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Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 761 - 767
An important regulator involved in oxygen-dependent gene expression is the transcription factor HIF (hypoxia-inducible factor), which is composed of an... 
Post-translational modification | Hypoxia-inducible factor | Protein degradation | Oxygen sensing | Prolyl hydroxylation | Von-Hippel-Lindau protein | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ALPHA | hypoxia-inducible factor | oxygen sensing | post-translational modification | von-Hippel-Lindau protein | HYDROXYLASES | DESTRUCTION | FACTOR-1-ALPHA | GENES | HIF-1-ALPHA | VHL | protein degradation | PROLYL | prolyl hydroxylation | Humans | Half-Life | Kidney Neoplasms - metabolism | Ubiquitin-Protein Ligases - physiology | Bone Neoplasms - pathology | Hypoxia-Inducible Factor 1, alpha Subunit | RNA, Messenger - biosynthesis | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Kidney Tubules, Proximal - cytology | DNA-Binding Proteins - physiology | Hypoxia - enzymology | Hydroxylation | Hypoxia-Inducible Factor 1 | Immediate-Early Proteins - biosynthesis | Carcinoma, Hepatocellular - enzymology | Tumor Suppressor Proteins - physiology | Epithelial Cells - enzymology | Liver Neoplasms - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein | Enzyme Induction - physiology | Osteosarcoma - pathology | Carcinoma, Hepatocellular - metabolism | Epithelial Cells - metabolism | Gene Expression Regulation, Enzymologic - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - biosynthesis | Bone Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Kidney Tubules, Proximal - enzymology | Gene Expression Regulation, Neoplastic - physiology | Osteosarcoma - metabolism | Cell Line | Transcription Factors - physiology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Adenocarcinoma, Clear Cell - metabolism | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - metabolism | Kidney Neoplasms - enzymology | Carcinoma, Hepatocellular - pathology | Kidney Tubules, Proximal - metabolism | Kidney Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Nuclear Proteins - physiology | Adenocarcinoma, Clear Cell - enzymology | DNA-Binding Proteins - biosynthesis | ODD, oxygen-dependent degradation domain | aRP, acidic ribosomal protein | RNAi, RNA interference | pVHL, von-Hippel-Lindau protein | EGLN, egg-laying deficient nine-like protein | HIF, hypoxia-inducible factor | siRNA, small interfering RNA | IVTT, in vitro transcription | PHD, prolyl hydroxylase domain containing protein | translation | RT, reverse transcriptase | RPTEC, human renal proximal tubular epithelial cells
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2010, Volume 6, Issue 9, p. e1001092
Journal Article
Cancer Research, ISSN 0008-5472, 05/2005, Volume 65, Issue 9, pp. 3868 - 3876
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131998
Somatic mutations in the isocitrate dehydrogenase (IDH) 1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite,... 
MAFFUCCI SYNDROME | OLLIER DISEASE | GLIOBLASTOMA | COL2A1 | MULTIDISCIPLINARY SCIENCES | MYELOPROLIFERATIVE NEOPLASMS | MUTATIONS | PROMOTER | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CANCER | EXPRESSION | Mesenchymal Stromal Cells - enzymology | Genetic Predisposition to Disease | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Enchondromatosis - enzymology | Genetic Association Studies | Epigenesis, Genetic | Humans | Cells, Cultured | Gene Expression Regulation, Neoplastic | Isocitrate Dehydrogenase - genetics | Mutation, Missense | Chondrosarcoma - enzymology | Chondrosarcoma - genetics | Bone Neoplasms - genetics | Cell Differentiation | Protein Processing, Post-Translational | Histones - metabolism | Osteosarcoma - genetics | Methylation | Enchondromatosis - genetics | Mesenchymal Stromal Cells - physiology | Histones | Stem cells | Mesenchyme | Leukemia | Genes | Sox9 protein | Central nervous system | Proteins | Cartilage | Biomedical materials | Cell growth | Osteosarcoma | Surgery | DNA methylation | Bone marrow | Biocompatibility | Inhibition | Isocitrate dehydrogenase | Deoxyribonucleic acid--DNA | Enzymes | Tissue engineering | Osteosarcoma cells | Gene expression | Medicine | Properties (attributes) | Animal behavior | Epigenetics | Mutation | Differentiation | Tumors | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e83144
Osteosarcoma is the most common primary bone tumour of both children and dogs. It is an aggressive tumour in both species with a rapid clinical course leading... 
BREAST-CANCER CELLS | MALIGNANT-TUMORS | CYCLOOXYGENASE-2 | SUBPOPULATION | PATHWAY | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | GROWTH | MELOXICAM | GASTROINTESTINAL STROMAL TUMORS | Doxorubicin - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Cell Survival - genetics | Spheroids, Cellular - enzymology | Bone Neoplasms - pathology | Dog Diseases - pathology | Osteosarcoma - veterinary | Cell Death - genetics | Neoplastic Stem Cells - metabolism | Cyclooxygenase 2 - genetics | Dog Diseases - enzymology | Neoplastic Stem Cells - pathology | Bone Neoplasms - genetics | Spheroids, Cellular - drug effects | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Bone Neoplasms - veterinary | Tumor Stem Cell Assay | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Cyclooxygenase 2 Inhibitors - pharmacology | Neoplasm Invasiveness | Carcinogenesis - genetics | Dog Diseases - genetics | Carcinogenesis - pathology | Drug Resistance, Neoplasm - genetics | Animals | Cyclooxygenase 2 - metabolism | Dogs | Osteosarcoma - genetics | Neoplastic Stem Cells - enzymology | Doxorubicin - pharmacology | Osteosarcoma - pathology | Drug Resistance, Neoplasm - drug effects | COX-2 inhibitors | Chemotherapy | Osteosarcoma | Analysis | Genes | Stem cells | Genetic research | Metastasis | Gene expression | Cancer | Adherent cells | Biotechnology | Bone tumors | Spheres | Kinases | Cancer therapies | Metastases | Skin cancer | Surgery | Population | Biocompatibility | Children | Inhibition | Meloxicam | Breast cancer | Studies | Bone cancer | DNA microarrays | Cyclooxygenase-2 | Tumors
Journal Article
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 32351 - 32361
Mutations in the human RecQ helicase, BLM, causes Bloom Syndrome, which is a rare autosomal recessive disorder and characterized by genomic instability and an... 
BLM | Tumorigenesis | Fanconi anemia | DNA damage | FANCD2 monoubiquitination | fanconi anemia | SYNDROME GENE-PRODUCT | DNA-DAMAGE | SYNDROME HELICASE | REPLICATION FORK RECOVERY | CONNECTS | BRCA PROTEINS | EPITHELIAL OVARIAN-CANCER | CELL BIOLOGY | DAMAGE RESPONSE NETWORK | FANCD2 | BLOOMS-SYNDROME | tumorigenesis | RecQ Helicases - metabolism | Cross-Linking Reagents - pharmacology | Humans | Ovarian Neoplasms - pathology | Fanconi Anemia Complementation Group L Protein - chemistry | RecQ Helicases - genetics | Bone Neoplasms - pathology | Ovarian Neoplasms - genetics | Transfection | Ultraviolet Rays | Neoplasms - genetics | RNA Interference | Fanconi Anemia - enzymology | Fanconi Anemia - pathology | Female | Bone Neoplasms - genetics | Fanconi Anemia - genetics | Protein Interaction Domains and Motifs | Signal Transduction - radiation effects | Bloom Syndrome - pathology | Bloom Syndrome - enzymology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Cell Survival | Fanconi Anemia Complementation Group L Protein - genetics | Neoplasms - enzymology | Bloom Syndrome - genetics | Ovarian Neoplasms - enzymology | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | RecQ Helicases - chemistry | Fanconi Anemia Complementation Group L Protein - metabolism | Mutation | Osteosarcoma - genetics | Neoplasms - pathology | Osteosarcoma - pathology
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2009, Volume 8, Issue 11, pp. 3024 - 3035
Rhabdomyosarcoma, consisting of alveolar (aRMS) and embryonal (eRMS) subtypes, is the most common type of sarcoma in children. Currently, there are no targeted... 
polo-like kinase 1 | siRNA library | kinases | rhabdomyosarcoma | phosphatases | CANCER-CELLS | GENE-EXPRESSION SIGNATURE | APOPTOSIS | TRANSLOCATION | ALVEOLAR RHABDOMYOSARCOMAS | ACTIVATION | ONCOLOGY | PATHWAY | CLASSIFICATION | TUMOR-GROWTH | PAX3-FKHR FUSION PROTEIN | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Glioblastoma - enzymology | Protein Kinases - genetics | Bone Neoplasms - therapy | Sarcoma, Ewing - therapy | Humans | Neuroblastoma - enzymology | Child, Preschool | Rhabdomyosarcoma - pathology | Apoptosis - genetics | Immunoblotting | Neuroblastoma - therapy | Cell Cycle Proteins - antagonists & inhibitors | Transfection | Glioblastoma - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Bone Neoplasms - genetics | Cell Growth Processes - genetics | Child | Protein-Serine-Threonine Kinases - metabolism | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Phosphoric Monoester Hydrolases - genetics | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Neuroblastoma - genetics | Cell Cycle Proteins - metabolism | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Glioblastoma - therapy | Rhabdomyosarcoma - enzymology | Animals | Cell Line, Tumor | Mice | Rhabdomyosarcoma - genetics | Osteosarcoma - genetics | Phosphoric Monoester Hydrolases - metabolism | RNA, Small Interfering - administration & dosage | Sarcoma, Ewing - genetics | Osteosarcoma - therapy | Rhabdomyosarcoma - therapy | Sarcoma, Ewing - enzymology | Genetic Therapy - methods
Journal Article
Cancer Research, ISSN 0008-5472, 09/2006, Volume 66, Issue 18, pp. 9270 - 9280
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 05/2011, Volume 71, Issue 9, pp. 3306 - 3316
Journal Article