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Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 418 - 429
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates... 
INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | ONCOLOGY | COMPARING STANDARD PANCREATICODUODENECTOMY | HUMAN OSTEOSARCOMA XENOGRAFTS | RANDOMIZED-TRIAL | HEAD ADENOCARCINOMA | TUMOR VASCULATURE | EXTENDED LYMPHADENECTOMY | CANCER | BLOOD-PRESSURE | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Adhesion Molecules - administration & dosage | Stromal Cells - pathology | Pancreatic Neoplasms - blood supply | Deoxycytidine - pharmacology | Hyaluronic Acid - physiology | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Stromal Cells - drug effects | Hyaluronoglucosaminidase - administration & dosage | Drug Evaluation, Preclinical | Hyaluronoglucosaminidase - therapeutic use | Tumor Microenvironment - drug effects | Animals, Genetically Modified | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Extracellular Fluid - drug effects | Polyethylene Glycols - administration & dosage | Adenocarcinoma - blood supply | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hyaluronic Acid - metabolism | Mice | Carcinoma, Pancreatic Ductal - blood supply | Cell Adhesion Molecules - therapeutic use | Deoxycytidine - analogs & derivatives | Enzymes | Medical colleges | Care and treatment | Glycosaminoglycans | Oncology, Experimental | Research | Chemotherapy | Universities and colleges | Drug therapy | Hyaluronic acid | Public health | Tumors | Cancer
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2015, Volume 137, Issue 1, pp. 73 - 85
Journal Article
Critical Reviews in Oncology and Hematology, ISSN 1040-8428, 2014, Volume 91, Issue 2, pp. 172 - 185
Abstract Sarcomas encompass a heterogeneous family of mesenchymal malignancies. In metastatic disease improvement in outcome has been limited and there is a... 
Hematology, Oncology and Palliative Medicine | Angiogenesis | GIST | Chondrosarcoma | Sarcoma | Osteosarcoma | VEGF | Soft tissue sarcoma | EWINGS-SARCOMA | FACTOR EXPRESSION | CELL-LINES | PRECLINICAL TESTING PROGRAM | PHASE-II TRIAL | ONCOLOGY | AFLIBERCEPT VEGF TRAP | REFRACTORY SOLID TUMORS | HEMATOLOGY | GASTROINTESTINAL STROMAL TUMORS | SOFT-TISSUE SARCOMA | ENDOTHELIAL GROWTH-FACTOR | Bone and Bones - pathology | Gastrointestinal Neoplasms - drug therapy | Humans | Vascular Endothelial Growth Factor A - metabolism | Bone Neoplasms - pathology | Gastrointestinal Tract - pathology | Sarcoma - blood supply | Bone Neoplasms - metabolism | Bone and Bones - drug effects | Neovascularization, Pathologic - pathology | Gastrointestinal Neoplasms - pathology | Bone Neoplasms - blood supply | Gastrointestinal Neoplasms - blood supply | Angiogenesis Inhibitors - therapeutic use | Bone Neoplasms - drug therapy | Drug Evaluation, Preclinical | Gastrointestinal Neoplasms - metabolism | Bone and Bones - blood supply | Gastrointestinal Tract - drug effects | Sarcoma - drug therapy | Sarcoma - pathology | Sarcoma - metabolism | Animals | Gastrointestinal Tract - blood supply | Neovascularization, Pathologic - drug therapy | Neovascularization, Pathologic - metabolism | Antimitotic agents | Drug therapy | Antineoplastic agents | Stem cells
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 10/2004, Volume 4, Issue 10, pp. 806 - 813
Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in... 
RADIATION RESPONSE | DRUG PENETRATION | SOLID TUMORS | ONCOLOGY | COLLAGEN GEL CONTRACTION | PERICYTE RECRUITMENT | HUMAN OSTEOSARCOMA XENOGRAFTS | BLOOD-VESSELS | EXPERIMENTAL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | BASEMENT-MEMBRANE | Extracellular Fluid - physiology | Humans | Alprostadil - pharmacology | Neoplasms - blood supply | Bradykinin - antagonists & inhibitors | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Hydrostatic Pressure | Neoplasms - drug therapy | Hyaluronoglucosaminidase - pharmacology | Animals | Biological Transport | Signal Transduction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Antineoplastic Agents - pharmacokinetics | Mice | Neoplasms - physiopathology | Niacinamide - pharmacology | Platelet-Derived Growth Factor - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Care and treatment | Research | Health aspects | Methods | Cancer | Alprostadil/pharmacology | Niacinamide/pharmacology | Bradykinin/antagonists & inhibitors | Signal Transduction/drug effects | Hyaluronoglucosaminidase/pharmacology | Neoplasms/blood supply/drug therapy/physiopathology | Tumor Necrosis Factor-alpha/antagonists & inhibitors | Platelet-Derived Growth Factor/antagonists & inhibitors | Antineoplastic Agents/pharmacokinetics | Extracellular Fluid/physiology | Transforming Growth Factor beta/antagonists & inhibitors | Research Support; Non-U.S. Gov't | Vascular Endothelial Growth Factor A/antagonists & inhibitors
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1424 - 1432
The activity of heparanase is responsible for heparan sulfate cleavage, thus resulting in the release of heparan sulfate-bound growth factors. Since heparanase... 
SST0001 | Antitumor activity | Pediatric sarcomas | Heparanase inhibitor | Antiangiogenic agents | TARGETED THERAPY | MATRIX | STIMULATION | CELL-LINES | HEPARIN | CANCER | SULFATE | RHABDOMYOSARCOMA | PHARMACOLOGY & PHARMACY | TUMOR MICROENVIRONMENT | ENDOTHELIAL GROWTH-FACTOR | Osteosarcoma - drug therapy | Humans | Glucuronidase - metabolism | Rhabdomyosarcoma - pathology | Heparin - therapeutic use | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Bone Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Bevacizumab | Rhabdomyosarcoma - blood supply | Bone Neoplasms - blood supply | Antibodies, Monoclonal, Humanized - pharmacology | Osteosarcoma - blood supply | Angiogenesis Inhibitors - therapeutic use | Female | Glucuronidase - antagonists & inhibitors | Indoles - pharmacology | Neovascularization, Pathologic - prevention & control | Rhabdomyosarcoma - drug therapy | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Pyrroles - therapeutic use | Child | Heparin - pharmacology | Antibodies, Monoclonal, Humanized - therapeutic use | Neoplasm Invasiveness | Angiogenesis Inhibitors - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Heparin - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Indoles - therapeutic use | Mice | Osteosarcoma - pathology | Antimitotic agents | Pediatrics | Sarcoma | Drug therapy | Antineoplastic agents
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 385, pp. 261 - 270
Abstract Chondrosarcoma is the second most common primary malignancy of bone after myeloma and osteosarcoma. Chondrosarcoma development may be linked to... 
Hematology, Oncology and Palliative Medicine | Angiogenesis | Amphiregulin | VEGF-A | miR-206 | METASTASIS | INTEGRIN | DOWN-REGULATION | TUMOR ANGIOGENESIS | MICRORNAS | CANCER | ONCOLOGY | SIGNALING PATHWAY | HUMAN OSTEOSARCOMA | DEPENDENT ANGIOGENESIS | EXPRESSION | Focal Adhesion Kinase 1 - genetics | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Male | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - metabolism | Endothelial Progenitor Cells - enzymology | Vascular Endothelial Growth Factor A - genetics | Bone Neoplasms - pathology | Chondrosarcoma - blood supply | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Bone Neoplasms - blood supply | src-Family Kinases - metabolism | Amphiregulin - metabolism | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Focal Adhesion Kinase 1 - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Chorioallantoic Membrane - blood supply | Amphiregulin - genetics | Bone Neoplasms - enzymology | Signal Transduction | Chick Embryo | Protein Kinase C-delta - metabolism | Amphiregulin - pharmacology | Animals | Chondrosarcoma - enzymology | Endothelial Progenitor Cells - pathology | Mice, Nude | Cell Line, Tumor | Mice, Inbred BALB C | MicroRNAs - genetics | Neoplasm Staging | src-Family Kinases - genetics | Protein Kinase C-delta - genetics
Journal Article
Advances in experimental medicine and biology, ISSN 0065-2598, 2014, Volume 804, pp. 67 - 92
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2001, Volume 98, Issue 2, pp. 620 - 624
We have shown previously that a polymeric form of fibronectin is strongly antimetastatic when administered systemically to tumor-bearing mice. The polymeric... 
Angiogenesis | Biological Sciences | Cell growth | Lungs | Blood vessels | Polymerization | Metastasis | Polymers | Heterologous transplantation | Tumors | Vehicles | MATRIX | ACTIVATION | INTEGRINS | ANGIOSTATIN | MULTIDISCIPLINARY SCIENCES | VITRONECTIN | TRANSDUCTION | ANTITHROMBIN | ENDOTHELIAL-CELL GROWTH | POTENT INHIBITORS | HEPARIN-BINDING FRAGMENTS | Osteosarcoma - drug therapy | Neoplasm Transplantation | Humans | Melanoma, Experimental - drug therapy | Peptide Fragments - pharmacology | Antineoplastic Agents - therapeutic use | Bone Neoplasms - pathology | Carcinoma, Ductal, Breast - drug therapy | Neoplasm Metastasis - drug therapy | Osteosarcoma - blood supply | Angiogenesis Inhibitors - therapeutic use | Carcinoma, Ductal, Breast - blood supply | Carcinoma, Ductal, Breast - pathology | Female | Fibrinogen - pharmacology | Receptors, Vitronectin - drug effects | Antineoplastic Agents - pharmacology | Fibronectins - pharmacology | Melanoma, Experimental - blood supply | Tumor Cells, Cultured - drug effects | Angiogenesis Inhibitors - pharmacology | Fibronectins - therapeutic use | Melanoma - pathology | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Peptide Fragments - chemistry | Animals | Fibronectins - chemistry | Breast Neoplasms - pathology | Neovascularization, Pathologic - drug therapy | Fibrinogen - therapeutic use | Mice | Mice, Inbred BALB C | Peptide Fragments - therapeutic use | Neoplasms, Experimental - drug therapy | Osteosarcoma - pathology | Angiogenesis Inhibitors - chemistry | Neoplasms, Experimental - blood supply | Fibronectins | Physiological aspects | Transforming growth factors
Journal Article