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Molecular Cell, ISSN 1097-2765, 02/2018, Volume 69, Issue 4, pp. 581 - 593.e7
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2007, Volume 28, Issue 5, pp. 823 - 837
Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind... 
PROTEINS | DNA | LOCALIZATION | RECOGNITION | RING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | COMPLEXES | TRANSCRIPTIONAL REPRESSION | SUMO MODIFICATION | KAP-1 COREPRESSOR | BINDING | CONTRIBUTES | CELL BIOLOGY | Chromatin - metabolism | Autoantigens - metabolism | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Saccharomyces cerevisiae - genetics | Humans | Protein Methyltransferases - genetics | RING Finger Domains | Tripartite Motif-Containing Protein 28 | Autoantigens - genetics | Bone Neoplasms - pathology | Protein Methyltransferases - metabolism | Repressor Proteins - antagonists & inhibitors | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Kidney - metabolism | Transcription, Genetic | Bone Neoplasms - genetics | DNA Helicases - genetics | Osteosarcoma - metabolism | Repressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Histone Deacetylases - genetics | Small Ubiquitin-Related Modifier Proteins - metabolism | Cells, Cultured | Gene Expression Regulation | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Ubiquitin-Conjugating Enzymes - genetics | DNA-Binding Proteins - genetics | DNA Helicases - metabolism | Two-Hybrid System Techniques | Ubiquitin-Conjugating Enzymes - metabolism | Adenosine Triphosphatases - genetics | Protein Processing, Post-Translational | Osteosarcoma - genetics | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 342 - 354
The tumor suppressor p53 is a transcription factor that responds to cellular stresses by initiating cell cycle arrest or apoptosis. One transcriptional target... 
PROTEINS | CELLCYCLE | TRANSCRIPTIONAL ACTIVATION | CHK2 KINASE | PROTEIN | ONCOLOGY | DNA-DAMAGE RESPONSE | MDM2 | ATM | P53 PATHWAY | CELL-GROWTH | IONIZING-RADIATION | PPM1D | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Phosphorylation | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Phosphoprotein Phosphatases - metabolism | Ubiquitin - metabolism | Homeostasis | DNA-Binding Proteins - deficiency | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Transfection | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Ubiquitin Thiolesterase - metabolism | Transcription, Genetic | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Osteosarcoma - enzymology | Cell Cycle Proteins - metabolism | Protein Phosphatase 2C | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Serine - metabolism | Mice, Knockout | Animals | Phosphoprotein Phosphatases - genetics | Fibroblasts - radiation effects | Cell Line, Tumor | Phosphoprotein Phosphatases - deficiency | Mice | DNA Damage | Mutation | Osteosarcoma - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Specific Peptidase 7 | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2012, Volume 181, Issue 5, pp. 1782 - 1795
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e104321 - e104321
The flavones apigenin (4',5,7,-trihydroxyflavone) and luteolin (3',4',5,7,-tetrahydroxyflavone) are plant secondary metabolites with antioxidant,... 
TRANSCRIPTION FACTORS | TRIAL | METABOLISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PREVENTION | RESVERATROL SUPPLEMENTATION | PROTEINS | INSULIN SENSITIVITY | DIETS | Fatty Acid Synthase, Type I - genetics | Sirtuin 1 - metabolism | Glucose-6-Phosphatase - genetics | Receptor, IGF Type 1 - metabolism | Humans | Sirtuin 1 - genetics | Acetyl-CoA Carboxylase - genetics | Proto-Oncogene Proteins c-akt - genetics | Forkhead Transcription Factors - metabolism | HEK293 Cells | NF-E2-Related Factor 2 - genetics | Osteoblasts - cytology | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Signal Transduction | Osteoblasts - drug effects | Forkhead Transcription Factors - genetics | Luteolin - pharmacology | Fatty Acid Synthase, Type I - metabolism | Receptor, IGF Type 1 - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | NF-E2-Related Factor 2 - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Forkhead Box Protein O1 | Adaptor Proteins, Signal Transducing - metabolism | Osteoblasts - metabolism | Acetyl-CoA Carboxylase - metabolism | Apigenin - pharmacology | Type 2 diabetes | Enzymes | Cysteine | Flavones | RNA | Bioflavonoids | Genes | Glucose | Gene expression | Cells | Dextrose | Antioxidants | Flavonoids | Metabolites | Cellular signal transduction | Transcription factors | Heart attacks | Disease | AKT protein | Anticancer properties | Proteins | Signal transduction | Secondary metabolites | Polyphenols | Forkhead protein | Biocompatibility | Inhibition | Free radicals | Metabolism | Insulin | Fatty-acid synthase | Disease prevention | Nutrition research | Micronutrients | N-Acetyl-L-cysteine | Glucose-6-phosphatase | Endocrinology | Oxidative stress | Phosphorylation | Insulin-like growth factor I | Homeostasis | Biology | Insulin-like growth factors | Hepatoma | Kinases | Biomedical materials | Pathways | FOXO1 protein | Osteosarcoma | Cell cycle | Localization | Diabetes mellitus (non-insulin dependent) | FOXO3 protein | Translocation | Diabetes mellitus | Nuclear transport | Medicine | Signaling | Insulin resistance | In vivo methods and tests | Diabetes | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 3, pp. 334 - 344
Sequestosome 1 (SQSTM1/p62) is a multifunctional protein involved in signal transduction, protein degradation and cell transformation. Hypoxia is a common... 
ATG8 | Prolyl hydroxylase | HIF | Autophagy | Sequestosome 1 | PVHL | CANCER-CELLS | autophagy | INCLUSIONS | prolyl hydroxylase | sequestosome 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALING ADAPTER P62 | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | INHIBITION | ONCOLOGY | DISEASE | GENETICS & HEREDITY | PROLINE HYDROXYLATION | IMPORTANT MEDIATOR | BODY FORMATION | HIF-ALPHA | pVHL | Phosphorylation | Sequestosome-1 Protein | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Bone Neoplasms - pathology | Head and Neck Neoplasms - metabolism | Oxygen - metabolism | Bone Neoplasms - metabolism | Hypoxia - metabolism | Procollagen-Proline Dioxygenase - metabolism | Kidney - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Osteosarcoma - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Keratinocytes - cytology | Kidney - cytology | Blotting, Western | Head and Neck Neoplasms - pathology | Mitogen-Activated Protein Kinase 3 - metabolism | Procollagen-Proline Dioxygenase - genetics | Keratinocytes - metabolism | Adaptor Proteins, Signal Transducing - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Osteosarcoma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Control | Physiological aspects | Hypoxia | Genetic aspects | Research | Health aspects | Phagocytosis | Cancer | Signal transduction | Oncology | Genetics | Cellular biology | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 10, pp. e26631 - e26631
Journal Article