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Journal of Neuroscience, ISSN 0270-6474, 05/2005, Volume 25, Issue 19, pp. 4856 - 4867
The transcription factor Otx2 is required to determine mesencephalic versus metencephalic ( cerebellum/ pons) territory during embryogenesis. This function of... 
Cerebellum | Dopaminergic neurons | Serotonergic neurons | Conditional inactivation | Neuronal identity | Midbrain | Otx2 | CEREBELLAR GRANULE NEURONS | midbrain | HINDBRAIN BOUNDARY | MID/HINDBRAIN ORGANIZER | conditional inactivation | IN-SITU HYBRIDIZATION | NEUROSCIENCES | cerebellum | DEVELOPING NERVOUS-SYSTEM | NEURAL DEVELOPMENT | MESENCEPHALIC DOPAMINERGIC-NEURONS | MUTANT MICE | neuronal identity | dopaminergic neurons | serotonergic neurons | ISTHMIC ORGANIZER | SONIC-HEDGEHOG | Nestin | Mesencephalon - cytology | Age Factors | Serotonin - genetics | Embryo, Mammalian | Homeodomain Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Receptors, Cell Surface | Intracellular Signaling Peptides and Proteins - metabolism | Wnt1 Protein - metabolism | Cell Differentiation - genetics | Fibroblast Growth Factor 8 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Kruppel-Like Transcription Factors - metabolism | Body Patterning | Intermediate Filament Proteins - genetics | Neurons - physiology | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Otx Transcription Factors - physiology | Patched Receptors | Cell Differentiation - physiology | In Situ Hybridization - methods | Dopamine - metabolism | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Embryonic Induction - genetics | Mice, Transgenic | In Situ Nick-End Labeling - methods | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Immunohistochemistry - methods | Transcription Factors - metabolism | Animals | Cell Count - methods | Mesencephalon - embryology | Serotonin - metabolism | Organizers, Embryonic - metabolism | Otx Transcription Factors - deficiency | Mesencephalon - growth & development | Mice | Zinc Finger Protein GLI1 | Immunohistochemistry | Wnt1 Protein | Embryo | Mesencephalon | Cell Count | Otx Transcription Factors | Bromodeoxyuridine | Life Sciences | In Situ Hybridization | Gene Expression Regulation, Developmental | Cell Differentiation | Organizers, Embryonic | Basic Helix-Loop-Helix Transcription Factors | In Situ Nick-End Labeling | Dopamine | Serotonin | Neurons | Biochemistry, Molecular Biology | Intracellular Signaling Peptides and Proteins | Embryonic Induction | Nerve Tissue Proteins | Kruppel-Like Transcription Factors | Membrane Proteins | Homeodomain Proteins | Transcription Factors | Molecular biology | Intermediate Filament Proteins | Fibroblast Growth Factor 8 | Plasticity | Development | Repair
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2008, Volume 28, Issue 31, pp. 7748 - 7764
Journal Article
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 12/2001, Volume 4, Issue 12, pp. 1175 - 1181
Local expression of FGF8 at the mid/hindbrain boundary (MHB) governs the development of multiple neurons and support cells. Here we show that the paired-domain... 
MOUSE-BRAIN | MIDBRAIN DEVELOPMENT | VISCERAL ENDODERM | MID/HINDBRAIN ORGANIZER | INT-1 PROTOONCOGENE | ANTERIOR NEURAL PLATE | OTX2 EXPRESSION | NEUROSCIENCES | ISTHMIC ORGANIZER | SEQUENTIAL ROLES | CONTAINING GENE | Wnt1 Protein | Mesencephalon - cytology | Mesencephalon - metabolism | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | Transcription Factors - deficiency | Fibroblast Growth Factors - genetics | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Otx Transcription Factors | Wnt Proteins | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Rhombencephalon - cytology | Cell Differentiation - genetics | Fibroblast Growth Factors - metabolism | Neuroglia - cytology | Trans-Activators - genetics | Fetus | Neurons - metabolism | Rhombencephalon - embryology | PAX2 Transcription Factor | Embryonic Induction - genetics | Proto-Oncogene Proteins - metabolism | Paired Box Transcription Factors | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chick Embryo | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Nuclear Proteins | Proteins - genetics | Transcription Factors - metabolism | PAX5 Transcription Factor | Animals | Mesencephalon - embryology | Proteins - metabolism | Trans-Activators - deficiency | Rhombencephalon - metabolism | Neuroglia - metabolism | Trans-Activators - metabolism | Mice | PAX8 Transcription Factor | Body Patterning - genetics | Fibroblast Growth Factor 8 | Physiological aspects | Fibroblast growth factors | Research | Mesencephalon | Neurons
Journal Article
Journal Article
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2002, Volume 115, Issue 3, pp. 657 - 667
Knock-out Otx1 mice show brain hypoplasia, spontaneous epileptic seizures and abnormalities of the dorsal region of the neocortex. We investigated structural... 
epilepsy | GABA | immunocytochemistry | homeobox | neocortex | Homeobox | Neocortex | Immunocytochemistry | Epilepsy | Immunohistochemistry | Pyramidal Cells - metabolism | Transcription Factors - deficiency | Receptors, N-Methyl-D-Aspartate - metabolism | Somatosensory Cortex - abnormalities | Gene Expression Regulation, Developmental - genetics | Parvalbumins - metabolism | Epilepsy - metabolism | Male | Otx Transcription Factors | Glial Fibrillary Acidic Protein - metabolism | Neural Inhibition - physiology | Neurons - ultrastructure | Nervous System Malformations - metabolism | Isoenzymes - metabolism | Epilepsy - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Nervous System Malformations - genetics | Pyramidal Cells - ultrastructure | Somatosensory Cortex - ultrastructure | Nervous System Malformations - pathology | Transcription Factors - genetics | Microscopy, Electron | Homeodomain Proteins - genetics | Mice, Knockout | Animals | Carrier Proteins - metabolism | Organic Anion Transporters | Neural Pathways - abnormalities | Biomarkers | Glutamate Decarboxylase - metabolism | Neural Pathways - metabolism | Mice | Neural Pathways - ultrastructure | GABA Plasma Membrane Transport Proteins | Neurofilament Proteins - metabolism | Epilepsy - pathology | Somatosensory Cortex - metabolism
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 04/2011, Volume 164, Issue 4, pp. 457 - 465
Background: Pituitary stalk interruption syndrome (PSIS) is a particular entity in the population of patients with hypopituitarism. Only rare cases have a... 
VARIABILITY | HYPOPITUITARISM | ENDOCRINOLOGY & METABOLISM | MAGNETIC-RESONANCE |