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The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 10, pp. 904 - 913
In this study of perinatal and infantile hypophosphatasia, patients received ENB-0040, a bone-targeted, recombinant, human tissue-nonspecific isozyme of... 
MEDICINE, GENERAL & INTERNAL | INFANTILE HYPOPHOSPHATASIA | GENE | NONSPECIFIC ALKALINE-PHOSPHATASE | DISEASE | MINERALIZATION | PYRIDOXAL-5'-PHOSPHATE | MURINE HYPOPHOSPHATASIA | BONE | INTRAVENOUS-INFUSION | TRANSPLANTATION | Recombinant Fusion Proteins - pharmacology | Rickets - diagnostic imaging | Humans | Recombinant Fusion Proteins - therapeutic use | Child, Preschool | Biological Availability | Infant | Male | Injections, Subcutaneous - adverse effects | Bone and Bones - drug effects | Enzyme Replacement Therapy - adverse effects | Bone and Bones - diagnostic imaging | Immunoglobulin G - pharmacology | Female | Infant, Newborn | Recombinant Fusion Proteins - administration & dosage | Alkaline Phosphatase - pharmacology | Immunoglobulin G - therapeutic use | Treatment Outcome | Immunoglobulin G - administration & dosage | Alkaline Phosphatase - therapeutic use | Hypophosphatasia - complications | Radiography | Rickets - drug therapy | Alkaline Phosphatase - administration & dosage | Hypophosphatasia - drug therapy | Infusions, Intravenous | Rickets - etiology | Enzymes | Care and treatment | Usage | Patient outcomes | Hypophosphatasia | Health aspects | Risk factors | Calcification (ectopic) | Alkaline phosphatase | Respiratory function | Lung | Cognitive ability | Infants | Bone diseases | Phosphatase | Rickets | Mineralization | Supplementation | Children | Osteomalacia | Parathyroid | Hypocalcemia | Age | Calcium (dietary) | Pharmacodynamics | Statistical analysis | Dietary supplements | Metabolism | Patients | Studies | Parathyroid hormone | Collaboration | Calcification | Plasma levels | Pharmacokinetics | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 21, pp. 1987 - 1998
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2001, Volume 345, Issue 26, pp. 1883 - 1888
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 29, pp. E3893 - E3900
Substantial advances have been made in the past two decades in the management of osteoporosis. However, none of the current medications can eliminate the risk... 
PDGFB | Bone formation | Gene therapy | Hematopoietic stem cells | RESORPTION | ANGIOGENESIS | RALOXIFENE | MULTIDISCIPLINARY SCIENCES | PARATHYROID-HORMONE 1-34 | gene therapy | OSTEOPOROSIS | PLASMA | bone formation | DIFFERENTIATION | hematopoietic stem cells | POSTMENOPAUSAL WOMEN | SELECTION | GROWTH FACTOR-BB | Genetic Therapy | Hyperparathyroidism - physiopathology | Body Weight | Cell Proliferation | Hyperparathyroidism - complications | Ki-67 Antigen - metabolism | Promoter Regions, Genetic - genetics | Lentivirus - metabolism | Hyperparathyroidism - metabolism | Osteocalcin - blood | Mesenchymal Stromal Cells - cytology | Osteomalacia - physiopathology | Antigens, Ly - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Hyperparathyroidism - therapy | Transgenes | Alkaline Phosphatase - blood | Phosphoglycerate Kinase - genetics | Proto-Oncogene Proteins c-sis - genetics | Transduction, Genetic | Hematopoietic Stem Cell Transplantation | Osteomalacia - complications | Spleen Focus-Forming Viruses - metabolism | Osteoblasts - pathology | Bone and Bones - physiopathology | Animals | Models, Biological | Proto-Oncogene Proteins c-sis - therapeutic use | Weight-Bearing | Mice | Osteoblasts - metabolism | Bone Remodeling | Neovascularization, Physiologic | Osteogenesis | Phosphoglycerate Kinase - metabolism | Osteoporosis | Stem cell research | Care and treatment | Genetic aspects | Research | Porosity | Transplants & implants | Risk assessment | Cells | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 05/2017, Volume 102, Issue 5, pp. 1750 - 1756
Journal Article