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1. Full Text Current practice of ototoxicity management across the United Kingdom (UK)
by Maru, Devina and Malky, Ghada-Al
International Journal of Audiology, ISSN 1499-2027, 08/2018, Volume 57, Issue sup4, pp. S29 - S41
Objective: Effective management of patients diagnosed with ototoxicity is needed to reduce hearing and balance damage which affects communication and life... 
ototoxicity education | paediatric ototoxicity management | ototoxicity monitoring | audiologists | ototoxicity management | Ototoxic agents | balance management | GPs | aminoglycoside ototoxicity | ENTS/AVPs | cisplatin ototoxicity | AMINOGLYCOSIDE-OTOTOXICITY | INNER-EAR | AVPs | REGENERATION | AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY | ENTS | PREVALENCE | CHILDREN | CISPLATIN-OTOTOXICITY | HEARING-LOSS | GRADING SYSTEM | TOBRAMYCIN | CYSTIC-FIBROSIS PATIENTS | OTORHINOLARYNGOLOGY
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2. Full Text Clinical trials, ototoxicity grading scales and the audiologist’s role in therapeutic decision making
by King, Kelly A and Brewer, Carmen C
International Journal of Audiology, ISSN 1499-2027, 08/2018, Volume 57, Issue 4, pp. S89 - S98
clinical trial | adverse event | ototoxicity grading scale | ototoxicity monitoring | Ototoxicity | Adverse event | Clinical trial | Ototoxicity monitoring | Ototoxicity grading scale
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3. Full Text Ototoxicity and cancer therapy
by Landier, Wendy
Cancer, ISSN 0008-543X, 06/2016, Volume 122, Issue 11, pp. 1647 - 1658
Ototoxicity is a well‐established toxicity associated with a subgroup of antineoplastic therapies that includes platinum chemotherapy, radiation or surgery... 
genetic predisposition | otoprotection | grading scales | management of hearing loss | ototoxicity | antineoplastic therapy | OSTEOSARCOMA PATIENTS | SENSORINEURAL HEARING-LOSS | PRACTICAL GRADING SYSTEM | PLATINUM-INDUCED OTOTOXICITY | GERM-CELL TUMORS | RECEIVING CISPLATIN | CHILDRENS ONCOLOGY GROUP | BRAIN-TUMORS | AMINOGLYCOSIDE OTOTOXICITY | ONCOLOGY | CISPLATIN-INDUCED OTOTOXICITY | Vertigo - epidemiology | Postoperative Complications - etiology | Prevalence | Age Factors | Ear - physiology | Hearing Loss - etiology | Humans | Postoperative Complications - prevention & control | Radiotherapy - adverse effects | Neoplasms - therapy | Vertigo - etiology | Ear Diseases - prevention & control | Antineoplastic Agents - adverse effects | Hearing Loss - therapy | Ear Diseases - etiology | Tinnitus - etiology | Ear Diseases - epidemiology | Ear - anatomy & histology | Genetic Predisposition to Disease | Hearing Loss - epidemiology | Radiation Injuries - complications | Tinnitus - epidemiology | Radiation Injuries - prevention & control | Ear - radiation effects | Medical Illustration | Antimitotic agents | Care and treatment | Chemotherapy | Usage | Genetic susceptibility | Hearing disorders | Dosage and administration | Research | Antineoplastic agents | Cancer | Index Medicus | Abridged Index Medicus
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4. Full Text Clinical trials, ototoxicity grading scales and the audiologist's role in therapeutic decision making
by King, Kelly A and Brewer, Carmen C
International Journal of Audiology, ISSN 1499-2027, 08/2018, Volume 57, Issue sup4, pp. S19 - S28
Objectives: Define clinical trials and adverse event (AE) monitoring from the perspective of the audiologist. Rationalise the importance of audiology's... 
clinical trial | adverse event | ototoxicity grading scale | ototoxicity monitoring | Ototoxicity | SYSTEM | CISPLATIN OTOTOXICITY | AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY | INTERNATIONAL SOCIETY | CONSENSUS | CONCORDANCE | CHILDRENS ONCOLOGY GROUP | CHEMOTHERAPY | OTORHINOLARYNGOLOGY
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5. Full Text Mind Your Ears: A New Antidote to Aminoglycoside Toxicity?
by O'Sullivan, Mary E and Cheng, Alan G
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 1, pp. 81 - 83
Aminoglycoside antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss. Using the zebrafish lateral line system as a platform for... 
OTOTOXICITY | CHEMISTRY, MEDICINAL | Index Medicus
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6. Full Text Increased risk of aminoglycoside-induced hearing loss in MDRTB patients with HIV coinfection
by Hong, H and Budhathoki, C and Farley, J.E
International Journal of Tuberculosis and Lung Disease, ISSN 1027-3719, 06/2018, Volume 22, Issue 6, pp. 667 - 674
Sub-Saharan Africa | Metaanalysis | Ototoxicity
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7. Full Text Drug‐induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies
by Lanvers‐Kaminsky, C and Zehnhoff‐Dinnesen, AG am and Parfitt, R and Ciarimboli, G
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 04/2017, Volume 101, Issue 4, pp. 491 - 500
Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children.... 
HEARING-LOSS | MITOCHONDRIAL RIBOSOMAL-RNA | PRACTICAL GRADING SYSTEM | PLATINUM-INDUCED OTOTOXICITY | OTOACOUSTIC EMISSIONS | PHARMACOLOGY & PHARMACY | CISPLATIN-INDUCED OTOTOXICITY | AMINOGLYCOSIDE ANTIBIOTICS | VANCOMYCIN OTOTOXICITY | DNA ADDUCTS | CHILDREN | Pharmacogenetics | Drug-Related Side Effects and Adverse Reactions - prevention & control | Hearing Loss - physiopathology | Hearing Loss - epidemiology | Humans | Drug-Related Side Effects and Adverse Reactions - epidemiology | Hearing Loss - genetics | Animals | Antineoplastic Agents - adverse effects | Drug-Related Side Effects and Adverse Reactions - genetics | Aminoglycosides - adverse effects | Child | Hearing Loss - chemically induced | Ear - physiopathology | Hearing Loss - prevention & control | Psychological aspects | Usage | Antibiotics | Analysis | Children | Health aspects | Quality of life
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8. Full Text Association between genetic polymorphisms and platinuminduced ototoxicity in children
by Lui, Gabrielle and Bouazza, Naïm and Denoyelle, Françoise and Moine, Marion and Brugières, Laurence and Chastagner, Pascal and Corradini, Nadège and Entz-Werle, Natacha and Vérité, Cécile and Landmanparker, Judith and Sudour-Bonnange, Hélène and Pasquet, Marlène and Verschuur, Arnauld and Faure-Conter, Cécile and Doz, François and Tréluyer, Jean-Marc
Oncotarget, 07/2018, Volume 9, Issue 56, pp. 30883 - 30893
Pharmacogenetics | Children | Platinum | Cancer | Ototoxicity
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9. Full Text The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea
by García-Alcántara, Fernando and Murillo-Cuesta, Silvia and Pulido, Sara and Bermúdez-Muñoz, Jose M and Martínez-Vega, Raquel and Milo, Marta and Varela-Nieto, Isabel and Rivera, Teresa
Hearing Research, ISSN 0378-5955, 02/2018, Volume 358, pp. 10 - 21
Aminoglycoside antibiotics are used widely in medicine despite their ototoxic side-effects. Oxidative stress and inflammation are key mechanisms determining... 
Il4 | Antioxidant therapy | Gpx1 | Il1b | Sod1 | PCR-arrays | PCR DATA | Sodi | AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY | GENTAMICIN OTOTOXICITY | SUSCEPTIBILITY | AUDITORY HAIR-CELLS | NOISE | MECHANISMS | NEUROSCIENCES | INDUCED HEARING-LOSS | AMINOGLYCOSIDE-INDUCED OTOTOXICITY | OTORHINOLARYNGOLOGY | CISPLATIN-INDUCED OTOTOXICITY | Ilib | NADPH OXIDASES
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10. Full Text Hearing loss in patients on treatment for drug-resistant tuberculosis
by Seddon, James A and Godfrey-Faussett, Peter and Jacobs, Kayleen and Ebrahim, Adam and Hesseling, Anneke C and Schaaf, H. Simon
European Respiratory Journal, ISSN 0903-1936, 11/2012, Volume 40, Issue 5, pp. 1277 - 1286
The treatment of drug-resistant (DR)-tuberculosis (TB) necessitates the use of second-line injectable anti-TB drugs which are associated with hearing loss.... 
Systematic review | Tuberculosis | Drug resistant | Hearing loss | Ototoxicity | CISPLATIN OTOTOXICITY | PRACTICAL GRADING SYSTEM | TREATMENT OUTCOMES | tuberculosis | RETROSPECTIVE COHORT | MDR-TB | systematic review | COMMUNITY-BASED THERAPY | AMINOGLYCOSIDE-INDUCED OTOTOXICITY | CURRENT STATE | ototoxicity | RESPIRATORY SYSTEM | STANDARDIZED TREATMENT | hearing loss | LANGUAGE-DEVELOPMENT | Hearing Loss - diagnosis | Antitubercular Agents - adverse effects | Humans | Hearing Loss - chemically induced | Hearing Tests | Antitubercular Agents - therapeutic use | Tuberculosis, Multidrug-Resistant - drug therapy
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11. Full Text PREVALENCE OF OTOTOXICITY FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PEDIATRIC PATIENTS
by Gertson, Kristen and Hayashi, Susan S and Trinkaus, Kathryn and Wan, Fei and Hayashi, Robert J
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, ISSN 1083-8791, 09/2019
The use of hematopoietic stem cell transplantation (HSCT) is increasing for a variety of diseases. Ototoxicity from this procedure has not been extensively... 
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12. Full Text Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium
by Clemens, Eva and van den Heuvel-Eibrink, Marry M and Mulder, Renée L and Kremer, Leontien C M and Hudson, Melissa M and Skinner, Roderick and Constine, Louis S and Bass, Johnnie K and Kuehni, Claudia E and Langer, Thorsten and van Dalen, Elvira C and Bardi, Edith and Bonne, Nicolas-Xavier and Brock, Penelope R and Brooks, Beth and Carleton, Bruce and Caron, Eric and Chang, Kay W and Johnston, Karen and Knight, Kristin and Nathan, Paul C and Orgel, Etan and Prasad, Pinki K and Rottenberg, Jan and Scheinemann, Katrin and de Vries, Andrica C H and Walwyn, Thomas and Weiss, Annette and am Zehnhoff-Dinnesen, Antoinette and Cohn, Richard J and Landier, Wendy and Int Guideline Harmonization Grp and International Guideline Harmonization Group ototoxicity group
The Lancet Oncology, ISSN 1470-2045, 01/2019, Volume 20, Issue 1, pp. e29 - e41
Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of... 
ONCOLOGY | PLATINUM-INDUCED OTOTOXICITY | PEDIATRIC-PATIENTS | SODIUM THIOSULFATE | TERM-FOLLOW-UP | GRADING SCALES | CISPLATIN-INDUCED OTOTOXICITY | CEREBROSPINAL-FLUID | INDUCED HEARING-LOSS | BRAIN-TUMORS | SHUNT PLACEMENT | Cancer survivors | Youth | Teenagers | Cancer in children
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13. Full Text An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
by Karasawa, Takatoshi and Steyger, Peter S
Toxicology Letters, ISSN 0378-4274, 09/2015, Volume 237, Issue 3, pp. 219 - 227
Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent... 
Intracellular mechanisms | Nephrotoxicity | Cisplatin | Ototoxicity | ACUTE KIDNEY INJURY | INNER-EAR | VERTEBRATE HAIR-CELLS | PLATINUM-INDUCED OTOTOXICITY | SHORT INTERFERING RNA | MITOCHONDRIAL PATHWAYS | GUINEA-PIG | RENAL-CELL APOPTOSIS | RECEIVING CISPLATIN | INDUCED HEARING-LOSS | TOXICOLOGY | Vestibular Diseases - pathology | Reactive Oxygen Species - metabolism | Antineoplastic Agents - adverse effects | Kidney Diseases - pathology | Humans | Kidney Diseases - chemically induced | Cisplatin - adverse effects | Vestibular Diseases - chemically induced | Antimitotic agents | Antineoplastic agents | Index Medicus
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14. Hearing health of workers exposed to noise and insecticides
by Teixeira, CF and Augusto, LGS and Morata, TC
Revista de Saude Publica, Sao Paulo, ISSN 0034-8910, 08/2003, Volume 37, Issue 4, pp. 417 - 423
Objective To examine the peripheral auditory disorders in a group of workers exposed to organophosphate and pyrethroid insecticides, used in vector control... 
ototoxicity
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15. Věk jako rizikový faktor ototoxicity způsobené cisplatinou
by Hošnová, D
Otorinolaryngologie a Foniatrie, ISSN 1210-7867, 01/2015, Volume 64, Issue 1, pp. 3 - 7
Cisplatin | Ototoxicity
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16. Full Text The side effects of platinum-based chemotherapy drugs: a review for chemists
by Oun, Rabbab and Moussa, Yvonne E and Wheate, Nial J
Dalton Transactions, ISSN 1477-9226, 5/2018, Volume 47, Issue 19, pp. 6645 - 6653
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is... 
THERAPY | POLYMORPHISMS | TOXICITIES | OXALIPLATIN-INDUCED NEUROTOXICITY | OTOTOXICITY | ANTICANCER DRUGS | HEPATOTOXICITY | CISPLATIN NEPHROTOXICITY | CANCER SURVIVORS | DELIVERY | CHEMISTRY, INORGANIC & NUCLEAR
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17. Full Text Aminoglycoside-induced cochleotoxicity: A review
by Jiang, Meiyan and Karasawa, Takatoshi and Steyger, Peter S
Frontiers in Cellular Neuroscience, ISSN 1662-5102, 10/2017, Volume 11, p. 308
Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-threatening bacterial infections, including tuberculosis, sepsis,... 
Systemic administration | Gentamicin | Aminoglycosides | Cochleotoxicity | Inflammation | Nephrotoxicity | Ototoxicity | HAIR CELL-DEATH | EAR SUPPORTING CELLS | INNER-EAR | GENTAMICIN OTOTOXICITY | cochleotoxicity | GUINEA-PIGS | systemic administration | ZEBRAFISH LATERAL-LINE | NEUROSCIENCES | INDUCED HEARING-LOSS | nephrotoxicity | ototoxicity | inflammation | gentamicin | aminoglycosides | NEONATAL INTENSIVE-CARE | LOW-DOSE KANAMYCIN | CISPLATIN-INDUCED OTOTOXICITY | Complications and side effects | Dosage and administration | Hearing disorders | Risk factors | Drugs | Intensive care | Prophylaxis | Cytotoxicity | Infections | Urinary tract | Hearing protection | Inner ear | Diuretics | Bacteria | Aminoglycoside antibiotics | Vestibular system | Cystic fibrosis | Hearing impairment | Hearing loss | Tuberculosis | Antibiotics | Endocarditis | Auditory system | Cochlea | Sepsis | Mutation | Intracellular | Glycopeptides
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