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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | Medical innovations | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
by Hendry, Shona and Salgado, Roberto and Gevaert, Thomas and Russell, Prudence A and John, Tom and Thapa, Bibhusal and Christie, Michael and van de Vijver, Koen and Estrada, M V and Gonzalez-Ericsson, Paula I and Sanders, Melinda and Solomon, Benjamin and Solinas, Cinzia and Van den Eynden, Gert G G M and Allory, Yves and Preusser, Matthias and Hainfellner, Johannes and Pruneri, Giancarlo and Vingiani, Andrea and Demaria, Sandra and Symmans, Fraser and Nuciforo, Paolo and Comerma, Laura and Thompson, E A and Lakhani, Sunil and Kim, Seong-Rim and Schnitt, Stuart and Colpaert, Cecile and Sotiriou, Christos and Scherer, Stefan J and Ignatiadis, Michail and Badve, Sunil and Pierce, Robert H and Viale, Giuseppe and Sirtaine, Nicolas and Penault-Llorca, Frederique and Sugie, Tomohagu and Fineberg, Susan and Paik, Soonmyung and Srinivasan, Ashok and Richardson, Andrea and Wang, Yihong and Chmielik, Ewa and Brock, Jane and Johnson, Douglas B and Balko, Justin and Wienert, Stephan and Bossuyt, Veerle and Michiels, Stefan and Ternes, Nils and Burchardi, Nicole and Luen, Stephen J and Savas, Peter and Klauschen, Frederick and Watson, Peter H and Nelson, Brad H and Criscitiello, Carmen and O'Toole, Sandra and Larsimont, Denis and de Wind, Roland and Curigliano, Giuseppe and André, Fabrice and Lacroix-Triki, Magali and van de Vijver, Mark and Rojo, Federico and Floris, Giuseppe and Bedri, Shahinaz and Sparano, Joseph and Rimm, David and Nielsen, Torsten and Kos, Zuzana and Hewitt, Stephen and Singh, Baljit and Farshid, Gelareh and Loibl, Sibylle and Allison, Kimberly H and Tung, Nadine and Adams, Sylvia and Willard-Gallo, Karen and Horlings, Hugo M and Gandhi, Leena and Moreira, Andre and Hirsch, Fred and Dieci, Maria V and Urbanowicz, Maria and Brcic, Iva and Korski, Konstanty and Gaire, Fabien and Koeppen, Hartmut and Lo, Amy and Giltnane, Jennifer and Rebelatto, Marlon C and Steele, Keith E and Zha, Jiping and Emancipator, Kenneth and Juco, Jonathan W and Denkert, Carsten and Reis-Filho, Jorge and Loi, Sherene and Fox, Stephen B
Advances in anatomic pathology, ISSN 1072-4109, 11/2017, Volume 24, Issue 6, pp. 311 - 335
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2017, Volume 170, Issue 5, pp. 927 - 938.e20
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57911
Background: Immune evasion is one of the recognized hallmarks of cancer. Inflammatory responses to cancer can also contribute directly to oncogenesis. Since... 
BREAST-CANCER | METASTASIS | POLYMERIC IMMUNOGLOBULIN RECEPTOR | BIOMARKER | MULTIDISCIPLINARY SCIENCES | TISSUE | GENE-EXPRESSION | DOWN-REGULATION | KARYOPHERIN-ALPHA 2 | EPITHELIAL OVARIAN-CANCER | T-CELLS | Cell Adhesion Molecules - genetics | Colonic Neoplasms - genetics | Prognosis | Carcinoma, Squamous Cell - genetics | Humans | Gene Expression Regulation, Neoplastic | Databases, Genetic | Data Mining | Gene Expression Profiling | Inflammation - complications | Neoplasms - complications | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Neoplasms - genetics | Colonic Neoplasms - immunology | Adenocarcinoma - genetics | Colonic Neoplasms - mortality | Gene Expression | Adenocarcinoma - immunology | Neoplasms - mortality | Workflow | Inflammation - immunology | Carcinoma, Squamous Cell - immunology | Adenocarcinoma - complications | Colonic Neoplasms - complications | Head and Neck Neoplasms - immunology | Neoplasms - immunology | Carcinoma, Squamous Cell - complications | alpha Karyopherins - genetics | Inflammation - genetics | Head and Neck Neoplasms - complications | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | Head and Neck Neoplasms - mortality | Neoplasm Staging | Adenocarcinoma - mortality | Cluster Analysis | Proteins | Immunohistochemistry | DNA microarrays | Analysis | Genes | Cancer | Ovarian cancer | Transcription factors | Ovarian carcinoma | Leukemia | Lung cancer | CXCL13 protein | Biochemistry | Genomes | Tissue analysis | Metastasis | Datasets | Liver cancer | Angiogenesis | Immunology | Colon cancer | Tumorigenesis | Colon | Neck | Protein transport | Pancreas | Bioinformatics | Immune system | Immunoglobulins | Head | Cytokines | Data processing | Inflammation | Breast cancer | CD36 antigen | Gene expression | Low level | Nuclear transport | Liquid oxygen | Biomarkers | Hypoxia | Molecular biology | Prostate | Prostate cancer
Journal Article
Anticancer Research, ISSN 0250-7005, 08/2009, Volume 29, Issue 8, pp. 2875 - 2884
Background: To identify immunosuppressive elements present in ovarian cancer associated ascites. Patients and Methods: Ascites and plasma were obtained from... 
Cell mediated immunity | Cytokines | Ascites | Chemokines | Ovarian cancer | DENDRITIC CELLS | PANCREATIC-CANCER | PERIPHERAL-BLOOD | chemokines | CYTOTOXIC T-LYMPHOCYTES | TUMOR-INFILTRATING LYMPHOCYTES | ascites | ADOPTIVE TRANSFER | ONCOLOGY | IN-VIVO | cytokines | cell mediated immunity | ANTIGEN-PRESENTING CELLS | PROGNOSTIC-SIGNIFICANCE | ENDOTHELIAL GROWTH-FACTOR | CD8-Positive T-Lymphocytes - pathology | Prognosis | Humans | Middle Aged | Cystadenocarcinoma, Serous - metabolism | Endometrial Neoplasms - metabolism | Ovarian Neoplasms - pathology | CD4-Positive T-Lymphocytes - pathology | Adenocarcinoma, Clear Cell - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Antigen-Presenting Cells - pathology | Endometrial Neoplasms - immunology | Flow Cytometry | Fallopian Tube Neoplasms - immunology | Aged, 80 and over | Ascites - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Ovarian Neoplasms - metabolism | Cystadenocarcinoma, Serous - immunology | Peritoneal Neoplasms - immunology | Peritoneal Neoplasms - pathology | Cystadenocarcinoma, Serous - secondary | Antigen-Presenting Cells - metabolism | Cytokines - metabolism | Adenocarcinoma, Clear Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Fallopian Tube Neoplasms - pathology | Survival Rate | Chromium - metabolism | Antigen-Presenting Cells - immunology | Endometrial Neoplasms - secondary | Adenocarcinoma, Clear Cell - secondary | Ascites - metabolism | Peritoneal Neoplasms - metabolism | Aged | Fallopian Tube Neoplasms - metabolism | CD8-Positive T-Lymphocytes - immunology | Ascites - pathology | Ovarian Neoplasms - immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 46, pp. E9942 - E9951
Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer therapy by releasing the power of the immune system. However, only... 
Mesothelin | Mucin 16 | Immunotherapy | Immunopeptidome | Ovarian cancer | SURVIVAL | ovarian cancer | mucin 16 | MULTIDISCIPLINARY SCIENCES | IMMUNE PRIVILEGE | immunopeptidome | TUMOR | ANTIGENS | CANCER-IMMUNOTHERAPY | IDENTIFICATION | mesothelin | ADVANCED MELANOMA | immunotherapy | EXPRESSION | T-CELLS | Membrane Glycoproteins - analysis | Kallikreins - immunology | CA-125 Antigen - immunology | Galectin 1 - immunology | Membrane Glycoproteins - metabolism | Humans | Vaccination | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Neoplasms, Glandular and Epithelial - immunology | Histocompatibility Antigens Class I - metabolism | Female | Histocompatibility Antigens Class II - metabolism | Ovarian Neoplasms - metabolism | Membrane Glycoproteins - immunology | HLA-DR Antigens - metabolism | Neoplasms, Glandular and Epithelial - pathology | GPI-Linked Proteins - immunology | Histocompatibility Antigens Class I - immunology | Membrane Proteins - immunology | Antigen Presentation - immunology | Membrane Glycoproteins - genetics | Histocompatibility Antigens Class II - immunology | Carcinoma, Ovarian Epithelial | Ligands | HLA-DR Antigens - immunology | Ovarian Neoplasms - immunology | Physiological aspects | Antigens | Peptides | Health aspects | Biological Sciences | PNAS Plus
Journal Article
Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma, non... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2014, Volume 106, Issue 11
Journal Article
Cancer cell, ISSN 1535-6108, 2019, Volume 35, Issue 2, pp. 221 - 237.e8
The high expression across multiple tumor types and restricted expression in normal tissues make B7-H3 an attractive target for immunotherapy. We generated... 
chimerc antigen receptor | pancreatic cancer | ovarian cancer | PD-1/PD-L1 | B7-H3 | CD28 | neuroblastoma | 4-1BB | solid tumors | B7 FAMILY-MEMBER | ONCOLOGY | IMMUNOTHERAPY | ADENOCARCINOMA | PROSTATE-CANCER | COSTIMULATORY MOLECULE | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | EXPRESSION | CARCINOMA | LYMPHOCYTES | CELL BIOLOGY | Coculture Techniques | Humans | Ovarian Neoplasms - pathology | Male | B7 Antigens - immunology | Neuroblastoma - therapy | Carcinoma, Pancreatic Ductal - genetics | Ovarian Neoplasms - genetics | B7 Antigens - genetics | Neuroblastoma - immunology | Female | Carcinoma, Pancreatic Ductal - immunology | Neuroblastoma - pathology | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Signal Transduction | Mice, Inbred C57BL | Neuroblastoma - genetics | Pancreatic Neoplasms - pathology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Pancreatic Neoplasms - genetics | CD28 Antigens - immunology | Carcinoma, Pancreatic Ductal - therapy | Tumor Burden | B7-H1 Antigen - immunology | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Animals | Pancreatic Neoplasms - immunology | Receptors, Chimeric Antigen - immunology | Cell Line, Tumor | Ovarian Neoplasms - therapy | Receptors, Chimeric Antigen - genetics | Ovarian Neoplasms - immunology | Pancreatic Neoplasms - therapy | Antigens | Microbiology | Pancreatic cancer | Immunotherapy | Physiological aspects | T cells | Cells | Ovarian cancer | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2012, Volume 130, Issue 9, pp. 2195 - 2203
Journal Article