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Developmental Cell, ISSN 1534-5807, 2002, Volume 3, Issue 6, pp. 889 - 901
Signaling by RANKL is essential for terminal differentiation of monocytes/mcrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play... 
LYMPH-NODE ORGANOGENESIS | CELLS | CYCLOSPORINE-A | OSTEOPROTEGERIN-LIGAND | KEY REGULATOR | C-FOS | RECEPTOR ACTIVATOR | GENE-EXPRESSION | DEVELOPMENTAL BIOLOGY | OSTEOPETROSIS | NF-KAPPA-B | CELL BIOLOGY | Transcription, Genetic - drug effects | Genetic Testing | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | RANK Ligand | Osteoclasts - cytology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Calcineurin - genetics | Cell Culture Techniques | Active Transport, Cell Nucleus - genetics | Signal Transduction - genetics | Nuclear Proteins | Signal Transduction - drug effects | Calcium Signaling - drug effects | Active Transport, Cell Nucleus - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-fos - genetics | Mice | Transcription, Genetic - genetics | Calcium Signaling - genetics | Receptor Activator of Nuclear Factor-kappa B | Transcription Factors - deficiency | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Carrier Proteins - pharmacology | Hematopoietic Stem Cells - drug effects | Gene Expression Regulation - genetics | Membrane Glycoproteins - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Hematopoietic Stem Cells - metabolism | NFATC Transcription Factors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Osteoclasts - metabolism | Membrane Glycoproteins - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Carrier Proteins - genetics | TNF Receptor-Associated Factor 6 | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Calcineurin - metabolism | Osteoclasts - drug effects
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2002, Volume 70, Issue 1, pp. 11 - 19
Journal Article
Human Genetics, ISSN 0340-6717, 1/2009, Volume 124, Issue 6, pp. 561 - 577
Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of osteopetrosis have provided instrumental information on bone... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | ALBERS-SCHONBERG-DISEASE | INFANTILE MALIGNANT OSTEOPETROSIS | EARLY POSTMENOPAUSAL WOMEN | CATHEPSIN-K DEFICIENCY | CARBONIC-ANHYDRASE-II | GENETICS & HEREDITY | RECEPTOR-RELATED PROTEIN-5 | CLCN7 GENE-MUTATIONS | RESISTANT ACID-PHOSPHATASE | AUTOSOMAL-DOMINANT OSTEOPETROSIS | MEDIATED EXTRACELLULAR ACIDIFICATION | Vacuolar Proton-Translocating ATPases - genetics | Osteopetrosis - physiopathology | Carbonic Anhydrase II - deficiency | Humans | Bone Remodeling - physiology | Chloride Channels - genetics | Receptor Activator of Nuclear Factor-kappa B - deficiency | Bone Resorption - genetics | Osteoclasts - physiology | Carbonic Anhydrase II - genetics | Osteopetrosis - genetics | Disease Models, Animal | Bone Resorption - physiopathology | Osteoclasts - pathology | Osteopetrosis - pathology | Cathepsin K | Membrane Proteins - genetics | Osteoblasts - physiology | Osteopetrosis - etiology | Membrane Glycoproteins - genetics | RANK Ligand - genetics | Osteoblasts - pathology | Animals | Cathepsins - genetics | Models, Biological | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | RANK Ligand - deficiency | Mice | Bone Remodeling - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Membrane Glycoproteins - deficiency
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2009, Volume 284, Issue 7, pp. 4667 - 4678
Micro-RNAs (miRNAs) are important in regulating cell fate determination because many of their target mRNA transcripts are engaged in cell proliferation,... 
B-CELL DEVELOPMENT | MYELOID PROGENITORS | CAENORHABDITIS-ELEGANS | NUCLEAR-FACTOR | KEY REGULATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TRANSCRIPTION FACTOR PU.1 | NF-KAPPA-B | T-CELLS | TRANSGENIC MICE | RNA, Small Interfering - genetics | Endoribonucleases - genetics | RNA-Binding Proteins | NFI Transcription Factors - genetics | Osteoclasts - cytology | Bone Resorption - genetics | Mice, Mutant Strains | Up-Regulation - physiology | Trans-Activators - genetics | Bone Resorption - metabolism | Eukaryotic Initiation Factor-2 - metabolism | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Osteopetrosis - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Endoribonucleases - metabolism | Receptor, Macrophage Colony-Stimulating Factor - genetics | MicroRNAs - biosynthesis | Osteopetrosis - metabolism | Proto-Oncogene Proteins - genetics | Macrophages - cytology | Osteoclasts - metabolism | Down-Regulation - physiology | Proteins - genetics | DEAD-box RNA Helicases - genetics | Macrophages - metabolism | Animals | Proteins - metabolism | NFI Transcription Factors - biosynthesis | Receptor, Macrophage Colony-Stimulating Factor - biosynthesis | Ribonuclease III | Eukaryotic Initiation Factor-2 - genetics | Homeostasis - physiology | Argonaute Proteins | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | RNA, Small Interfering - metabolism | Mechanisms of Signal Transduction
Journal Article
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