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Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
CA: a cancer journal for clinicians, ISSN 0007-9235, 2016, Volume 66, Issue 5, pp. 408 - 436
... when most invasive cancers in most anatomic sites might be prevented with similar interventions. This review, amassed with the collective expertise of pathology colleagues... 
carcinoma in situ | dysplasia | intraepithelial neoplasia | preinvasive neoplasia | precancer | HIGH-GRADE DYSPLASIA | URINARY-BLADDER | BARRETTS-ESOPHAGUS | HUMAN-PAPILLOMAVIRUS | INTRADUCTAL CARCINOMA | CARCINOMA IN-SITU | PAPILLARY UROTHELIAL HYPERPLASIA | ONCOLOGY | SINGLE ACADEMIC CENTER | TERM-FOLLOW-UP | NECK-CANCER IMPLICATIONS | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | Uterine Cervical Neoplasms - pathology | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Esophageal Neoplasms - pathology | Breast Neoplasms - therapy | American Cancer Society | Uterine Cervical Neoplasms - metabolism | Skin Neoplasms - diagnosis | Urinary Bladder Neoplasms - pathology | Female | Ovarian Neoplasms - metabolism | Uterine Cervical Neoplasms - therapy | Skin Neoplasms - pathology | Prostatic Neoplasms - pathology | Uterine Cervical Neoplasms - diagnosis | Skin Neoplasms - therapy | Carcinoma in Situ - pathology | Ovarian Neoplasms - diagnosis | Pancreatic Neoplasms - pathology | Risk Factors | Head and Neck Neoplasms - therapy | Lung Neoplasms - therapy | Carcinoma in Situ - therapy | Head and Neck Neoplasms - pathology | Skin Neoplasms - metabolism | Breast Neoplasms - pathology | Ovarian Neoplasms - therapy | Head and Neck Neoplasms - diagnosis | Breast Neoplasms - diagnosis | Carcinoma in Situ - diagnosis | Carcinoma in Situ - metabolism | Lung Neoplasms - diagnosis | Population Surveillance | Prevention | Care and treatment | Gastrointestinal system | Practice | Pathologists | Metastasis | Patients | Health aspects | Cervical cancer | Risk factors | Pathology | Usage | Diagnosis | Tumors | Medical diagnosis | Cancer
Journal Article
The lancet oncology, ISSN 1470-2045, 2017, Volume 18, Issue 1, pp. 75 - 87
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1... 
Hematology, Oncology and Palliative Medicine | POLY(ADP-RIBOSE) POLYMERASE | OLAPARIB | ONCOLOGY | HOMOLOGOUS RECOMBINATION DEFICIENCY | MUTANT-CELLS | DNA-REPAIR | CANCER | HETEROZYGOSITY | TUMORS | BREAST | GENOMIC LOSS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Germ-Line Mutation - genetics | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Poly(ADP-ribose) Polymerases - chemistry | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Fallopian Tube Neoplasms - pathology | Survival Rate | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | BRCA1 Protein - genetics | International Agencies | Peritoneal Neoplasms - genetics | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indoles - therapeutic use | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Sugars | Monosaccharides | Ovarian cancer | Analysis | Carcinoma | Cancer
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 15500 - 10
Journal Article
Human pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma, non... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer
Journal Article
by Jiang, Xia and Finucane, Hilary K and Schumacher, Fredrick R and Schmit, Stephanie L and Tyrer, Jonathan P and Han, Younghun and Michailidou, Kyriaki and Lesseur, Corina and Kuchenbaecker, Karoline B and Dennis, Joe and Conti, David V and Casey, Graham and Gaudet, Mia M and Huyghe, Jeroen R and Albanes, Demetrius and Aldrich, Melinda C and Andrew, Angeline S and Andrulis, Irene L and Anton-Culver, Hoda and Antoniou, Antonis C and Antonenkova, Natalia N and Arnold, Susanne M and Aronson, Kristan J and Arun, Banu K and Bandera, Elisa V and Barkardottir, Rosa B and Barnes, Daniel R and Batra, Jyotsna and Beckmann, Matthias W and Benitez, Javier and Benlloch, Sara and Berchuck, Andrew and Berndt, Sonja I and Bickeböller, Heike and Bien, Stephanie A and Blomqvist, Carl and Boccia, Stefania and Bogdanova, Natalia V and Bojesen, Stig E and Bolla, Manjeet K and Brauch, Hiltrud and Brenner, Hermann and Brenton, James D and Brook, Mark N and Brunet, Joan and Brunnström, Hans and Buchanan, Daniel D and Burwinkel, Barbara and Butzow, Ralf and Cadoni, Gabriella and Caldés, Trinidad and Caligo, Maria A and Campbell, Ian and Campbell, Peter T and Cancel-Tassin, Géraldine and Cannon-Albright, Lisa and Campa, Daniele and Caporaso, Neil and Carvalho, André L and Chan, Andrew T and Chang-Claude, Jenny and Chanock, Stephen J and Chen, Chu and Christiani, David C and Claes, Kathleen B. M and Claessens, Frank and Clements, Judith and Collée, J. Margriet and Correa, Marcia Cruz and Couch, Fergus J and Cox, Angela and Cunningham, Julie M and Cybulski, Cezary and Czene, Kamila and Daly, Mary B and deFazio, Anna and Devilee, Peter and Diez, Orland and Gago-Dominguez, Manuela and Donovan, Jenny L and Dörk, Thilo and Duell, Eric J and Dunning, Alison M and Dwek, Miriam and Eccles, Diana M and Edlund, Christopher K and Edwards, Digna R Velez and Ellberg, Carolina and Evans, D. Gareth and Fasching, Peter A and Ferris, Robert L and Liloglou, Triantafillos and Figueiredo, Jane C and Fletcher, Olivia and Fortner, Renée T and Fostira, Florentia and Franceschi, Silvia and Friedman, Eitan and Gallinger, Steven J and Ganz, Patricia A and ... and Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Clinical Sciences, Department of Obstetrics and Gynecology and Sahlgrenska Academy
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 431 - 23
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association... 
BREAST-CANCER | LUNG-CANCER | RISK-FACTORS | PARTITIONING HERITABILITY | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | GENETIC ARCHITECTURE | ANALYSES IDENTIFY | MENDELIAN RANDOMIZATION | CELL-TYPES | GENOME-WIDE ASSOCIATION | Lung Neoplasms - ethnology | Colorectal Neoplasms - genetics | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | Prostatic Neoplasms - diagnosis | Case-Control Studies | Colorectal Neoplasms - diagnosis | Ovarian Neoplasms - ethnology | Inheritance Patterns | Ovarian Neoplasms - genetics | Mental Disorders - genetics | Prostatic Neoplasms - genetics | Smoking - physiopathology | Head and Neck Neoplasms - ethnology | Female | Neoplasm Proteins - genetics | Breast Neoplasms - ethnology | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Colorectal Neoplasms - ethnology | Ovarian Neoplasms - diagnosis | European Continental Ancestry Group | Smoking - genetics | Prostatic Neoplasms - ethnology | Head and Neck Neoplasms - pathology | Mental Disorders - physiopathology | Smoking - ethnology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Head and Neck Neoplasms - diagnosis | Head and Neck Neoplasms - genetics | Breast Neoplasms - diagnosis | Mental Disorders - ethnology | Polymorphism, Single Nucleotide | Colorectal Neoplasms - pathology | Lung Neoplasms - diagnosis | Enrichment | Correlation | Statistical analysis | Ovarian carcinoma | Mental disorders | Lung cancer | Colorectal carcinoma | Genomes | Breast cancer | Regulatory sequences | Ovarian cancer | Etiology | Breast | Heritability | Neck | Solid tumors | Prostate cancer | Prostate | Cancer | Smoking | Andrew R.] Univ Bristol | 3400 Civ Ctr | risk-factors | England | Miranda] Univ Bristol | Clalit Natl Canc Control Ctr | Kenneth] Mem Sloan Kettering Canc Ctr | Kinghorn Canc Ctr | randomization | Pring | Div Populat Hlth Hlth Serv Res & Primary Care | Seattle | Upper Maudlin St | Stanford | Sch Womens & Childrens Hlth | Offit | Duarte | Ulrike | Susan J.] Garvan Inst Med Res | Sydney | Moreno | Plaseska-Karanfilska | Victor] Univ Barcelona | Warwick Med Sch | Dept | Lab Med Program | Wilbert H. M.] Radboud Univ Nijmegen | Elizabeth J.] Univ Pretoria | Anna Marie] Univ Hlth Network | Peters | Nielsen | Ness | 18 High St | lung-cancer | Lindstrom | 1275 York | Kenneth] Univ Warwick | Kari] Decode Genet | Blegdamsvej 9 | Harvey A.] Yale Sch Publ Hlth | Neal | Liene] Latvian Biomed Res & Study Ctr | Kirsten B.] Roswell Pk Canc Inst | Science & Technology - Other Topics | partitioning heritability | Dept Genet | Dept Res | Billrothstr11 | Bristol BS2 | Israel | Dept Obstet & Gynecol | Geert Grooteplein Zuid | Dept Canc Biol & Genet | Res Ctr Genet Engn & Biotechnol Georgi | Nussbaum | Iceland | WA 98195 USA | Haartmaninkatu 8 | Paolo] INT | Robert L.] Univ Calif San Francisco | NSW 2010 | Buffalo | 384 Victoria St | Rosenstein | cell-types | CT 06510 USA | Med Ctr | van Rensburg | Gad | Dept Urol | Angela] Salzburg Univ | Dept Chron Dis Epidemiol | Finn Cilius] Copenhagen Univ Hosp | Clin Genet Serv | Dijana] Macedonian Acad Sci & Arts | Nikitina-Zake | 200 Elizabeth St | Susan L.] Beckman Res Inst City Hope | Dept Genet & Genom Sci | Canc Ctr Cluster Salzburg | Muir | IS-101 Reykjavik | Risch | Div Hlth Sci | Sch Med | Canc Genet & Prevent Program | Wei] Vanderbilt Univ | New York | susceptibility loci | genetic architecture | 60 Coll St | Anna Marie] Univ Toronto | Avon | IBELL | Roobol | Dept Populat Sci | NL-3015 CN Rotterdam | Lower Maudlin St | 1275 York Ave | Div Epidemiol | Radice | Fdn IRCCS | Neuenheimer Feld 280 | breast-cancer | 1600 Div St | Wytemaweg 80 | Sturlugata 8 | Latvia | Helsinki Univ Hosp | Coventry CV4 7AL | W Midlands | Catalan Inst Oncol | Unit Mol Bases Genet Risk & Genet Testing | Leon | Lisa F.] Univ Washington | ON M5S | Skopje 1000 | Sch Publ Hlth | Dept Oncol | Susan J.] Univ NSW Sydney | 7 Michal St | Bristol Dent Sch | Cambridge CB1 8RN | NSW | New Haven | Raskin | Moysich | Ratsupites Str 1 | Ctr Genom Med | TLRC H | Toronto | Germany | David E.] Univ Cambridge | Dept Radiat Oncol | Dept Med | Elm & Carlton St | Addenbrookes Hosp | A-5020 | Stefansson | Div Epigen & Canc Risk Factors | Katherine L.] Univ Penn | Abramson Canc Ctr | Via Giacomo | South | Bristol BS1 2LY | Rennert | Spain | Rigshosp | Mulligan | Obstetrics, Gynecology and Reproductive Medicine | Perelman Sch Med | Sara] Univ Washington | Blvd Krste Petkov Misirkov | 1500 E Duarte | genome-wide association | 1 Kings Coll Circle | Dept Gastroenterol | 1425 Madison Ave | Fac Med | mendelian | ZA-0007 Arcadia | Hedy S.] Technion Fac Med | Barry S.] Icahn Sch Med Mt Sinai | Angela] German Ctr Lung Res DZL | Nathanson | Dept Lab Med & Pathobiol | Clin Genet Res Lab | Nevanlinna | Heli] Univ Helsinki | Amanda I | Private Bag X323 | Ramus | ON M5G 2C4 | DK-2100 | 97239 USA | Newcomb | Macedonia | IL-34362 Haifa | PLUS | Div Canc Prevent & Control | San | Janet L | D-69120 Heidelberg | Barcelona 08908 | Monique J.] Erasmus Univ | CA 91010 | Kenneth] Univ Manchester | LV-1067 Riga | Neuhausen | Dept Mol Biol | fremov | NIHR Bristol Biomed Res Ctr Nutr Theme | Hedy S.] Carmel Hosp | analyses identify | FIN | Vanderbilt Ingram Canc Ctr | Oxford Rd | Phipps | Zheng | Angela] DKFZ German Canc Res Ctr | Reproduktionsmedicin och gynekologi
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 1976 - 1985.e10
Background & Aims MUTYH -associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation... 
Gastroenterology and Hepatology | BASE-EXCISION-REPAIR | URINARY-TRACT CANCER | APC GENE MUTATION | MUIR-TORRE-SYNDROME | NONPOLYPOSIS COLORECTAL-CANCER | DUODENAL ADENOMATOSIS | FAMILIAL ADENOMATOUS POLYPOSIS | MYH-ASSOCIATED POLYPOSIS | LYNCH SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | MSH2 MUTATION CARRIERS | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Adenomatous Polyposis Coli - epidemiology | Ovarian Neoplasms - pathology | Male | Adenomatous Polyposis Coli - pathology | Incidence | Ovarian Neoplasms - genetics | Young Adult | Gastrointestinal Neoplasms - pathology | Gastrointestinal Neoplasms - epidemiology | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - pathology | Adult | Female | Retrospective Studies | Endoscopy | Adenomatous Polyposis Coli - genetics | Child | Urinary Bladder Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Skin Neoplasms - pathology | Genetic Predisposition to Disease | Sebaceous Gland Neoplasms - epidemiology | Risk Assessment | Risk Factors | Sebaceous Gland Neoplasms - genetics | DNA Glycosylases - genetics | Kaplan-Meier Estimate | Europe - epidemiology | Skin Neoplasms - epidemiology | Ovarian Neoplasms - epidemiology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Sebaceous Gland Neoplasms - pathology | Skin Neoplasms - genetics | Adolescent | Age of Onset | Aged | Medical colleges | Animal pigments | Genetic disorders | Oncology, Experimental | Colorectal cancer | Research | Cancer | Tumors | Medical informatics
Journal Article