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Current Pharmaceutical Design, ISSN 1381-6128, 02/2007, Volume 13, Issue 4, pp. 387 - 403
Journal Article
eLife, ISSN 2050-084X, 2018, Volume 7
The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA... 
IMMUNITY | DOUBLE-STRANDED-RNA | IFIH1 MUTATION | VIRAL-RNA | STRUCTURAL BASIS | TOLERANCE | BIOLOGY | GENE-EXPRESSION | SIGNAL-ACTIVATION | SENSOR | MDA5 | Odontodysplasia - pathology | Muscular Diseases - enzymology | Humans | Vascular Calcification - genetics | Immunity, Innate - genetics | Metacarpus - abnormalities | RNA, Viral - genetics | Osteoporosis - enzymology | AAA Proteins - genetics | DEAD Box Protein 58 - genetics | Adenosine Triphosphate - metabolism | Osteoporosis - genetics | Vascular Calcification - enzymology | Aortic Diseases - enzymology | RNA, Double-Stranded - chemistry | Aortic Diseases - pathology | DEAD Box Protein 58 - chemistry | Odontodysplasia - enzymology | Metacarpus - enzymology | AAA Proteins - chemistry | Muscular Diseases - pathology | Dental Enamel Hypoplasia - enzymology | Vascular Calcification - pathology | Cytosol - virology | Hydrolysis | Aortic Diseases - genetics | RNA, Viral - chemistry | Osteoporosis - pathology | Metacarpus - pathology | RNA, Double-Stranded - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Conformation | Adenosine Triphosphatases - genetics | Odontodysplasia - genetics | Muscular Diseases - genetics | Mutation | Adenosine Triphosphate - chemistry | Dental Enamel Hypoplasia - pathology | Dental Enamel Hypoplasia - genetics | RNA sequencing | Physiological aspects | Genetic disorders | Genetic variation | Health aspects | Methods
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2013, Volume 28, Issue 7, pp. 1599 - 1610
ABSTRACT Bone remodeling, a physiological process characterized by bone formation by osteoblasts (OBs) and resorption of preexisting bone matrix by osteoclasts... 
CA2+/CALMODULIN (CAM)‐DEPENDENT PROTEIN KINASE KINASE 2 | OSTEOCLASTS | STO‐609 | PROTEIN KINASE A | OSTEOBLASTS | CALMODULIN (CAM)-DEPENDENT PROTEIN KINASE KINASE 2 | STO-609 | ELEMENT-BINDING PROTEIN | CAMKK2 | DEPENDENT KINASE | CA2 | CALMODULIN | CALCIUM | ENDOCRINOLOGY & METABOLISM | PARATHYROID-HORMONE | CELL-CYCLE | GROWTH-FACTOR | BONE MASS | EXPRESSION | Mesenchymal Stromal Cells - enzymology | Bone Marrow Cells - enzymology | Humans | Osteoporosis - drug therapy | Bone Remodeling - physiology | Osteoclasts - cytology | Bone Remodeling - drug effects | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Osteoporosis - enzymology | Adult | Female | Osteoporosis - genetics | Osteoblasts - cytology | Cell Differentiation - physiology | Cyclic AMP-Dependent Protein Kinases - metabolism | Osteoblasts - enzymology | Ovariectomy | NFATC Transcription Factors - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Mice, Knockout | Animals | Naphthalimides - pharmacology | Cell Differentiation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Benzimidazoles - pharmacology | Mice | Osteoclasts - enzymology | NFATC Transcription Factors - genetics | Osteoporosis | Protein kinases | Calmodulin | Proteins | Bone marrow | Kinases
Journal Article
Journal Article
Bone (New York, N.Y.), ISSN 8756-3282, 2011, Volume 49, Issue 4, pp. 623 - 635
Journal Article
The FASEB Journal, ISSN 0892-6638, 12/2017, Volume 31, Issue 12, pp. 5495 - 5506
ABSTRACT Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine β‐synthase (CBS),... 
homocysteine | PEGylation | rare inherited disease | cystathionine β‐synthase | preclinical drug development | Cystathionine b-synthase | Homocysteine | Preclinical drug development | Rare inherited disease | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GUIDELINES | BIOLOGY | cystathionine beta-synthase | MODEL | DEFICIENCY | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Liver - pathology | Liver - enzymology | Homocystinuria - drug therapy | Osteoporosis - prevention & control | Liver - metabolism | Liver Diseases - prevention & control | Fatty Liver - prevention & control | Male | Cystathionine beta-Synthase - metabolism | Homocystinuria - metabolism | Homocystinuria - pathology | Mice, Knockout | Homocystinuria - enzymology | Animals | Cystathionine beta-Synthase - therapeutic use | Liver - drug effects | Body Composition - drug effects | Fatty Liver - enzymology | Liver Diseases - enzymology | Female | Mice | Cystathionine beta-Synthase - genetics | Disease Models, Animal | Neonates | Brain | Liver | Amino acids | Damage prevention | Body composition | Osteoporosis | Mitochondria | Homocystinuria | Fatty liver | Body composition (biology) | Polyethylene glycol | Rodents | Animal tissues | Biocompatibility | Sulfur | Enzymes | Kidneys | Liver diseases | Abnormalities | Medical treatment | Mortality | Metabolism | Patients | Steatosis | Diet | Hepatocytes | Death | Endoplasmic reticulum | Research | cystathionine β-synthase
Journal Article