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Toxicology, ISSN 0300-483X, 2008, Volume 250, Issue 2, pp. 75 - 81
Abstract Endocrine disrupting chemicals can induce malformations and impairment of reproductive function in experimental animals and may have similar effects in humans... 
Emergency | Prenatal | Testis | Diisobutyl phthalate | Rat | Perfluorooctaonate | Leptin | Paraben | Rosiglitazone | Steroidogenesis | Insulin | POLYCYSTIC-OVARY-SYNDROME | DIETHYLHEXYL PHTHALATE | TESTICULAR DYSGENESIS SYNDROME | TESTOSTERONE SYNTHESIS | rat | insulin | steroidogenesis | testis | leptin | AMMONIUM PERFLUOROOCTANOATE | MALE REPRODUCTIVE-SYSTEM | perfluorooctaonate | DI(N-BUTYL) PHTHALATE | prenatal | N-BUTYL PHTHALATE | ENVIRONMENTAL OBESOGENS | diisobutyl phthalate | GENE-EXPRESSION | rosiglitazone | PHARMACOLOGY & PHARMACY | TOXICOLOGY | paraben | Estradiol - blood | Immunohistochemistry | Testis - metabolism | Gene Expression - drug effects | Rats, Wistar | Fetus - metabolism | Body Weight - drug effects | Dibutyl Phthalate - analogs & derivatives | Male | Insulin - blood | Testis - drug effects | RNA, Messenger - biosynthesis | Leptin - blood | Liver - drug effects | Female | Ovary - drug effects | Testosterone - blood | Adrenal Glands - drug effects | Steroids - biosynthesis | Ovary - metabolism | Peroxisome Proliferator-Activated Receptors - agonists | Liver - metabolism | RNA, Messenger - genetics | Rats | Gestational Age | Pregnancy | Animals | Adrenal Glands - metabolism | PPAR gamma - agonists | PPAR alpha - agonists | Dibutyl Phthalate - pharmacology | Testosterone | RNA | Physiological aspects | Insulin resistance | Thiazolidinediones | Ovary/drug effects/metabolism | PPAR alpha/agonists | Leptin/blood | Medical and Health Sciences | Dibutyl Phthalate/analogs & derivatives/pharmacology | Medicin och hälsovetenskap | Insulin/blood | Klinisk medicin | Messenger/biosynthesis/genetics | Fetus/metabolism | Estradiol/blood | Adrenal Glands/drug effects/metabolism | Steroids/biosynthesis | Gene Expression/drug effects | Body Weight/drug effects | PPAR gamma/agonists | Liver/drug effects/metabolism | Clinical Medicine | Obstetrics, Gynecology and Reproductive Medicine | Peroxisome Proliferator-Activated Receptors/agonists | Wistar | Testis/drug effects/metabolism | Reproduktionsmedicin och gynekologi | Testosterone/blood
Journal Article
Endocrinology (Philadelphia), ISSN 0013-7227, 10/2017, Volume 158, Issue 10, pp. 3647 - 3660
...) is a member of the epidermal growth factor-like factor family that mediates its effects by binding to a member of the erythroblastoma (ErbB) family... 
OOCYTE MATURATION | NERVOUS-SYSTEM | SPERMATOGONIAL PROLIFERATION | EPIDERMAL-GROWTH-FACTOR | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | PRIMORDIAL FOLLICLES | CYCLE PROGRESSION | FACTOR RECEPTOR | ERBB RECEPTORS | LUTEINIZING-HORMONE | Phosphoproteins - drug effects | Receptor, ErbB-3 - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | Ovary - cytology | Phosphoproteins - metabolism | Gonadotropins - pharmacology | Follicular Fluid | Granulosa Cells - drug effects | Granulosa Cells - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Receptor, ErbB-3 - drug effects | Caspase 3 - drug effects | Female | Ovary - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Receptor, ErbB-2 - drug effects | Ovary - metabolism | ErbB Receptors - metabolism | Cell Survival | Ovarian Follicle - growth & development | Rats | Protein Kinase C - antagonists & inhibitors | Neuregulin-1 - pharmacology | Theca Cells | ErbB Receptors - drug effects | Neuregulin-1 - drug effects | Rats, Sprague-Dawley | Animals | Neuregulin-1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - drug effects | In Vitro Techniques | bcl-X Protein - metabolism | Staurosporine - pharmacology | Proto-Oncogene Proteins c-akt - drug effects | Protein kinase C | Neuregulin 1 | Staurosporine | Crosstalk | Intracellular signalling | Hormones | Estrus cycle | Kinases | Caspase-3 | Proteins | Receptors | Epidermal growth factor | Rodents | Granulosa cells | Neuregulin | Estrus | Cell survival | Maturation | ErbB protein | Caspase | Pituitary (anterior) | Gonadotropins | ErbB-3 protein | Ovaries | Follicular fluid | Secretions | Survival | ErbB-2 protein | Cell death | Survival factor | Steroid hormones | Theca | Apoptosis
Journal Article
Journal Article
Journal Article
Reproductive toxicology (Elmsford, N.Y.), ISSN 0890-6238, 2013, Volume 36, pp. 104 - 116
[Display omitted] ► First observation that a hydrocarbon mixture (jet fuel JP-8) promotes epigenetic transgenerational inheritance of disease. ► Ancestral... 
Obesity | Ovary | Puberty | Systems biology | DNA methylation | Hydrocarbons | Environmental epigenetics | Transgenerational | POLYCYSTIC-OVARY-SYNDROME | ENDOCRINE DISRUPTOR VINCLOZOLIN | MOUSE | RATS | INDUCED IMMUNOTOXICITY | PREVALENCE | VAPOR | REPRODUCTIVE BIOLOGY | ADULT-ONSET DISEASE | FAT DIET | TOXICOLOGY | EXPOSURE | Abnormalities, Multiple - metabolism | Abnormalities, Multiple - pathology | Mutagens - toxicity | Genitalia, Male - abnormalities | Male | Genitalia, Male - pathology | Hydrocarbons - toxicity | Spermatozoa - metabolism | Infertility, Female - genetics | Obesity - genetics | Abnormalities, Drug-Induced - metabolism | Paternal Exposure - adverse effects | Infertility, Male - genetics | Infertility, Female - chemically induced | Maternal Exposure - adverse effects | Female | Ovary - drug effects | Epigenesis, Genetic - drug effects | Ovary - metabolism | Ovary - pathology | Spermatozoa - pathology | Obesity - chemically induced | Rats | Genitalia, Male - metabolism | Random Allocation | Abnormalities, Drug-Induced - pathology | Abnormalities, Multiple - chemically induced | Infertility, Male - pathology | Spermatozoa - drug effects | Rats, Sprague-Dawley | Infertility, Female - metabolism | Obesity - metabolism | Obesity - pathology | Pregnancy | Infertility, Female - pathology | Animals | Mutation - drug effects | Genitalia, Male - drug effects | Ovary - abnormalities | Infertility, Male - metabolism | Infertility, Male - chemically induced | DNA Methylation - drug effects | Fuel and fuel systems | Methylation | Jet planes | Ovarian cancer | Environmental Epigenetics | DNA Methylation | Systems Biology
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2013, Volume 271, Issue 2, pp. 156 - 167
.... Despite an increased awareness of the adverse effects of cigarette smoke exposure on systemic health, many women remain unaware of the adverse effects of cigarette smoke on female fertility... 
Cigarette | Atresia | Oxidative stress | Bioactivation | Infertility | Ovotoxicity | ACTIVATION | TGF-BETA | MICE DEFICIENT | INDUCED PREANTRAL OVOTOXICITY | 4-VINYLCYCLOHEXENE | OVEREXPRESSION | PATHWAY | HORMONE CONCENTRATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | MOUSE OVARY | Immunohistochemistry | Reactive Oxygen Species - metabolism | Oocytes - pathology | Ovarian Follicle - drug effects | RNA - isolation & purification | Caspases - metabolism | Microarray Analysis | Fertilization - drug effects | Lipid Peroxidation - drug effects | Fertility - drug effects | Infertility, Female - chemically induced | Oocytes - drug effects | Female | Real-Time Polymerase Chain Reaction | DNA Damage - drug effects | In Situ Nick-End Labeling | Ovary - pathology | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | RNA - biosynthesis | Animals | Tobacco Smoke Pollution - adverse effects | Signal Transduction - drug effects | Litter Size - drug effects | Mice | Oxidative Stress - drug effects | Ovarian Follicle - pathology | DNA microarrays | Analysis | Cytochrome P-450 | Smoking | Index Medicus | OXIDATION | APOPTOSIS | MITOCHONDRIA | MEMBRANES | 60 APPLIED LIFE SCIENCES | FERTILITY | STRESSES | TOBACCO SMOKES | METABOLISM | ENZYMES | OVULATION | OVARIES | OOCYTES | MICE
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 473, Issue 7348, pp. 478 - 483
.... Surprisingly, it also showed similar effects in the fruitfly (Drosophila melanogaster). Mechanistic studies revealed that royalactin activated p70 S6 kinase... 
CULTURED RAT HEPATOCYTES | APIS-MELLIFERA | CASTE DIFFERENTIATION | BODY-SIZE | PROTHORACIC GLAND | MULTIDISCIPLINARY SCIENCES | ENHANCES PROLIFERATION | PROTEINS | DROSOPHILA | REGULATES GROWTH | FAMILY | Temperature | Drosophila melanogaster - physiology | Longevity - drug effects | Glycoproteins - metabolism | Body Weight - drug effects | Receptor, Epidermal Growth Factor - deficiency | Bees - growth & development | Glycoproteins - pharmacology | Ovary - growth & development | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Time Factors | Larva - drug effects | Larva - growth & development | Fertility - drug effects | Female | Glycoproteins - deficiency | Ovary - drug effects | Protein Stability | Fat Body - metabolism | Fatty Acids - metabolism | Insect Proteins - metabolism | Glycoproteins - genetics | Body Size - drug effects | Fatty Acids - chemistry | Insect Proteins - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Juvenile Hormones - metabolism | Cell Size - drug effects | Drosophila melanogaster - cytology | Insect Proteins - genetics | Social Dominance | Drosophila melanogaster - drug effects | Bees - physiology | Phenotype | Animals | Signal Transduction - drug effects | Body Size - physiology | Bees - drug effects | Drosophila melanogaster - enzymology | Bees - genetics | Fat Body - drug effects | Caseins - pharmacology | Fatty Acids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Mass spectrometry | Bees
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2008, Volume 233, Issue 2, pp. 286 - 296
Methoxychlor (MXC) is an organochlorine pesticide with estrogenic, anti-estrogenic, and anti-androgenic properties. To investigate whether transient... 
Endocrine disruptors | Ovary | Folliculogenesis | Estrogen receptor-β | Development | Luteinizing hormone receptor | Steroidogenesis | Anti-Mullerian hormone | GRANULOSA-CELL DIFFERENTIATION | ALPHA | ESTROGEN-RECEPTOR-BETA | IN-VITRO | FOLLICULAR DEVELOPMENT | PHARMACOLOGY & PHARMACY | Estrogen receptor-beta | BISPHENOL-A | TOXICOLOGY | LH RECEPTORS | MOUSE OVARY | Immunohistochemistry | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Rats, Inbred F344 | Luteinizing Hormone - metabolism | Sexual Maturation - drug effects | Estrogen Receptor beta - drug effects | Dose-Response Relationship, Drug | Estrogen Receptor beta - metabolism | Insecticides - administration & dosage | Ovarian Follicle - drug effects | Fertility - drug effects | Female | Ovulation - drug effects | Luteinizing Hormone - drug effects | Cholesterol Side-Chain Cleavage Enzyme - drug effects | Rats | Estrous Cycle - drug effects | Gene Expression Regulation - drug effects | Pregnancy | Methoxychlor - toxicity | Animals | Methoxychlor - administration & dosage | Progesterone - metabolism | Litter Size - drug effects | Anti-Mullerian Hormone - metabolism | Ovarian Follicle - pathology | Insecticides - toxicity | Index Medicus | ESTROGENS | LUTEINIZING HORMONE | ORGANIC CHLORINE COMPOUNDS | PROGESTERONE | LITTER SIZE | RATS | AGING | 60 APPLIED LIFE SCIENCES | FERTILITY | PESTICIDES | DOSES | GENES | OVARIES | RECEPTORS | MORPHOLOGY | folliculogenesis | ovary | development | anti-Mullerian hormone | endocrine disruptors | steroidogenesis | luteinizing hormone receptor | estrogen receptor-β
Journal Article