | Receptors, Growth Factor - biosynthesis | Bone Morphogenetic Protein Receptors | Mice | Osteoblasts - metabolism | DNA-Binding Proteins - biosynthesis | Bone Morphogenetic Protein 7
BMP receptor expression | osteogenic protein‐1 | C2C12 | bone morphogenetic protein‐7 | osteoblastic cell differentiation | gene expression | BMP expression | Osteogenic protein-1 | Osteoblastic cell differentiation | Bone morphogenetic protein-7 | Gene expression | SIGNALING PATHWAYS | BONE MORPHOGENETIC PROTEIN-2 | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRIMARY CULTURES | CELL BIOLOGY | I RECEPTORS | bone morphogenetic protein-7 | osteogenic protein-1 | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | FACTOR-BETA SUPERFAMILY | TERMINAL DIFFERENTIATION | GROWTH-FACTOR BETA-1 | Gene Expression - drug effects | Integrin-Binding Sialoprotein | Microscopy, Phase-Contrast | Humans | Alkaline Phosphatase - metabolism | Mesoderm - drug effects | Mesoderm - cytology | Muscle Fibers, Skeletal - drug effects | Proto-Oncogene Proteins - biosynthesis | RNA, Messenger - biosynthesis | Sialoglycoproteins - biosynthesis | Core Binding Factor Alpha 2 Subunit | Bone Morphogenetic Proteins - biosynthesis | Osteoblasts - cytology | Bone Morphogenetic Proteins - genetics | Bone Morphogenetic Proteins - pharmacology | Transforming Growth Factor beta | Cell Line | Osteocalcin - biosynthesis | Neoplasm Proteins - biosynthesis | Osteoblasts - drug effects | Transcription Factors - biosynthesis | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Collagen Type I - biosynthesis | Animals | Cell Differentiation - drug effects | Receptors, Growth Factor - biosynthesis | Bone Morphogenetic Protein Receptors | Mice | Osteoblasts - metabolism | DNA-Binding Proteins - biosynthesis | Bone Morphogenetic Protein 7
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 2011, Volume 7, Issue 2, pp. 463 - 477
Mesenchymal stromal cells (MSCs) can be isolated from various tissues such as bone marrow aspirates, fat or umbilical cord blood. These cells have the ability...
Osteoblast | Mesenchymal stromal cell | Cell culture medium | Proliferation | Differentiation | MATERIALS SCIENCE, BIOMATERIALS | ADIPOSE-TISSUE DEVELOPMENT | ENGINEERING, BIOMEDICAL | OSTEOGENIC PROTEIN-1 OP-1,BMP-7 | FIBROBLAST-GROWTH-FACTOR | SMOOTH-MUSCLE-CELL | PLATELET-RICH PLASMA | CHONDROCYTE-SPECIFIC ENHANCER | ADIPOCYTE PRECURSOR CELLS | HUMAN BONE-MARROW | SERUM RESPONSE FACTOR | ADULT STEM-CELLS | Cell Differentiation - drug effects | Humans | Culture Media - pharmacology | Mesoderm - drug effects | Stromal Cells - drug effects | Cell Culture Techniques | Mesoderm - cytology | Stromal Cells - cytology | Biomedical materials | Media | Muscles | In vitro testing | Blood | Culture | Optimization
Osteoblast | Mesenchymal stromal cell | Cell culture medium | Proliferation | Differentiation | MATERIALS SCIENCE, BIOMATERIALS | ADIPOSE-TISSUE DEVELOPMENT | ENGINEERING, BIOMEDICAL | OSTEOGENIC PROTEIN-1 OP-1,BMP-7 | FIBROBLAST-GROWTH-FACTOR | SMOOTH-MUSCLE-CELL | PLATELET-RICH PLASMA | CHONDROCYTE-SPECIFIC ENHANCER | ADIPOCYTE PRECURSOR CELLS | HUMAN BONE-MARROW | SERUM RESPONSE FACTOR | ADULT STEM-CELLS | Cell Differentiation - drug effects | Humans | Culture Media - pharmacology | Mesoderm - drug effects | Stromal Cells - drug effects | Cell Culture Techniques | Mesoderm - cytology | Stromal Cells - cytology | Biomedical materials | Media | Muscles | In vitro testing | Blood | Culture | Optimization
Journal Article
International Journal of Spine Surgery, ISSN 2211-4599, 2016, Volume 10, Issue 2016, p. 33
A narrative review of literature. This manuscript intends to provide a review of clinically relevant bone substitutes and bone expanders for spinal surgery in...
I-factor | Spine fusion | Allografts | Autologous growth factors | Îtricalcium phosphate (ß-tcp) | Demineralized bone matrix (dbm) | Hydroxyapatite | Synthetic peptides | Ceramics | Rhbmp-2 | Bone substitutes | Osteogenic protein-1 (op-1)
I-factor | Spine fusion | Allografts | Autologous growth factors | Îtricalcium phosphate (ß-tcp) | Demineralized bone matrix (dbm) | Hydroxyapatite | Synthetic peptides | Ceramics | Rhbmp-2 | Bone substitutes | Osteogenic protein-1 (op-1)
Journal Article
Food Chemistry, ISSN 0308-8146, 2009, Volume 116, Issue 4, pp. 990 - 994
Fucoidan extracted from the marine brown alga , significantly induced osteoblastic cell differentiation. Our results indicated that a non-toxic sulphated...
Osteoblastic differentiation | Fucoidan | Osteocalcin (OC) | Bone morphogenetic protein-2 (BMP-2) | Alkaline phosphatase (ALP) | FOOD SCIENCE & TECHNOLOGY | OSTEOGENIC PROTEIN-1 OP-1,BMP-7 | ANTICOAGULANT | IN-VITRO | NUTRITION & DIETETICS | BONE-FORMATION | CHEMISTRY, APPLIED | EXPRESSION | Phosphatases | Carrageenin | Analysis | Dietary supplements | Marine biology | Bone morphogenetic proteins | Universities and colleges
Osteoblastic differentiation | Fucoidan | Osteocalcin (OC) | Bone morphogenetic protein-2 (BMP-2) | Alkaline phosphatase (ALP) | FOOD SCIENCE & TECHNOLOGY | OSTEOGENIC PROTEIN-1 OP-1,BMP-7 | ANTICOAGULANT | IN-VITRO | NUTRITION & DIETETICS | BONE-FORMATION | CHEMISTRY, APPLIED | EXPRESSION | Phosphatases | Carrageenin | Analysis | Dietary supplements | Marine biology | Bone morphogenetic proteins | Universities and colleges
Journal Article
Inflammation Research, ISSN 1023-3830, 04/1999, Volume 48, Issue 4, pp. 199 - 204
Objective and Design: The abilities of osteogenic protein-1 (OP-1) and TGF-β1 to affect cartilage damage caused by fibronectin fragments (Fn-fs) that are known...
Allergology | Neurology | Biomedicine | Immunology | OP-1 — TGF-β— Fibronectin fragments — Cartilage — Cartilage repair | Dermatology | Rheumatology | Pharmacology/Toxicology | OP-1 | Cartilage | TGF-β | Fibronectin fragments | Cartilage repair | INTERLEUKIN-1 | ANTIOXIDANTS | cartilage | HUMAN ARTICULAR CHONDROCYTES | RELEASE | IMMUNOLOGY | CELL BIOLOGY | TGF-beta | GROWTH-FACTOR-BETA | INHIBITION | fibronectin fragments | CHONDROLYSIS | DEGRADATION | DIFFERENTIATION | cartilage repair | Cartilage - pathology | Half-Life | Proteoglycans - biosynthesis | Proteoglycans - metabolism | Peptide Fragments - pharmacology | Cartilage - drug effects | Cartilage - metabolism | Fibronectins - metabolism | Animals | Cartilage Diseases - prevention & control | Cattle | Cartilage Diseases - chemically induced | Bone Morphogenetic Proteins - pharmacology | Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 | Transforming growth factor-^b1 | Osteogenic protein 1
Allergology | Neurology | Biomedicine | Immunology | OP-1 — TGF-β— Fibronectin fragments — Cartilage — Cartilage repair | Dermatology | Rheumatology | Pharmacology/Toxicology | OP-1 | Cartilage | TGF-β | Fibronectin fragments | Cartilage repair | INTERLEUKIN-1 | ANTIOXIDANTS | cartilage | HUMAN ARTICULAR CHONDROCYTES | RELEASE | IMMUNOLOGY | CELL BIOLOGY | TGF-beta | GROWTH-FACTOR-BETA | INHIBITION | fibronectin fragments | CHONDROLYSIS | DEGRADATION | DIFFERENTIATION | cartilage repair | Cartilage - pathology | Half-Life | Proteoglycans - biosynthesis | Proteoglycans - metabolism | Peptide Fragments - pharmacology | Cartilage - drug effects | Cartilage - metabolism | Fibronectins - metabolism | Animals | Cartilage Diseases - prevention & control | Cattle | Cartilage Diseases - chemically induced | Bone Morphogenetic Proteins - pharmacology | Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 | Transforming growth factor-^b1 | Osteogenic protein 1
Journal Article
The American Journal of Sports Medicine, ISSN 0363-5465, 10/2004, Volume 32, Issue 7, pp. 1619 - 1625
Background Bone morphogenetic proteins induce new bone both in patients with bone defects and at extraskeletal sites in animals. After anterior cruciate...
Bone morphogenetic protein-7 (BMP-7) | Ligament reconstruction | Anterior cruciate ligament (ACL) | Osteogenic protein-1 (OP-1) | TUNNEL | LOCALIZATION | SPORT SCIENCES | DEFECTS | osteogenic protein-1 (OP-1) | bone morphogenetic protein-7 (BMP-7) | anterior cruciate ligament (ACL) | ligament reconstruction | REPAIR | HUMAN EMBRYONIC-DEVELOPMENT | GROWTH | AUTOGRAFT | GENE FAMILY | OSSIFICATION | ORTHOPEDICS | EXPRESSION | Activin Receptors, Type I | Anterior Cruciate Ligament - surgery | Anterior Cruciate Ligament Injuries | Orthopedic Procedures - methods | Male | Bone Development | Random Allocation | Tendons - transplantation | Orthopedic Procedures - veterinary | Animals | Sheep | Proteins - pharmacology | Reconstructive Surgical Procedures | Anterior Cruciate Ligament - growth & development | Tendon injuries | Bone morphogenetic proteins | Care and treatment | Research | Athletes | Health aspects
Bone morphogenetic protein-7 (BMP-7) | Ligament reconstruction | Anterior cruciate ligament (ACL) | Osteogenic protein-1 (OP-1) | TUNNEL | LOCALIZATION | SPORT SCIENCES | DEFECTS | osteogenic protein-1 (OP-1) | bone morphogenetic protein-7 (BMP-7) | anterior cruciate ligament (ACL) | ligament reconstruction | REPAIR | HUMAN EMBRYONIC-DEVELOPMENT | GROWTH | AUTOGRAFT | GENE FAMILY | OSSIFICATION | ORTHOPEDICS | EXPRESSION | Activin Receptors, Type I | Anterior Cruciate Ligament - surgery | Anterior Cruciate Ligament Injuries | Orthopedic Procedures - methods | Male | Bone Development | Random Allocation | Tendons - transplantation | Orthopedic Procedures - veterinary | Animals | Sheep | Proteins - pharmacology | Reconstructive Surgical Procedures | Anterior Cruciate Ligament - growth & development | Tendon injuries | Bone morphogenetic proteins | Care and treatment | Research | Athletes | Health aspects
Journal Article
Bone, ISSN 8756-3282, 07/2002, Volume 31, Issue 1, pp. 158 - 164
Osteogenic protein-1 (OP-1), or bone morphogenetic protein-7, is an osteoinductive morphogen that is involved in embryonic skeletogenesis and in bone repair....
Bone repair | Bone morphogenetic protein (BMP) | Fracture healing | Tissue engineering | Growth factors | Osteogenic protein-1 (OP-1) | CELLS | tissue engineering | growth factors | ENDOCRINOLOGY & METABOLISM | BONE MORPHOGENETIC PROTEINS | osteogenic protein-1 (OP-1) | bone morphogenetic protein (BMP) | DIFFERENTIATION | EXPRESSION | fracture healing | bone repair | Diaphyses - injuries | Recombinant Proteins - therapeutic use | Diaphyses - diagnostic imaging | Goats | Humans | Tibial Fractures - diagnostic imaging | Tomography, X-Ray Computed - methods | Tibial Fractures - drug therapy | Animals | Absorptiometry, Photon - methods | Female | Bone Morphogenetic Proteins - therapeutic use | Bone Morphogenetic Protein 7 | Transforming Growth Factor beta | Bone morphogenetic proteins | Collagen | Analysis | CT imaging | Usage | Cells
Bone repair | Bone morphogenetic protein (BMP) | Fracture healing | Tissue engineering | Growth factors | Osteogenic protein-1 (OP-1) | CELLS | tissue engineering | growth factors | ENDOCRINOLOGY & METABOLISM | BONE MORPHOGENETIC PROTEINS | osteogenic protein-1 (OP-1) | bone morphogenetic protein (BMP) | DIFFERENTIATION | EXPRESSION | fracture healing | bone repair | Diaphyses - injuries | Recombinant Proteins - therapeutic use | Diaphyses - diagnostic imaging | Goats | Humans | Tibial Fractures - diagnostic imaging | Tomography, X-Ray Computed - methods | Tibial Fractures - drug therapy | Animals | Absorptiometry, Photon - methods | Female | Bone Morphogenetic Proteins - therapeutic use | Bone Morphogenetic Protein 7 | Transforming Growth Factor beta | Bone morphogenetic proteins | Collagen | Analysis | CT imaging | Usage | Cells
Journal Article
Growth Factors, ISSN 0897-7194, 1994, Volume 11, Issue 3, pp. 215 - 225
Abstract We have characterized the expression and processing of Osteogenic Protein-1 (hOP-1), a bone morphogenic protein of the TGF-β family, in Chinese...
growth factor | BMP-7 | Osteogenic Protein 1 (OP-1) | bone morphogenesis | protein processing | TGF-β family | Bone morphogenesis | Protein processing | Growth factor | PROTEIN PROCESSING | MANNOSE 6-PHOSPHATE | ACTIVATION | BONE MORPHOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-BETA-1 PRECURSOR | TRANSFORMING GROWTH-FACTOR | CELL BIOLOGY | GROWTH FACTOR | BONE-FORMATION | RECOMBINANT | OSTEOGENIC PROTEIN 1 (OP-1) | ENDOPLASMIC-RETICULUM | FACTOR-BETA SUPERFAMILY | SECRETION | KIDNEY | TGF-BETA FAMILY | Amino Acid Sequence | Cricetinae | Protein Biosynthesis | Molecular Weight | Protein Processing, Post-Translational - genetics | Molecular Sequence Data | Glycosylation | Proteins - isolation & purification | Precipitin Tests | Animals | Transfection - genetics | Protein Conformation | Proteins - chemistry | Bone Morphogenetic Proteins | Chromatography, Gel | Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 | CHO Cells
growth factor | BMP-7 | Osteogenic Protein 1 (OP-1) | bone morphogenesis | protein processing | TGF-β family | Bone morphogenesis | Protein processing | Growth factor | PROTEIN PROCESSING | MANNOSE 6-PHOSPHATE | ACTIVATION | BONE MORPHOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-BETA-1 PRECURSOR | TRANSFORMING GROWTH-FACTOR | CELL BIOLOGY | GROWTH FACTOR | BONE-FORMATION | RECOMBINANT | OSTEOGENIC PROTEIN 1 (OP-1) | ENDOPLASMIC-RETICULUM | FACTOR-BETA SUPERFAMILY | SECRETION | KIDNEY | TGF-BETA FAMILY | Amino Acid Sequence | Cricetinae | Protein Biosynthesis | Molecular Weight | Protein Processing, Post-Translational - genetics | Molecular Sequence Data | Glycosylation | Proteins - isolation & purification | Precipitin Tests | Animals | Transfection - genetics | Protein Conformation | Proteins - chemistry | Bone Morphogenetic Proteins | Chromatography, Gel | Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 | CHO Cells
Journal Article
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, ISSN 1617-7959, 08/2008, Volume 7, Issue 4, pp. 263 - 276
Cartilage growth may involve alterations in the balance between the swelling tendency of proteoglycans and the restraining function of the collagen network....
LONG-TERM CULTURE | FACTOR-BETA | PROTEOGLYCAN SYNTHESIS | BIOPHYSICS | BOVINE ARTICULAR-CARTILAGE | ENGINEERING, BIOMEDICAL | AGE-RELATED-CHANGES | FEMORAL-HEAD CARTILAGE | TENSILE PROPERTIES | OSTEOGENIC PROTEIN-1 OP-1 | MANDIBULAR CONDYLAR CARTILAGE | MECHANICAL-PROPERTIES | Cartilage | Networks | Proteoglycans | Collagens | Mathematical models | Serums | Metabolism | Integrity
LONG-TERM CULTURE | FACTOR-BETA | PROTEOGLYCAN SYNTHESIS | BIOPHYSICS | BOVINE ARTICULAR-CARTILAGE | ENGINEERING, BIOMEDICAL | AGE-RELATED-CHANGES | FEMORAL-HEAD CARTILAGE | TENSILE PROPERTIES | OSTEOGENIC PROTEIN-1 OP-1 | MANDIBULAR CONDYLAR CARTILAGE | MECHANICAL-PROPERTIES | Cartilage | Networks | Proteoglycans | Collagens | Mathematical models | Serums | Metabolism | Integrity
Journal Article
15.
Full Text
Insulin-like growth factor-binding protein-5 (IGFBP-5): A critical member of the IGF axis
Biochemical Journal, ISSN 0264-6021, 04/2006, Volume 395, Issue 1, pp. 1 - 19
The six members of the insulin-like growth factor-binding protein family (IGFBP-1-6) are important components of the IGF (insulin-like growth factor) axis. In...
Insulin-like growth factor-I (IGF-I) | Extracellular matrix (ECM) | Insulin-like growth factor-binding protein 5 (IGFBP-5) | Glycosaminoglycan | Mammary gland | Proteolysis | insulin-like growth factor-binding protein 5 (IGFBP-5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR (IGF)-BINDING PROTEIN-5 | ADULT-RAT SERUM | LOW-MOLECULAR-WEIGHT | FACTOR BINDING-PROTEIN-5 GENE | BREAST-CANCER CELLS | extracellular matrix (ECM) | insulin-like growth factor-I (IGF-I) | SMOOTH-MUSCLE-CELLS | mammary gland | ACID-LABILE SUBUNIT | glycosaminoglycan | FACTOR-I RECEPTOR | proteolysis | C-TERMINAL FRAGMENTS | MAMMARY EPITHELIAL-CELLS | Neoplasms - metabolism | Insulin-Like Growth Factor Binding Protein 5 - chemistry | Animals | Extracellular Matrix - metabolism | Protein Binding | Insulin-Like Growth Factor Binding Protein 5 - metabolism | Protein Processing, Post-Translational | Insulin-Like Growth Factor Binding Protein 5 - genetics | Somatomedins - metabolism | IGF-IIR, IGF-II receptor | ECM, extracellular matrix | PGE2, prostaglandin E2 | RT, reverse transcription | Review | IRS, IR substrate | OE2, oestradiol | tPA, tissue plasminogen activator | PAI-1, plasminogen activator inhibitor-1 | TSP-1, thrombospondin-1 | ERK1 | pSMC, porcine smooth-muscle cell | IGFBP, IGF-binding protein | NBP-4, N-terminus of IGFBP-4 (residues 3–82) | OP-1, osteogenic protein-1 | IGF, insulin-like growth factor | RA, retinoic acid | enhancer-binding protein | IR, insulin receptor | FHL-2, four-and-a-half LIM domain 2 | VN, vitronectin | 2, extracellular-signal-regulated protein kinase 1 | EBP, CCAAT | OPN, osteopontin | GAG, glycosaminoglycan | GH, growth hormone | RASSF1C, isoform C of the Ras association family 1 protein group | ADAM, adisintegrin and metalloprotease | ER, oestrogen receptor | AP-2, activator protein 2 | IGF-IR, IGF-I receptor | CAT, chloramphenicol acetyltransferase | CBP-4, C-terminus of insulin-like growth factor-binding protein 4 (residues 151–232) | SPR, surface plasmon resonance | MAPK, mitogen-activated protein kinase | PAPP, pregnancy-associated plasma protease
Insulin-like growth factor-I (IGF-I) | Extracellular matrix (ECM) | Insulin-like growth factor-binding protein 5 (IGFBP-5) | Glycosaminoglycan | Mammary gland | Proteolysis | insulin-like growth factor-binding protein 5 (IGFBP-5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR (IGF)-BINDING PROTEIN-5 | ADULT-RAT SERUM | LOW-MOLECULAR-WEIGHT | FACTOR BINDING-PROTEIN-5 GENE | BREAST-CANCER CELLS | extracellular matrix (ECM) | insulin-like growth factor-I (IGF-I) | SMOOTH-MUSCLE-CELLS | mammary gland | ACID-LABILE SUBUNIT | glycosaminoglycan | FACTOR-I RECEPTOR | proteolysis | C-TERMINAL FRAGMENTS | MAMMARY EPITHELIAL-CELLS | Neoplasms - metabolism | Insulin-Like Growth Factor Binding Protein 5 - chemistry | Animals | Extracellular Matrix - metabolism | Protein Binding | Insulin-Like Growth Factor Binding Protein 5 - metabolism | Protein Processing, Post-Translational | Insulin-Like Growth Factor Binding Protein 5 - genetics | Somatomedins - metabolism | IGF-IIR, IGF-II receptor | ECM, extracellular matrix | PGE2, prostaglandin E2 | RT, reverse transcription | Review | IRS, IR substrate | OE2, oestradiol | tPA, tissue plasminogen activator | PAI-1, plasminogen activator inhibitor-1 | TSP-1, thrombospondin-1 | ERK1 | pSMC, porcine smooth-muscle cell | IGFBP, IGF-binding protein | NBP-4, N-terminus of IGFBP-4 (residues 3–82) | OP-1, osteogenic protein-1 | IGF, insulin-like growth factor | RA, retinoic acid | enhancer-binding protein | IR, insulin receptor | FHL-2, four-and-a-half LIM domain 2 | VN, vitronectin | 2, extracellular-signal-regulated protein kinase 1 | EBP, CCAAT | OPN, osteopontin | GAG, glycosaminoglycan | GH, growth hormone | RASSF1C, isoform C of the Ras association family 1 protein group | ADAM, adisintegrin and metalloprotease | ER, oestrogen receptor | AP-2, activator protein 2 | IGF-IR, IGF-I receptor | CAT, chloramphenicol acetyltransferase | CBP-4, C-terminus of insulin-like growth factor-binding protein 4 (residues 151–232) | SPR, surface plasmon resonance | MAPK, mitogen-activated protein kinase | PAPP, pregnancy-associated plasma protease
Journal Article