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Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 07/2013, Volume 228, Issue 7, pp. 1506 - 1515
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2005, Volume 115, Issue 12, pp. 3418 - 3427
TNF-alpha is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | COLONY-STIMULATING FACTOR | C-FMS | OSTEOPROTEGERIN LIGAND | JOINT DESTRUCTION | ALPHA | STROMAL CELLS | OSTEOCLAST DIFFERENTIATION | BONE DESTRUCTION | Tumor Necrosis Factor-alpha - metabolism | Bone and Bones | Inflammation - pathology | Tartrate-Resistant Acid Phosphatase | NF-kappa B - metabolism | Isoenzymes - chemistry | RNA, Messenger - metabolism | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Dose-Response Relationship, Drug | Flow Cytometry | T-Lymphocytes - metabolism | Time Factors | Female | Antibodies, Monoclonal - chemistry | Osteolysis - pathology | Interleukin-1 - metabolism | Bone Resorption | Cytokines - metabolism | Signal Transduction | Bone Marrow Cells - cytology | Cell Separation | Mice, Inbred C57BL | Stromal Cells - metabolism | Gene Expression Regulation | Rats | CD8 Antigens - biosynthesis | Mice, Transgenic | Macrophage Colony-Stimulating Factor - metabolism | Recombinant Fusion Proteins - chemistry | Mice, SCID | Osteoclasts - metabolism | Mice, Inbred ICR | Mice, Knockout | Macrophages - metabolism | Animals | Acid Phosphatase - chemistry | Mice | Antibodies, Monoclonal - metabolism | CD4 Antigens - biosynthesis | Macrophage Colony-Stimulating Factor - physiology | Bone Marrow Cells - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125316 - e0125316
Missense mutations of the GJA1 gene encoding the gap junction channel protein connexin43 (Cx43) cause bone malformations resulting in oculodentodigital... 
CORNEAL FIBROBLASTS | MARROW | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TISSUE | GENE-EXPRESSION | MYOFIBROBLASTS | GROWTH-FACTOR | CX43 | DIFFERENTIATION | COMMUNICATION | Bone and Bones - pathology | Gap Junctions - metabolism | Humans | Middle Aged | Actins - metabolism | Gene Expression Regulation, Neoplastic | Child, Preschool | Hematopoietic Stem Cells - pathology | Monocytes - metabolism | Antigens, CD - genetics | Bone Neoplasms - pathology | Actins - genetics | Antigens, CD - metabolism | Bone Neoplasms - metabolism | Giant Cell Tumor of Bone - pathology | Neoplastic Stem Cells - metabolism | Bone and Bones - metabolism | Monocytes - pathology | Neoplastic Stem Cells - pathology | Adult | Bone Neoplasms - genetics | Giant Cell Tumor of Bone - diagnosis | Child | Giant Cell Tumor of Bone - genetics | Connexin 43 - genetics | Gap Junctions - pathology | Alkaline Phosphatase - genetics | Bone Neoplasms - diagnosis | Connexin 43 - metabolism | Macrophages - pathology | Signal Transduction | Giant Cells - metabolism | Bone Marrow Cells - pathology | Receptors, Cell Surface - metabolism | Hematopoietic Stem Cells - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Macrophages - metabolism | Giant Cell Tumor of Bone - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Survival Analysis | Aged | Primary Cell Culture | Alkaline Phosphatase - deficiency | Bone Marrow Cells - metabolism | Giant Cells - pathology | Receptors, Cell Surface - genetics | Immunohistochemistry | Dysplasia | Muscle proteins | Tumors | Nests | Smooth muscle | Osteolysis | Proteins | Animal tissues | Bone marrow | Fibroblasts | Bone dysplasia | Biocompatibility | Growth factors | Medical research | Gap junctions | Cultures | Cell membranes (biology) | Survival | Golgi apparatus | CD163 antigen | Pathology | DNA microarrays | Stem cells | Mutation | Binding sites | Alkaline phosphatase | Phosphorylation | Membranes | Oculodentodigital dysplasia | Laboratories | Oncology | Connexin 43 | Macrophages | Western blotting | Defects | Biomedical materials | Missense mutation | Actin | Rodents | Giant cells | Coupling | Localization | Calcein | Communication | Cell survival | Muscles | Cell membranes | Monocytes | Bone | Cancer | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2000, Volume 98, Issue 3, pp. 585 - 598
The aim of this investigation was to determine whether murine models of inflammatory, neuropathic and cancer pain are each characterized by a unique set of... 
dynorphin | bone | astrocyte hypertrophy | c-Fos protein | osteolysis | persistent pain | Astrocyte hypertrophy | Bone | Osteolysis | Persistent pain | Dynorphin | INBRED MOUSE STRAINS | GENE-RELATED PEPTIDE | ROOT GANGLION-CELLS | PRIMARY AFFERENT NEURONS | NITRIC-OXIDE SYNTHASE | NEUROSCIENCES | GROWTH-ASSOCIATED PROTEIN | PERIPHERAL TISSUE INFLAMMATION | MORPHINE-INDUCED ANALGESIA | SUBSTANCE-P RECEPTOR | C-FOS EXPRESSION | Neuritis - metabolism | Neoplasm Transplantation | Palpation | Sciatic Nerve - injuries | Spinal Cord - metabolism | Sarcoma, Experimental - metabolism | Astrocytes - pathology | Neuralgia - metabolism | Tumor Cells, Cultured - transplantation | Male | Neuritis - pathology | Neuralgia - pathology | Pain - metabolism | Neurons, Afferent - chemistry | Sarcoma, Experimental - complications | Axotomy | Sciatic Nerve - metabolism | Neuralgia - chemically induced | Pain - etiology | Receptors, Neurokinin-1 - metabolism | Spinal Cord - cytology | Dynorphins - metabolism | Osteolysis - pathology | Spinal Nerves - injuries | Disease Models, Animal | Physical Stimulation | Proto-Oncogene Proteins c-fos - analysis | Proto-Oncogene Proteins c-fos - metabolism | Receptors, Neurokinin-1 - analysis | Behavior, Animal - physiology | Spinal Nerves - metabolism | Dynorphins - analysis | Sarcoma, Experimental - pathology | Osteolysis - metabolism | Pain - pathology | Mice, Inbred C3H | Freund's Adjuvant | Animals | Fluorescent Antibody Technique | Ganglia, Spinal - pathology | Mice | Neurons, Afferent - metabolism | Ganglia, Spinal - metabolism | Index Medicus
Journal Article
PHYTOMEDICINE, ISSN 0944-7113, 01/2011, Volume 18, Issue 2-3, pp. 176 - 185
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e15383 - e15383
Background: Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone, and osteoblasts, which build bone.... 
MULTIPLE-MYELOMA | TUMOR-NECROSIS-FACTOR | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | MICE | INDUCTION | LIGAND | CELL-DIFFERENTIATION | NF-KAPPA-B | Arthritis - metabolism | Male | NF-kappa B - metabolism | Arthritis - genetics | Osteoclasts - cytology | Osteocalcin - blood | RANK Ligand - pharmacology | Osteoporosis - metabolism | TNF Receptor-Associated Factor 3 - genetics | Female | Osteoporosis - genetics | Protein-Serine-Threonine Kinases - metabolism | Bone Density | Bone Marrow Cells - cytology | Osteolysis - genetics | Muramidase - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Muramidase - metabolism | Binding Sites - genetics | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Osteolysis - metabolism | Blotting, Western | Cathepsin K - genetics | Macrophages - metabolism | Animals | Cathepsin K - metabolism | Protein Binding | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Rheumatoid factor | Osteoporosis | Analysis | Arthritis | Postmenopausal women | Genetic engineering | B cells | Muscle proteins | Lysozyme | Multiple myeloma | Homeostasis | Activation | Neurotrophin 3 | Osteolysis | Osteoblasts | Bone surgery | Bone resorption | Biomedical materials | Actin | Transgenic animals | Rodents | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Bone loss | NF-κB protein | Transgenic mice | Inflammation | Post-menopause | Medicine | Osteoclastogenesis | Signaling | Rheumatoid arthritis | Osteoclasts | Bone | Disruption | Differentiation | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2004, Volume 114, Issue 12, pp. 1714 - 1725
The role of lysophosphatidic acid (LPA) in cancer is poorly understood. Here we provide evidence for a role of LPA in the progression of breast cancer bone... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | EDG FAMILY | HORMONE-RELATED PROTEIN | PROTEIN-COUPLED RECEPTOR | IN-VIVO | MOLECULAR-CLONING | OVARIAN-CANCER | IDENTIFICATION | EXPRESSION | AUTOTAXIN | Immunohistochemistry | Bone and Bones - pathology | Lysophospholipids - metabolism | Cell Proliferation | Humans | Bone Neoplasms - secondary | Osteolysis | Bone Neoplasms - pathology | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Neoplasm Metastasis | Transfection | Time Factors | Bone and Bones - metabolism | Female | Interleukin-8 - metabolism | Interleukin-6 - metabolism | RNA - metabolism | Cell Line | Bone Resorption | Cricetinae | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Mitogens - metabolism | RNA - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Phospholipase D - metabolism | Disease Progression | Platelet Aggregation | Animals | Blood Platelets - metabolism | Breast Neoplasms - pathology | Mice, Nude | Models, Biological | Platelet Activation | Culture Media - pharmacology | Cell Line, Tumor | Doxycycline - pharmacology | Ki-67 Antigen - biosynthesis | Mice | Mice, Inbred BALB C | Bone and Bones | Cytokines | Enzyme | Blood Platelets | Breast Neoplasms | Cellular Biology | Bone Neoplasms | Life Sciences | Culture Media | Doxycycline
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 5, pp. 485 - 496
We developed a rodent model that mimics the osteoblastic and osteolytic changes associated with human metastatic prostate cancer. Microarray analysis... 
ONCOLOGY | MATRIX-METALLOPROTEINASE INHIBITORS | BONE METASTASES | IN-VIVO | GROWTH | TUMOR | MICE | OSTEOPROTEGERIN | MODEL | EXPRESSION | T-ANTIGEN | Prostatic Neoplasms - metabolism | Receptor Activator of Nuclear Factor-kappa B | Membrane Glycoproteins - metabolism | Gene Expression - genetics | Humans | Rats, Inbred F344 | Actins - metabolism | Tartrate-Resistant Acid Phosphatase | Male | Monocytes - metabolism | Osteolysis - etiology | RANK Ligand | Gene Expression Profiling | Osteoprotegerin | Acid Phosphatase - metabolism | Matrix Metalloproteinase 7 - metabolism | Isoenzymes - metabolism | Skull - pathology | Carrier Proteins - pharmacology | Osteolysis - pathology | Disease Models, Animal | Receptors, Tumor Necrosis Factor - genetics | Glycoproteins - genetics | Osteoclasts - pathology | Membrane Glycoproteins - pharmacology | Mice, Inbred C57BL | Parathyroid Hormone-Related Protein - genetics | Rats | Up-Regulation - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Osteoclasts - metabolism | Osteolysis - metabolism | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Monocytes - drug effects | Carrier Proteins - genetics | Matrix Metalloproteinase 7 - genetics | Animals | Carrier Proteins - metabolism | Models, Biological | Mice | Prostatic Neoplasms - complications | Prostate cancer | Analysis | Metastasis | Index Medicus
Journal Article