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Developmental Cell, ISSN 1534-5807, 2002, Volume 3, Issue 6, pp. 889 - 901
Signaling by RANKL is essential for terminal differentiation of monocytes/mcrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play... 
LYMPH-NODE ORGANOGENESIS | CELLS | CYCLOSPORINE-A | OSTEOPROTEGERIN-LIGAND | KEY REGULATOR | C-FOS | RECEPTOR ACTIVATOR | GENE-EXPRESSION | DEVELOPMENTAL BIOLOGY | OSTEOPETROSIS | NF-KAPPA-B | CELL BIOLOGY | Transcription, Genetic - drug effects | Genetic Testing | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | RANK Ligand | Osteoclasts - cytology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Calcineurin - genetics | Cell Culture Techniques | Active Transport, Cell Nucleus - genetics | Signal Transduction - genetics | Nuclear Proteins | Signal Transduction - drug effects | Calcium Signaling - drug effects | Active Transport, Cell Nucleus - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-fos - genetics | Mice | Transcription, Genetic - genetics | Calcium Signaling - genetics | Receptor Activator of Nuclear Factor-kappa B | Transcription Factors - deficiency | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Carrier Proteins - pharmacology | Hematopoietic Stem Cells - drug effects | Gene Expression Regulation - genetics | Membrane Glycoproteins - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Hematopoietic Stem Cells - metabolism | NFATC Transcription Factors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Osteoclasts - metabolism | Membrane Glycoproteins - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Carrier Proteins - genetics | TNF Receptor-Associated Factor 6 | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Calcineurin - metabolism | Osteoclasts - drug effects | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102797 - e102797
In diabetics, methylglyoxal (MG), a glucose-derived metabolite, plays a noxious role by inducing oxidative stress, which causes and exacerbates a series of... 
LRP5 GENE | HIGH-BONE-MASS | INDUCED OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | PROMOTER REGION | RECEPTOR-RELATED PROTEIN-5 | METHYLATION STATUS | HYDROGEN-PEROXIDE | MICE | TRANSCRIPTIONAL REGULATION | GLYCATION END-PRODUCTS | Diabetes Mellitus - genetics | Gene Expression - genetics | Methyl-CpG-Binding Protein 2 - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Methyl-CpG-Binding Protein 2 - genetics | Pyruvaldehyde - metabolism | Wnt Proteins - genetics | Epigenomics - methods | Receptor Activator of Nuclear Factor-kappa B - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Oxidative Stress - genetics | Diabetes Mellitus - metabolism | Mesenchymal Stromal Cells - metabolism | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | DNA Methylation - genetics | Signal Transduction - genetics | beta Catenin - metabolism | Down-Regulation - genetics | beta Catenin - genetics | Bone Diseases, Metabolic - metabolism | Animals | Epigenesis, Genetic - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | Mice | Bone Diseases, Metabolic - genetics | Oxidative stress | Bisulfite | Frizzled-related protein | Wnt protein | Frizzled protein | Genes | DNA damage | Inactivation | Osteoblasts | Gene sequencing | Osteoprotegerin | Proteins | Osteoporosis | β-catenin | Demethylation | Biomedical materials | Methyl-CpG binding protein | Rodents | DNA methylation | Bone marrow | Aging | Biocompatibility | Physiology | Bioindicators | TRANCE protein | Deoxyribonucleic acid--DNA | Osteopenia | University graduates | CpG islands | NF-κB protein | Deactivation | Complications | Legal medicine | Diabetes mellitus | Stroma | Gene expression | Medicine | Pathology | Signaling | Deoxyguanosine | Sodium | MeCP2 protein | Derepression | Epigenetics | Biomarkers | Diabetes | Pyruvaldehyde | Index Medicus | Stresses | Deoxyribonucleic acid | DNA
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 12/2010, Volume 191, Issue 7, pp. 1271 - 1283
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2... 
Osteomyelitis | Phenotypes | Antibodies | Bones | Mice | Repression | Bone marrow cells | Osteoblasts | Zinc | Mesenchymal stem cells | CLEIDOCRANIAL DYSPLASIA | CELLS | OSTEOBLAST DIFFERENTIATION | TGF-BETA | OSTEOCALCIN GENE | HOMEODOMAIN PROTEINS | CBFA1 | PARATHYROID-HORMONE | EXPRESSION | TRANSGENIC MICE | CELL BIOLOGY | Osteopontin - genetics | Bone and Bones - pathology | Transcription, Genetic - drug effects | Osteogenesis - physiology | Fractures, Spontaneous - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Bone Development - physiology | Cell Count | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Bone Remodeling - physiology | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Bone and Bones - metabolism | Osteoprotegerin - genetics | Osteoblasts - cytology | Response Elements - physiology | Animals, Newborn | Calcification, Physiologic - genetics | Histone Deacetylases - genetics | Extracellular Matrix Proteins - genetics | Rats | Histone Deacetylases - metabolism | Mice, Transgenic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Inbred Strains | Bone Diseases, Metabolic - metabolism | RANK Ligand - genetics | Animals | Sp7 Transcription Factor | Heterozygote | Histone Deacetylase Inhibitors - pharmacology | Zinc Fingers - physiology | Bone Diseases, Metabolic - genetics | Transcription, Genetic - genetics | Bone and Bones - abnormalities | Bone and Bones - embryology | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Protein Binding - physiology | Proteins | Enzymes | Transcription factors | Research | Properties | Density | Cell division | Maturation | Transgenic animals | Rodents | Index Medicus
Journal Article
International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, 2011, Volume 40, Issue 6, pp. 605 - 611
Abstract Bisphosphonate induced osteonecrosis of the jaw (BONJ) is a complication in patients taking bisphosphonate (BP) that affects their quality of life and... 
Surgery | Osteonecrosis of the jaw (ONJ) | Bisphosphonates | Genetic polymorphisms | Multiple myeloma | Pharmacogenomics | MULTIPLE-MYELOMA | SURGERY | CELLS | RESORPTION | BONE-MINERAL DENSITY | OSTEOPONTIN | DENTISTRY, ORAL SURGERY & MEDICINE | BINDING | Osteopontin - genetics | Cytochrome P-450 CYP2C8 | Gene Frequency - genetics | Injections, Intravenous | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Aryl Hydrocarbon Hydroxylases - genetics | Imidazoles - administration & dosage | Male | Jaw Diseases - chemically induced | Osteonecrosis - genetics | Multiple Myeloma - drug therapy | Collagen Type I - genetics | Time Factors | Jaw Diseases - genetics | Osteoprotegerin - genetics | Adult | Female | Diphosphonates - adverse effects | Bone Density Conservation Agents - adverse effects | Imidazoles - adverse effects | Risk Factors | Diphosphonates - administration & dosage | Bone Density Conservation Agents - administration & dosage | Matrix Metalloproteinase 2 - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | Polymorphism, Single Nucleotide - genetics | Polymorphism, Genetic - genetics | Aged | Osteonecrosis - chemically induced | Cohort Studies | Smoking | Phosphonates | Genetic research | Physiological aspects | Bones | Genetic aspects | Risk factors | Necrosis | Index Medicus | Dentistry
Journal Article
BBA - General Subjects, ISSN 0304-4165, 06/2013, Volume 1830, Issue 6, pp. 3756 - 3766
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 10, pp. e13217 - e13217
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0147345 - e0147345
Journal Article
PLoS One, ISSN 1932-6203, 2016, Volume 11, Issue 4, pp. e0152966 - e0152966
Journal Article
American Journal of Orthodontics and Dentofacial Orthopedics, ISSN 0889-5406, 2014, Volume 146, Issue 3, pp. 337 - 345