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1. Full Text Vascular endothelial FSH receptor, a target of interest for cancer therapy
by Ghinea, Nicolae
Endocrinology, ISSN 0013-7227, 2018, Volume 159, Issue 9, pp. 3268 - 3274
Improved molecular understanding of tumor microenvironment has resulted in the identification of various cancer cell targets for diagnostic and therapeutic... 
ANTIANGIOGENIC THERAPY | NEUROENDOCRINE TUMORS | FUNCTIONAL EXPRESSION | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | GROWTH-FACTOR | MONOCLONAL-ANTIBODIES | IMMUNOHISTOCHEMICAL DETECTION | TUMOR BLOOD-VESSELS | EPITHELIAL OVARIAN-CANCER | LUTEINIZING-HORMONE | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Cell Proliferation | Receptors, FSH - immunology | Humans | Ovarian Neoplasms - pathology | Tumor Microenvironment | Male | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Sarcoma - blood supply | Breast Neoplasms - metabolism | Drug Delivery Systems | Antibodies, Monoclonal, Humanized | Female | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Receptors, FSH - metabolism | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Neoplasm Invasiveness | Neoplasms - blood supply | Breast Neoplasms - blood supply | Sarcoma - drug therapy | Sarcoma - pathology | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Sarcoma - metabolism | Breast Neoplasms - pathology | Endothelium, Vascular - metabolism | Neoplasms - pathology | Cell Movement | Cell proliferation | Therapy | Ovarian carcinoma | Coupling agents | Arterioles | Epithelial cells | Menopause | Antibodies | Cancer therapies | Cell surface | Blood | Ovarian cancer | Angiogenesis | Capillaries | Localization | Follicle-stimulating hormone | Reproductive systems | Therapeutic applications | Markers | Glycoprotein | Blood vessels | Breast cancer | Pharmacology | Chemical compounds | Endothelial cells | Blood circulation | Diagnostic systems | Reproductive system | Solid tumors | Prostate cancer | Prostate | Cell migration | Tumors
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2. Full Text Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
by Grange, Cristina and Tapparo, Marta and Collino, Federica and Vitillo, Loriana and Damasco, Christian and Deregibus, Maria Chiara and Tetta, Ciro and Bussolati, Benedetta and Camussi, Giovanni
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5346 - 5356
Recent studies suggest that tumor-derived microvesicles (MV) act as a vehicle for exchange of genetic information between tumor and stromal cells, engendering... 
HORIZONTAL TRANSFER | CIRCULATING MICRORNA | MESSENGER-RNA | ONCOLOGY | ENDOTHELIAL-CELLS | EXOSOMES | DIAGNOSTIC BIOMARKERS | OVARIAN-CANCER | TUMOR-DERIVED MICROVESICLES | EXPRESSION | MICRORNA SIGNATURES | Angiogenic Proteins - genetics | Neoplastic Stem Cells - cytology | Humans | Receptors, Cell Surface - analysis | Tumor Microenvironment | Transplantation, Heterologous | Antigens, CD - analysis | Endoglin | Immunomagnetic Separation | Lung Neoplasms - secondary | Matrix Metalloproteinase 9 - genetics | Exosomes - physiology | Epithelial-Mesenchymal Transition | Neovascularization, Pathologic - physiopathology | Antigens, Neoplasm - analysis | Angiogenic Proteins - biosynthesis | Carcinoma, Renal Cell - blood supply | Exosomes - secretion | Lung Neoplasms - blood supply | Matrix Metalloproteinase 9 - biosynthesis | Carcinoma, Renal Cell - pathology | Neoplasm Invasiveness | Cells, Cultured | MicroRNAs - biosynthesis | Mice, SCID | Neoplastic Stem Cells - transplantation | Animals | RNA, Neoplasm - biosynthesis | Endothelial Cells - cytology | Carcinoma, Renal Cell - secondary | Kidney Neoplasms - pathology | Exosomes - chemistry | Mice
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3. Full Text A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment
by Kerbel, Robert S
Cancer Journal (United States), ISSN 1528-9117, 07/2015, Volume 21, Issue 4, pp. 274 - 283
The clinical circumstance of treating spontaneous metastatic disease, after resection of primary tumors, whether advanced/overt or microscopic in nature, is... 
antiangiogenic drugs | metronomic low-dose chemotherapy | spontaneous metastatic disease | experimental therapeutic investigations | 1ST-LINE TREATMENT | ANTITUMOR-ACTIVITY | PLUS PACLITAXEL | MOUSE MODELS | PHASE-III TRIAL | BREAST-CANCER | THERAPY | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | DOUBLE-BLIND | ORAL TOPOTECAN | Neoplasm Transplantation | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Melanoma - blood supply | Administration, Metronomic | Humans | Ovarian Neoplasms - pathology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Angiogenesis Inhibitors - administration & dosage | Neoplasm Metastasis - drug therapy | Colorectal Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Female | Ovarian Neoplasms - blood supply | Drug Evaluation, Preclinical | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Tumor Microenvironment - drug effects | Colorectal Neoplasms - blood supply | Neoplasms - blood supply | Breast Neoplasms - blood supply | Melanoma - pathology | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Neovascularization, Pathologic - drug therapy | Melanoma - drug therapy | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Colorectal Neoplasms - pathology | Kidney Neoplasms - drug therapy | Kidney Neoplasms - blood supply
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4. Full Text Targeting the tumour microenvironment in ovarian cancer
by Hansen, Jean M and Coleman, Robert L and Sood, Anil K
European Journal of Cancer, ISSN 0959-8049, 2015, Volume 56, pp. 131 - 143
Abstract The study of cancer initiation, growth, and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to... 
Hematology, Oncology and Palliative Medicine | Tumour microenvironment | Ovarian cancer | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | INFILTRATING LYMPHOCYTES | PHASE-II | OPEN-LABEL | RECURRENT OVARIAN | MYELOID CELLS | MAINTENANCE THERAPY | ONCOLOGY | CD8(+) T-LYMPHOCYTES | MACROPHAGE POLARIZATION | EPITHELIAL OVARIAN | Neoplasms, Glandular and Epithelial - blood supply | Humans | Neovascularization, Pathologic | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Neoplasms, Glandular and Epithelial - immunology | Angiogenesis Inhibitors - therapeutic use | Female | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Ovarian Neoplasms - drug therapy | Fibroblasts - metabolism | Tumor Microenvironment - drug effects | Neoplasms, Glandular and Epithelial - pathology | Endothelial Cells - metabolism | Fibroblasts - pathology | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Fibroblasts - drug effects | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Cell Proliferation - drug effects | Endothelial Cells - pathology | Endothelial Cells - drug effects | Ovarian Neoplasms - immunology | Chemotherapy | Relapse | RNA | Metastasis | Health aspects | Diseases | Cancer | tumor microenvironment
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5. Full Text Microvesicles: Mediators of extracellular communication during cancer progression
by Muralidharan-Chari, Vandhana and Clancy, James W and Sedgwick, Alanna and D'Souza-Schorey, Crislyn
Journal of Cell Science, ISSN 0021-9533, 05/2010, Volume 123, Issue 10, pp. 1603 - 1611
Microvesicles are generated by the outward budding and fission of membrane vesicles from the cell surface. Recent studies suggest that microvesicle shedding is... 
Signaling | Tumor invasion | Microvesicles | OVARIAN-CANCER | DIAGNOSTIC BIOMARKERS | CELL-LINES | PLASMA-MEMBRANE | BIOLOGICAL-MEMBRANES | CELL BIOLOGY | MEMBRANE-VESICLES | GROWTH-FACTOR | RELEASED MICROVESICLES | TUMOR-DERIVED MICROVESICLES | TISSUE FACTOR | Tumor Escape | Neoplasm Invasiveness | Humans | Neovascularization, Pathologic | Cell Communication | Drug Resistance, Neoplasm | Lipid Metabolism | Neoplasms - blood supply | Disease Progression | Animals | Cell Transformation, Neoplastic | Cell-Derived Microparticles - immunology | Blood Coagulation | Biomarkers, Tumor - metabolism | Cell-Derived Microparticles - pathology | Cell-Derived Microparticles - metabolism | Neoplasms - physiopathology | Neoplasms - pathology | Oncogenes | Commentaries
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6. Full Text Bevacizumab-Induced Normalization of Blood Vessels in Tumors Hampers Antibody Uptake
by Arjaans, Marlous and Munnink, Thijs H. Oude and Oosting, Sjoukje F and Terwisscha Van Scheltinga, Anton and Gietema, Jourik A and Garbacik, Erik T and Timmer-Bosscha, Hetty and Lub-de Hooge, Marjolijn N and Schroder, Carolina P and de Vries, Elisabeth G. E
Cancer Research, ISSN 0008-5472, 06/2013, Volume 73, Issue 11, pp. 3347 - 3355
In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired lymphatic drainage that is associated with increased vascular... 
VASCULAR NORMALIZATION | CETUXIMAB | THERAPY | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | VEGF | BLOCKADE | CANCER | ENDOTHELIAL GROWTH-FACTOR | XENOGRAFTS | DELIVERY | Humans | Radioisotopes | Male | Positron-Emission Tomography | Bevacizumab | Ovarian Neoplasms - diagnostic imaging | Drug Interactions | Zirconium - pharmacokinetics | Antibodies, Monoclonal, Humanized - pharmacokinetics | Antibodies, Monoclonal, Humanized - pharmacology | Esophageal Neoplasms - metabolism | Female | Antineoplastic Agents - pharmacokinetics | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Ovarian Neoplasms - drug therapy | Radiopharmaceuticals - pharmacokinetics | Angiogenesis Inhibitors - pharmacology | Xenograft Model Antitumor Assays | Animals | Esophageal Neoplasms - blood supply | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Esophageal Neoplasms - drug therapy | Esophageal Neoplasms - diagnostic imaging | Trastuzumab | Immunoglobulin G - metabolism
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7. Full Text The clinical implication of cancer-associated microvasculature and fibroblast in advanced colorectal cancer patients with synchronous or metachronous metastases
by Kwak, Yoonjin and Lee, Hee Eun and Kim, Woo Ho and Kim, Duck-Woo and Kang, Sung-Bum and Lee, Hye Seung
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91811
Background: We aimed to evaluate the clinical significance of microvessel density (MVD), lymphatic vessel density (LVD), and cancer-associated fibroblasts... 
HETEROGENEITY | SURVIVAL | MULTIDISCIPLINARY SCIENCES | BREAST CARCINOMAS | PTEN | MICROVESSEL DENSITY | STROMA | MUTATIONS | LYMPHATIC VESSEL DENSITY | TUMOR-GROWTH | EXPRESSION | Prognosis | Lung Neoplasms - mortality | Colorectal Neoplasms - genetics | Humans | Middle Aged | Neovascularization, Pathologic | Microvessels - pathology | Male | Ovarian Neoplasms - mortality | Liver Neoplasms - mortality | Actins - genetics | Ovarian Neoplasms - genetics | Lymphatic Vessels - blood supply | Ovarian Neoplasms - secondary | Lung Neoplasms - secondary | Aged, 80 and over | Peritoneal Neoplasms - blood supply | Adult | Female | Ovarian Neoplasms - blood supply | Liver Neoplasms - secondary | Lung Neoplasms - blood supply | Peritoneal Neoplasms - secondary | Colorectal Neoplasms - mortality | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Colorectal Neoplasms - blood supply | Liver Neoplasms - genetics | Lymphatic Metastasis | Fibroblasts - pathology | Peritoneal Neoplasms - mortality | Liver Neoplasms - blood supply | Peritoneal Neoplasms - genetics | Lymphatic Vessels - pathology | Survival Analysis | Desmin - genetics | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Immunohistochemistry | Cancer patients | Care and treatment | Metastasis | Muscle proteins | Colorectal cancer | Liver | Colorectal carcinoma | Regional analysis | Muscles | Smooth muscle | Patients | Desmin | Lymph nodes | Metastases | Studies | Pathology | Heterogeneity | Lungs | Actin | Rodents | Fibroblasts | Microenvironments | Microvasculature | Mutation | PTEN protein | Cancer | Peritoneum
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8. Full Text Tumor delivery of macromolecular drugs based on the EPR effect
by Torchilin, Vladimir
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2011, Volume 63, Issue 3, pp. 131 - 135
Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This... 
Intracellular drug delivery | Tumor targeting | EPR effect | Peptide drugs | Polymeric drugs | Drug delivery | Protein drugs | Tumors | Pharmaceutical nanocarriers | ADVANCED SOLID TUMORS | OVARIAN-CANCER | LONG-CIRCULATING LIPOSOMES | PHASE-II TRIAL | ENHANCED PERMEABILITY | METASTATIC BREAST-CANCER | IN-VIVO | PHARMACOLOGY & PHARMACY | PEGYLATED-LIPOSOMAL DOXORUBICIN | TARGETED DELIVERY | Neoplasms - metabolism | Gene Transfer Techniques | Animals | Capillary Permeability | Humans | Neoplasms - blood supply | Extravasation of Diagnostic and Therapeutic Materials - metabolism | Neoplasms - physiopathology | Macromolecular Substances - metabolism | Drug Delivery Systems | Extravasation of Diagnostic and Therapeutic Materials - physiopathology | Neoplasms - drug therapy | Data processing
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9. Full Text Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer
by Carpini, Jennifer Delli and Karam, Amer K and Montgomery, Leslie
Angiogenesis, ISSN 0969-6970, 3/2010, Volume 13, Issue 1, pp. 43 - 58
Tumor neovascularization is a complex process that plays a crucial role in the development of many different types of cancer. Vascular endothelial growth... 
VEGF | Oncology | Breast cancer | Biomedicine general | Cell Biology | Ovarian cancer | Biomedicine | Cancer Research | Mitogen | Ophthalmology | Cardiology | Vascular endothelial growth factor | Cervical cancer | TUMOR STROMA GENERATION | PERMEABILITY FACTOR | ESTROGEN-RECEPTOR STATUS | HUMAN-PAPILLOMAVIRUS | CELL GROWTH | FACTOR VEGF EXPRESSION | ANGIOGENIC FACTORS | SIGNAL-TRANSDUCTION | PERIPHERAL VASCULAR DISEASE | PHASE-II CONSORTIA | PRIMARY PERITONEAL | Neoplasms - metabolism | Prognosis | Uterine Cervical Neoplasms - blood supply | Uterine Cervical Neoplasms - diagnosis | Ovarian Neoplasms - diagnosis | Humans | Ovarian Neoplasms - pathology | Neoplasms - blood supply | Uterine Cervical Neoplasms - pathology | Neoplasms - diagnosis | Vascular Endothelial Growth Factor A - metabolism | Breast Neoplasms - blood supply | Breast Neoplasms - therapy | Neoplasms - therapy | Breast Neoplasms - pathology | Ovarian Neoplasms - therapy | Female | Breast Neoplasms - diagnosis | Neovascularization, Pathologic - metabolism | Ovarian Neoplasms - blood supply | Uterine Cervical Neoplasms - therapy | Care and treatment | Physiological aspects | Genetic aspects | Research | Neovascularization
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10. Full Text Tumor angiogenic marker expression levels during tumor growth: Longitudinal assessment with molecularly targeted microbubbles and US imaging
by Deshpande, Nirupama and Ren, Ying and Foygel, Kira and Rosenberg, Jarrett and Willmann, Jürgen K
Radiology, ISSN 0033-8419, 03/2011, Volume 258, Issue 3, pp. 804 - 811
Purpose: To evaluate the use of molecularly targeted microbubbles (MBs) and ultrasonography (US) in the noninvasive assessment of the level of expression of... 
ULTRASOUND | ENDOGLIN | INTEGRIN | MICE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CONTRAST AGENT | CANCER-THERAPY | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - blood supply | Intracellular Signaling Peptides and Proteins - metabolism | Mammary Neoplasms, Experimental - metabolism | Integrins - metabolism | Neovascularization, Pathologic - diagnostic imaging | Ovarian Neoplasms - diagnostic imaging | Endoglin | Flow Cytometry | Statistics, Nonparametric | Ultrasonography | Biomarkers, Tumor - metabolism | Microbubbles | Female | Mammary Neoplasms, Experimental - blood supply | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mammary Neoplasms, Experimental - diagnostic imaging | Animals | Image Processing, Computer-Assisted | Contrast Media - metabolism | Mice | Pancreatic Neoplasms - diagnostic imaging | Original Research
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11. Full Text T-Regulatory cells: Key players in tumor immune escape and angiogenesis
by Facciabene, Andrea and Motz, Gregory T and Coukos, George
Cancer Research, ISSN 0008-5472, 05/2012, Volume 72, Issue 9, pp. 2162 - 2171
T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical... 
METASTATIC MELANOMA | TGF-BETA | ONCOLOGY | PHASE-I TRIAL | COLON-CANCER PATIENTS | LOW-DOSE CYCLOPHOSPHAMIDE | STAGE OVARIAN-CANCER | CHRONIC LYMPHOCYTIC-LEUKEMIA | MEDIATED SUPPRESSION | MONOCLONAL-ANTIBODY | ANTITUMOR IMMUNITY | Neoplasms - therapy | Animals | Neoplasms - immunology | Humans | Neoplasms - blood supply | Neovascularization, Pathologic - immunology | Neovascularization, Pathologic - therapy | T-Lymphocytes, Regulatory - immunology | Tumor Escape - immunology
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12. Full Text Tumor–platelet interaction in solid tumors
by Buergy, Daniel and Wenz, Frederik and Groden, Christoph and Brockmann, Marc A
International Journal of Cancer, ISSN 0020-7136, 06/2012, Volume 130, Issue 12, pp. 2747 - 2760
Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of... 
thrombocytosis | cancer | metastasis | angiogenesis | platelets | GYNECOLOGIC-ONCOLOGY-GROUP | HEMATOPOIETIC STEM-CELL | LEUKEMIA INHIBITORY FACTOR | MPL-DEFICIENT MICE | RENAL-CELL CARCINOMA | EPITHELIAL OVARIAN-CARCINOMA | METASTATIC MALIGNANT-MELANOMA | LUNG-CANCER | COLORECTAL-CANCER PATIENTS | ONCOLOGY | ENDOTHELIAL GROWTH-FACTOR | Blood Platelets - pathology | Neoplasm Metastasis | Neoplasms - blood | Platelet Count | Humans | Neovascularization, Pathologic | Neoplasms - blood supply | Neoplasms - pathology | Survival | Thrombocytosis - pathology | Medical prognosis | Rodents | Tumors
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